Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKY0_LEIMU

TriTrypDb:

LmxM.06.1010

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.681
CLV_C14_Caspase3-7	295	299	PF00656	0.575
CLV_C14_Caspase3-7	583	587	PF00656	0.676
CLV_NRD_NRD_1	128	130	PF00675	0.694
CLV_NRD_NRD_1	170	172	PF00675	0.581
CLV_NRD_NRD_1	296	298	PF00675	0.683
CLV_NRD_NRD_1	499	501	PF00675	0.516
CLV_NRD_NRD_1	51	53	PF00675	0.602
CLV_NRD_NRD_1	651	653	PF00675	0.408
CLV_NRD_NRD_1	749	751	PF00675	0.548
CLV_NRD_NRD_1	753	755	PF00675	0.574
CLV_NRD_NRD_1	8	10	PF00675	0.615
CLV_PCSK_KEX2_1	128	130	PF00082	0.698
CLV_PCSK_KEX2_1	170	172	PF00082	0.581
CLV_PCSK_KEX2_1	296	298	PF00082	0.652
CLV_PCSK_KEX2_1	499	501	PF00082	0.516
CLV_PCSK_KEX2_1	651	653	PF00082	0.371
CLV_PCSK_KEX2_1	753	755	PF00082	0.577
CLV_PCSK_KEX2_1	8	10	PF00082	0.615
CLV_PCSK_SKI1_1	100	104	PF00082	0.469
CLV_PCSK_SKI1_1	114	118	PF00082	0.614
CLV_PCSK_SKI1_1	214	218	PF00082	0.448
CLV_PCSK_SKI1_1	280	284	PF00082	0.549
CLV_PCSK_SKI1_1	347	351	PF00082	0.471
CLV_PCSK_SKI1_1	382	386	PF00082	0.455
CLV_PCSK_SKI1_1	499	503	PF00082	0.521
CLV_PCSK_SKI1_1	643	647	PF00082	0.490
CLV_PCSK_SKI1_1	694	698	PF00082	0.449
CLV_PCSK_SKI1_1	730	734	PF00082	0.549
DEG_APCC_DBOX_1	346	354	PF00400	0.413
DEG_APCC_DBOX_1	498	506	PF00400	0.516
DEG_APCC_DBOX_1	693	701	PF00400	0.442
DEG_COP1_1	27	35	PF00400	0.475
DEG_Nend_Nbox_1	1	3	PF02207	0.642
DOC_CYCLIN_RxL_1	100	109	PF00134	0.469
DOC_CYCLIN_RxL_1	379	388	PF00134	0.450
DOC_CYCLIN_RxL_1	521	532	PF00134	0.525
DOC_CYCLIN_RxL_1	727	737	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.451
DOC_MAPK_gen_1	692	699	PF00069	0.472
DOC_MAPK_HePTP_8	648	665	PF00069	0.386
DOC_MAPK_MEF2A_6	656	665	PF00069	0.386
DOC_PP2B_LxvP_1	262	265	PF13499	0.481
DOC_PP2B_LxvP_1	725	728	PF13499	0.513
DOC_USP7_MATH_1	120	124	PF00917	0.611
DOC_USP7_MATH_1	133	137	PF00917	0.584
DOC_USP7_MATH_1	26	30	PF00917	0.568
DOC_USP7_MATH_1	31	35	PF00917	0.568
DOC_USP7_MATH_1	318	322	PF00917	0.674
DOC_USP7_MATH_1	405	409	PF00917	0.515
DOC_USP7_MATH_1	569	573	PF00917	0.713
DOC_WW_Pin1_4	313	318	PF00397	0.706
DOC_WW_Pin1_4	397	402	PF00397	0.526
DOC_WW_Pin1_4	414	419	PF00397	0.654
DOC_WW_Pin1_4	51	56	PF00397	0.561
DOC_WW_Pin1_4	570	575	PF00397	0.658
LIG_14-3-3_CanoR_1	134	139	PF00244	0.610
LIG_14-3-3_CanoR_1	229	239	PF00244	0.478
LIG_14-3-3_CanoR_1	280	289	PF00244	0.567
LIG_14-3-3_CanoR_1	382	388	PF00244	0.423
LIG_14-3-3_CanoR_1	426	430	PF00244	0.631
LIG_14-3-3_CanoR_1	457	465	PF00244	0.448
LIG_14-3-3_CanoR_1	466	472	PF00244	0.406
LIG_14-3-3_CanoR_1	485	494	PF00244	0.336
LIG_14-3-3_CanoR_1	507	513	PF00244	0.447
LIG_14-3-3_CanoR_1	656	661	PF00244	0.426
LIG_14-3-3_CanoR_1	692	697	PF00244	0.364
LIG_14-3-3_CanoR_1	8	15	PF00244	0.525
LIG_Actin_WH2_2	264	282	PF00022	0.387
LIG_APCC_ABBAyCdc20_2	538	544	PF00400	0.490
LIG_BIR_III_4	298	302	PF00653	0.626
LIG_Clathr_ClatBox_1	525	529	PF01394	0.534
LIG_DLG_GKlike_1	134	141	PF00625	0.614
LIG_DLG_GKlike_1	656	663	PF00625	0.426
LIG_FHA_1	185	191	PF00498	0.518
LIG_FHA_1	231	237	PF00498	0.488
LIG_FHA_1	246	252	PF00498	0.357
LIG_FHA_1	253	259	PF00498	0.426
LIG_FHA_1	322	328	PF00498	0.517
LIG_FHA_1	429	435	PF00498	0.534
LIG_FHA_1	478	484	PF00498	0.443
LIG_FHA_1	594	600	PF00498	0.501
LIG_FHA_1	636	642	PF00498	0.455
LIG_FHA_1	674	680	PF00498	0.438
LIG_FHA_1	73	79	PF00498	0.468
LIG_FHA_2	148	154	PF00498	0.677
LIG_FHA_2	290	296	PF00498	0.619
LIG_FHA_2	301	307	PF00498	0.656
LIG_FHA_2	34	40	PF00498	0.478
LIG_FHA_2	369	375	PF00498	0.617
LIG_FHA_2	466	472	PF00498	0.443
LIG_FHA_2	530	536	PF00498	0.564
LIG_FHA_2	571	577	PF00498	0.671
LIG_FHA_2	734	740	PF00498	0.558
LIG_Integrin_RGD_1	652	654	PF01839	0.356
LIG_LIR_Gen_1	269	277	PF02991	0.549
LIG_LIR_Gen_1	622	632	PF02991	0.463
LIG_LIR_Gen_1	695	704	PF02991	0.376
LIG_LIR_Gen_1	76	87	PF02991	0.467
LIG_LIR_Nem_3	269	273	PF02991	0.546
LIG_LIR_Nem_3	396	402	PF02991	0.483
LIG_LIR_Nem_3	622	627	PF02991	0.376
LIG_LIR_Nem_3	695	699	PF02991	0.371
LIG_LIR_Nem_3	76	82	PF02991	0.465
LIG_NRBOX	81	87	PF00104	0.484
LIG_PCNA_PIPBox_1	392	401	PF02747	0.489
LIG_PCNA_yPIPBox_3	694	708	PF02747	0.408
LIG_Pex14_2	212	216	PF04695	0.454
LIG_PTB_Apo_2	351	358	PF02174	0.408
LIG_Rb_pABgroove_1	442	450	PF01858	0.466
LIG_SH2_CRK	399	403	PF00017	0.426
LIG_SH2_CRK	624	628	PF00017	0.362
LIG_SH2_CRK	632	636	PF00017	0.394
LIG_SH2_GRB2like	352	355	PF00017	0.407
LIG_SH2_GRB2like	667	670	PF00017	0.491
LIG_SH2_NCK_1	399	403	PF00017	0.511
LIG_SH2_NCK_1	448	452	PF00017	0.465
LIG_SH2_SRC	448	451	PF00017	0.472
LIG_SH2_STAP1	542	546	PF00017	0.402
LIG_SH2_STAT3	377	380	PF00017	0.480
LIG_SH2_STAT5	352	355	PF00017	0.483
LIG_SH2_STAT5	383	386	PF00017	0.500
LIG_SH2_STAT5	399	402	PF00017	0.598
LIG_SH2_STAT5	497	500	PF00017	0.522
LIG_SH3_3	706	712	PF00018	0.462
LIG_SUMO_SIM_anti_2	449	455	PF11976	0.468
LIG_SUMO_SIM_anti_2	676	681	PF11976	0.424
LIG_SUMO_SIM_par_1	186	191	PF11976	0.600
LIG_SUMO_SIM_par_1	275	281	PF11976	0.438
LIG_SUMO_SIM_par_1	383	388	PF11976	0.458
LIG_SUMO_SIM_par_1	524	532	PF11976	0.526
LIG_SUMO_SIM_par_1	644	650	PF11976	0.413
LIG_TRAF2_1	468	471	PF00917	0.491
LIG_TRAF2_1	718	721	PF00917	0.416
LIG_TRFH_1	179	183	PF08558	0.637
LIG_TYR_ITIM	106	111	PF00017	0.459
LIG_TYR_ITIM	268	273	PF00017	0.463
LIG_UBA3_1	81	88	PF00899	0.466
LIG_WW_3	316	320	PF00397	0.650
LIG_WW_3	727	731	PF00397	0.574
MOD_CDC14_SPxK_1	316	319	PF00782	0.655
MOD_CDK_SPxK_1	313	319	PF00069	0.658
MOD_CK1_1	123	129	PF00069	0.563
MOD_CK1_1	166	172	PF00069	0.743
MOD_CK1_1	184	190	PF00069	0.684
MOD_CK1_1	321	327	PF00069	0.604
MOD_CK1_1	413	419	PF00069	0.773
MOD_CK1_1	548	554	PF00069	0.484
MOD_CK1_1	572	578	PF00069	0.725
MOD_CK1_1	668	674	PF00069	0.296
MOD_CK2_1	106	112	PF00069	0.445
MOD_CK2_1	289	295	PF00069	0.686
MOD_CK2_1	465	471	PF00069	0.475
MOD_CK2_1	529	535	PF00069	0.570
MOD_CK2_1	548	554	PF00069	0.470
MOD_CK2_1	711	717	PF00069	0.410
MOD_GlcNHglycan	10	13	PF01048	0.555
MOD_GlcNHglycan	108	111	PF01048	0.478
MOD_GlcNHglycan	143	146	PF01048	0.742
MOD_GlcNHglycan	165	168	PF01048	0.561
MOD_GlcNHglycan	18	21	PF01048	0.517
MOD_GlcNHglycan	190	193	PF01048	0.586
MOD_GlcNHglycan	197	200	PF01048	0.496
MOD_GlcNHglycan	242	246	PF01048	0.440
MOD_GlcNHglycan	33	36	PF01048	0.564
MOD_GlcNHglycan	407	410	PF01048	0.663
MOD_GlcNHglycan	480	483	PF01048	0.576
MOD_GlcNHglycan	519	522	PF01048	0.547
MOD_GlcNHglycan	742	745	PF01048	0.606
MOD_GSK3_1	159	166	PF00069	0.738
MOD_GSK3_1	16	23	PF00069	0.445
MOD_GSK3_1	177	184	PF00069	0.675
MOD_GSK3_1	227	234	PF00069	0.588
MOD_GSK3_1	241	248	PF00069	0.545
MOD_GSK3_1	313	320	PF00069	0.704
MOD_GSK3_1	393	400	PF00069	0.480
MOD_GSK3_1	401	408	PF00069	0.614
MOD_GSK3_1	410	417	PF00069	0.615
MOD_GSK3_1	425	432	PF00069	0.563
MOD_GSK3_1	544	551	PF00069	0.557
MOD_GSK3_1	613	620	PF00069	0.324
MOD_GSK3_1	711	718	PF00069	0.467
MOD_LATS_1	132	138	PF00433	0.559
MOD_LATS_1	690	696	PF00433	0.454
MOD_N-GLC_1	139	144	PF02516	0.631
MOD_N-GLC_1	668	673	PF02516	0.326
MOD_NEK2_1	188	193	PF00069	0.517
MOD_NEK2_1	385	390	PF00069	0.478
MOD_NEK2_1	425	430	PF00069	0.584
MOD_NEK2_1	434	439	PF00069	0.496
MOD_NEK2_1	545	550	PF00069	0.361
MOD_NEK2_1	680	685	PF00069	0.427
MOD_NEK2_1	740	745	PF00069	0.519
MOD_PIKK_1	214	220	PF00454	0.347
MOD_PIKK_1	227	233	PF00454	0.552
MOD_PIKK_1	393	399	PF00454	0.436
MOD_PIKK_1	593	599	PF00454	0.511
MOD_PKA_1	8	14	PF00069	0.592
MOD_PKA_2	133	139	PF00069	0.729
MOD_PKA_2	184	190	PF00069	0.609
MOD_PKA_2	318	324	PF00069	0.597
MOD_PKA_2	425	431	PF00069	0.630
MOD_PKA_2	456	462	PF00069	0.457
MOD_PKA_2	465	471	PF00069	0.441
MOD_PKA_2	557	563	PF00069	0.607
MOD_PKA_2	72	78	PF00069	0.523
MOD_PKA_2	8	14	PF00069	0.531
MOD_Plk_1	123	129	PF00069	0.624
MOD_Plk_1	26	32	PF00069	0.466
MOD_Plk_1	668	674	PF00069	0.323
MOD_Plk_2-3	529	535	PF00069	0.570
MOD_Plk_4	177	183	PF00069	0.668
MOD_Plk_4	184	190	PF00069	0.473
MOD_Plk_4	74	80	PF00069	0.456
MOD_ProDKin_1	313	319	PF00069	0.706
MOD_ProDKin_1	397	403	PF00069	0.536
MOD_ProDKin_1	414	420	PF00069	0.652
MOD_ProDKin_1	51	57	PF00069	0.557
MOD_ProDKin_1	570	576	PF00069	0.661
MOD_SUMO_rev_2	717	725	PF00179	0.393
TRG_DiLeu_BaEn_4	470	476	PF01217	0.498
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.472
TRG_ENDOCYTIC_2	108	111	PF00928	0.462
TRG_ENDOCYTIC_2	270	273	PF00928	0.459
TRG_ENDOCYTIC_2	399	402	PF00928	0.413
TRG_ENDOCYTIC_2	4	7	PF00928	0.568
TRG_ENDOCYTIC_2	448	451	PF00928	0.464
TRG_ENDOCYTIC_2	542	545	PF00928	0.413
TRG_ENDOCYTIC_2	624	627	PF00928	0.357
TRG_ENDOCYTIC_2	632	635	PF00928	0.391
TRG_ER_diArg_1	127	129	PF00400	0.691
TRG_ER_diArg_1	498	500	PF00400	0.537
TRG_ER_diArg_1	555	558	PF00400	0.450
TRG_ER_diArg_1	691	694	PF00400	0.385
TRG_ER_diArg_1	7	9	PF00400	0.669
TRG_ER_diArg_1	752	754	PF00400	0.601
TRG_NES_CRM1_1	517	531	PF08389	0.509
TRG_NES_CRM1_1	76	90	PF08389	0.423
TRG_NLS_MonoExtC_3	749	754	PF00514	0.443
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP3	Leptomonas seymouri	54%	100%
A0A3R7K270	Trypanosoma rangeli	34%	100%
A0A3S5H5T7	Leishmania donovani	91%	99%
A4H4R4	Leishmania braziliensis	79%	99%
A4HSZ3	Leishmania infantum	91%	99%
C9ZTM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QIX5	Leishmania major	89%	100%