Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9AKY2_LEIMU

TriTrypDb:

LmxM.06.1030

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	3
GO:0032991	protein-containing complex	1	3
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	3
GO:0035869	ciliary transition zone	2	1

Expansion

Sequence features

E9AKY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKY2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0051231	spindle elongation	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140657	ATP-dependent activity	1	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003824	catalytic activity	1	11
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.204
CLV_C14_Caspase3-7	569	573	PF00656	0.510
CLV_C14_Caspase3-7	631	635	PF00656	0.624
CLV_C14_Caspase3-7	726	730	PF00656	0.563
CLV_C14_Caspase3-7	771	775	PF00656	0.591
CLV_C14_Caspase3-7	777	781	PF00656	0.549
CLV_NRD_NRD_1	156	158	PF00675	0.211
CLV_NRD_NRD_1	231	233	PF00675	0.314
CLV_NRD_NRD_1	390	392	PF00675	0.577
CLV_NRD_NRD_1	398	400	PF00675	0.526
CLV_NRD_NRD_1	484	486	PF00675	0.398
CLV_NRD_NRD_1	505	507	PF00675	0.634
CLV_NRD_NRD_1	510	512	PF00675	0.580
CLV_NRD_NRD_1	535	537	PF00675	0.474
CLV_NRD_NRD_1	664	666	PF00675	0.581
CLV_NRD_NRD_1	746	748	PF00675	0.609
CLV_NRD_NRD_1	778	780	PF00675	0.592
CLV_NRD_NRD_1	792	794	PF00675	0.512
CLV_NRD_NRD_1	823	825	PF00675	0.587
CLV_PCSK_FUR_1	388	392	PF00082	0.484
CLV_PCSK_KEX2_1	156	158	PF00082	0.211
CLV_PCSK_KEX2_1	231	233	PF00082	0.286
CLV_PCSK_KEX2_1	390	392	PF00082	0.577
CLV_PCSK_KEX2_1	398	400	PF00082	0.526
CLV_PCSK_KEX2_1	509	511	PF00082	0.546
CLV_PCSK_KEX2_1	535	537	PF00082	0.506
CLV_PCSK_KEX2_1	664	666	PF00082	0.581
CLV_PCSK_KEX2_1	778	780	PF00082	0.820
CLV_PCSK_KEX2_1	792	794	PF00082	0.512
CLV_PCSK_KEX2_1	823	825	PF00082	0.587
CLV_PCSK_PC7_1	227	233	PF00082	0.289
CLV_PCSK_PC7_1	506	512	PF00082	0.404
CLV_PCSK_PC7_1	819	825	PF00082	0.548
CLV_PCSK_SKI1_1	166	170	PF00082	0.320
CLV_PCSK_SKI1_1	187	191	PF00082	0.260
CLV_PCSK_SKI1_1	231	235	PF00082	0.311
CLV_PCSK_SKI1_1	40	44	PF00082	0.425
CLV_PCSK_SKI1_1	476	480	PF00082	0.407
CLV_PCSK_SKI1_1	511	515	PF00082	0.506
CLV_PCSK_SKI1_1	568	572	PF00082	0.633
CLV_PCSK_SKI1_1	575	579	PF00082	0.559
CLV_PCSK_SKI1_1	707	711	PF00082	0.541
CLV_PCSK_SKI1_1	87	91	PF00082	0.289
CLV_PCSK_SKI1_1	884	888	PF00082	0.440
CLV_Separin_Metazoa	844	848	PF03568	0.429
DEG_APCC_DBOX_1	876	884	PF00400	0.403
DOC_ANK_TNKS_1	143	150	PF00023	0.182
DOC_CYCLIN_RxL_1	436	447	PF00134	0.428
DOC_MAPK_gen_1	271	280	PF00069	0.289
DOC_MAPK_gen_1	869	878	PF00069	0.435
DOC_MAPK_MEF2A_6	273	282	PF00069	0.289
DOC_MAPK_MEF2A_6	4	11	PF00069	0.426
DOC_MAPK_MEF2A_6	588	595	PF00069	0.587
DOC_MAPK_MEF2A_6	871	880	PF00069	0.429
DOC_USP7_MATH_1	118	122	PF00917	0.261
DOC_USP7_MATH_1	152	156	PF00917	0.308
DOC_USP7_MATH_1	233	237	PF00917	0.261
DOC_USP7_MATH_1	241	245	PF00917	0.223
DOC_USP7_MATH_1	329	333	PF00917	0.371
DOC_USP7_MATH_1	432	436	PF00917	0.398
DOC_USP7_MATH_1	448	452	PF00917	0.465
DOC_USP7_MATH_1	597	601	PF00917	0.622
DOC_USP7_MATH_1	701	705	PF00917	0.583
DOC_USP7_MATH_1	742	746	PF00917	0.556
DOC_USP7_MATH_1	750	754	PF00917	0.529
DOC_USP7_MATH_1	762	766	PF00917	0.548
DOC_USP7_MATH_1	769	773	PF00917	0.558
DOC_WW_Pin1_4	120	125	PF00397	0.414
DOC_WW_Pin1_4	176	181	PF00397	0.313
DOC_WW_Pin1_4	197	202	PF00397	0.286
DOC_WW_Pin1_4	391	396	PF00397	0.626
DOC_WW_Pin1_4	398	403	PF00397	0.549
DOC_WW_Pin1_4	622	627	PF00397	0.661
DOC_WW_Pin1_4	666	671	PF00397	0.640
DOC_WW_Pin1_4	694	699	PF00397	0.628
DOC_WW_Pin1_4	738	743	PF00397	0.707
DOC_WW_Pin1_4	781	786	PF00397	0.560
LIG_14-3-3_CanoR_1	176	180	PF00244	0.273
LIG_14-3-3_CanoR_1	604	610	PF00244	0.607
LIG_14-3-3_CanoR_1	618	626	PF00244	0.659
LIG_14-3-3_CanoR_1	747	755	PF00244	0.592
LIG_14-3-3_CanoR_1	796	802	PF00244	0.540
LIG_Actin_WH2_2	95	111	PF00022	0.278
LIG_APCC_ABBA_1	136	141	PF00400	0.394
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BRCT_BRCA1_1	38	42	PF00533	0.182
LIG_BRCT_BRCA1_1	793	797	PF00533	0.507
LIG_Clathr_ClatBox_1	189	193	PF01394	0.218
LIG_Clathr_ClatBox_1	875	879	PF01394	0.408
LIG_CtBP_PxDLS_1	409	413	PF00389	0.569
LIG_EH1_1	88	96	PF00400	0.311
LIG_FHA_1	125	131	PF00498	0.454
LIG_FHA_1	24	30	PF00498	0.507
LIG_FHA_1	273	279	PF00498	0.292
LIG_FHA_1	288	294	PF00498	0.210
LIG_FHA_1	334	340	PF00498	0.394
LIG_FHA_1	347	353	PF00498	0.394
LIG_FHA_1	490	496	PF00498	0.450
LIG_FHA_1	52	58	PF00498	0.300
LIG_FHA_1	569	575	PF00498	0.607
LIG_FHA_1	638	644	PF00498	0.587
LIG_FHA_1	750	756	PF00498	0.489
LIG_FHA_1	796	802	PF00498	0.521
LIG_FHA_1	86	92	PF00498	0.488
LIG_FHA_2	140	146	PF00498	0.283
LIG_FHA_2	470	476	PF00498	0.428
LIG_FHA_2	557	563	PF00498	0.681
LIG_FHA_2	695	701	PF00498	0.559
LIG_FHA_2	765	771	PF00498	0.755
LIG_FHA_2	775	781	PF00498	0.545
LIG_FHA_2	849	855	PF00498	0.447
LIG_Integrin_RGD_1	227	229	PF01839	0.246
LIG_LIR_Gen_1	368	379	PF02991	0.311
LIG_LIR_Gen_1	447	456	PF02991	0.416
LIG_LIR_Nem_3	368	374	PF02991	0.311
LIG_LIR_Nem_3	447	452	PF02991	0.414
LIG_LIR_Nem_3	640	645	PF02991	0.772
LIG_LIR_Nem_3	704	708	PF02991	0.693
LIG_NRBOX	334	340	PF00104	0.394
LIG_Pex14_2	69	73	PF04695	0.311
LIG_SH2_CRK	371	375	PF00017	0.311
LIG_SH2_CRK	449	453	PF00017	0.415
LIG_SH2_PTP2	135	138	PF00017	0.311
LIG_SH2_PTP2	642	645	PF00017	0.559
LIG_SH2_SRC	135	138	PF00017	0.311
LIG_SH2_SRC	58	61	PF00017	0.253
LIG_SH2_STAP1	257	261	PF00017	0.311
LIG_SH2_STAP1	456	460	PF00017	0.448
LIG_SH2_STAP1	58	62	PF00017	0.253
LIG_SH2_STAT3	456	459	PF00017	0.395
LIG_SH2_STAT5	132	135	PF00017	0.325
LIG_SH2_STAT5	371	374	PF00017	0.311
LIG_SH2_STAT5	642	645	PF00017	0.640
LIG_SH2_STAT5	708	711	PF00017	0.608
LIG_SH3_3	144	150	PF00018	0.227
LIG_SH3_3	25	31	PF00018	0.409
LIG_SH3_3	623	629	PF00018	0.574
LIG_SH3_3	667	673	PF00018	0.708
LIG_SH3_3	695	701	PF00018	0.559
LIG_SUMO_SIM_anti_2	834	842	PF11976	0.452
LIG_SUMO_SIM_par_1	25	30	PF11976	0.378
LIG_SUMO_SIM_par_1	408	414	PF11976	0.571
LIG_SUMO_SIM_par_1	441	447	PF11976	0.415
LIG_SUMO_SIM_par_1	805	811	PF11976	0.524
LIG_SUMO_SIM_par_1	95	101	PF11976	0.289
LIG_TRAF2_1	497	500	PF00917	0.411
LIG_TRAF2_1	644	647	PF00917	0.594
LIG_TYR_ITIM	133	138	PF00017	0.311
LIG_TYR_ITIM	369	374	PF00017	0.311
LIG_UBA3_1	98	106	PF00899	0.261
MOD_CDC14_SPxK_1	181	184	PF00782	0.218
MOD_CDC14_SPxK_1	625	628	PF00782	0.645
MOD_CDK_SPxK_1	178	184	PF00069	0.218
MOD_CDK_SPxK_1	622	628	PF00069	0.648
MOD_CDK_SPxxK_3	391	398	PF00069	0.521
MOD_CK1_1	200	206	PF00069	0.204
MOD_CK1_1	243	249	PF00069	0.386
MOD_CK1_1	333	339	PF00069	0.394
MOD_CK1_1	435	441	PF00069	0.374
MOD_CK1_1	469	475	PF00069	0.419
MOD_CK1_1	622	628	PF00069	0.648
MOD_CK1_1	690	696	PF00069	0.588
MOD_CK1_1	741	747	PF00069	0.625
MOD_CK1_1	749	755	PF00069	0.622
MOD_CK1_1	765	771	PF00069	0.544
MOD_CK1_1	791	797	PF00069	0.532
MOD_CK2_1	266	272	PF00069	0.376
MOD_CK2_1	408	414	PF00069	0.583
MOD_CK2_1	469	475	PF00069	0.484
MOD_CK2_1	694	700	PF00069	0.571
MOD_CK2_1	764	770	PF00069	0.520
MOD_CK2_1	807	813	PF00069	0.563
MOD_CK2_1	848	854	PF00069	0.415
MOD_Cter_Amidation	662	665	PF01082	0.546
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.302
MOD_DYRK1A_RPxSP_1	391	395	PF00069	0.509
MOD_GlcNHglycan	109	112	PF01048	0.342
MOD_GlcNHglycan	119	123	PF01048	0.274
MOD_GlcNHglycan	172	175	PF01048	0.182
MOD_GlcNHglycan	346	349	PF01048	0.274
MOD_GlcNHglycan	402	405	PF01048	0.580
MOD_GlcNHglycan	446	449	PF01048	0.416
MOD_GlcNHglycan	607	610	PF01048	0.791
MOD_GlcNHglycan	621	624	PF01048	0.572
MOD_GlcNHglycan	689	692	PF01048	0.670
MOD_GlcNHglycan	748	751	PF01048	0.577
MOD_GlcNHglycan	834	838	PF01048	0.422
MOD_GSK3_1	118	125	PF00069	0.292
MOD_GSK3_1	166	173	PF00069	0.208
MOD_GSK3_1	227	234	PF00069	0.369
MOD_GSK3_1	32	39	PF00069	0.275
MOD_GSK3_1	329	336	PF00069	0.386
MOD_GSK3_1	444	451	PF00069	0.482
MOD_GSK3_1	462	469	PF00069	0.394
MOD_GSK3_1	515	522	PF00069	0.648
MOD_GSK3_1	686	693	PF00069	0.560
MOD_GSK3_1	737	744	PF00069	0.650
MOD_GSK3_1	746	753	PF00069	0.603
MOD_GSK3_1	764	771	PF00069	0.523
MOD_GSK3_1	791	798	PF00069	0.489
MOD_N-GLC_1	73	78	PF02516	0.311
MOD_NEK2_1	167	172	PF00069	0.311
MOD_NEK2_1	282	287	PF00069	0.311
MOD_NEK2_1	339	344	PF00069	0.334
MOD_NEK2_1	466	471	PF00069	0.426
MOD_NEK2_1	589	594	PF00069	0.582
MOD_NEK2_1	73	78	PF00069	0.311
MOD_NEK2_1	797	802	PF00069	0.546
MOD_NEK2_2	139	144	PF00069	0.327
MOD_NEK2_2	248	253	PF00069	0.311
MOD_NEK2_2	742	747	PF00069	0.495
MOD_PIKK_1	435	441	PF00454	0.424
MOD_PIKK_1	489	495	PF00454	0.579
MOD_PIKK_1	597	603	PF00454	0.624
MOD_PIKK_1	637	643	PF00454	0.555
MOD_PKA_1	231	237	PF00069	0.271
MOD_PKA_2	175	181	PF00069	0.261
MOD_PKA_2	194	200	PF00069	0.182
MOD_PKA_2	231	237	PF00069	0.394
MOD_PKA_2	330	336	PF00069	0.394
MOD_PKA_2	746	752	PF00069	0.577
MOD_PKA_2	791	797	PF00069	0.532
MOD_Plk_1	362	368	PF00069	0.311
MOD_Plk_1	589	595	PF00069	0.513
MOD_Plk_1	73	79	PF00069	0.311
MOD_Plk_1	812	818	PF00069	0.493
MOD_Plk_1	833	839	PF00069	0.408
MOD_Plk_2-3	813	819	PF00069	0.492
MOD_Plk_4	208	214	PF00069	0.261
MOD_Plk_4	23	29	PF00069	0.476
MOD_Plk_4	248	254	PF00069	0.311
MOD_Plk_4	346	352	PF00069	0.379
MOD_Plk_4	701	707	PF00069	0.551
MOD_Plk_4	73	79	PF00069	0.324
MOD_Plk_4	750	756	PF00069	0.489
MOD_Plk_4	802	808	PF00069	0.481
MOD_Plk_4	90	96	PF00069	0.386
MOD_ProDKin_1	120	126	PF00069	0.414
MOD_ProDKin_1	176	182	PF00069	0.313
MOD_ProDKin_1	197	203	PF00069	0.286
MOD_ProDKin_1	391	397	PF00069	0.628
MOD_ProDKin_1	398	404	PF00069	0.549
MOD_ProDKin_1	622	628	PF00069	0.661
MOD_ProDKin_1	666	672	PF00069	0.641
MOD_ProDKin_1	694	700	PF00069	0.618
MOD_ProDKin_1	738	744	PF00069	0.705
MOD_ProDKin_1	781	787	PF00069	0.556
MOD_SUMO_rev_2	269	275	PF00179	0.353
MOD_SUMO_rev_2	428	438	PF00179	0.470
MOD_SUMO_rev_2	879	886	PF00179	0.432
TRG_DiLeu_BaEn_1	23	28	PF01217	0.411
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.289
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.394
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.289
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.311
TRG_ENDOCYTIC_2	135	138	PF00928	0.311
TRG_ENDOCYTIC_2	371	374	PF00928	0.311
TRG_ENDOCYTIC_2	386	389	PF00928	0.533
TRG_ENDOCYTIC_2	449	452	PF00928	0.416
TRG_ENDOCYTIC_2	642	645	PF00928	0.636
TRG_ER_diArg_1	388	391	PF00400	0.555
TRG_ER_diArg_1	508	511	PF00400	0.507
TRG_ER_diArg_1	9	12	PF00400	0.431
TRG_NES_CRM1_1	569	582	PF08389	0.467
TRG_NLS_MonoExtC_3	505	510	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	43%	100%
A0A3Q8IEL2	Leishmania donovani	29%	100%
A0A3Q8IHG6	Leishmania donovani	28%	100%
A0A3S7WPL3	Leishmania donovani	88%	100%
A4H4R6	Leishmania braziliensis	75%	99%
A4HHN8	Leishmania braziliensis	28%	100%
A4HHY2	Leishmania braziliensis	25%	100%
A4HSZ5	Leishmania infantum	89%	100%
A4I4V2	Leishmania infantum	28%	100%
A4I4V3	Leishmania infantum	29%	100%
E9AEA0	Leishmania major	29%	100%
E9AEA1	Leishmania major	29%	100%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O23826	Nicotiana tabacum	26%	88%
Q4QIX3	Leishmania major	88%	99%
Q8NI77	Homo sapiens	25%	99%