Arginine N-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein arginine n-methyltransferase 7

Species:

Leishmania mexicana

UniProt:

E9AKW5_LEIMU

TriTrypDb:

LmxM.06.0870

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKW5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008213	protein alkylation	5	12
GO:0009987	cellular process	1	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018195	peptidyl-arginine modification	6	12
GO:0018216	peptidyl-arginine methylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0032259	methylation	2	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0034969	histone arginine methylation	6	1
GO:0035246	peptidyl-arginine N-methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016273	arginine N-methyltransferase activity	6	12
GO:0016274	protein-arginine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0035241	protein-arginine omega-N monomethyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.312
CLV_NRD_NRD_1	4	6	PF00675	0.475
CLV_NRD_NRD_1	426	428	PF00675	0.546
CLV_NRD_NRD_1	87	89	PF00675	0.493
CLV_PCSK_FUR_1	85	89	PF00082	0.440
CLV_PCSK_KEX2_1	119	121	PF00082	0.239
CLV_PCSK_KEX2_1	290	292	PF00082	0.280
CLV_PCSK_KEX2_1	307	309	PF00082	0.417
CLV_PCSK_KEX2_1	4	6	PF00082	0.555
CLV_PCSK_KEX2_1	425	427	PF00082	0.552
CLV_PCSK_KEX2_1	87	89	PF00082	0.443
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.249
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.528
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.552
CLV_PCSK_SKI1_1	227	231	PF00082	0.368
CLV_PCSK_SKI1_1	312	316	PF00082	0.506
DOC_ANK_TNKS_1	119	126	PF00023	0.146
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.297
DOC_MAPK_DCC_7	190	200	PF00069	0.437
DOC_MAPK_DCC_7	291	301	PF00069	0.441
DOC_MAPK_gen_1	290	298	PF00069	0.279
DOC_MAPK_gen_1	312	319	PF00069	0.464
DOC_PP2B_PxIxI_1	195	201	PF00149	0.455
DOC_PP4_FxxP_1	34	37	PF00568	0.515
DOC_PP4_FxxP_1	81	84	PF00568	0.358
DOC_USP7_MATH_1	124	128	PF00917	0.524
DOC_USP7_MATH_1	19	23	PF00917	0.658
DOC_USP7_MATH_1	253	257	PF00917	0.477
DOC_USP7_MATH_1	321	325	PF00917	0.311
DOC_USP7_MATH_1	383	387	PF00917	0.222
DOC_USP7_MATH_1	392	396	PF00917	0.474
DOC_USP7_MATH_1	43	47	PF00917	0.606
DOC_USP7_UBL2_3	145	149	PF12436	0.479
DOC_WW_Pin1_4	185	190	PF00397	0.485
DOC_WW_Pin1_4	372	377	PF00397	0.425
LIG_14-3-3_CanoR_1	283	288	PF00244	0.325
LIG_14-3-3_CanoR_1	308	312	PF00244	0.512
LIG_14-3-3_CanoR_1	397	403	PF00244	0.408
LIG_14-3-3_CanoR_1	408	416	PF00244	0.606
LIG_Actin_WH2_2	73	89	PF00022	0.389
LIG_BRCT_BRCA1_1	200	204	PF00533	0.423
LIG_BRCT_BRCA1_1	272	276	PF00533	0.309
LIG_BRCT_BRCA1_1	285	289	PF00533	0.321
LIG_BRCT_BRCA1_1	385	389	PF00533	0.330
LIG_BRCT_BRCA1_2	272	278	PF00533	0.306
LIG_Clathr_ClatBox_1	298	302	PF01394	0.285
LIG_EVH1_1	192	196	PF00568	0.479
LIG_FHA_1	204	210	PF00498	0.288
LIG_FHA_1	226	232	PF00498	0.348
LIG_FHA_1	269	275	PF00498	0.326
LIG_FHA_1	4	10	PF00498	0.551
LIG_FHA_2	186	192	PF00498	0.501
LIG_FHA_2	245	251	PF00498	0.229
LIG_FHA_2	335	341	PF00498	0.369
LIG_FHA_2	343	349	PF00498	0.350
LIG_FHA_2	427	433	PF00498	0.580
LIG_GBD_Chelix_1	199	207	PF00786	0.255
LIG_LIR_Apic_2	31	37	PF02991	0.555
LIG_LIR_Gen_1	112	123	PF02991	0.402
LIG_LIR_Gen_1	99	109	PF02991	0.345
LIG_LIR_Nem_3	112	118	PF02991	0.408
LIG_LIR_Nem_3	201	207	PF02991	0.494
LIG_LIR_Nem_3	255	260	PF02991	0.344
LIG_LIR_Nem_3	286	292	PF02991	0.314
LIG_LIR_Nem_3	309	314	PF02991	0.440
LIG_Pex14_2	311	315	PF04695	0.480
LIG_Pex14_2	72	76	PF04695	0.389
LIG_SH2_CRK	115	119	PF00017	0.464
LIG_SH2_CRK	239	243	PF00017	0.270
LIG_SH2_GRB2like	114	117	PF00017	0.455
LIG_SH2_STAT5	216	219	PF00017	0.291
LIG_SH2_STAT5	404	407	PF00017	0.515
LIG_SH3_1	190	196	PF00018	0.377
LIG_SH3_3	190	196	PF00018	0.440
LIG_SUMO_SIM_par_1	150	155	PF11976	0.412
LIG_SUMO_SIM_par_1	205	212	PF11976	0.339
LIG_SUMO_SIM_par_1	297	302	PF11976	0.302
LIG_SUMO_SIM_par_1	315	320	PF11976	0.277
LIG_UBA3_1	138	145	PF00899	0.479
LIG_WW_3	1	5	PF00397	0.468
LIG_WW_3	82	86	PF00397	0.444
MOD_CDK_SPK_2	185	190	PF00069	0.437
MOD_CK1_1	407	413	PF00069	0.356
MOD_CK2_1	334	340	PF00069	0.375
MOD_CK2_1	342	348	PF00069	0.397
MOD_CK2_1	379	385	PF00069	0.486
MOD_CK2_1	426	432	PF00069	0.612
MOD_GlcNHglycan	126	129	PF01048	0.261
MOD_GlcNHglycan	135	138	PF01048	0.224
MOD_GlcNHglycan	211	214	PF01048	0.284
MOD_GlcNHglycan	323	326	PF01048	0.311
MOD_GlcNHglycan	381	384	PF01048	0.338
MOD_GlcNHglycan	409	412	PF01048	0.603
MOD_GlcNHglycan	56	59	PF01048	0.764
MOD_GlcNHglycan	6	9	PF01048	0.655
MOD_GSK3_1	13	20	PF00069	0.673
MOD_GSK3_1	133	140	PF00069	0.426
MOD_GSK3_1	155	162	PF00069	0.524
MOD_GSK3_1	181	188	PF00069	0.433
MOD_GSK3_1	194	201	PF00069	0.476
MOD_GSK3_1	270	277	PF00069	0.391
MOD_GSK3_1	303	310	PF00069	0.397
MOD_GSK3_1	317	324	PF00069	0.367
MOD_GSK3_1	368	375	PF00069	0.446
MOD_GSK3_1	379	386	PF00069	0.320
MOD_GSK3_1	398	405	PF00069	0.522
MOD_N-GLC_1	352	357	PF02516	0.482
MOD_NEK2_1	163	168	PF00069	0.515
MOD_NEK2_1	17	22	PF00069	0.785
MOD_NEK2_1	209	214	PF00069	0.281
MOD_NEK2_1	268	273	PF00069	0.354
MOD_NEK2_1	282	287	PF00069	0.292
MOD_NEK2_1	303	308	PF00069	0.350
MOD_NEK2_1	379	384	PF00069	0.493
MOD_NEK2_1	402	407	PF00069	0.485
MOD_NEK2_2	347	352	PF00069	0.390
MOD_PK_1	283	289	PF00069	0.309
MOD_PKA_1	13	19	PF00069	0.713
MOD_PKA_1	307	313	PF00069	0.491
MOD_PKA_1	4	10	PF00069	0.672
MOD_PKA_1	426	432	PF00069	0.534
MOD_PKA_2	282	288	PF00069	0.308
MOD_PKA_2	3	9	PF00069	0.699
MOD_PKA_2	307	313	PF00069	0.491
MOD_PKA_2	407	413	PF00069	0.556
MOD_PKA_2	426	432	PF00069	0.662
MOD_PKA_2	54	60	PF00069	0.606
MOD_Plk_1	260	266	PF00069	0.366
MOD_Plk_1	269	275	PF00069	0.326
MOD_Plk_1	347	353	PF00069	0.512
MOD_Plk_2-3	244	250	PF00069	0.213
MOD_Plk_4	137	143	PF00069	0.424
MOD_Plk_4	194	200	PF00069	0.472
MOD_Plk_4	203	209	PF00069	0.226
MOD_Plk_4	270	276	PF00069	0.342
MOD_ProDKin_1	185	191	PF00069	0.485
MOD_ProDKin_1	372	378	PF00069	0.423
MOD_SUMO_rev_2	302	309	PF00179	0.412
TRG_DiLeu_BaEn_2	76	82	PF01217	0.506
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.336
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.376
TRG_ENDOCYTIC_2	102	105	PF00928	0.360
TRG_ENDOCYTIC_2	114	117	PF00928	0.354
TRG_ER_diArg_1	221	224	PF00400	0.408
TRG_ER_diArg_1	289	291	PF00400	0.322
TRG_ER_diArg_1	3	5	PF00400	0.467
TRG_ER_diArg_1	84	87	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.177
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL4	Leptomonas seymouri	75%	100%
A0A0S4IRB2	Bodo saltans	56%	98%
A0A1X0NKR3	Trypanosomatidae	59%	91%
A0A3S7WPK3	Leishmania donovani	93%	100%
A0A422NZF0	Trypanosoma rangeli	59%	100%
A2YPT7	Oryza sativa subsp. indica	29%	83%
A4H4P9	Leishmania braziliensis	83%	100%
A4HSX9	Leishmania infantum	93%	100%
C9ZTK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
O60678	Homo sapiens	27%	83%
O70467	Rattus norvegicus	28%	83%
Q174R2	Aedes aegypti	25%	74%
Q4AE70	Rattus norvegicus	27%	68%
Q4QIZ0	Leishmania major	91%	100%
Q582G4	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	56%	100%
Q5XK84	Xenopus laevis	26%	73%
Q6DC04	Danio rerio	27%	75%
Q7Q2B7	Anopheles gambiae	24%	71%
Q7XI75	Oryza sativa subsp. japonica	29%	83%
Q86X55	Homo sapiens	27%	72%
Q922H1	Mus musculus	28%	83%
Q9WVG6	Mus musculus	27%	72%
V5BT47	Trypanosoma cruzi	56%	100%