Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AKY5_LEIMU

TriTrypDb:

LmxM.06.1060

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKY5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.708
CLV_NRD_NRD_1	265	267	PF00675	0.441
CLV_NRD_NRD_1	331	333	PF00675	0.744
CLV_PCSK_FUR_1	328	332	PF00082	0.708
CLV_PCSK_KEX2_1	264	266	PF00082	0.438
CLV_PCSK_KEX2_1	327	329	PF00082	0.716
CLV_PCSK_KEX2_1	330	332	PF00082	0.734
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.752
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.769
CLV_PCSK_SKI1_1	209	213	PF00082	0.301
CLV_PCSK_SKI1_1	28	32	PF00082	0.609
CLV_PCSK_SKI1_1	324	328	PF00082	0.751
DEG_Kelch_Keap1_1	313	318	PF01344	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DOC_CKS1_1	249	254	PF01111	0.487
DOC_CYCLIN_RxL_1	206	216	PF00134	0.487
DOC_MAPK_FxFP_2	222	225	PF00069	0.476
DOC_MAPK_gen_1	193	203	PF00069	0.472
DOC_MAPK_MEF2A_6	196	205	PF00069	0.476
DOC_PP1_RVXF_1	207	214	PF00149	0.476
DOC_PP4_FxxP_1	141	144	PF00568	0.481
DOC_PP4_FxxP_1	222	225	PF00568	0.476
DOC_SPAK_OSR1_1	256	260	PF12202	0.518
DOC_USP7_MATH_1	207	211	PF00917	0.501
DOC_USP7_MATH_1	308	312	PF00917	0.699
DOC_USP7_MATH_1	56	60	PF00917	0.554
DOC_WW_Pin1_4	248	253	PF00397	0.487
LIG_14-3-3_CanoR_1	264	269	PF00244	0.455
LIG_14-3-3_CanoR_1	286	292	PF00244	0.530
LIG_BRCT_BRCA1_1	147	151	PF00533	0.396
LIG_BRCT_BRCA1_1	209	213	PF00533	0.501
LIG_deltaCOP1_diTrp_1	134	141	PF00928	0.505
LIG_FHA_1	1	7	PF00498	0.606
LIG_FHA_1	198	204	PF00498	0.476
LIG_FHA_1	206	212	PF00498	0.476
LIG_FHA_1	233	239	PF00498	0.476
LIG_FHA_1	241	247	PF00498	0.476
LIG_FHA_2	148	154	PF00498	0.462
LIG_FHA_2	265	271	PF00498	0.499
LIG_FHA_2	288	294	PF00498	0.472
LIG_FHA_2	308	314	PF00498	0.728
LIG_Integrin_isoDGR_2	284	286	PF01839	0.403
LIG_LIR_Apic_2	221	225	PF02991	0.562
LIG_LIR_Gen_1	148	159	PF02991	0.370
LIG_LIR_Gen_1	255	261	PF02991	0.520
LIG_LIR_Gen_1	59	68	PF02991	0.330
LIG_LIR_Gen_1	85	95	PF02991	0.461
LIG_LIR_Nem_3	148	154	PF02991	0.377
LIG_LIR_Nem_3	160	164	PF02991	0.328
LIG_LIR_Nem_3	221	227	PF02991	0.553
LIG_LIR_Nem_3	255	260	PF02991	0.520
LIG_LIR_Nem_3	59	63	PF02991	0.536
LIG_LIR_Nem_3	85	90	PF02991	0.403
LIG_SH2_CRK	111	115	PF00017	0.428
LIG_SH2_STAP1	167	171	PF00017	0.486
LIG_SH2_STAT5	161	164	PF00017	0.457
LIG_SH2_STAT5	97	100	PF00017	0.367
LIG_SH3_3	246	252	PF00018	0.460
LIG_SH3_3	32	38	PF00018	0.690
MOD_CK1_1	145	151	PF00069	0.487
MOD_CK2_1	110	116	PF00069	0.504
MOD_CK2_1	264	270	PF00069	0.471
MOD_CK2_1	312	318	PF00069	0.655
MOD_Cter_Amidation	262	265	PF01082	0.414
MOD_DYRK1A_RPxSP_1	248	252	PF00069	0.470
MOD_GlcNHglycan	128	131	PF01048	0.671
MOD_GlcNHglycan	20	23	PF01048	0.512
MOD_GlcNHglycan	277	280	PF01048	0.689
MOD_GlcNHglycan	310	313	PF01048	0.735
MOD_GlcNHglycan	315	318	PF01048	0.714
MOD_GlcNHglycan	7	10	PF01048	0.620
MOD_GlcNHglycan	75	78	PF01048	0.484
MOD_GlcNHglycan	85	90	PF01048	0.270
MOD_GSK3_1	122	129	PF00069	0.406
MOD_GSK3_1	197	204	PF00069	0.487
MOD_GSK3_1	308	315	PF00069	0.725
MOD_NEK2_1	110	115	PF00069	0.528
MOD_NEK2_1	126	131	PF00069	0.567
MOD_NEK2_1	205	210	PF00069	0.487
MOD_NEK2_1	44	49	PF00069	0.489
MOD_PIKK_1	145	151	PF00454	0.538
MOD_PIKK_1	175	181	PF00454	0.562
MOD_PIKK_1	215	221	PF00454	0.562
MOD_PKA_1	264	270	PF00069	0.458
MOD_PKA_2	255	261	PF00069	0.525
MOD_PKA_2	264	270	PF00069	0.465
MOD_Plk_1	197	203	PF00069	0.476
MOD_Plk_1	85	91	PF00069	0.525
MOD_Plk_4	122	128	PF00069	0.573
MOD_Plk_4	45	51	PF00069	0.443
MOD_ProDKin_1	248	254	PF00069	0.487
MOD_SUMO_for_1	114	117	PF00179	0.417
MOD_SUMO_rev_2	21	30	PF00179	0.721
TRG_ENDOCYTIC_2	111	114	PF00928	0.408
TRG_ENDOCYTIC_2	161	164	PF00928	0.487
TRG_ER_diArg_1	264	266	PF00400	0.454
TRG_ER_diArg_1	331	333	PF00400	0.716
TRG_ER_diArg_1	38	41	PF00400	0.549
TRG_ER_diArg_1	50	53	PF00400	0.549
TRG_NES_CRM1_1	153	165	PF08389	0.382
TRG_NLS_MonoCore_2	326	331	PF00514	0.605
TRG_NLS_MonoExtC_3	326	331	PF00514	0.634
TRG_NLS_MonoExtN_4	324	331	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD0	Leptomonas seymouri	74%	90%
A0A0S4JRX9	Bodo saltans	49%	100%
A0A1X0NKP4	Trypanosomatidae	63%	100%
A0A3R7KF49	Trypanosoma rangeli	62%	98%
A0A3S7WPM5	Leishmania donovani	90%	100%
A4H4R9	Leishmania braziliensis	79%	100%
A4HSZ8	Leishmania infantum	90%	97%
C9ZTN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
Q4QIX0	Leishmania major	88%	100%
V5BXY4	Trypanosoma cruzi	65%	100%