Protein disulfide isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein disulfide isomerase

Species:

Leishmania mexicana

UniProt:

E9AKY4_LEIMU

TriTrypDb:

LmxM.06.1050

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 3
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

E9AKY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKY4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	10
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016860	intramolecular oxidoreductase activity	3	10
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.574
CLV_PCSK_SKI1_1	35	39	PF00082	0.308
CLV_PCSK_SKI1_1	42	46	PF00082	0.288
DEG_APCC_DBOX_1	4	12	PF00400	0.531
DOC_MAPK_gen_1	5	12	PF00069	0.540
DOC_MAPK_MEF2A_6	5	14	PF00069	0.548
DOC_PP4_FxxP_1	48	51	PF00568	0.333
DOC_USP7_MATH_1	123	127	PF00917	0.433
DOC_USP7_UBL2_3	102	106	PF12436	0.374
DOC_USP7_UBL2_3	38	42	PF12436	0.336
LIG_14-3-3_CanoR_1	5	9	PF00244	0.593
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	89	93	PF00533	0.428
LIG_FHA_1	5	11	PF00498	0.648
LIG_FHA_2	60	66	PF00498	0.361
LIG_GBD_Chelix_1	8	16	PF00786	0.557
LIG_LIR_Apic_2	112	118	PF02991	0.416
LIG_LIR_Gen_1	61	71	PF02991	0.296
LIG_LIR_Nem_3	122	127	PF02991	0.443
LIG_LIR_Nem_3	61	66	PF02991	0.384
LIG_LIR_Nem_3	84	89	PF02991	0.395
LIG_LYPXL_yS_3	70	73	PF13949	0.462
LIG_NRBOX	7	13	PF00104	0.642
LIG_Pex14_2	48	52	PF04695	0.333
LIG_REV1ctd_RIR_1	101	111	PF16727	0.299
LIG_SH2_CRK	86	90	PF00017	0.519
LIG_SH2_STAT5	127	130	PF00017	0.504
LIG_SH3_3	34	40	PF00018	0.357
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.496
MOD_CK1_1	126	132	PF00069	0.223
MOD_CK2_1	59	65	PF00069	0.475
MOD_GlcNHglycan	109	112	PF01048	0.492
MOD_GlcNHglycan	120	124	PF01048	0.401
MOD_GlcNHglycan	128	131	PF01048	0.494
MOD_GSK3_1	119	126	PF00069	0.278
MOD_N-GLC_1	107	112	PF02516	0.273
MOD_NEK2_1	59	64	PF00069	0.373
MOD_PKA_2	4	10	PF00069	0.609
MOD_Plk_1	119	125	PF00069	0.422
MOD_Plk_4	123	129	PF00069	0.318
MOD_Plk_4	59	65	PF00069	0.357
TRG_DiLeu_BaEn_2	119	125	PF01217	0.299
TRG_ENDOCYTIC_2	70	73	PF00928	0.474
TRG_ENDOCYTIC_2	86	89	PF00928	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I216	Leptomonas seymouri	35%	94%
A0A0N1I5T9	Leptomonas seymouri	53%	100%
A0A0N1IJS7	Leptomonas seymouri	26%	81%
A0A0S4JA26	Bodo saltans	49%	80%
A0A1X0NGQ4	Trypanosomatidae	35%	90%
A0A1X0NT33	Trypanosomatidae	30%	80%
A0A3R7NHA8	Trypanosoma rangeli	51%	73%
A0A422NM49	Trypanosoma rangeli	35%	89%
A4H4R8	Leishmania braziliensis	75%	100%
A4H4T0	Leishmania braziliensis	34%	100%
A4HSZ7	Leishmania infantum	83%	100%
A4HT10	Leishmania infantum	34%	90%
C9ZTP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	88%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
E9AKZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	90%
O64432	Brassica campestris	29%	100%
P07591	Spinacia oleracea	29%	73%
P29451	Macaca mulatta	33%	100%
P52228	Corynebacterium nephridii	31%	92%
Q10N04	Oryza sativa subsp. japonica	28%	90%
Q4QIV7	Leishmania major	34%	70%
Q4QIX1	Leishmania major	82%	100%
Q8GYD1	Arabidopsis thaliana	26%	91%
Q8I7Z7	Leishmania donovani	84%	100%