Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKV3_LEIMU

TriTrypDb:

LmxM.06.0740

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.653
CLV_C14_Caspase3-7	479	483	PF00656	0.602
CLV_C14_Caspase3-7	507	511	PF00656	0.483
CLV_C14_Caspase3-7	704	708	PF00656	0.488
CLV_C14_Caspase3-7	862	866	PF00656	0.499
CLV_NRD_NRD_1	162	164	PF00675	0.625
CLV_NRD_NRD_1	230	232	PF00675	0.666
CLV_NRD_NRD_1	255	257	PF00675	0.640
CLV_NRD_NRD_1	267	269	PF00675	0.618
CLV_NRD_NRD_1	317	319	PF00675	0.534
CLV_NRD_NRD_1	339	341	PF00675	0.725
CLV_NRD_NRD_1	387	389	PF00675	0.511
CLV_NRD_NRD_1	399	401	PF00675	0.615
CLV_NRD_NRD_1	494	496	PF00675	0.608
CLV_NRD_NRD_1	513	515	PF00675	0.499
CLV_NRD_NRD_1	554	556	PF00675	0.530
CLV_NRD_NRD_1	639	641	PF00675	0.523
CLV_NRD_NRD_1	705	707	PF00675	0.526
CLV_NRD_NRD_1	729	731	PF00675	0.532
CLV_NRD_NRD_1	781	783	PF00675	0.492
CLV_PCSK_FUR_1	385	389	PF00082	0.492
CLV_PCSK_KEX2_1	162	164	PF00082	0.625
CLV_PCSK_KEX2_1	230	232	PF00082	0.666
CLV_PCSK_KEX2_1	254	256	PF00082	0.640
CLV_PCSK_KEX2_1	263	265	PF00082	0.632
CLV_PCSK_KEX2_1	267	269	PF00082	0.609
CLV_PCSK_KEX2_1	317	319	PF00082	0.534
CLV_PCSK_KEX2_1	339	341	PF00082	0.578
CLV_PCSK_KEX2_1	387	389	PF00082	0.511
CLV_PCSK_KEX2_1	399	401	PF00082	0.615
CLV_PCSK_KEX2_1	476	478	PF00082	0.618
CLV_PCSK_KEX2_1	494	496	PF00082	0.475
CLV_PCSK_KEX2_1	513	515	PF00082	0.499
CLV_PCSK_KEX2_1	553	555	PF00082	0.544
CLV_PCSK_KEX2_1	639	641	PF00082	0.523
CLV_PCSK_KEX2_1	705	707	PF00082	0.526
CLV_PCSK_KEX2_1	729	731	PF00082	0.526
CLV_PCSK_KEX2_1	781	783	PF00082	0.492
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.611
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.615
CLV_PCSK_SKI1_1	236	240	PF00082	0.548
CLV_PCSK_SKI1_1	256	260	PF00082	0.476
CLV_PCSK_SKI1_1	47	51	PF00082	0.530
CLV_PCSK_SKI1_1	730	734	PF00082	0.487
DEG_APCC_DBOX_1	716	724	PF00400	0.544
DEG_APCC_DBOX_1	814	822	PF00400	0.477
DEG_Nend_UBRbox_4	1	3	PF02207	0.480
DOC_ANK_TNKS_1	267	274	PF00023	0.657
DOC_CKS1_1	10	15	PF01111	0.473
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.656
DOC_MAPK_gen_1	347	356	PF00069	0.500
DOC_MAPK_gen_1	813	820	PF00069	0.473
DOC_MAPK_MEF2A_6	33	41	PF00069	0.565
DOC_PP2B_LxvP_1	124	127	PF13499	0.562
DOC_PP2B_LxvP_1	147	150	PF13499	0.551
DOC_PP2B_LxvP_1	4	7	PF13499	0.466
DOC_PP2B_LxvP_1	466	469	PF13499	0.555
DOC_PP2B_LxvP_1	843	846	PF13499	0.582
DOC_PP4_FxxP_1	16	19	PF00568	0.490
DOC_SPAK_OSR1_1	598	602	PF12202	0.493
DOC_USP7_MATH_1	132	136	PF00917	0.639
DOC_USP7_MATH_1	138	142	PF00917	0.622
DOC_USP7_MATH_1	190	194	PF00917	0.608
DOC_USP7_MATH_1	280	284	PF00917	0.544
DOC_USP7_MATH_1	469	473	PF00917	0.624
DOC_USP7_MATH_1	504	508	PF00917	0.593
DOC_USP7_MATH_1	651	655	PF00917	0.615
DOC_USP7_MATH_1	799	803	PF00917	0.521
DOC_USP7_UBL2_3	813	817	PF12436	0.472
DOC_WW_Pin1_4	145	150	PF00397	0.695
DOC_WW_Pin1_4	15	20	PF00397	0.513
DOC_WW_Pin1_4	23	28	PF00397	0.506
DOC_WW_Pin1_4	231	236	PF00397	0.647
DOC_WW_Pin1_4	364	369	PF00397	0.836
DOC_WW_Pin1_4	647	652	PF00397	0.618
DOC_WW_Pin1_4	660	665	PF00397	0.546
DOC_WW_Pin1_4	69	74	PF00397	0.662
DOC_WW_Pin1_4	9	14	PF00397	0.501
LIG_14-3-3_CanoR_1	116	124	PF00244	0.549
LIG_14-3-3_CanoR_1	212	220	PF00244	0.666
LIG_14-3-3_CanoR_1	47	52	PF00244	0.546
LIG_14-3-3_CanoR_1	477	486	PF00244	0.526
LIG_14-3-3_CanoR_1	628	632	PF00244	0.392
LIG_14-3-3_CanoR_1	647	651	PF00244	0.579
LIG_14-3-3_CanoR_1	750	756	PF00244	0.510
LIG_14-3-3_CanoR_1	853	857	PF00244	0.541
LIG_14-3-3_CanoR_1	9	13	PF00244	0.494
LIG_APCC_ABBA_1	202	207	PF00400	0.590
LIG_APCC_ABBA_1	606	611	PF00400	0.475
LIG_BIR_III_4	508	512	PF00653	0.646
LIG_Clathr_ClatBox_1	698	702	PF01394	0.499
LIG_CSL_BTD_1	63	66	PF09270	0.568
LIG_FHA_1	32	38	PF00498	0.544
LIG_FHA_1	364	370	PF00498	0.831
LIG_FHA_1	534	540	PF00498	0.608
LIG_FHA_1	543	549	PF00498	0.514
LIG_FHA_1	574	580	PF00498	0.591
LIG_FHA_1	677	683	PF00498	0.572
LIG_FHA_1	845	851	PF00498	0.623
LIG_FHA_1	884	890	PF00498	0.519
LIG_FHA_1	904	910	PF00498	0.520
LIG_FHA_2	224	230	PF00498	0.607
LIG_FHA_2	237	243	PF00498	0.553
LIG_FHA_2	257	263	PF00498	0.494
LIG_FHA_2	532	538	PF00498	0.610
LIG_FHA_2	708	714	PF00498	0.423
LIG_FHA_2	847	853	PF00498	0.642
LIG_FXI_DFP_1	930	934	PF00024	0.465
LIG_Integrin_RGD_1	883	885	PF01839	0.609
LIG_Integrin_RGD_1	890	892	PF01839	0.616
LIG_LIR_Apic_2	15	19	PF02991	0.485
LIG_LIR_Apic_2	60	66	PF02991	0.631
LIG_LIR_Nem_3	15	20	PF02991	0.518
LIG_SH2_CRK	161	165	PF00017	0.559
LIG_SH2_CRK	874	878	PF00017	0.546
LIG_SH2_GRB2like	874	877	PF00017	0.565
LIG_SH2_NCK_1	874	878	PF00017	0.648
LIG_SH2_SRC	874	877	PF00017	0.588
LIG_SH2_STAP1	198	202	PF00017	0.535
LIG_SH2_STAT5	609	612	PF00017	0.575
LIG_SH3_2	664	669	PF14604	0.637
LIG_SH3_3	109	115	PF00018	0.593
LIG_SH3_3	119	125	PF00018	0.619
LIG_SH3_3	229	235	PF00018	0.611
LIG_SH3_3	572	578	PF00018	0.588
LIG_SH3_3	661	667	PF00018	0.534
LIG_SH3_3	67	73	PF00018	0.681
LIG_SH3_3	7	13	PF00018	0.483
LIG_SH3_3	721	727	PF00018	0.463
LIG_SUMO_SIM_anti_2	679	684	PF11976	0.561
LIG_SUMO_SIM_anti_2	816	822	PF11976	0.477
LIG_SUMO_SIM_anti_2	847	852	PF11976	0.637
LIG_SUMO_SIM_par_1	18	24	PF11976	0.499
LIG_SUMO_SIM_par_1	676	684	PF11976	0.540
LIG_SUMO_SIM_par_1	697	702	PF11976	0.396
LIG_SUMO_SIM_par_1	846	852	PF11976	0.633
LIG_TRAF2_1	372	375	PF00917	0.645
LIG_TRAF2_1	557	560	PF00917	0.522
LIG_TRAF2_1	769	772	PF00917	0.447
LIG_TRAF2_1	942	945	PF00917	0.564
LIG_WRC_WIRS_1	584	589	PF05994	0.518
LIG_WW_3	148	152	PF00397	0.543
MOD_CDC14_SPxK_1	148	151	PF00782	0.542
MOD_CDC14_SPxK_1	666	669	PF00782	0.521
MOD_CDK_SPK_2	231	236	PF00069	0.579
MOD_CDK_SPxK_1	145	151	PF00069	0.548
MOD_CDK_SPxK_1	663	669	PF00069	0.513
MOD_CK1_1	185	191	PF00069	0.668
MOD_CK1_1	210	216	PF00069	0.651
MOD_CK1_1	225	231	PF00069	0.566
MOD_CK1_1	240	246	PF00069	0.541
MOD_CK1_1	285	291	PF00069	0.641
MOD_CK1_1	301	307	PF00069	0.502
MOD_CK1_1	358	364	PF00069	0.682
MOD_CK1_1	414	420	PF00069	0.691
MOD_CK1_1	42	48	PF00069	0.603
MOD_CK1_1	429	435	PF00069	0.500
MOD_CK1_1	53	59	PF00069	0.652
MOD_CK1_1	533	539	PF00069	0.638
MOD_CK1_1	663	669	PF00069	0.568
MOD_CK1_1	676	682	PF00069	0.569
MOD_CK1_1	754	760	PF00069	0.467
MOD_CK1_1	816	822	PF00069	0.506
MOD_CK1_1	854	860	PF00069	0.590
MOD_CK2_1	223	229	PF00069	0.595
MOD_CK2_1	236	242	PF00069	0.550
MOD_CK2_1	256	262	PF00069	0.485
MOD_CK2_1	369	375	PF00069	0.636
MOD_CK2_1	707	713	PF00069	0.533
MOD_CK2_1	816	822	PF00069	0.506
MOD_CMANNOS	320	323	PF00535	0.504
MOD_Cter_Amidation	779	782	PF01082	0.358
MOD_DYRK1A_RPxSP_1	231	235	PF00069	0.643
MOD_DYRK1A_RPxSP_1	647	651	PF00069	0.579
MOD_DYRK1A_RPxSP_1	69	73	PF00069	0.659
MOD_DYRK1A_RPxSP_1	9	13	PF00069	0.472
MOD_GlcNHglycan	140	143	PF01048	0.609
MOD_GlcNHglycan	169	172	PF01048	0.697
MOD_GlcNHglycan	184	187	PF01048	0.537
MOD_GlcNHglycan	190	193	PF01048	0.581
MOD_GlcNHglycan	207	212	PF01048	0.624
MOD_GlcNHglycan	282	285	PF01048	0.594
MOD_GlcNHglycan	311	314	PF01048	0.549
MOD_GlcNHglycan	421	424	PF01048	0.678
MOD_GlcNHglycan	47	50	PF01048	0.620
MOD_GlcNHglycan	471	474	PF01048	0.631
MOD_GlcNHglycan	478	481	PF01048	0.571
MOD_GlcNHglycan	500	503	PF01048	0.579
MOD_GlcNHglycan	517	520	PF01048	0.534
MOD_GlcNHglycan	653	656	PF01048	0.622
MOD_GlcNHglycan	856	859	PF01048	0.635
MOD_GlcNHglycan	861	864	PF01048	0.585
MOD_GlcNHglycan	899	902	PF01048	0.572
MOD_GlcNHglycan	911	914	PF01048	0.636
MOD_GlcNHglycan	923	926	PF01048	0.575
MOD_GSK3_1	163	170	PF00069	0.643
MOD_GSK3_1	181	188	PF00069	0.572
MOD_GSK3_1	207	214	PF00069	0.642
MOD_GSK3_1	218	225	PF00069	0.594
MOD_GSK3_1	23	30	PF00069	0.528
MOD_GSK3_1	236	243	PF00069	0.537
MOD_GSK3_1	280	287	PF00069	0.651
MOD_GSK3_1	31	38	PF00069	0.539
MOD_GSK3_1	355	362	PF00069	0.667
MOD_GSK3_1	370	377	PF00069	0.553
MOD_GSK3_1	39	46	PF00069	0.581
MOD_GSK3_1	406	413	PF00069	0.725
MOD_GSK3_1	415	422	PF00069	0.704
MOD_GSK3_1	429	436	PF00069	0.605
MOD_GSK3_1	464	471	PF00069	0.655
MOD_GSK3_1	47	54	PF00069	0.631
MOD_GSK3_1	531	538	PF00069	0.613
MOD_GSK3_1	647	654	PF00069	0.628
MOD_GSK3_1	659	666	PF00069	0.559
MOD_GSK3_1	681	688	PF00069	0.529
MOD_GSK3_1	771	778	PF00069	0.391
MOD_GSK3_1	8	15	PF00069	0.493
MOD_GSK3_1	905	912	PF00069	0.653
MOD_N-GLC_1	875	880	PF02516	0.559
MOD_NEK2_1	220	225	PF00069	0.695
MOD_NEK2_1	286	291	PF00069	0.639
MOD_NEK2_1	37	42	PF00069	0.622
MOD_NEK2_1	380	385	PF00069	0.631
MOD_NEK2_1	433	438	PF00069	0.606
MOD_NEK2_1	464	469	PF00069	0.657
MOD_NEK2_1	51	56	PF00069	0.633
MOD_NEK2_1	8	13	PF00069	0.485
MOD_NEK2_1	909	914	PF00069	0.516
MOD_NEK2_1	947	952	PF00069	0.580
MOD_NEK2_2	171	176	PF00069	0.547
MOD_NEK2_2	406	411	PF00069	0.674
MOD_OFUCOSY	291	297	PF10250	0.504
MOD_PIKK_1	256	262	PF00454	0.507
MOD_PIKK_1	531	537	PF00454	0.629
MOD_PIKK_1	670	676	PF00454	0.655
MOD_PIKK_1	707	713	PF00454	0.423
MOD_PIKK_1	799	805	PF00454	0.520
MOD_PKA_1	476	482	PF00069	0.612
MOD_PKA_2	115	121	PF00069	0.538
MOD_PKA_2	211	217	PF00069	0.667
MOD_PKA_2	464	470	PF00069	0.614
MOD_PKA_2	476	482	PF00069	0.538
MOD_PKA_2	528	534	PF00069	0.640
MOD_PKA_2	627	633	PF00069	0.376
MOD_PKA_2	646	652	PF00069	0.581
MOD_PKA_2	751	757	PF00069	0.471
MOD_PKA_2	8	14	PF00069	0.493
MOD_PKA_2	852	858	PF00069	0.505
MOD_PKA_2	947	953	PF00069	0.585
MOD_PKB_1	254	262	PF00069	0.502
MOD_Plk_1	198	204	PF00069	0.620
MOD_Plk_1	245	251	PF00069	0.640
MOD_Plk_1	352	358	PF00069	0.544
MOD_Plk_1	406	412	PF00069	0.673
MOD_Plk_1	573	579	PF00069	0.475
MOD_Plk_1	775	781	PF00069	0.512
MOD_Plk_1	851	857	PF00069	0.537
MOD_Plk_2-3	374	380	PF00069	0.560
MOD_Plk_2-3	415	421	PF00069	0.540
MOD_Plk_2-3	583	589	PF00069	0.519
MOD_Plk_4	12	18	PF00069	0.480
MOD_Plk_4	198	204	PF00069	0.620
MOD_Plk_4	47	53	PF00069	0.536
MOD_Plk_4	681	687	PF00069	0.614
MOD_Plk_4	689	695	PF00069	0.579
MOD_Plk_4	816	822	PF00069	0.477
MOD_Plk_4	846	852	PF00069	0.633
MOD_Plk_4	89	95	PF00069	0.652
MOD_Plk_4	905	911	PF00069	0.531
MOD_ProDKin_1	145	151	PF00069	0.697
MOD_ProDKin_1	23	29	PF00069	0.507
MOD_ProDKin_1	231	237	PF00069	0.649
MOD_ProDKin_1	364	370	PF00069	0.838
MOD_ProDKin_1	647	653	PF00069	0.623
MOD_ProDKin_1	660	666	PF00069	0.547
MOD_ProDKin_1	69	75	PF00069	0.662
MOD_ProDKin_1	9	15	PF00069	0.499
MOD_SUMO_rev_2	558	567	PF00179	0.436
TRG_DiLeu_BaEn_4	375	381	PF01217	0.495
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.644
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.580
TRG_DiLeu_BaLyEn_6	716	721	PF01217	0.542
TRG_ENDOCYTIC_2	161	164	PF00928	0.570
TRG_ENDOCYTIC_2	874	877	PF00928	0.497
TRG_ER_diArg_1	161	163	PF00400	0.628
TRG_ER_diArg_1	230	232	PF00400	0.666
TRG_ER_diArg_1	253	256	PF00400	0.640
TRG_ER_diArg_1	266	268	PF00400	0.600
TRG_ER_diArg_1	330	333	PF00400	0.576
TRG_ER_diArg_1	385	388	PF00400	0.502
TRG_ER_diArg_1	398	400	PF00400	0.581
TRG_ER_diArg_1	494	496	PF00400	0.608
TRG_ER_diArg_1	553	555	PF00400	0.544
TRG_ER_diArg_1	613	616	PF00400	0.518
TRG_ER_diArg_1	749	752	PF00400	0.615
TRG_NES_CRM1_1	809	824	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	782	786	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPI2	Leishmania donovani	76%	90%
A4H4N8	Leishmania braziliensis	58%	100%
A4HSW6	Leishmania infantum	78%	100%
Q4QJ03	Leishmania major	77%	100%