Putative cell cycle associated protein MOB1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell cycle associated protein MOB1, putative

Species:

Leishmania mexicana

UniProt:

E9AKX4_LEIMU

TriTrypDb:

LmxM.06.0960

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKX4

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	1
GO:0001934	positive regulation of protein phosphorylation	8	1
GO:0007165	signal transduction	2	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0042325	regulation of phosphorylation	7	1
GO:0042327	positive regulation of phosphorylation	8	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0008047	enzyme activator activity	3	1
GO:0019207	kinase regulator activity	3	1
GO:0019209	kinase activator activity	4	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0030295	protein kinase activator activity	5	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.318
CLV_PCSK_KEX2_1	155	157	PF00082	0.262
CLV_PCSK_SKI1_1	151	155	PF00082	0.272
DEG_APCC_DBOX_1	199	207	PF00400	0.529
DEG_Nend_UBRbox_1	1	4	PF02207	0.561
DEG_SCF_FBW7_2	203	208	PF00400	0.556
DOC_USP7_MATH_1	87	91	PF00917	0.467
DOC_USP7_UBL2_3	147	151	PF12436	0.507
DOC_USP7_UBL2_3	18	22	PF12436	0.472
DOC_WW_Pin1_4	201	206	PF00397	0.475
LIG_14-3-3_CanoR_1	110	114	PF00244	0.556
LIG_Actin_WH2_2	30	46	PF00022	0.447
LIG_BRCT_BRCA1_1	5	9	PF00533	0.554
LIG_FHA_1	68	74	PF00498	0.462
LIG_IBAR_NPY_1	140	142	PF08397	0.462
LIG_LIR_Apic_2	96	102	PF02991	0.483
LIG_LIR_Gen_1	167	175	PF02991	0.462
LIG_LIR_Gen_1	194	203	PF02991	0.462
LIG_LIR_Nem_3	136	142	PF02991	0.535
LIG_LIR_Nem_3	145	149	PF02991	0.477
LIG_LIR_Nem_3	167	172	PF02991	0.484
LIG_LIR_Nem_3	183	188	PF02991	0.462
LIG_LIR_Nem_3	194	198	PF02991	0.432
LIG_LIR_Nem_3	63	69	PF02991	0.435
LIG_PCNA_yPIPBox_3	200	214	PF02747	0.529
LIG_Pex14_2	154	158	PF04695	0.462
LIG_Pex14_2	191	195	PF04695	0.462
LIG_PTB_Apo_2	68	75	PF02174	0.462
LIG_PTB_Phospho_1	68	74	PF10480	0.462
LIG_SH2_CRK	74	78	PF00017	0.462
LIG_SH2_NCK_1	161	165	PF00017	0.462
LIG_SH2_SRC	161	164	PF00017	0.462
LIG_SH2_STAP1	161	165	PF00017	0.462
LIG_SH2_STAP1	95	99	PF00017	0.462
LIG_SH2_STAT5	116	119	PF00017	0.542
LIG_SH2_STAT5	149	152	PF00017	0.556
LIG_SH2_STAT5	190	193	PF00017	0.475
LIG_SH2_STAT5	80	83	PF00017	0.541
LIG_SH2_STAT5	97	100	PF00017	0.393
LIG_SH3_1	100	106	PF00018	0.475
LIG_SH3_3	100	106	PF00018	0.455
LIG_SH3_3	108	114	PF00018	0.455
LIG_SH3_3	44	50	PF00018	0.472
LIG_SH3_5	135	139	PF00018	0.556
LIG_TRAF2_1	199	202	PF00917	0.475
LIG_TRAF2_1	205	208	PF00917	0.517
LIG_TRFH_1	195	199	PF08558	0.475
LIG_TYR_ITIM	72	77	PF00017	0.462
LIG_WW_1	102	105	PF00397	0.475
MOD_CK1_1	11	17	PF00069	0.568
MOD_CK1_1	167	173	PF00069	0.556
MOD_CK1_1	60	66	PF00069	0.462
MOD_CK1_1	82	88	PF00069	0.545
MOD_GlcNHglycan	111	114	PF01048	0.269
MOD_GlcNHglycan	39	42	PF01048	0.262
MOD_GlcNHglycan	90	93	PF01048	0.282
MOD_GSK3_1	33	40	PF00069	0.441
MOD_GSK3_1	4	11	PF00069	0.617
MOD_GSK3_1	75	82	PF00069	0.488
MOD_N-GLC_1	67	72	PF02516	0.262
MOD_NEK2_1	3	8	PF00069	0.580
MOD_NEK2_1	33	38	PF00069	0.440
MOD_OFUCOSY	81	86	PF10250	0.263
MOD_PKA_2	109	115	PF00069	0.556
MOD_Plk_1	11	17	PF00069	0.543
MOD_Plk_4	145	151	PF00069	0.489
MOD_Plk_4	4	10	PF00069	0.614
MOD_ProDKin_1	201	207	PF00069	0.475
TRG_DiLeu_BaEn_4	201	207	PF01217	0.475
TRG_ENDOCYTIC_2	116	119	PF00928	0.462
TRG_ENDOCYTIC_2	161	164	PF00928	0.462
TRG_ENDOCYTIC_2	166	169	PF00928	0.462
TRG_ENDOCYTIC_2	74	77	PF00928	0.462
TRG_ENDOCYTIC_2	95	98	PF00928	0.462
TRG_ER_diArg_1	154	156	PF00400	0.518
TRG_NLS_MonoExtC_3	17	22	PF00514	0.471
TRG_NLS_MonoExtN_4	16	22	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJX4	Leptomonas seymouri	97%	100%
A0A0S4JRY9	Bodo saltans	70%	99%
A0A1X0NMF7	Trypanosomatidae	74%	99%
A0A3R7LB49	Trypanosoma rangeli	75%	100%
A0A3S5H5T5	Leishmania donovani	99%	100%
A4H4Q9	Leishmania braziliensis	96%	100%
A4HSY8	Leishmania infantum	99%	100%
C9ZTL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
F4K495	Arabidopsis thaliana	43%	100%
O74558	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	91%
O94360	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
P40484	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	71%
P43563	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	78%
Q29RK9	Bos taurus	48%	100%
Q2WBN3	Medicago sativa subsp. falcata	49%	100%
Q3T1J9	Rattus norvegicus	52%	100%
Q4QIY1	Leishmania major	99%	100%
Q54BM4	Dictyostelium discoideum	47%	100%
Q54CR8	Dictyostelium discoideum	51%	100%
Q54QV0	Dictyostelium discoideum	35%	100%
Q54XJ0	Dictyostelium discoideum	50%	100%
Q58D63	Bos taurus	50%	100%
Q5ABC6	Candida albicans (strain SC5314 / ATCC MYA-2876)	36%	71%
Q5EAA4	Bos taurus	46%	100%
Q5R5Z0	Pongo abelii	51%	100%
Q5RAE0	Pongo abelii	52%	100%
Q70IA6	Homo sapiens	31%	94%
Q70IA8	Homo sapiens	46%	100%
Q7L9L4	Homo sapiens	51%	100%
Q86TA1	Homo sapiens	48%	100%
Q8BJG4	Mus musculus	46%	100%
Q8BPB0	Mus musculus	51%	100%
Q8BSU7	Mus musculus	50%	100%
Q8GYX0	Arabidopsis thaliana	50%	100%
Q8VE04	Mus musculus	49%	100%
Q8VI63	Mus musculus	31%	95%
Q921Y0	Mus musculus	52%	100%
Q949G5	Medicago sativa subsp. falcata	49%	100%
Q95RA8	Drosophila melanogaster	49%	100%
Q96BX8	Homo sapiens	51%	100%
Q9FHI1	Arabidopsis thaliana	51%	100%
Q9H8S9	Homo sapiens	52%	100%
Q9P601	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	39%	100%
Q9VL13	Drosophila melanogaster	47%	100%