Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKU8_LEIMU

TriTrypDb:

LmxM.06.0685

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	6

Expansion

Sequence features

E9AKU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKU8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	6
GO:0007062	sister chromatid cohesion	3	6
GO:0007064	mitotic sister chromatid cohesion	4	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022402	cell cycle process	2	6
GO:0051276	chromosome organization	5	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:1903047	mitotic cell cycle process	3	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.384
CLV_C14_Caspase3-7	351	355	PF00656	0.645
CLV_C14_Caspase3-7	93	97	PF00656	0.606
CLV_NRD_NRD_1	169	171	PF00675	0.320
CLV_NRD_NRD_1	222	224	PF00675	0.515
CLV_NRD_NRD_1	226	228	PF00675	0.332
CLV_NRD_NRD_1	338	340	PF00675	0.588
CLV_NRD_NRD_1	39	41	PF00675	0.565
CLV_NRD_NRD_1	43	45	PF00675	0.625
CLV_NRD_NRD_1	46	48	PF00675	0.628
CLV_PCSK_FUR_1	44	48	PF00082	0.625
CLV_PCSK_KEX2_1	169	171	PF00082	0.320
CLV_PCSK_KEX2_1	208	210	PF00082	0.226
CLV_PCSK_KEX2_1	226	228	PF00082	0.238
CLV_PCSK_KEX2_1	340	342	PF00082	0.704
CLV_PCSK_KEX2_1	38	40	PF00082	0.570
CLV_PCSK_KEX2_1	43	45	PF00082	0.625
CLV_PCSK_KEX2_1	46	48	PF00082	0.628
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.215
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.704
CLV_PCSK_PC7_1	204	210	PF00082	0.221
CLV_PCSK_PC7_1	39	45	PF00082	0.692
CLV_PCSK_SKI1_1	236	240	PF00082	0.659
CLV_PCSK_SKI1_1	242	246	PF00082	0.639
DEG_COP1_1	362	372	PF00400	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.471
DEG_SPOP_SBC_1	133	137	PF00917	0.671
DEG_SPOP_SBC_1	75	79	PF00917	0.639
DOC_MAPK_gen_1	169	176	PF00069	0.333
DOC_MAPK_gen_1	208	214	PF00069	0.215
DOC_MAPK_MEF2A_6	169	178	PF00069	0.395
DOC_PP4_FxxP_1	207	210	PF00568	0.395
DOC_USP7_MATH_1	108	112	PF00917	0.542
DOC_USP7_MATH_1	132	136	PF00917	0.658
DOC_USP7_MATH_1	138	142	PF00917	0.612
DOC_USP7_MATH_1	165	169	PF00917	0.444
DOC_USP7_MATH_1	28	32	PF00917	0.438
DOC_USP7_MATH_1	323	327	PF00917	0.606
DOC_USP7_MATH_1	51	55	PF00917	0.693
DOC_USP7_MATH_1	71	75	PF00917	0.712
DOC_USP7_MATH_1	76	80	PF00917	0.685
DOC_WW_Pin1_4	161	166	PF00397	0.332
DOC_WW_Pin1_4	215	220	PF00397	0.315
DOC_WW_Pin1_4	268	273	PF00397	0.699
DOC_WW_Pin1_4	356	361	PF00397	0.641
DOC_WW_Pin1_4	67	72	PF00397	0.513
LIG_14-3-3_CanoR_1	105	113	PF00244	0.573
LIG_14-3-3_CanoR_1	204	208	PF00244	0.335
LIG_AP2alpha_1	297	301	PF02296	0.651
LIG_BIR_III_4	61	65	PF00653	0.585
LIG_BRCT_BRCA1_1	392	396	PF00533	0.360
LIG_eIF4E_1	381	387	PF01652	0.421
LIG_FHA_1	190	196	PF00498	0.330
LIG_FHA_1	274	280	PF00498	0.547
LIG_FHA_2	300	306	PF00498	0.495
LIG_FHA_2	313	319	PF00498	0.529
LIG_FHA_2	349	355	PF00498	0.644
LIG_FHA_2	56	62	PF00498	0.633
LIG_FHA_2	63	69	PF00498	0.658
LIG_LIR_Apic_2	205	210	PF02991	0.314
LIG_LIR_Gen_1	383	390	PF02991	0.359
LIG_LIR_Nem_3	379	384	PF02991	0.464
LIG_Pex14_2	207	211	PF04695	0.395
LIG_Pex14_2	297	301	PF04695	0.651
LIG_SH2_NCK_1	384	388	PF00017	0.410
LIG_SH3_1	159	165	PF00018	0.651
LIG_SH3_3	154	160	PF00018	0.754
LIG_SH3_3	171	177	PF00018	0.275
LIG_SH3_3	235	241	PF00018	0.507
LIG_SH3_3	258	264	PF00018	0.701
LIG_SH3_3	354	360	PF00018	0.735
LIG_SH3_3	364	370	PF00018	0.657
LIG_TRAF2_1	303	306	PF00917	0.480
LIG_UBA3_1	15	21	PF00899	0.544
MOD_CDK_SPxK_1	215	221	PF00069	0.315
MOD_CK1_1	203	209	PF00069	0.474
MOD_CK1_1	270	276	PF00069	0.620
MOD_CK1_1	292	298	PF00069	0.706
MOD_CK1_1	326	332	PF00069	0.692
MOD_CK1_1	359	365	PF00069	0.634
MOD_CK1_1	70	76	PF00069	0.702
MOD_CK1_1	79	85	PF00069	0.705
MOD_CK1_1	87	93	PF00069	0.637
MOD_CK2_1	299	305	PF00069	0.508
MOD_DYRK1A_RPxSP_1	161	165	PF00069	0.345
MOD_GlcNHglycan	136	139	PF01048	0.630
MOD_GlcNHglycan	140	143	PF01048	0.612
MOD_GlcNHglycan	153	156	PF01048	0.671
MOD_GlcNHglycan	165	168	PF01048	0.311
MOD_GlcNHglycan	249	252	PF01048	0.691
MOD_GlcNHglycan	30	33	PF01048	0.458
MOD_GlcNHglycan	306	312	PF01048	0.611
MOD_GlcNHglycan	323	326	PF01048	0.611
MOD_GlcNHglycan	328	331	PF01048	0.669
MOD_GlcNHglycan	364	367	PF01048	0.708
MOD_GlcNHglycan	370	373	PF01048	0.662
MOD_GlcNHglycan	48	51	PF01048	0.635
MOD_GlcNHglycan	53	56	PF01048	0.652
MOD_GlcNHglycan	60	65	PF01048	0.640
MOD_GlcNHglycan	73	76	PF01048	0.547
MOD_GlcNHglycan	82	85	PF01048	0.700
MOD_GSK3_1	104	111	PF00069	0.647
MOD_GSK3_1	134	141	PF00069	0.677
MOD_GSK3_1	145	152	PF00069	0.774
MOD_GSK3_1	161	168	PF00069	0.318
MOD_GSK3_1	232	239	PF00069	0.601
MOD_GSK3_1	266	273	PF00069	0.630
MOD_GSK3_1	274	281	PF00069	0.646
MOD_GSK3_1	321	328	PF00069	0.637
MOD_GSK3_1	368	375	PF00069	0.635
MOD_GSK3_1	51	58	PF00069	0.720
MOD_GSK3_1	67	74	PF00069	0.608
MOD_GSK3_1	75	82	PF00069	0.639
MOD_GSK3_1	83	90	PF00069	0.727
MOD_NEK2_1	395	400	PF00069	0.484
MOD_NEK2_2	194	199	PF00069	0.315
MOD_PKA_1	46	52	PF00069	0.606
MOD_PKA_2	104	110	PF00069	0.490
MOD_PKA_2	143	149	PF00069	0.654
MOD_PKA_2	203	209	PF00069	0.339
MOD_PKA_2	390	396	PF00069	0.341
MOD_PKA_2	46	52	PF00069	0.676
MOD_PKA_2	88	94	PF00069	0.670
MOD_PKB_1	44	52	PF00069	0.488
MOD_Plk_1	274	280	PF00069	0.644
MOD_Plk_4	274	280	PF00069	0.600
MOD_Plk_4	292	298	PF00069	0.699
MOD_Plk_4	376	382	PF00069	0.611
MOD_Plk_4	390	396	PF00069	0.376
MOD_ProDKin_1	161	167	PF00069	0.332
MOD_ProDKin_1	215	221	PF00069	0.315
MOD_ProDKin_1	268	274	PF00069	0.696
MOD_ProDKin_1	356	362	PF00069	0.641
MOD_ProDKin_1	67	73	PF00069	0.513
TRG_DiLeu_BaEn_1	240	245	PF01217	0.635
TRG_ENDOCYTIC_2	384	387	PF00928	0.383
TRG_ER_diArg_1	159	162	PF00400	0.587
TRG_ER_diArg_1	225	227	PF00400	0.315
TRG_ER_diArg_1	339	342	PF00400	0.582
TRG_ER_diArg_1	38	40	PF00400	0.662
TRG_ER_diArg_1	42	44	PF00400	0.661
TRG_ER_diArg_1	45	47	PF00400	0.639
TRG_NLS_Bipartite_1	208	227	PF00514	0.345
TRG_NLS_MonoExtC_3	222	227	PF00514	0.395
TRG_NLS_MonoExtC_3	338	343	PF00514	0.579
TRG_NLS_MonoExtN_4	221	227	PF00514	0.395
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I714	Leptomonas seymouri	40%	100%
A0A3S7WPI0	Leishmania donovani	83%	100%
A4H4N4	Leishmania braziliensis	60%	94%
A4HSW0	Leishmania infantum	84%	100%
Q4QJ09	Leishmania major	84%	100%