Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AKX8_LEIMU

TriTrypDb:

LmxM.06.0995

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AKX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	71	77	PF00089	0.422
CLV_NRD_NRD_1	63	65	PF00675	0.382
CLV_PCSK_KEX2_1	63	65	PF00082	0.420
DOC_MAPK_gen_1	48	57	PF00069	0.582
DOC_WW_Pin1_4	114	119	PF00397	0.642
LIG_14-3-3_CanoR_1	108	114	PF00244	0.643
LIG_14-3-3_CanoR_1	50	56	PF00244	0.532
LIG_BRCT_BRCA1_1	30	34	PF00533	0.200
LIG_BRCT_BRCA1_1	36	40	PF00533	0.200
LIG_FHA_1	2	8	PF00498	0.469
LIG_FHA_1	52	58	PF00498	0.625
LIG_FHA_1	66	72	PF00498	0.596
LIG_LIR_Apic_2	98	103	PF02991	0.685
LIG_LIR_Nem_3	37	43	PF02991	0.331
LIG_MLH1_MIPbox_1	30	34	PF16413	0.200
LIG_MLH1_MIPbox_1	36	40	PF16413	0.200
LIG_PDZ_Class_3	150	155	PF00595	0.319
LIG_SH2_CRK	100	104	PF00017	0.676
LIG_SH2_GRB2like	56	59	PF00017	0.586
LIG_SH2_NCK_1	100	104	PF00017	0.676
LIG_SH2_STAP1	3	7	PF00017	0.495
LIG_SH2_STAT5	146	149	PF00017	0.427
LIG_SH2_STAT5	3	6	PF00017	0.539
LIG_SH2_STAT5	51	54	PF00017	0.604
LIG_SH2_STAT5	56	59	PF00017	0.603
LIG_SH3_1	115	121	PF00018	0.475
LIG_SH3_3	103	109	PF00018	0.668
LIG_SH3_3	115	121	PF00018	0.462
LIG_SH3_3	6	12	PF00018	0.388
LIG_SUMO_SIM_par_1	127	132	PF11976	0.325
LIG_WW_3	108	112	PF00397	0.698
MOD_CK1_1	132	138	PF00069	0.300
MOD_CK1_1	28	34	PF00069	0.209
MOD_GlcNHglycan	137	140	PF01048	0.466
MOD_GlcNHglycan	26	30	PF01048	0.620
MOD_GlcNHglycan	40	43	PF01048	0.305
MOD_GlcNHglycan	87	90	PF01048	0.499
MOD_GSK3_1	129	136	PF00069	0.415
MOD_GSK3_1	34	41	PF00069	0.214
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	129	134	PF00069	0.312
MOD_NEK2_1	34	39	PF00069	0.304
MOD_NEK2_1	67	72	PF00069	0.605
MOD_NEK2_2	35	40	PF00069	0.404
MOD_NEK2_2	51	56	PF00069	0.524
MOD_Plk_4	28	34	PF00069	0.303
MOD_Plk_4	35	41	PF00069	0.412
MOD_Plk_4	51	57	PF00069	0.525
MOD_ProDKin_1	114	120	PF00069	0.639
TRG_ER_diArg_1	47	50	PF00400	0.586
TRG_ER_diArg_1	71	74	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL5	Leptomonas seymouri	40%	100%
A0A3S7WPM7	Leishmania donovani	89%	100%
A4HSZ1	Leishmania infantum	90%	100%
E9AI23	Leishmania braziliensis	60%	100%
Q4QIX7	Leishmania major	88%	100%