Haemolysin-III_related_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania mexicana

UniProt:

E9AKV4_LEIMU

TriTrypDb:

LmxM.06.0750

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AKV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	1
GO:0060089	molecular transducer activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.653
CLV_C14_Caspase3-7	140	144	PF00656	0.400
CLV_C14_Caspase3-7	187	191	PF00656	0.474
CLV_MEL_PAP_1	26	32	PF00089	0.373
CLV_NRD_NRD_1	159	161	PF00675	0.631
CLV_NRD_NRD_1	292	294	PF00675	0.346
CLV_NRD_NRD_1	38	40	PF00675	0.423
CLV_NRD_NRD_1	432	434	PF00675	0.383
CLV_NRD_NRD_1	531	533	PF00675	0.374
CLV_NRD_NRD_1	538	540	PF00675	0.391
CLV_NRD_NRD_1	58	60	PF00675	0.327
CLV_NRD_NRD_1	66	68	PF00675	0.338
CLV_PCSK_FUR_1	157	161	PF00082	0.605
CLV_PCSK_FUR_1	290	294	PF00082	0.321
CLV_PCSK_FUR_1	430	434	PF00082	0.338
CLV_PCSK_KEX2_1	159	161	PF00082	0.631
CLV_PCSK_KEX2_1	292	294	PF00082	0.345
CLV_PCSK_KEX2_1	38	40	PF00082	0.423
CLV_PCSK_KEX2_1	432	434	PF00082	0.383
CLV_PCSK_KEX2_1	531	533	PF00082	0.374
CLV_PCSK_KEX2_1	538	540	PF00082	0.391
CLV_PCSK_KEX2_1	58	60	PF00082	0.327
CLV_PCSK_KEX2_1	68	70	PF00082	0.334
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.334
CLV_PCSK_PC7_1	64	70	PF00082	0.337
CLV_PCSK_SKI1_1	206	210	PF00082	0.667
CLV_PCSK_SKI1_1	69	73	PF00082	0.373
DEG_APCC_DBOX_1	259	267	PF00400	0.225
DEG_APCC_DBOX_1	68	76	PF00400	0.578
DEG_Nend_UBRbox_3	1	3	PF02207	0.683
DEG_SPOP_SBC_1	451	455	PF00917	0.595
DEG_SPOP_SBC_1	569	573	PF00917	0.694
DOC_CKS1_1	600	605	PF01111	0.571
DOC_MAPK_DCC_7	260	270	PF00069	0.331
DOC_MAPK_DCC_7	430	439	PF00069	0.553
DOC_MAPK_DCC_7	615	623	PF00069	0.650
DOC_MAPK_gen_1	38	44	PF00069	0.542
DOC_MAPK_gen_1	430	439	PF00069	0.553
DOC_MAPK_gen_1	579	588	PF00069	0.568
DOC_MAPK_MEF2A_6	615	623	PF00069	0.650
DOC_PP2B_LxvP_1	101	104	PF13499	0.403
DOC_PP2B_LxvP_1	250	253	PF13499	0.401
DOC_PP2B_LxvP_1	412	415	PF13499	0.673
DOC_PP2B_LxvP_1	616	619	PF13499	0.648
DOC_USP7_MATH_1	131	135	PF00917	0.505
DOC_USP7_MATH_1	177	181	PF00917	0.505
DOC_USP7_MATH_1	216	220	PF00917	0.463
DOC_USP7_MATH_1	230	234	PF00917	0.488
DOC_USP7_MATH_1	323	327	PF00917	0.319
DOC_USP7_MATH_1	387	391	PF00917	0.603
DOC_USP7_MATH_1	452	456	PF00917	0.645
DOC_USP7_MATH_1	568	572	PF00917	0.749
DOC_USP7_MATH_1	71	75	PF00917	0.509
DOC_USP7_MATH_2	414	420	PF00917	0.620
DOC_WW_Pin1_4	13	18	PF00397	0.713
DOC_WW_Pin1_4	201	206	PF00397	0.458
DOC_WW_Pin1_4	217	222	PF00397	0.532
DOC_WW_Pin1_4	223	228	PF00397	0.503
DOC_WW_Pin1_4	235	240	PF00397	0.358
DOC_WW_Pin1_4	389	394	PF00397	0.618
DOC_WW_Pin1_4	432	437	PF00397	0.554
DOC_WW_Pin1_4	581	586	PF00397	0.706
DOC_WW_Pin1_4	599	604	PF00397	0.628
LIG_14-3-3_CanoR_1	105	109	PF00244	0.303
LIG_14-3-3_CanoR_1	157	167	PF00244	0.456
LIG_14-3-3_CanoR_1	260	266	PF00244	0.296
LIG_14-3-3_CanoR_1	7	17	PF00244	0.650
LIG_APCC_ABBA_1	655	660	PF00400	0.503
LIG_BIR_III_4	563	567	PF00653	0.612
LIG_BRCT_BRCA1_1	219	223	PF00533	0.516
LIG_CSL_BTD_1	101	104	PF09270	0.422
LIG_deltaCOP1_diTrp_1	48	53	PF00928	0.522
LIG_EVH1_1	250	254	PF00568	0.451
LIG_FHA_1	181	187	PF00498	0.400
LIG_FHA_1	273	279	PF00498	0.308
LIG_FHA_1	39	45	PF00498	0.534
LIG_FHA_1	445	451	PF00498	0.664
LIG_FHA_1	465	471	PF00498	0.401
LIG_FHA_1	535	541	PF00498	0.619
LIG_FHA_1	594	600	PF00498	0.622
LIG_FHA_1	622	628	PF00498	0.647
LIG_FHA_1	81	87	PF00498	0.531
LIG_FHA_2	138	144	PF00498	0.397
LIG_FHA_2	452	458	PF00498	0.689
LIG_FHA_2	609	615	PF00498	0.660
LIG_GBD_Chelix_1	257	265	PF00786	0.507
LIG_GBD_Chelix_1	376	384	PF00786	0.396
LIG_IBAR_NPY_1	54	56	PF08397	0.576
LIG_LIR_Apic_2	238	244	PF02991	0.366
LIG_LIR_Apic_2	624	628	PF02991	0.517
LIG_LIR_Gen_1	25	35	PF02991	0.567
LIG_LIR_Gen_1	279	287	PF02991	0.333
LIG_LIR_Gen_1	313	323	PF02991	0.390
LIG_LIR_Gen_1	48	57	PF02991	0.519
LIG_LIR_Gen_1	505	515	PF02991	0.276
LIG_LIR_Gen_1	611	621	PF02991	0.652
LIG_LIR_Gen_1	82	92	PF02991	0.510
LIG_LIR_LC3C_4	467	470	PF02991	0.209
LIG_LIR_Nem_3	25	30	PF02991	0.566
LIG_LIR_Nem_3	279	285	PF02991	0.333
LIG_LIR_Nem_3	313	318	PF02991	0.390
LIG_LIR_Nem_3	48	53	PF02991	0.529
LIG_LIR_Nem_3	505	510	PF02991	0.324
LIG_LIR_Nem_3	518	524	PF02991	0.312
LIG_LIR_Nem_3	611	616	PF02991	0.602
LIG_LIR_Nem_3	663	667	PF02991	0.531
LIG_LIR_Nem_3	82	87	PF02991	0.510
LIG_NRBOX	269	275	PF00104	0.277
LIG_NRBOX	94	100	PF00104	0.332
LIG_PCNA_yPIPBox_3	293	307	PF02747	0.507
LIG_PCNA_yPIPBox_3	421	433	PF02747	0.579
LIG_Pex14_2	61	65	PF04695	0.550
LIG_PTB_Apo_2	501	508	PF02174	0.315
LIG_PTB_Apo_2	78	85	PF02174	0.503
LIG_PTB_Phospho_1	501	507	PF10480	0.312
LIG_SH2_CRK	295	299	PF00017	0.509
LIG_SH2_CRK	473	477	PF00017	0.313
LIG_SH2_CRK	664	668	PF00017	0.545
LIG_SH2_GRB2like	502	505	PF00017	0.308
LIG_SH2_NCK_1	129	133	PF00017	0.502
LIG_SH2_NCK_1	664	668	PF00017	0.600
LIG_SH2_PTP2	346	349	PF00017	0.390
LIG_SH2_PTP2	507	510	PF00017	0.351
LIG_SH2_PTP2	625	628	PF00017	0.515
LIG_SH2_STAP1	129	133	PF00017	0.502
LIG_SH2_STAT5	129	132	PF00017	0.501
LIG_SH2_STAT5	146	149	PF00017	0.482
LIG_SH2_STAT5	317	320	PF00017	0.313
LIG_SH2_STAT5	346	349	PF00017	0.262
LIG_SH2_STAT5	473	476	PF00017	0.313
LIG_SH2_STAT5	481	484	PF00017	0.313
LIG_SH2_STAT5	507	510	PF00017	0.332
LIG_SH2_STAT5	56	59	PF00017	0.581
LIG_SH2_STAT5	625	628	PF00017	0.589
LIG_SH2_STAT5	634	637	PF00017	0.527
LIG_SH2_STAT5	78	81	PF00017	0.515
LIG_SH3_3	233	239	PF00018	0.498
LIG_SH3_3	248	254	PF00018	0.503
LIG_SH3_3	346	352	PF00018	0.313
LIG_SH3_3	390	396	PF00018	0.651
LIG_SH3_3	408	414	PF00018	0.731
LIG_SH3_3	600	606	PF00018	0.622
LIG_SH3_CIN85_PxpxPR_1	389	394	PF14604	0.552
LIG_SUMO_SIM_anti_2	262	267	PF11976	0.229
LIG_SUMO_SIM_anti_2	93	99	PF11976	0.209
LIG_SUMO_SIM_par_1	40	46	PF11976	0.528
LIG_SUMO_SIM_par_1	584	591	PF11976	0.561
LIG_SxIP_EBH_1	260	272	PF03271	0.229
LIG_WRC_WIRS_1	273	278	PF05994	0.313
LIG_WW_3	102	106	PF00397	0.401
LIG_WW_3	196	200	PF00397	0.400
MOD_CDC14_SPxK_1	435	438	PF00782	0.566
MOD_CDK_SPK_2	201	206	PF00069	0.452
MOD_CDK_SPK_2	389	394	PF00069	0.552
MOD_CDK_SPxK_1	432	438	PF00069	0.557
MOD_CDK_SPxxK_3	217	224	PF00069	0.491
MOD_CK1_1	161	167	PF00069	0.421
MOD_CK1_1	180	186	PF00069	0.466
MOD_CK1_1	219	225	PF00069	0.550
MOD_CK1_1	22	28	PF00069	0.650
MOD_CK1_1	571	577	PF00069	0.695
MOD_CK1_1	601	607	PF00069	0.657
MOD_CK1_1	649	655	PF00069	0.521
MOD_CK1_1	8	14	PF00069	0.734
MOD_CK2_1	131	137	PF00069	0.411
MOD_CK2_1	40	46	PF00069	0.583
MOD_Cter_Amidation	157	160	PF01082	0.606
MOD_GlcNHglycan	110	113	PF01048	0.624
MOD_GlcNHglycan	179	182	PF01048	0.715
MOD_GlcNHglycan	21	24	PF01048	0.476
MOD_GlcNHglycan	232	235	PF01048	0.702
MOD_GlcNHglycan	310	313	PF01048	0.354
MOD_GlcNHglycan	325	328	PF01048	0.528
MOD_GlcNHglycan	389	392	PF01048	0.469
MOD_GlcNHglycan	418	421	PF01048	0.343
MOD_GlcNHglycan	461	464	PF01048	0.364
MOD_GlcNHglycan	576	579	PF01048	0.539
MOD_GlcNHglycan	648	651	PF01048	0.303
MOD_GSK3_1	104	111	PF00069	0.446
MOD_GSK3_1	127	134	PF00069	0.529
MOD_GSK3_1	161	168	PF00069	0.443
MOD_GSK3_1	18	25	PF00069	0.565
MOD_GSK3_1	219	226	PF00069	0.482
MOD_GSK3_1	230	237	PF00069	0.466
MOD_GSK3_1	272	279	PF00069	0.297
MOD_GSK3_1	29	36	PF00069	0.496
MOD_GSK3_1	441	448	PF00069	0.631
MOD_GSK3_1	5	12	PF00069	0.762
MOD_GSK3_1	570	577	PF00069	0.723
MOD_GSK3_1	594	601	PF00069	0.697
MOD_LATS_1	5	11	PF00433	0.605
MOD_N-GLC_1	503	508	PF02516	0.510
MOD_N-GLC_1	516	521	PF02516	0.313
MOD_N-GLC_1	80	85	PF02516	0.293
MOD_NEK2_1	261	266	PF00069	0.276
MOD_NEK2_1	272	277	PF00069	0.313
MOD_NEK2_1	464	469	PF00069	0.546
MOD_NEK2_1	515	520	PF00069	0.327
MOD_NEK2_1	527	532	PF00069	0.554
MOD_NEK2_1	621	626	PF00069	0.652
MOD_NEK2_1	90	95	PF00069	0.290
MOD_NEK2_2	40	45	PF00069	0.527
MOD_PIKK_1	494	500	PF00454	0.393
MOD_PKA_1	38	44	PF00069	0.542
MOD_PKA_2	104	110	PF00069	0.431
MOD_PKA_2	158	164	PF00069	0.401
MOD_PKA_2	259	265	PF00069	0.332
MOD_PKA_2	38	44	PF00069	0.545
MOD_PKA_2	534	540	PF00069	0.592
MOD_PKA_2	574	580	PF00069	0.702
MOD_PKA_2	6	12	PF00069	0.709
MOD_Plk_1	503	509	PF00069	0.312
MOD_Plk_1	516	522	PF00069	0.313
MOD_Plk_1	80	86	PF00069	0.476
MOD_Plk_4	104	110	PF00069	0.293
MOD_Plk_4	165	171	PF00069	0.439
MOD_Plk_4	22	28	PF00069	0.585
MOD_Plk_4	261	267	PF00069	0.295
MOD_Plk_4	272	278	PF00069	0.298
MOD_Plk_4	338	344	PF00069	0.313
MOD_Plk_4	480	486	PF00069	0.244
MOD_Plk_4	497	503	PF00069	0.330
MOD_Plk_4	608	614	PF00069	0.589
MOD_Plk_4	621	627	PF00069	0.678
MOD_Plk_4	71	77	PF00069	0.524
MOD_Plk_4	90	96	PF00069	0.215
MOD_ProDKin_1	13	19	PF00069	0.712
MOD_ProDKin_1	201	207	PF00069	0.458
MOD_ProDKin_1	217	223	PF00069	0.534
MOD_ProDKin_1	235	241	PF00069	0.359
MOD_ProDKin_1	389	395	PF00069	0.621
MOD_ProDKin_1	432	438	PF00069	0.557
MOD_ProDKin_1	581	587	PF00069	0.706
MOD_ProDKin_1	599	605	PF00069	0.626
TRG_ENDOCYTIC_2	282	285	PF00928	0.487
TRG_ENDOCYTIC_2	295	298	PF00928	0.511
TRG_ENDOCYTIC_2	315	318	PF00928	0.390
TRG_ENDOCYTIC_2	346	349	PF00928	0.313
TRG_ENDOCYTIC_2	473	476	PF00928	0.313
TRG_ENDOCYTIC_2	481	484	PF00928	0.313
TRG_ENDOCYTIC_2	507	510	PF00928	0.343
TRG_ENDOCYTIC_2	659	662	PF00928	0.485
TRG_ENDOCYTIC_2	664	667	PF00928	0.537
TRG_ER_diArg_1	156	159	PF00400	0.433
TRG_ER_diArg_1	290	293	PF00400	0.560
TRG_ER_diArg_1	37	39	PF00400	0.615
TRG_ER_diArg_1	430	433	PF00400	0.574
TRG_ER_diArg_1	538	540	PF00400	0.572
TRG_ER_diArg_1	57	59	PF00400	0.527
TRG_ER_diArg_1	61	64	PF00400	0.516
TRG_ER_diArg_1	66	69	PF00400	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X6	Leptomonas seymouri	45%	87%
A0A3S5H5S3	Leishmania donovani	86%	100%
A4H4N9	Leishmania braziliensis	71%	100%
A4HSW7	Leishmania infantum	86%	100%
Q4QJ02	Leishmania major	85%	100%