Coiled-coil domain-containing protein 170

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKY8_LEIMU

TriTrypDb:

LmxM.06.1090

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0034451	centriolar satellite	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AKY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKY8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	384	386	PF00675	0.550
CLV_NRD_NRD_1	398	400	PF00675	0.409
CLV_NRD_NRD_1	574	576	PF00675	0.632
CLV_NRD_NRD_1	73	75	PF00675	0.637
CLV_NRD_NRD_1	9	11	PF00675	0.621
CLV_NRD_NRD_1	96	98	PF00675	0.481
CLV_PCSK_KEX2_1	197	199	PF00082	0.462
CLV_PCSK_KEX2_1	384	386	PF00082	0.628
CLV_PCSK_KEX2_1	409	411	PF00082	0.418
CLV_PCSK_KEX2_1	574	576	PF00082	0.632
CLV_PCSK_KEX2_1	73	75	PF00082	0.637
CLV_PCSK_KEX2_1	9	11	PF00082	0.621
CLV_PCSK_KEX2_1	96	98	PF00082	0.481
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.520
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.410
CLV_PCSK_PC7_1	5	11	PF00082	0.777
CLV_PCSK_SKI1_1	30	34	PF00082	0.794
CLV_PCSK_SKI1_1	443	447	PF00082	0.427
CLV_PCSK_SKI1_1	481	485	PF00082	0.430
CLV_PCSK_SKI1_1	496	500	PF00082	0.420
CLV_PCSK_SKI1_1	509	513	PF00082	0.421
CLV_PCSK_SKI1_1	81	85	PF00082	0.549
CLV_Separin_Metazoa	504	508	PF03568	0.408
DEG_APCC_DBOX_1	442	450	PF00400	0.581
DEG_APCC_DBOX_1	501	509	PF00400	0.397
DEG_APCC_DBOX_1	80	88	PF00400	0.568
DEG_SPOP_SBC_1	56	60	PF00917	0.610
DOC_CYCLIN_RxL_1	407	415	PF00134	0.391
DOC_CYCLIN_RxL_1	507	519	PF00134	0.473
DOC_MAPK_gen_1	397	407	PF00069	0.417
DOC_MAPK_gen_1	481	488	PF00069	0.596
DOC_MAPK_gen_1	507	517	PF00069	0.444
DOC_MAPK_MEF2A_6	144	151	PF00069	0.611
DOC_MAPK_MEF2A_6	481	488	PF00069	0.467
DOC_MAPK_NFAT4_5	481	489	PF00069	0.467
DOC_PP2B_LxvP_1	393	396	PF13499	0.465
DOC_PP4_FxxP_1	521	524	PF00568	0.713
DOC_USP7_MATH_1	135	139	PF00917	0.468
DOC_USP7_MATH_1	364	368	PF00917	0.550
DOC_USP7_MATH_1	545	549	PF00917	0.688
DOC_USP7_MATH_1	56	60	PF00917	0.731
DOC_USP7_MATH_1	562	566	PF00917	0.795
DOC_USP7_MATH_1	568	572	PF00917	0.746
DOC_WW_Pin1_4	44	49	PF00397	0.742
DOC_WW_Pin1_4	448	453	PF00397	0.427
DOC_WW_Pin1_4	578	583	PF00397	0.729
DOC_WW_Pin1_4	87	92	PF00397	0.571
LIG_14-3-3_CanoR_1	132	140	PF00244	0.457
LIG_14-3-3_CanoR_1	288	292	PF00244	0.455
LIG_14-3-3_CanoR_1	340	346	PF00244	0.444
LIG_14-3-3_CanoR_1	384	392	PF00244	0.446
LIG_14-3-3_CanoR_1	493	499	PF00244	0.508
LIG_Actin_WH2_2	174	191	PF00022	0.552
LIG_Actin_WH2_2	504	520	PF00022	0.500
LIG_APCC_ABBAyCdc20_2	409	415	PF00400	0.542
LIG_BRCT_BRCA1_1	355	359	PF00533	0.469
LIG_CtBP_PxDLS_1	590	594	PF00389	0.615
LIG_FHA_1	109	115	PF00498	0.549
LIG_FHA_1	124	130	PF00498	0.351
LIG_FHA_1	276	282	PF00498	0.398
LIG_FHA_1	402	408	PF00498	0.454
LIG_FHA_2	154	160	PF00498	0.488
LIG_FHA_2	227	233	PF00498	0.557
LIG_FHA_2	346	352	PF00498	0.414
LIG_FHA_2	523	529	PF00498	0.587
LIG_LIR_Apic_2	519	524	PF02991	0.676
LIG_LIR_Gen_1	157	166	PF02991	0.548
LIG_LIR_Gen_1	390	396	PF02991	0.468
LIG_LIR_Gen_1	451	461	PF02991	0.422
LIG_LIR_LC3C_4	404	407	PF02991	0.560
LIG_LIR_Nem_3	157	163	PF02991	0.478
LIG_LIR_Nem_3	319	324	PF02991	0.388
LIG_LIR_Nem_3	390	395	PF02991	0.470
LIG_LIR_Nem_3	451	456	PF02991	0.423
LIG_PCNA_yPIPBox_3	170	183	PF02747	0.481
LIG_SH2_CRK	182	186	PF00017	0.414
LIG_SH2_NCK_1	75	79	PF00017	0.363
LIG_SH2_PTP2	453	456	PF00017	0.565
LIG_SH2_SRC	75	78	PF00017	0.363
LIG_SH2_STAP1	322	326	PF00017	0.376
LIG_SH2_STAT3	266	269	PF00017	0.394
LIG_SH2_STAT5	266	269	PF00017	0.454
LIG_SH2_STAT5	453	456	PF00017	0.565
LIG_SH3_3	12	18	PF00018	0.684
LIG_SH3_3	85	91	PF00018	0.553
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.479
LIG_SUMO_SIM_par_1	331	336	PF11976	0.459
LIG_SUMO_SIM_par_1	403	408	PF11976	0.453
LIG_TRAF2_1	156	159	PF00917	0.511
LIG_TRAF2_1	341	344	PF00917	0.434
LIG_TRAF2_1	577	580	PF00917	0.583
LIG_UBA3_1	505	510	PF00899	0.495
LIG_UBA3_1	83	92	PF00899	0.524
LIG_WW_3	10	14	PF00397	0.664
MOD_CDK_SPK_2	87	92	PF00069	0.617
MOD_CK1_1	123	129	PF00069	0.400
MOD_CK1_1	42	48	PF00069	0.717
MOD_CK1_1	494	500	PF00069	0.428
MOD_CK1_1	54	60	PF00069	0.509
MOD_CK2_1	153	159	PF00069	0.479
MOD_CK2_1	226	232	PF00069	0.564
MOD_CK2_1	522	528	PF00069	0.579
MOD_CK2_1	574	580	PF00069	0.739
MOD_Cter_Amidation	382	385	PF01082	0.435
MOD_DYRK1A_RPxSP_1	44	48	PF00069	0.750
MOD_GlcNHglycan	273	276	PF01048	0.558
MOD_GlcNHglycan	547	550	PF01048	0.714
MOD_GlcNHglycan	551	554	PF01048	0.682
MOD_GlcNHglycan	576	579	PF01048	0.605
MOD_GlcNHglycan	59	62	PF01048	0.661
MOD_GSK3_1	149	156	PF00069	0.561
MOD_GSK3_1	184	191	PF00069	0.417
MOD_GSK3_1	222	229	PF00069	0.536
MOD_GSK3_1	271	278	PF00069	0.412
MOD_GSK3_1	293	300	PF00069	0.479
MOD_GSK3_1	30	37	PF00069	0.719
MOD_GSK3_1	358	365	PF00069	0.472
MOD_GSK3_1	40	47	PF00069	0.673
MOD_GSK3_1	401	408	PF00069	0.459
MOD_GSK3_1	48	55	PF00069	0.628
MOD_GSK3_1	543	550	PF00069	0.736
MOD_GSK3_1	574	581	PF00069	0.756
MOD_N-GLC_1	133	138	PF02516	0.568
MOD_N-GLC_1	261	266	PF02516	0.553
MOD_NEK2_1	108	113	PF00069	0.437
MOD_NEK2_1	149	154	PF00069	0.587
MOD_NEK2_1	188	193	PF00069	0.536
MOD_NEK2_1	202	207	PF00069	0.562
MOD_NEK2_1	358	363	PF00069	0.450
MOD_NEK2_1	401	406	PF00069	0.427
MOD_NEK2_1	556	561	PF00069	0.746
MOD_NEK2_2	287	292	PF00069	0.473
MOD_NEK2_2	491	496	PF00069	0.430
MOD_PIKK_1	133	139	PF00454	0.423
MOD_PIKK_1	142	148	PF00454	0.454
MOD_PIKK_1	188	194	PF00454	0.557
MOD_PIKK_1	222	228	PF00454	0.551
MOD_PIKK_1	297	303	PF00454	0.534
MOD_PIKK_1	353	359	PF00454	0.486
MOD_PIKK_1	364	370	PF00454	0.622
MOD_PIKK_1	557	563	PF00454	0.698
MOD_PKA_1	574	580	PF00069	0.547
MOD_PKA_2	188	194	PF00069	0.418
MOD_PKA_2	287	293	PF00069	0.471
MOD_PKA_2	339	345	PF00069	0.374
MOD_PKA_2	383	389	PF00069	0.655
MOD_PKA_2	537	543	PF00069	0.703
MOD_PKA_2	574	580	PF00069	0.697
MOD_Plk_1	120	126	PF00069	0.459
MOD_Plk_1	261	267	PF00069	0.551
MOD_Plk_4	261	267	PF00069	0.478
MOD_Plk_4	401	407	PF00069	0.502
MOD_ProDKin_1	44	50	PF00069	0.739
MOD_ProDKin_1	448	454	PF00069	0.421
MOD_ProDKin_1	578	584	PF00069	0.726
MOD_ProDKin_1	87	93	PF00069	0.569
MOD_SUMO_for_1	317	320	PF00179	0.374
MOD_SUMO_rev_2	212	218	PF00179	0.553
MOD_SUMO_rev_2	308	314	PF00179	0.389
MOD_SUMO_rev_2	319	326	PF00179	0.388
MOD_SUMO_rev_2	342	346	PF00179	0.564
MOD_SUMO_rev_2	478	484	PF00179	0.548
TRG_DiLeu_BaEn_1	110	115	PF01217	0.482
TRG_DiLeu_BaEn_2	354	360	PF01217	0.415
TRG_ENDOCYTIC_2	160	163	PF00928	0.477
TRG_ENDOCYTIC_2	182	185	PF00928	0.417
TRG_ENDOCYTIC_2	321	324	PF00928	0.401
TRG_ENDOCYTIC_2	453	456	PF00928	0.565
TRG_ER_diArg_1	396	399	PF00400	0.455
TRG_ER_diArg_1	574	576	PF00400	0.499
TRG_ER_diArg_1	73	75	PF00400	0.637
TRG_ER_diArg_1	9	11	PF00400	0.615
TRG_ER_diArg_1	95	97	PF00400	0.485
TRG_NES_CRM1_1	172	184	PF08389	0.478
TRG_NES_CRM1_1	344	355	PF08389	0.402
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D2	Leptomonas seymouri	60%	100%
A0A0S4KJ48	Bodo saltans	37%	100%
A0A1X0NFW7	Trypanosomatidae	52%	100%
A0A1X0NGS8	Trypanosomatidae	52%	98%
A0A3R7KEX6	Trypanosoma rangeli	49%	97%
A0A3S7WPN7	Leishmania donovani	92%	100%
A4H4S1	Leishmania braziliensis	79%	100%
A4HT01	Leishmania infantum	93%	100%
C9ZTN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4QIW7	Leishmania major	92%	100%
V5BXW3	Trypanosoma cruzi	51%	97%