DUF4384 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKX0_LEIMU

TriTrypDb:

LmxM.06.0920

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.748
CLV_NRD_NRD_1	103	105	PF00675	0.476
CLV_NRD_NRD_1	141	143	PF00675	0.525
CLV_NRD_NRD_1	204	206	PF00675	0.388
CLV_PCSK_SKI1_1	149	153	PF00082	0.496
CLV_PCSK_SKI1_1	4	8	PF00082	0.425
DEG_APCC_DBOX_1	37	45	PF00400	0.406
DEG_APCC_DBOX_1	389	397	PF00400	0.660
DOC_CYCLIN_RxL_1	1	9	PF00134	0.487
DOC_MAPK_gen_1	104	111	PF00069	0.419
DOC_MAPK_gen_1	205	213	PF00069	0.393
DOC_MAPK_MEF2A_6	104	113	PF00069	0.414
DOC_MAPK_MEF2A_6	226	234	PF00069	0.380
DOC_PP2B_LxvP_1	170	173	PF13499	0.568
DOC_PP2B_LxvP_1	356	359	PF13499	0.643
DOC_PP2B_PxIxI_1	403	409	PF00149	0.671
DOC_USP7_MATH_1	281	285	PF00917	0.740
DOC_USP7_MATH_1	332	336	PF00917	0.700
DOC_USP7_MATH_1	341	345	PF00917	0.642
DOC_USP7_MATH_1	402	406	PF00917	0.654
DOC_USP7_MATH_1	97	101	PF00917	0.281
DOC_USP7_UBL2_3	145	149	PF12436	0.502
DOC_WW_Pin1_4	122	127	PF00397	0.476
DOC_WW_Pin1_4	255	260	PF00397	0.773
DOC_WW_Pin1_4	276	281	PF00397	0.624
DOC_WW_Pin1_4	71	76	PF00397	0.342
LIG_14-3-3_CanoR_1	104	112	PF00244	0.559
LIG_14-3-3_CanoR_1	30	37	PF00244	0.554
LIG_14-3-3_CanoR_1	43	49	PF00244	0.414
LIG_AP2alpha_2	348	350	PF02296	0.705
LIG_BIR_III_2	401	405	PF00653	0.639
LIG_CaM_IQ_9	213	228	PF13499	0.515
LIG_Clathr_ClatBox_1	110	114	PF01394	0.433
LIG_FHA_1	104	110	PF00498	0.508
LIG_FHA_1	127	133	PF00498	0.504
LIG_FHA_1	135	141	PF00498	0.466
LIG_FHA_1	155	161	PF00498	0.486
LIG_FHA_1	213	219	PF00498	0.410
LIG_FHA_2	123	129	PF00498	0.455
LIG_LIR_Apic_2	277	281	PF02991	0.501
LIG_LIR_Gen_1	347	358	PF02991	0.709
LIG_LIR_Gen_1	47	56	PF02991	0.456
LIG_LIR_LC3C_4	176	181	PF02991	0.455
LIG_LIR_Nem_3	122	127	PF02991	0.516
LIG_LIR_Nem_3	219	225	PF02991	0.528
LIG_LIR_Nem_3	347	353	PF02991	0.699
LIG_LIR_Nem_3	401	406	PF02991	0.706
LIG_LIR_Nem_3	47	51	PF02991	0.420
LIG_MYND_1	255	259	PF01753	0.779
LIG_NRBOX	40	46	PF00104	0.533
LIG_PDZ_Class_2	430	435	PF00595	0.698
LIG_Pex14_2	429	433	PF04695	0.565
LIG_SH2_CRK	222	226	PF00017	0.573
LIG_SH2_CRK	278	282	PF00017	0.502
LIG_SH2_CRK	317	321	PF00017	0.715
LIG_SH2_CRK	48	52	PF00017	0.414
LIG_SH2_NCK_1	124	128	PF00017	0.391
LIG_SH2_NCK_1	168	172	PF00017	0.491
LIG_SH2_NCK_1	278	282	PF00017	0.610
LIG_SH2_NCK_1	317	321	PF00017	0.715
LIG_SH2_NCK_1	48	52	PF00017	0.438
LIG_SH2_STAP1	168	172	PF00017	0.511
LIG_SH2_STAP1	48	52	PF00017	0.475
LIG_SH2_STAP1	80	84	PF00017	0.540
LIG_SH2_STAT5	124	127	PF00017	0.539
LIG_SH2_STAT5	131	134	PF00017	0.525
LIG_SH2_STAT5	158	161	PF00017	0.369
LIG_SH2_STAT5	168	171	PF00017	0.477
LIG_SH2_STAT5	278	281	PF00017	0.501
LIG_SH2_STAT5	55	58	PF00017	0.363
LIG_SH2_STAT5	64	67	PF00017	0.405
LIG_SH3_2	325	330	PF14604	0.602
LIG_SH3_3	177	183	PF00018	0.473
LIG_SH3_3	301	307	PF00018	0.675
LIG_SH3_3	322	328	PF00018	0.656
LIG_SH3_3	356	362	PF00018	0.701
LIG_SH3_3	373	379	PF00018	0.655
LIG_SH3_3	411	417	PF00018	0.686
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.546
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.426
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.421
LIG_SUMO_SIM_par_1	209	215	PF11976	0.399
LIG_TYR_ITIM	220	225	PF00017	0.562
MOD_CDK_SPK_2	71	76	PF00069	0.342
MOD_CK1_1	100	106	PF00069	0.278
MOD_CK1_1	258	264	PF00069	0.703
MOD_CK1_1	274	280	PF00069	0.746
MOD_CK1_1	32	38	PF00069	0.605
MOD_CK1_1	335	341	PF00069	0.684
MOD_CK1_1	47	53	PF00069	0.502
MOD_CK2_1	138	144	PF00069	0.509
MOD_CK2_1	184	190	PF00069	0.615
MOD_CK2_1	341	347	PF00069	0.717
MOD_GlcNHglycan	186	189	PF01048	0.617
MOD_GlcNHglycan	222	225	PF01048	0.517
MOD_GlcNHglycan	245	248	PF01048	0.695
MOD_GlcNHglycan	250	253	PF01048	0.720
MOD_GlcNHglycan	283	286	PF01048	0.814
MOD_GlcNHglycan	320	323	PF01048	0.722
MOD_GlcNHglycan	334	337	PF01048	0.679
MOD_GlcNHglycan	339	342	PF01048	0.754
MOD_GlcNHglycan	344	347	PF01048	0.724
MOD_GSK3_1	122	129	PF00069	0.487
MOD_GSK3_1	134	141	PF00069	0.424
MOD_GSK3_1	154	161	PF00069	0.519
MOD_GSK3_1	257	264	PF00069	0.720
MOD_GSK3_1	32	39	PF00069	0.537
MOD_GSK3_1	332	339	PF00069	0.766
MOD_GSK3_1	412	419	PF00069	0.689
MOD_GSK3_1	78	85	PF00069	0.478
MOD_N-GLC_1	100	105	PF02516	0.538
MOD_N-GLC_1	281	286	PF02516	0.783
MOD_N-GLC_1	332	337	PF02516	0.671
MOD_N-GLC_1	82	87	PF02516	0.536
MOD_NEK2_1	151	156	PF00069	0.509
MOD_NEK2_1	29	34	PF00069	0.616
MOD_NEK2_2	126	131	PF00069	0.559
MOD_NEK2_2	158	163	PF00069	0.452
MOD_PKA_2	184	190	PF00069	0.615
MOD_PKA_2	220	226	PF00069	0.443
MOD_PKA_2	29	35	PF00069	0.575
MOD_PKA_2	65	71	PF00069	0.435
MOD_PKA_2	97	103	PF00069	0.567
MOD_Plk_1	149	155	PF00069	0.463
MOD_Plk_1	166	172	PF00069	0.544
MOD_Plk_1	211	217	PF00069	0.431
MOD_Plk_4	126	132	PF00069	0.514
MOD_Plk_4	154	160	PF00069	0.390
MOD_Plk_4	369	375	PF00069	0.742
MOD_Plk_4	416	422	PF00069	0.636
MOD_Plk_4	47	53	PF00069	0.432
MOD_ProDKin_1	122	128	PF00069	0.476
MOD_ProDKin_1	255	261	PF00069	0.773
MOD_ProDKin_1	276	282	PF00069	0.625
MOD_ProDKin_1	71	77	PF00069	0.339
MOD_SUMO_rev_2	190	199	PF00179	0.555
TRG_DiLeu_BaEn_1	40	45	PF01217	0.462
TRG_DiLeu_BaEn_1	9	14	PF01217	0.413
TRG_DiLeu_BaEn_2	415	421	PF01217	0.708
TRG_DiLeu_LyEn_5	40	45	PF01217	0.530
TRG_ENDOCYTIC_2	124	127	PF00928	0.286
TRG_ENDOCYTIC_2	222	225	PF00928	0.572
TRG_ENDOCYTIC_2	48	51	PF00928	0.391
TRG_ER_diArg_1	390	393	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKD5	Leptomonas seymouri	65%	97%
A0A1X0NKR8	Trypanosomatidae	38%	100%
A0A3R7KW02	Trypanosoma rangeli	38%	100%
A0A3S5H5T3	Leishmania donovani	88%	97%
A4H4Q5	Leishmania braziliensis	76%	100%
A4HSY4	Leishmania infantum	88%	97%
C9ZTL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QIY5	Leishmania major	86%	100%
V5BXU6	Trypanosoma cruzi	35%	100%