Aminoacyl-tRNA hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-tRNA hydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9AKW9_LEIMU

TriTrypDb:

LmxM.06.0910

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9AKW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKW9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004045	aminoacyl-tRNA hydrolase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0052689	carboxylic ester hydrolase activity	4	17
GO:0140098	catalytic activity, acting on RNA	3	17
GO:0140101	catalytic activity, acting on a tRNA	4	17
GO:0140640	catalytic activity, acting on a nucleic acid	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.425
CLV_NRD_NRD_1	96	98	PF00675	0.248
CLV_PCSK_KEX2_1	70	72	PF00082	0.450
CLV_PCSK_KEX2_1	96	98	PF00082	0.200
CLV_PCSK_SKI1_1	133	137	PF00082	0.194
CLV_PCSK_SKI1_1	157	161	PF00082	0.249
CLV_PCSK_SKI1_1	90	94	PF00082	0.284
CLV_PCSK_SKI1_1	97	101	PF00082	0.262
CLV_Separin_Metazoa	36	40	PF03568	0.342
DEG_APCC_DBOX_1	132	140	PF00400	0.409
DEG_SPOP_SBC_1	10	14	PF00917	0.307
DOC_PP4_FxxP_1	69	72	PF00568	0.592
DOC_USP7_MATH_1	123	127	PF00917	0.462
DOC_USP7_MATH_1	31	35	PF00917	0.393
DOC_USP7_MATH_1	8	12	PF00917	0.301
DOC_WW_Pin1_4	128	133	PF00397	0.481
LIG_14-3-3_CanoR_1	62	72	PF00244	0.507
LIG_14-3-3_CanoR_1	77	83	PF00244	0.584
LIG_Actin_WH2_2	86	102	PF00022	0.428
LIG_BIR_II_1	1	5	PF00653	0.335
LIG_FHA_1	213	219	PF00498	0.509
LIG_LIR_Apic_2	66	72	PF02991	0.579
LIG_LIR_Gen_1	53	61	PF02991	0.224
LIG_Pex14_1	143	147	PF04695	0.486
LIG_Pex14_2	42	46	PF04695	0.251
LIG_Pex14_2	54	58	PF04695	0.329
LIG_SH2_STAP1	3	7	PF00017	0.415
LIG_SH2_STAT5	183	186	PF00017	0.545
LIG_SH3_3	35	41	PF00018	0.398
LIG_SH3_3	4	10	PF00018	0.337
LIG_SUMO_SIM_anti_2	11	20	PF11976	0.291
LIG_UBA3_1	168	173	PF00899	0.505
LIG_WRC_WIRS_1	51	56	PF05994	0.217
MOD_CDK_SPK_2	128	133	PF00069	0.432
MOD_CK1_1	11	17	PF00069	0.384
MOD_CK1_1	131	137	PF00069	0.489
MOD_CK1_1	153	159	PF00069	0.508
MOD_CK1_1	78	84	PF00069	0.501
MOD_CMANNOS	143	146	PF00535	0.270
MOD_GlcNHglycan	133	136	PF01048	0.385
MOD_GlcNHglycan	139	142	PF01048	0.310
MOD_GlcNHglycan	150	153	PF01048	0.245
MOD_GlcNHglycan	33	36	PF01048	0.678
MOD_GSK3_1	123	130	PF00069	0.514
MOD_GSK3_1	78	85	PF00069	0.581
MOD_NEK2_1	23	28	PF00069	0.412
MOD_NEK2_1	50	55	PF00069	0.320
MOD_NEK2_1	64	69	PF00069	0.582
MOD_NEK2_1	99	104	PF00069	0.528
MOD_PIKK_1	188	194	PF00454	0.440
MOD_Plk_4	11	17	PF00069	0.380
MOD_Plk_4	196	202	PF00069	0.473
MOD_Plk_4	206	212	PF00069	0.477
MOD_Plk_4	50	56	PF00069	0.332
MOD_Plk_4	64	70	PF00069	0.591
MOD_ProDKin_1	128	134	PF00069	0.481
TRG_ER_diArg_1	69	71	PF00400	0.655
TRG_ER_diArg_1	95	97	PF00400	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P574	Leptomonas seymouri	65%	100%
A0A0N1IHT0	Leptomonas seymouri	33%	92%
A0A1X0NKN2	Trypanosomatidae	52%	100%
A0A1X0P1N6	Trypanosomatidae	29%	85%
A0A3Q8IED2	Leishmania donovani	34%	100%
A0A3R7N0D9	Trypanosoma rangeli	48%	100%
A0A3S7WPI5	Leishmania donovani	85%	100%
A4H4Q4	Leishmania braziliensis	70%	100%
A4HIH3	Leishmania braziliensis	29%	100%
A4I5S0	Leishmania infantum	34%	100%
C9ZR39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	86%
C9ZTL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B115	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q751	Leishmania major	32%	100%
Q4QIY6	Leishmania major	83%	100%