Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKW7_LEIMU

TriTrypDb:

LmxM.06.0890

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.579
CLV_C14_Caspase3-7	654	658	PF00656	0.524
CLV_NRD_NRD_1	213	215	PF00675	0.493
CLV_NRD_NRD_1	229	231	PF00675	0.516
CLV_NRD_NRD_1	254	256	PF00675	0.521
CLV_NRD_NRD_1	290	292	PF00675	0.670
CLV_NRD_NRD_1	387	389	PF00675	0.672
CLV_NRD_NRD_1	469	471	PF00675	0.536
CLV_NRD_NRD_1	501	503	PF00675	0.630
CLV_NRD_NRD_1	515	517	PF00675	0.464
CLV_NRD_NRD_1	617	619	PF00675	0.586
CLV_NRD_NRD_1	673	675	PF00675	0.530
CLV_NRD_NRD_1	694	696	PF00675	0.647
CLV_PCSK_FUR_1	252	256	PF00082	0.462
CLV_PCSK_KEX2_1	213	215	PF00082	0.493
CLV_PCSK_KEX2_1	229	231	PF00082	0.516
CLV_PCSK_KEX2_1	254	256	PF00082	0.514
CLV_PCSK_KEX2_1	290	292	PF00082	0.627
CLV_PCSK_KEX2_1	387	389	PF00082	0.672
CLV_PCSK_KEX2_1	469	471	PF00082	0.536
CLV_PCSK_KEX2_1	500	502	PF00082	0.533
CLV_PCSK_KEX2_1	515	517	PF00082	0.524
CLV_PCSK_KEX2_1	617	619	PF00082	0.586
CLV_PCSK_KEX2_1	673	675	PF00082	0.530
CLV_PCSK_KEX2_1	694	696	PF00082	0.742
CLV_PCSK_PC1ET2_1	694	696	PF00082	0.688
CLV_PCSK_PC7_1	383	389	PF00082	0.665
CLV_PCSK_PC7_1	496	502	PF00082	0.514
CLV_PCSK_SKI1_1	11	15	PF00082	0.543
CLV_PCSK_SKI1_1	198	202	PF00082	0.457
CLV_PCSK_SKI1_1	216	220	PF00082	0.586
CLV_PCSK_SKI1_1	240	244	PF00082	0.564
CLV_PCSK_SKI1_1	291	295	PF00082	0.630
CLV_PCSK_SKI1_1	440	444	PF00082	0.641
CLV_PCSK_SKI1_1	502	506	PF00082	0.513
CLV_PCSK_SKI1_1	516	520	PF00082	0.555
CLV_PCSK_SKI1_1	530	534	PF00082	0.543
CLV_PCSK_SKI1_1	685	689	PF00082	0.653
DEG_APCC_DBOX_1	232	240	PF00400	0.513
DEG_COP1_1	25	34	PF00400	0.515
DEG_Nend_UBRbox_2	1	3	PF02207	0.586
DEG_SCF_TRCP1_1	568	573	PF00400	0.653
DEG_SCF_TRCP1_1	653	658	PF00400	0.648
DEG_SPOP_SBC_1	98	102	PF00917	0.478
DOC_CDC14_PxL_1	740	748	PF14671	0.498
DOC_CKS1_1	121	126	PF01111	0.556
DOC_CKS1_1	338	343	PF01111	0.490
DOC_CYCLIN_yCln2_LP_2	741	747	PF00134	0.468
DOC_MAPK_gen_1	229	238	PF00069	0.539
DOC_MAPK_gen_1	387	393	PF00069	0.651
DOC_PP1_RVXF_1	329	335	PF00149	0.518
DOC_PP1_RVXF_1	491	498	PF00149	0.537
DOC_PP2B_LxvP_1	172	175	PF13499	0.481
DOC_PP2B_LxvP_1	353	356	PF13499	0.597
DOC_PP2B_LxvP_1	504	507	PF13499	0.410
DOC_PP2B_LxvP_1	741	744	PF13499	0.461
DOC_PP4_FxxP_1	14	17	PF00568	0.549
DOC_USP7_MATH_1	293	297	PF00917	0.640
DOC_USP7_MATH_1	382	386	PF00917	0.637
DOC_USP7_MATH_1	435	439	PF00917	0.693
DOC_USP7_MATH_1	572	576	PF00917	0.616
DOC_USP7_MATH_1	98	102	PF00917	0.571
DOC_WW_Pin1_4	120	125	PF00397	0.566
DOC_WW_Pin1_4	138	143	PF00397	0.519
DOC_WW_Pin1_4	30	35	PF00397	0.618
DOC_WW_Pin1_4	318	323	PF00397	0.618
DOC_WW_Pin1_4	337	342	PF00397	0.432
DOC_WW_Pin1_4	484	489	PF00397	0.554
DOC_WW_Pin1_4	530	535	PF00397	0.677
DOC_WW_Pin1_4	648	653	PF00397	0.586
DOC_WW_Pin1_4	66	71	PF00397	0.628
DOC_WW_Pin1_4	76	81	PF00397	0.588
DOC_WW_Pin1_4	99	104	PF00397	0.551
LIG_14-3-3_CanoR_1	11	17	PF00244	0.635
LIG_14-3-3_CanoR_1	118	122	PF00244	0.645
LIG_14-3-3_CanoR_1	198	205	PF00244	0.575
LIG_14-3-3_CanoR_1	290	298	PF00244	0.543
LIG_14-3-3_CanoR_1	350	354	PF00244	0.586
LIG_14-3-3_CanoR_1	383	387	PF00244	0.638
LIG_14-3-3_CanoR_1	388	392	PF00244	0.588
LIG_14-3-3_CanoR_1	470	478	PF00244	0.506
LIG_14-3-3_CanoR_1	500	505	PF00244	0.549
LIG_14-3-3_CanoR_1	515	525	PF00244	0.531
LIG_14-3-3_CanoR_1	61	67	PF00244	0.539
LIG_14-3-3_CanoR_1	622	631	PF00244	0.695
LIG_14-3-3_CanoR_1	723	732	PF00244	0.725
LIG_BIR_III_2	485	489	PF00653	0.618
LIG_BIR_III_4	377	381	PF00653	0.636
LIG_deltaCOP1_diTrp_1	400	404	PF00928	0.630
LIG_Dynein_DLC8_1	59	65	PF01221	0.597
LIG_EVH1_2	175	179	PF00568	0.358
LIG_FHA_1	100	106	PF00498	0.492
LIG_FHA_1	206	212	PF00498	0.474
LIG_FHA_1	256	262	PF00498	0.613
LIG_FHA_1	618	624	PF00498	0.683
LIG_FHA_1	66	72	PF00498	0.604
LIG_FHA_1	713	719	PF00498	0.546
LIG_FHA_1	747	753	PF00498	0.560
LIG_FHA_1	79	85	PF00498	0.592
LIG_GBD_Chelix_1	551	559	PF00786	0.563
LIG_Integrin_RGD_1	394	396	PF01839	0.587
LIG_LIR_Gen_1	25	34	PF02991	0.526
LIG_LIR_Gen_1	340	351	PF02991	0.624
LIG_LIR_Nem_3	25	30	PF02991	0.561
LIG_LIR_Nem_3	340	346	PF02991	0.565
LIG_LIR_Nem_3	400	405	PF02991	0.630
LIG_NRBOX	522	528	PF00104	0.586
LIG_PDZ_Class_2	749	754	PF00595	0.599
LIG_Pex14_1	401	405	PF04695	0.561
LIG_PROFILIN_1	536	542	PF00235	0.526
LIG_Rb_pABgroove_1	14	22	PF01858	0.556
LIG_SH2_CRK	27	31	PF00017	0.566
LIG_SH2_NCK_1	47	51	PF00017	0.501
LIG_SH2_NCK_1	483	487	PF00017	0.634
LIG_SH2_SRC	20	23	PF00017	0.640
LIG_SH2_SRC	483	486	PF00017	0.578
LIG_SH2_STAP1	27	31	PF00017	0.577
LIG_SH2_STAP1	47	51	PF00017	0.501
LIG_SH2_STAT5	405	408	PF00017	0.565
LIG_SH3_3	118	124	PF00018	0.655
LIG_SH3_3	139	145	PF00018	0.486
LIG_SH3_3	28	34	PF00018	0.620
LIG_SH3_3	335	341	PF00018	0.445
LIG_SH3_3	446	452	PF00018	0.519
LIG_SH3_3	531	537	PF00018	0.598
LIG_SH3_3	559	565	PF00018	0.654
LIG_SH3_3	613	619	PF00018	0.679
LIG_SH3_3	625	631	PF00018	0.652
LIG_SH3_3	74	80	PF00018	0.698
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.571
LIG_TRAF2_1	232	235	PF00917	0.512
LIG_WRC_WIRS_1	509	514	PF05994	0.516
MOD_CDK_SPK_2	337	342	PF00069	0.547
MOD_CDK_SPxxK_3	66	73	PF00069	0.599
MOD_CK1_1	116	122	PF00069	0.536
MOD_CK1_1	270	276	PF00069	0.576
MOD_CK1_1	296	302	PF00069	0.594
MOD_CK1_1	320	326	PF00069	0.549
MOD_CK1_1	633	639	PF00069	0.559
MOD_CK1_1	677	683	PF00069	0.791
MOD_CK1_1	69	75	PF00069	0.626
MOD_CK2_1	76	82	PF00069	0.640
MOD_CMANNOS	401	404	PF00535	0.561
MOD_Cter_Amidation	288	291	PF01082	0.622
MOD_GlcNHglycan	115	118	PF01048	0.517
MOD_GlcNHglycan	138	141	PF01048	0.482
MOD_GlcNHglycan	162	165	PF01048	0.448
MOD_GlcNHglycan	193	196	PF01048	0.506
MOD_GlcNHglycan	269	272	PF01048	0.706
MOD_GlcNHglycan	291	294	PF01048	0.752
MOD_GlcNHglycan	322	325	PF01048	0.593
MOD_GlcNHglycan	357	360	PF01048	0.685
MOD_GlcNHglycan	419	423	PF01048	0.674
MOD_GlcNHglycan	437	440	PF01048	0.539
MOD_GlcNHglycan	445	449	PF01048	0.598
MOD_GlcNHglycan	456	459	PF01048	0.577
MOD_GlcNHglycan	544	547	PF01048	0.728
MOD_GlcNHglycan	568	571	PF01048	0.615
MOD_GlcNHglycan	574	577	PF01048	0.640
MOD_GlcNHglycan	582	586	PF01048	0.657
MOD_GlcNHglycan	591	595	PF01048	0.487
MOD_GlcNHglycan	624	627	PF01048	0.601
MOD_GlcNHglycan	635	638	PF01048	0.647
MOD_GlcNHglycan	653	656	PF01048	0.700
MOD_GlcNHglycan	659	662	PF01048	0.776
MOD_GlcNHglycan	669	672	PF01048	0.644
MOD_GlcNHglycan	73	76	PF01048	0.587
MOD_GSK3_1	113	120	PF00069	0.541
MOD_GSK3_1	175	182	PF00069	0.487
MOD_GSK3_1	201	208	PF00069	0.483
MOD_GSK3_1	266	273	PF00069	0.563
MOD_GSK3_1	289	296	PF00069	0.665
MOD_GSK3_1	3	10	PF00069	0.448
MOD_GSK3_1	314	321	PF00069	0.755
MOD_GSK3_1	429	436	PF00069	0.567
MOD_GSK3_1	454	461	PF00069	0.720
MOD_GSK3_1	472	479	PF00069	0.702
MOD_GSK3_1	55	62	PF00069	0.748
MOD_GSK3_1	566	573	PF00069	0.651
MOD_GSK3_1	617	624	PF00069	0.809
MOD_GSK3_1	633	640	PF00069	0.558
MOD_GSK3_1	644	651	PF00069	0.692
MOD_GSK3_1	65	72	PF00069	0.618
MOD_GSK3_1	663	670	PF00069	0.580
MOD_GSK3_1	673	680	PF00069	0.565
MOD_N-GLC_1	471	476	PF02516	0.629
MOD_N-GLC_1	678	683	PF02516	0.530
MOD_NEK2_1	12	17	PF00069	0.618
MOD_NEK2_1	179	184	PF00069	0.463
MOD_NEK2_1	272	277	PF00069	0.646
MOD_NEK2_1	294	299	PF00069	0.716
MOD_NEK2_1	349	354	PF00069	0.695
MOD_NEK2_1	598	603	PF00069	0.549
MOD_NEK2_1	644	649	PF00069	0.539
MOD_NEK2_1	84	89	PF00069	0.591
MOD_NEK2_2	382	387	PF00069	0.640
MOD_NEK2_2	612	617	PF00069	0.636
MOD_PIKK_1	516	522	PF00454	0.545
MOD_PIKK_1	60	66	PF00454	0.654
MOD_PK_1	387	393	PF00069	0.674
MOD_PKA_1	387	393	PF00069	0.651
MOD_PKA_1	500	506	PF00069	0.417
MOD_PKA_1	617	623	PF00069	0.581
MOD_PKA_1	673	679	PF00069	0.531
MOD_PKA_2	117	123	PF00069	0.705
MOD_PKA_2	160	166	PF00069	0.562
MOD_PKA_2	289	295	PF00069	0.537
MOD_PKA_2	349	355	PF00069	0.585
MOD_PKA_2	382	388	PF00069	0.637
MOD_PKA_2	500	506	PF00069	0.417
MOD_PKA_2	60	66	PF00069	0.584
MOD_PKA_2	617	623	PF00069	0.630
MOD_PKA_2	655	661	PF00069	0.604
MOD_PKA_2	673	679	PF00069	0.671
MOD_Plk_1	599	605	PF00069	0.571
MOD_Plk_2-3	36	42	PF00069	0.604
MOD_Plk_4	15	21	PF00069	0.560
MOD_Plk_4	349	355	PF00069	0.634
MOD_Plk_4	4	10	PF00069	0.549
MOD_Plk_4	599	605	PF00069	0.527
MOD_Plk_4	630	636	PF00069	0.603
MOD_ProDKin_1	120	126	PF00069	0.566
MOD_ProDKin_1	138	144	PF00069	0.508
MOD_ProDKin_1	30	36	PF00069	0.615
MOD_ProDKin_1	318	324	PF00069	0.616
MOD_ProDKin_1	337	343	PF00069	0.435
MOD_ProDKin_1	484	490	PF00069	0.553
MOD_ProDKin_1	530	536	PF00069	0.681
MOD_ProDKin_1	648	654	PF00069	0.586
MOD_ProDKin_1	66	72	PF00069	0.629
MOD_ProDKin_1	76	82	PF00069	0.581
MOD_ProDKin_1	99	105	PF00069	0.555
MOD_SUMO_for_1	261	264	PF00179	0.608
TRG_DiLeu_BaEn_1	234	239	PF01217	0.523
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.558
TRG_ENDOCYTIC_2	27	30	PF00928	0.569
TRG_ENDOCYTIC_2	405	408	PF00928	0.633
TRG_ER_diArg_1	213	216	PF00400	0.494
TRG_ER_diArg_1	228	230	PF00400	0.519
TRG_ER_diArg_1	252	255	PF00400	0.501
TRG_ER_diArg_1	386	388	PF00400	0.665
TRG_ER_diArg_1	469	471	PF00400	0.536
TRG_ER_diArg_1	500	502	PF00400	0.631
TRG_ER_diArg_1	514	516	PF00400	0.467
TRG_ER_diArg_1	616	618	PF00400	0.583
TRG_ER_diArg_1	672	674	PF00400	0.530
TRG_NLS_MonoCore_2	693	698	PF00514	0.520
TRG_NLS_MonoExtN_4	692	699	PF00514	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4D6	Leptomonas seymouri	35%	100%
A0A3S7WPJ7	Leishmania donovani	80%	97%
A4H4Q1	Leishmania braziliensis	60%	96%
A4HSY1	Leishmania infantum	80%	97%
Q4QIY8	Leishmania major	78%	100%