Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich Repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AKX6_LEIMU

TriTrypDb:

LmxM.06.0980

Length:

1036

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AKX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	622	626	PF00656	0.651
CLV_C14_Caspase3-7	657	661	PF00656	0.710
CLV_NRD_NRD_1	1006	1008	PF00675	0.649
CLV_NRD_NRD_1	192	194	PF00675	0.507
CLV_NRD_NRD_1	473	475	PF00675	0.614
CLV_NRD_NRD_1	628	630	PF00675	0.650
CLV_NRD_NRD_1	859	861	PF00675	0.690
CLV_PCSK_FUR_1	187	191	PF00082	0.512
CLV_PCSK_KEX2_1	1006	1008	PF00082	0.611
CLV_PCSK_KEX2_1	189	191	PF00082	0.536
CLV_PCSK_KEX2_1	192	194	PF00082	0.545
CLV_PCSK_KEX2_1	211	213	PF00082	0.464
CLV_PCSK_KEX2_1	286	288	PF00082	0.696
CLV_PCSK_KEX2_1	358	360	PF00082	0.482
CLV_PCSK_KEX2_1	473	475	PF00082	0.623
CLV_PCSK_KEX2_1	628	630	PF00082	0.637
CLV_PCSK_KEX2_1	652	654	PF00082	0.624
CLV_PCSK_KEX2_1	859	861	PF00082	0.711
CLV_PCSK_KEX2_1	873	875	PF00082	0.675
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.536
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.518
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.696
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.482
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.663
CLV_PCSK_PC1ET2_1	873	875	PF00082	0.785
CLV_PCSK_SKI1_1	1022	1026	PF00082	0.681
CLV_PCSK_SKI1_1	145	149	PF00082	0.479
CLV_PCSK_SKI1_1	283	287	PF00082	0.616
CLV_PCSK_SKI1_1	474	478	PF00082	0.572
CLV_PCSK_SKI1_1	513	517	PF00082	0.636
CLV_PCSK_SKI1_1	520	524	PF00082	0.587
CLV_PCSK_SKI1_1	525	529	PF00082	0.555
CLV_PCSK_SKI1_1	548	552	PF00082	0.529
CLV_PCSK_SKI1_1	553	557	PF00082	0.500
CLV_PCSK_SKI1_1	607	611	PF00082	0.591
CLV_PCSK_SKI1_1	71	75	PF00082	0.558
CLV_PCSK_SKI1_1	725	729	PF00082	0.593
CLV_PCSK_SKI1_1	742	746	PF00082	0.566
CLV_PCSK_SKI1_1	760	764	PF00082	0.475
CLV_PCSK_SKI1_1	873	877	PF00082	0.711
CLV_PCSK_SKI1_1	959	963	PF00082	0.517
DEG_APCC_DBOX_1	211	219	PF00400	0.509
DEG_APCC_DBOX_1	858	866	PF00400	0.697
DEG_COP1_1	882	889	PF00400	0.553
DEG_SPOP_SBC_1	27	31	PF00917	0.715
DOC_AGCK_PIF_3	1033	1036	PF00069	0.705
DOC_CDC14_PxL_1	113	121	PF14671	0.447
DOC_CDC14_PxL_1	135	143	PF14671	0.507
DOC_CYCLIN_RxL_1	137	148	PF00134	0.531
DOC_CYCLIN_RxL_1	259	268	PF00134	0.487
DOC_CYCLIN_RxL_1	471	481	PF00134	0.594
DOC_CYCLIN_RxL_1	82	94	PF00134	0.480
DOC_MAPK_FxFP_2	521	524	PF00069	0.658
DOC_MAPK_gen_1	105	114	PF00069	0.408
DOC_MAPK_gen_1	115	124	PF00069	0.408
DOC_MAPK_gen_1	187	196	PF00069	0.499
DOC_MAPK_gen_1	211	220	PF00069	0.505
DOC_MAPK_gen_1	262	269	PF00069	0.441
DOC_MAPK_gen_1	452	459	PF00069	0.598
DOC_MAPK_gen_1	463	472	PF00069	0.522
DOC_MAPK_gen_1	628	635	PF00069	0.583
DOC_MAPK_MEF2A_6	105	114	PF00069	0.447
DOC_MAPK_MEF2A_6	118	126	PF00069	0.403
DOC_MAPK_MEF2A_6	452	459	PF00069	0.598
DOC_MAPK_MEF2A_6	544	551	PF00069	0.401
DOC_PP1_RVXF_1	1020	1027	PF00149	0.680
DOC_PP1_RVXF_1	260	267	PF00149	0.501
DOC_PP1_RVXF_1	433	440	PF00149	0.544
DOC_PP1_RVXF_1	551	558	PF00149	0.499
DOC_PP1_RVXF_1	638	645	PF00149	0.528
DOC_PP1_RVXF_1	758	765	PF00149	0.633
DOC_PP1_SILK_1	926	931	PF00149	0.623
DOC_PP2B_LxvP_1	251	254	PF13499	0.515
DOC_PP2B_LxvP_1	793	796	PF13499	0.722
DOC_PP2B_PxIxI_1	175	181	PF00149	0.485
DOC_PP2B_PxIxI_1	886	892	PF00149	0.614
DOC_PP4_FxxP_1	227	230	PF00568	0.444
DOC_PP4_FxxP_1	521	524	PF00568	0.658
DOC_USP7_MATH_1	1005	1009	PF00917	0.673
DOC_USP7_MATH_1	128	132	PF00917	0.491
DOC_USP7_MATH_1	27	31	PF00917	0.715
DOC_USP7_MATH_1	332	336	PF00917	0.739
DOC_USP7_MATH_1	418	422	PF00917	0.643
DOC_USP7_MATH_1	700	704	PF00917	0.623
DOC_USP7_MATH_1	717	721	PF00917	0.630
DOC_USP7_MATH_1	843	847	PF00917	0.745
DOC_USP7_MATH_1	858	862	PF00917	0.651
DOC_USP7_MATH_1	868	872	PF00917	0.612
DOC_USP7_MATH_1	983	987	PF00917	0.733
DOC_USP7_UBL2_3	372	376	PF12436	0.509
DOC_USP7_UBL2_3	820	824	PF12436	0.795
DOC_WW_Pin1_4	28	33	PF00397	0.732
DOC_WW_Pin1_4	446	451	PF00397	0.602
LIG_14-3-3_CanoR_1	1022	1027	PF00244	0.727
LIG_14-3-3_CanoR_1	121	127	PF00244	0.440
LIG_14-3-3_CanoR_1	140	145	PF00244	0.443
LIG_14-3-3_CanoR_1	212	220	PF00244	0.418
LIG_14-3-3_CanoR_1	359	363	PF00244	0.474
LIG_14-3-3_CanoR_1	463	468	PF00244	0.636
LIG_14-3-3_CanoR_1	71	77	PF00244	0.385
LIG_14-3-3_CanoR_1	859	863	PF00244	0.670
LIG_14-3-3_CanoR_1	874	878	PF00244	0.724
LIG_14-3-3_CanoR_1	899	906	PF00244	0.584
LIG_APCC_ABBA_1	937	942	PF00400	0.648
LIG_APCC_ABBAyCdc20_2	742	748	PF00400	0.402
LIG_BRCT_BRCA1_1	30	34	PF00533	0.698
LIG_Clathr_ClatBox_1	911	915	PF01394	0.594
LIG_deltaCOP1_diTrp_1	641	650	PF00928	0.544
LIG_deltaCOP1_diTrp_1	748	758	PF00928	0.646
LIG_DLG_GKlike_1	140	147	PF00625	0.500
LIG_eIF4E_1	906	912	PF01652	0.603
LIG_FHA_1	274	280	PF00498	0.443
LIG_FHA_1	332	338	PF00498	0.724
LIG_FHA_1	350	356	PF00498	0.586
LIG_FHA_1	404	410	PF00498	0.523
LIG_FHA_1	680	686	PF00498	0.666
LIG_FHA_1	777	783	PF00498	0.662
LIG_FHA_1	797	803	PF00498	0.774
LIG_FHA_1	849	855	PF00498	0.577
LIG_FHA_1	886	892	PF00498	0.617
LIG_FHA_1	898	904	PF00498	0.538
LIG_FHA_2	146	152	PF00498	0.513
LIG_FHA_2	214	220	PF00498	0.465
LIG_FHA_2	224	230	PF00498	0.461
LIG_FHA_2	464	470	PF00498	0.635
LIG_FHA_2	514	520	PF00498	0.695
LIG_FHA_2	524	530	PF00498	0.520
LIG_FHA_2	590	596	PF00498	0.577
LIG_FHA_2	688	694	PF00498	0.719
LIG_IRF3_LxIS_1	215	221	PF10401	0.412
LIG_LIR_Apic_2	226	230	PF02991	0.446
LIG_LIR_Apic_2	519	524	PF02991	0.662
LIG_LIR_Gen_1	552	562	PF02991	0.537
LIG_LIR_Gen_1	695	704	PF02991	0.688
LIG_LIR_Nem_3	1030	1036	PF02991	0.656
LIG_LIR_Nem_3	125	129	PF02991	0.447
LIG_LIR_Nem_3	424	428	PF02991	0.501
LIG_LIR_Nem_3	490	496	PF02991	0.544
LIG_LIR_Nem_3	552	557	PF02991	0.519
LIG_LIR_Nem_3	603	609	PF02991	0.630
LIG_LIR_Nem_3	641	647	PF02991	0.543
LIG_LIR_Nem_3	755	761	PF02991	0.568
LIG_LIR_Nem_3	950	956	PF02991	0.644
LIG_Pex14_1	936	940	PF04695	0.597
LIG_PTB_Apo_2	809	816	PF02174	0.763
LIG_REV1ctd_RIR_1	230	237	PF16727	0.525
LIG_SH2_CRK	565	569	PF00017	0.542
LIG_SH2_CRK	580	584	PF00017	0.528
LIG_SH2_NCK_1	940	944	PF00017	0.689
LIG_SH2_SRC	940	943	PF00017	0.698
LIG_SH2_STAP1	565	569	PF00017	0.595
LIG_SH2_STAP1	940	944	PF00017	0.659
LIG_SH2_STAP1	999	1003	PF00017	0.712
LIG_SH2_STAT3	955	958	PF00017	0.678
LIG_SH2_STAT5	373	376	PF00017	0.473
LIG_SH2_STAT5	493	496	PF00017	0.541
LIG_SH2_STAT5	554	557	PF00017	0.487
LIG_SH2_STAT5	761	764	PF00017	0.557
LIG_SH2_STAT5	821	824	PF00017	0.652
LIG_SH2_STAT5	944	947	PF00017	0.604
LIG_SH2_STAT5	955	958	PF00017	0.630
LIG_SH3_3	111	117	PF00018	0.420
LIG_SH3_3	348	354	PF00018	0.559
LIG_SH3_3	407	413	PF00018	0.479
LIG_SH3_3	52	58	PF00018	0.571
LIG_SH3_3	565	571	PF00018	0.515
LIG_SH3_3	958	964	PF00018	0.686
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.453
LIG_SUMO_SIM_anti_2	52	57	PF11976	0.555
LIG_SUMO_SIM_anti_2	574	579	PF11976	0.594
LIG_SUMO_SIM_anti_2	915	921	PF11976	0.670
LIG_SUMO_SIM_par_1	140	146	PF11976	0.432
LIG_SUMO_SIM_par_1	700	706	PF11976	0.484
LIG_TRAF2_1	787	790	PF00917	0.744
LIG_TYR_ITIM	578	583	PF00017	0.602
LIG_WRC_WIRS_1	606	611	PF05994	0.627
MOD_CDC14_SPxK_1	449	452	PF00782	0.638
MOD_CDK_SPxK_1	446	452	PF00069	0.639
MOD_CK1_1	1028	1034	PF00069	0.698
MOD_CK1_1	143	149	PF00069	0.461
MOD_CK1_1	293	299	PF00069	0.696
MOD_CK1_1	331	337	PF00069	0.659
MOD_CK1_1	340	346	PF00069	0.611
MOD_CK1_1	349	355	PF00069	0.484
MOD_CK1_1	6	12	PF00069	0.665
MOD_CK1_1	703	709	PF00069	0.631
MOD_CK1_1	720	726	PF00069	0.568
MOD_CK1_1	861	867	PF00069	0.690
MOD_CK2_1	237	243	PF00069	0.413
MOD_CK2_1	383	389	PF00069	0.470
MOD_CK2_1	418	424	PF00069	0.652
MOD_CK2_1	463	469	PF00069	0.637
MOD_CK2_1	496	502	PF00069	0.624
MOD_CK2_1	504	510	PF00069	0.555
MOD_CK2_1	513	519	PF00069	0.472
MOD_CK2_1	523	529	PF00069	0.578
MOD_CK2_1	589	595	PF00069	0.606
MOD_CK2_1	687	693	PF00069	0.695
MOD_CK2_1	834	840	PF00069	0.768
MOD_CMANNOS	439	442	PF00535	0.486
MOD_GlcNHglycan	10	13	PF01048	0.731
MOD_GlcNHglycan	1027	1030	PF01048	0.634
MOD_GlcNHglycan	219	223	PF01048	0.484
MOD_GlcNHglycan	330	333	PF01048	0.680
MOD_GlcNHglycan	35	38	PF01048	0.639
MOD_GlcNHglycan	47	51	PF01048	0.392
MOD_GlcNHglycan	636	639	PF01048	0.605
MOD_GlcNHglycan	656	659	PF01048	0.687
MOD_GlcNHglycan	666	669	PF01048	0.690
MOD_GlcNHglycan	705	708	PF01048	0.610
MOD_GlcNHglycan	729	733	PF01048	0.390
MOD_GlcNHglycan	816	820	PF01048	0.746
MOD_GlcNHglycan	844	848	PF01048	0.792
MOD_GlcNHglycan	854	857	PF01048	0.712
MOD_GlcNHglycan	978	982	PF01048	0.721
MOD_GSK3_1	12	19	PF00069	0.699
MOD_GSK3_1	214	221	PF00069	0.384
MOD_GSK3_1	233	240	PF00069	0.423
MOD_GSK3_1	295	302	PF00069	0.721
MOD_GSK3_1	328	335	PF00069	0.649
MOD_GSK3_1	4	11	PF00069	0.731
MOD_GSK3_1	446	453	PF00069	0.578
MOD_GSK3_1	660	667	PF00069	0.627
MOD_GSK3_1	670	677	PF00069	0.712
MOD_GSK3_1	716	723	PF00069	0.598
MOD_GSK3_1	72	79	PF00069	0.447
MOD_GSK3_1	811	818	PF00069	0.639
MOD_GSK3_1	848	855	PF00069	0.701
MOD_GSK3_1	983	990	PF00069	0.712
MOD_N-GLC_1	122	127	PF02516	0.355
MOD_N-GLC_1	293	298	PF02516	0.675
MOD_N-GLC_1	337	342	PF02516	0.550
MOD_N-GLC_1	394	399	PF02516	0.502
MOD_N-GLC_1	4	9	PF02516	0.749
MOD_N-GLC_1	446	451	PF02516	0.593
MOD_N-GLC_1	811	816	PF02516	0.637
MOD_N-GLC_2	741	743	PF02516	0.647
MOD_NEK2_1	10	15	PF00069	0.749
MOD_NEK2_1	213	218	PF00069	0.476
MOD_NEK2_1	233	238	PF00069	0.324
MOD_NEK2_1	249	254	PF00069	0.461
MOD_NEK2_1	634	639	PF00069	0.575
MOD_NEK2_1	654	659	PF00069	0.646
MOD_NEK2_1	69	74	PF00069	0.566
MOD_NEK2_1	730	735	PF00069	0.586
MOD_NEK2_1	76	81	PF00069	0.150
MOD_NEK2_1	815	820	PF00069	0.729
MOD_NEK2_1	929	934	PF00069	0.634
MOD_NEK2_2	128	133	PF00069	0.489
MOD_NEK2_2	394	399	PF00069	0.525
MOD_NEK2_2	581	586	PF00069	0.584
MOD_NMyristoyl	1	7	PF02799	0.679
MOD_PIKK_1	349	355	PF00454	0.619
MOD_PIKK_1	416	422	PF00454	0.673
MOD_PIKK_1	692	698	PF00454	0.686
MOD_PIKK_1	929	935	PF00454	0.637
MOD_PK_1	798	804	PF00069	0.644
MOD_PKA_1	358	364	PF00069	0.479
MOD_PKA_1	873	879	PF00069	0.713
MOD_PKA_2	1005	1011	PF00069	0.623
MOD_PKA_2	213	219	PF00069	0.453
MOD_PKA_2	358	364	PF00069	0.479
MOD_PKA_2	654	660	PF00069	0.712
MOD_PKA_2	76	82	PF00069	0.470
MOD_PKA_2	797	803	PF00069	0.684
MOD_PKA_2	858	864	PF00069	0.664
MOD_PKA_2	873	879	PF00069	0.697
MOD_PKA_2	898	904	PF00069	0.589
MOD_PKB_1	212	220	PF00069	0.491
MOD_Plk_1	122	128	PF00069	0.378
MOD_Plk_1	394	400	PF00069	0.500
MOD_Plk_1	496	502	PF00069	0.638
MOD_Plk_1	674	680	PF00069	0.694
MOD_Plk_1	747	753	PF00069	0.609
MOD_Plk_1	811	817	PF00069	0.640
MOD_Plk_2-3	619	625	PF00069	0.661
MOD_Plk_4	12	18	PF00069	0.509
MOD_Plk_4	237	243	PF00069	0.427
MOD_Plk_4	394	400	PF00069	0.522
MOD_Plk_4	481	487	PF00069	0.573
MOD_Plk_4	619	625	PF00069	0.648
MOD_Plk_4	674	680	PF00069	0.619
MOD_Plk_4	747	753	PF00069	0.655
MOD_Plk_4	763	769	PF00069	0.503
MOD_Plk_4	798	804	PF00069	0.682
MOD_Plk_4	873	879	PF00069	0.784
MOD_Plk_4	907	913	PF00069	0.645
MOD_Plk_4	970	976	PF00069	0.504
MOD_ProDKin_1	28	34	PF00069	0.720
MOD_ProDKin_1	446	452	PF00069	0.604
MOD_SPalmitoyl_4	1	7	PF01529	0.711
MOD_SUMO_rev_2	171	181	PF00179	0.513
TRG_DiLeu_BaEn_1	789	794	PF01217	0.754
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.539
TRG_DiLeu_BaLyEn_6	681	686	PF01217	0.715
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.480
TRG_ENDOCYTIC_2	493	496	PF00928	0.543
TRG_ENDOCYTIC_2	554	557	PF00928	0.479
TRG_ENDOCYTIC_2	565	568	PF00928	0.501
TRG_ENDOCYTIC_2	580	583	PF00928	0.461
TRG_ENDOCYTIC_2	606	609	PF00928	0.527
TRG_ENDOCYTIC_2	761	764	PF00928	0.546
TRG_ENDOCYTIC_2	807	810	PF00928	0.698
TRG_ENDOCYTIC_2	906	909	PF00928	0.532
TRG_ER_diArg_1	1005	1007	PF00400	0.634
TRG_ER_diArg_1	190	193	PF00400	0.248
TRG_ER_diArg_1	212	215	PF00400	0.480
TRG_ER_diArg_1	462	465	PF00400	0.659
TRG_ER_diArg_1	472	474	PF00400	0.495
TRG_ER_diArg_1	628	630	PF00400	0.650
TRG_NLS_MonoExtC_3	188	193	PF00514	0.365
TRG_NLS_MonoExtN_4	187	193	PF00514	0.370
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	879	883	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY3	Leptomonas seymouri	69%	98%
A0A0S4JW61	Bodo saltans	27%	100%
A0A3S7WPK9	Leishmania donovani	91%	100%
A0A422NZ80	Trypanosoma rangeli	42%	100%
A4H4R1	Leishmania braziliensis	79%	99%
C9ZTM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AG69	Leishmania infantum	91%	100%
Q4QIX9	Leishmania major	90%	99%
V5BNJ3	Trypanosoma cruzi	38%	100%