Qb-SNARE_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKW0_LEIMU

TriTrypDb:

LmxM.06.0820

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9AKW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKW0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.618
CLV_C14_Caspase3-7	180	184	PF00656	0.590
CLV_NRD_NRD_1	117	119	PF00675	0.529
CLV_NRD_NRD_1	145	147	PF00675	0.365
CLV_NRD_NRD_1	363	365	PF00675	0.394
CLV_NRD_NRD_1	366	368	PF00675	0.386
CLV_NRD_NRD_1	85	87	PF00675	0.382
CLV_PCSK_FUR_1	205	209	PF00082	0.286
CLV_PCSK_FUR_1	364	368	PF00082	0.410
CLV_PCSK_KEX2_1	116	118	PF00082	0.537
CLV_PCSK_KEX2_1	145	147	PF00082	0.377
CLV_PCSK_KEX2_1	2	4	PF00082	0.494
CLV_PCSK_KEX2_1	207	209	PF00082	0.280
CLV_PCSK_KEX2_1	363	365	PF00082	0.406
CLV_PCSK_KEX2_1	366	368	PF00082	0.397
CLV_PCSK_KEX2_1	47	49	PF00082	0.331
CLV_PCSK_KEX2_1	85	87	PF00082	0.382
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.494
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.292
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.396
CLV_PCSK_PC7_1	113	119	PF00082	0.336
CLV_PCSK_PC7_1	141	147	PF00082	0.409
CLV_PCSK_SKI1_1	299	303	PF00082	0.444
CLV_PCSK_SKI1_1	70	74	PF00082	0.369
DEG_APCC_DBOX_1	69	77	PF00400	0.576
DEG_Nend_UBRbox_1	1	4	PF02207	0.703
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.698
DOC_MAPK_gen_1	2	13	PF00069	0.668
DOC_MAPK_MEF2A_6	6	15	PF00069	0.582
DOC_USP7_MATH_1	177	181	PF00917	0.770
DOC_USP7_MATH_1	235	239	PF00917	0.727
DOC_USP7_MATH_1	251	255	PF00917	0.732
DOC_USP7_MATH_1	278	282	PF00917	0.727
DOC_WW_Pin1_4	281	286	PF00397	0.654
DOC_WW_Pin1_4	50	55	PF00397	0.605
LIG_14-3-3_CanoR_1	217	223	PF00244	0.586
LIG_14-3-3_CanoR_1	3	9	PF00244	0.632
LIG_14-3-3_CanoR_1	318	326	PF00244	0.578
LIG_14-3-3_CanoR_1	32	38	PF00244	0.661
LIG_14-3-3_CanoR_1	85	91	PF00244	0.598
LIG_14-3-3_CterR_2	396	399	PF00244	0.339
LIG_Actin_WH2_2	380	398	PF00022	0.306
LIG_CaM_IQ_9	356	372	PF13499	0.584
LIG_EH1_1	379	387	PF00400	0.410
LIG_eIF4E_1	380	386	PF01652	0.410
LIG_FHA_1	128	134	PF00498	0.599
LIG_FHA_1	284	290	PF00498	0.607
LIG_FHA_1	377	383	PF00498	0.178
LIG_GBD_Chelix_1	381	389	PF00786	0.355
LIG_LIR_Gen_1	300	307	PF02991	0.577
LIG_LIR_Nem_3	295	301	PF02991	0.557
LIG_LIR_Nem_3	321	327	PF02991	0.444
LIG_LIR_Nem_3	59	63	PF02991	0.537
LIG_MAD2	217	225	PF02301	0.591
LIG_NRBOX	384	390	PF00104	0.430
LIG_Pex14_2	298	302	PF04695	0.588
LIG_SH2_STAT5	210	213	PF00017	0.453
LIG_SH2_STAT5	380	383	PF00017	0.322
LIG_SH3_3	229	235	PF00018	0.784
LIG_SUMO_SIM_par_1	284	292	PF11976	0.614
LIG_TRAF2_1	140	143	PF00917	0.472
LIG_TRAF2_1	264	267	PF00917	0.632
LIG_TRAF2_1	338	341	PF00917	0.610
LIG_TRAF2_1	94	97	PF00917	0.736
MOD_CDK_SPxK_1	50	56	PF00069	0.558
MOD_CK1_1	125	131	PF00069	0.508
MOD_CK1_1	185	191	PF00069	0.560
MOD_CK1_1	238	244	PF00069	0.687
MOD_CK1_1	25	31	PF00069	0.729
MOD_CK1_1	254	260	PF00069	0.645
MOD_CK1_1	281	287	PF00069	0.644
MOD_CK1_1	376	382	PF00069	0.195
MOD_CK1_1	4	10	PF00069	0.550
MOD_CK2_1	123	129	PF00069	0.495
MOD_CK2_1	137	143	PF00069	0.401
MOD_CK2_1	14	20	PF00069	0.372
MOD_CK2_1	261	267	PF00069	0.551
MOD_CK2_1	288	294	PF00069	0.489
MOD_CK2_1	91	97	PF00069	0.670
MOD_Cter_Amidation	83	86	PF01082	0.448
MOD_GlcNHglycan	110	113	PF01048	0.398
MOD_GlcNHglycan	174	177	PF01048	0.719
MOD_GlcNHglycan	183	187	PF01048	0.656
MOD_GlcNHglycan	237	240	PF01048	0.737
MOD_GlcNHglycan	24	27	PF01048	0.521
MOD_GlcNHglycan	263	266	PF01048	0.693
MOD_GlcNHglycan	267	271	PF01048	0.672
MOD_GlcNHglycan	87	90	PF01048	0.571
MOD_GSK3_1	123	130	PF00069	0.569
MOD_GSK3_1	22	29	PF00069	0.727
MOD_GSK3_1	279	286	PF00069	0.533
MOD_GSK3_1	347	354	PF00069	0.389
MOD_GSK3_1	372	379	PF00069	0.557
MOD_N-GLC_1	170	175	PF02516	0.429
MOD_NEK2_1	1	6	PF00069	0.566
MOD_NEK2_1	137	142	PF00069	0.509
MOD_NEK2_1	288	293	PF00069	0.546
MOD_NEK2_1	301	306	PF00069	0.463
MOD_NEK2_1	372	377	PF00069	0.552
MOD_PIKK_1	356	362	PF00454	0.425
MOD_PKA_1	85	91	PF00069	0.497
MOD_PKA_2	13	19	PF00069	0.613
MOD_PKA_2	31	37	PF00069	0.420
MOD_PKA_2	317	323	PF00069	0.424
MOD_PKA_2	84	90	PF00069	0.614
MOD_Plk_1	347	353	PF00069	0.424
MOD_Plk_1	372	378	PF00069	0.476
MOD_Plk_4	283	289	PF00069	0.517
MOD_Plk_4	376	382	PF00069	0.173
MOD_ProDKin_1	281	287	PF00069	0.576
MOD_ProDKin_1	50	56	PF00069	0.505
TRG_DiLeu_BaEn_1	110	115	PF01217	0.635
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.466
TRG_DiLeu_LyEn_5	110	115	PF01217	0.531
TRG_ENDOCYTIC_2	210	213	PF00928	0.476
TRG_ENDOCYTIC_2	324	327	PF00928	0.289
TRG_ENDOCYTIC_2	60	63	PF00928	0.409
TRG_ER_diArg_1	115	118	PF00400	0.550
TRG_ER_diArg_1	363	366	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P557	Leptomonas seymouri	45%	89%
A0A0S4JA95	Bodo saltans	25%	100%
A0A1X0NMF9	Trypanosomatidae	27%	100%
A0A3S7WPJ4	Leishmania donovani	83%	97%
A0A422NZG0	Trypanosoma rangeli	31%	100%
A4H4P4	Leishmania braziliensis	70%	100%
A4HSX4	Leishmania infantum	83%	97%
Q4QIZ5	Leishmania major	81%	100%
V5BT43	Trypanosoma cruzi	29%	91%