SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKX9_LEIMU

TriTrypDb:

LmxM.06.1000

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKX9

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0040029	epigenetic regulation of gene expression	6	1
GO:0045814	negative regulation of gene expression, epigenetic	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0042799	histone H4K20 methyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.492
CLV_NRD_NRD_1	163	165	PF00675	0.515
CLV_NRD_NRD_1	435	437	PF00675	0.263
CLV_NRD_NRD_1	473	475	PF00675	0.388
CLV_NRD_NRD_1	83	85	PF00675	0.454
CLV_PCSK_KEX2_1	163	165	PF00082	0.501
CLV_PCSK_KEX2_1	31	33	PF00082	0.536
CLV_PCSK_KEX2_1	435	437	PF00082	0.282
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.367
CLV_PCSK_SKI1_1	168	172	PF00082	0.518
CLV_PCSK_SKI1_1	288	292	PF00082	0.333
CLV_PCSK_SKI1_1	316	320	PF00082	0.228
DEG_APCC_DBOX_1	315	323	PF00400	0.438
DEG_SPOP_SBC_1	105	109	PF00917	0.513
DOC_MAPK_gen_1	449	459	PF00069	0.428
DOC_PP2B_LxvP_1	339	342	PF13499	0.450
DOC_USP7_MATH_1	105	109	PF00917	0.554
DOC_USP7_MATH_1	112	116	PF00917	0.530
DOC_USP7_MATH_1	180	184	PF00917	0.413
DOC_USP7_MATH_1	197	201	PF00917	0.559
DOC_USP7_MATH_1	419	423	PF00917	0.492
DOC_WW_Pin1_4	101	106	PF00397	0.645
DOC_WW_Pin1_4	168	173	PF00397	0.430
DOC_WW_Pin1_4	202	207	PF00397	0.501
DOC_WW_Pin1_4	423	428	PF00397	0.569
LIG_14-3-3_CanoR_1	316	324	PF00244	0.547
LIG_14-3-3_CanoR_1	435	445	PF00244	0.497
LIG_14-3-3_CanoR_1	474	478	PF00244	0.275
LIG_14-3-3_CanoR_1	63	71	PF00244	0.421
LIG_Actin_WH2_2	155	170	PF00022	0.394
LIG_EH1_1	403	411	PF00400	0.492
LIG_FHA_1	111	117	PF00498	0.764
LIG_FHA_1	137	143	PF00498	0.657
LIG_FHA_1	169	175	PF00498	0.377
LIG_FHA_1	190	196	PF00498	0.504
LIG_FHA_1	464	470	PF00498	0.391
LIG_FHA_1	50	56	PF00498	0.365
LIG_FHA_2	63	69	PF00498	0.409
LIG_GBD_Chelix_1	365	373	PF00786	0.228
LIG_LIR_Gen_1	385	395	PF02991	0.446
LIG_LIR_Nem_3	262	268	PF02991	0.447
LIG_LIR_Nem_3	385	390	PF02991	0.456
LIG_LIR_Nem_3	455	461	PF02991	0.424
LIG_SH2_CRK	404	408	PF00017	0.445
LIG_SH2_NCK_1	34	38	PF00017	0.327
LIG_SH2_NCK_1	353	357	PF00017	0.467
LIG_SH2_SRC	353	356	PF00017	0.533
LIG_SH2_STAP1	34	38	PF00017	0.332
LIG_SH2_STAT3	12	15	PF00017	0.482
LIG_SH2_STAT3	20	23	PF00017	0.356
LIG_SH2_STAT3	64	67	PF00017	0.336
LIG_SH2_STAT5	148	151	PF00017	0.397
LIG_SH2_STAT5	20	23	PF00017	0.402
LIG_SH2_STAT5	255	258	PF00017	0.473
LIG_SH2_STAT5	40	43	PF00017	0.355
LIG_SH2_STAT5	486	489	PF00017	0.472
LIG_SH2_STAT5	64	67	PF00017	0.336
LIG_SH3_3	234	240	PF00018	0.505
LIG_SH3_3	242	248	PF00018	0.483
LIG_SUMO_SIM_par_1	123	132	PF11976	0.511
LIG_TRAF2_1	13	16	PF00917	0.384
LIG_TRAF2_1	77	80	PF00917	0.433
MOD_CK1_1	104	110	PF00069	0.654
MOD_CK1_1	225	231	PF00069	0.359
MOD_CK1_1	272	278	PF00069	0.482
MOD_CK1_1	300	306	PF00069	0.376
MOD_CK1_1	320	326	PF00069	0.332
MOD_CK1_1	405	411	PF00069	0.401
MOD_CK1_1	66	72	PF00069	0.543
MOD_CK2_1	308	314	PF00069	0.403
MOD_CK2_1	436	442	PF00069	0.288
MOD_CK2_1	86	92	PF00069	0.391
MOD_DYRK1A_RPxSP_1	168	172	PF00069	0.404
MOD_GlcNHglycan	120	123	PF01048	0.512
MOD_GlcNHglycan	168	171	PF01048	0.508
MOD_GlcNHglycan	224	227	PF01048	0.297
MOD_GlcNHglycan	299	302	PF01048	0.373
MOD_GlcNHglycan	310	313	PF01048	0.419
MOD_GlcNHglycan	369	372	PF01048	0.433
MOD_GlcNHglycan	398	401	PF01048	0.268
MOD_GlcNHglycan	421	424	PF01048	0.352
MOD_GlcNHglycan	438	441	PF01048	0.306
MOD_GSK3_1	106	113	PF00069	0.524
MOD_GSK3_1	114	121	PF00069	0.661
MOD_GSK3_1	162	169	PF00069	0.515
MOD_GSK3_1	228	235	PF00069	0.344
MOD_GSK3_1	419	426	PF00069	0.401
MOD_GSK3_1	62	69	PF00069	0.402
MOD_GSK3_1	97	104	PF00069	0.456
MOD_N-GLC_1	410	415	PF02516	0.309
MOD_NEK2_1	189	194	PF00069	0.335
MOD_NEK2_1	396	401	PF00069	0.358
MOD_NEK2_1	428	433	PF00069	0.293
MOD_NEK2_1	78	83	PF00069	0.440
MOD_NEK2_2	26	31	PF00069	0.352
MOD_PIKK_1	114	120	PF00454	0.492
MOD_PIKK_1	63	69	PF00454	0.444
MOD_PKA_2	162	168	PF00069	0.408
MOD_PKA_2	197	203	PF00069	0.369
MOD_PKA_2	347	353	PF00069	0.438
MOD_PKA_2	473	479	PF00069	0.333
MOD_PKA_2	62	68	PF00069	0.363
MOD_Plk_4	143	149	PF00069	0.396
MOD_Plk_4	197	203	PF00069	0.440
MOD_Plk_4	382	388	PF00069	0.288
MOD_Plk_4	402	408	PF00069	0.162
MOD_Plk_4	66	72	PF00069	0.444
MOD_ProDKin_1	101	107	PF00069	0.650
MOD_ProDKin_1	168	174	PF00069	0.422
MOD_ProDKin_1	202	208	PF00069	0.356
MOD_ProDKin_1	423	429	PF00069	0.452
MOD_SUMO_for_1	133	136	PF00179	0.482
MOD_SUMO_for_1	142	145	PF00179	0.565
MOD_SUMO_rev_2	213	218	PF00179	0.372
MOD_SUMO_rev_2	472	477	PF00179	0.331
TRG_DiLeu_BaEn_1	204	209	PF01217	0.401
TRG_DiLeu_BaEn_4	472	478	PF01217	0.331
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.288
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.323
TRG_ENDOCYTIC_2	404	407	PF00928	0.262
TRG_ER_diArg_1	162	164	PF00400	0.514
TRG_ER_diArg_1	2	5	PF00400	0.452
TRG_ER_diArg_1	21	24	PF00400	0.313
TRG_NES_CRM1_1	382	394	PF08389	0.259
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P571	Leptomonas seymouri	66%	100%
A0A0S4JRV8	Bodo saltans	39%	100%
A0A1X0NL17	Trypanosomatidae	47%	100%
A0A3R7KQ99	Trypanosoma rangeli	47%	100%
A0A3S7WPJ6	Leishmania donovani	91%	99%
A0A3S7WYH0	Leishmania donovani	25%	100%
A4H4R3	Leishmania braziliensis	80%	100%
A4HDM9	Leishmania braziliensis	28%	100%
A4HSZ2	Leishmania infantum	91%	99%
C9ZTM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AH76	Leishmania infantum	25%	100%
E9AX14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QAG2	Leishmania major	27%	100%
Q4QIX6	Leishmania major	89%	100%
V5BT58	Trypanosoma cruzi	45%	100%