Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich Repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AKX6_LEIMU

TriTrypDb:

LmxM.06.0980

Length:

1036

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

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Expansion

Sequence features

E9AKX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKX6

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	622	626	PF00656	0.651
CLV_C14_Caspase3-7	657	661	PF00656	0.710
CLV_NRD_NRD_1	1006	1008	PF00675	0.649
CLV_NRD_NRD_1	192	194	PF00675	0.507
CLV_NRD_NRD_1	473	475	PF00675	0.614
CLV_NRD_NRD_1	628	630	PF00675	0.650
CLV_NRD_NRD_1	859	861	PF00675	0.690
CLV_PCSK_FUR_1	187	191	PF00082	0.512
CLV_PCSK_KEX2_1	1006	1008	PF00082	0.611
CLV_PCSK_KEX2_1	189	191	PF00082	0.536

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY3	Leptomonas seymouri	69%	98%
A0A0S4JW61	Bodo saltans	27%	100%
A0A3S7WPK9	Leishmania donovani	91%	100%
A0A422NZ80	Trypanosoma rangeli	42%	100%
A4H4R1	Leishmania braziliensis	79%	99%
C9ZTM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AG69	Leishmania infantum	91%	100%
Q4QIX9	Leishmania major	90%	99%
V5BNJ3	Trypanosoma cruzi	38%	100%

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