NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKU7_LEIMU

TriTrypDb:

LmxM.06.0680

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	8
GO:0005758	mitochondrial intermembrane space	6	8
GO:0016020	membrane	2	8
GO:0019866	organelle inner membrane	4	8
GO:0031090	organelle membrane	3	8
GO:0031966	mitochondrial membrane	4	8
GO:0031970	organelle envelope lumen	5	8
GO:0031974	membrane-enclosed lumen	2	8
GO:0043233	organelle lumen	3	8
GO:0070013	intracellular organelle lumen	4	8
GO:0070469	respirasome	2	8
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9AKU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.490
CLV_NRD_NRD_1	65	67	PF00675	0.564
CLV_NRD_NRD_1	79	81	PF00675	0.601
CLV_PCSK_KEX2_1	144	146	PF00082	0.491
CLV_PCSK_KEX2_1	65	67	PF00082	0.579
CLV_PCSK_KEX2_1	78	80	PF00082	0.645
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.579
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.645
DEG_SCF_FBW7_1	44	51	PF00400	0.712
DEG_SPOP_SBC_1	9	13	PF00917	0.762
DOC_CKS1_1	56	61	PF01111	0.640
DOC_MAPK_gen_1	203	210	PF00069	0.589
DOC_PP2B_LxvP_1	124	127	PF13499	0.662
DOC_USP7_MATH_1	137	141	PF00917	0.582
DOC_USP7_MATH_1	3	7	PF00917	0.701
DOC_USP7_MATH_1	48	52	PF00917	0.664
DOC_USP7_MATH_1	8	12	PF00917	0.693
DOC_USP7_MATH_1	96	100	PF00917	0.770
DOC_WW_Pin1_4	17	22	PF00397	0.575
DOC_WW_Pin1_4	44	49	PF00397	0.697
DOC_WW_Pin1_4	55	60	PF00397	0.634
DOC_WW_Pin1_4	71	76	PF00397	0.598
LIG_14-3-3_CanoR_1	203	209	PF00244	0.456
LIG_BRCT_BRCA1_1	111	115	PF00533	0.413
LIG_CaM_IQ_9	131	147	PF13499	0.511
LIG_deltaCOP1_diTrp_1	159	165	PF00928	0.514
LIG_FHA_1	205	211	PF00498	0.373
LIG_FHA_1	99	105	PF00498	0.662
LIG_FHA_2	56	62	PF00498	0.635
LIG_LIR_Gen_1	112	123	PF02991	0.557
LIG_LIR_Gen_1	172	182	PF02991	0.537
LIG_LIR_Nem_3	112	118	PF02991	0.556
LIG_LIR_Nem_3	172	178	PF02991	0.528
LIG_Pex14_1	226	230	PF04695	0.536
LIG_SH2_STAP1	111	115	PF00017	0.424
LIG_SH2_STAT5	206	209	PF00017	0.422
LIG_SH3_1	187	193	PF00018	0.712
LIG_SH3_1	78	84	PF00018	0.476
LIG_SH3_2	81	86	PF14604	0.484
LIG_SH3_3	187	193	PF00018	0.644
LIG_SH3_3	78	84	PF00018	0.476
LIG_TRAF2_1	58	61	PF00917	0.610
LIG_TYR_ITSM	171	178	PF00017	0.611
LIG_WRC_WIRS_1	199	204	PF05994	0.642
MOD_CDK_SPxxK_3	71	78	PF00069	0.710
MOD_CK1_1	25	31	PF00069	0.713
MOD_CK1_1	37	43	PF00069	0.757
MOD_CK1_1	51	57	PF00069	0.608
MOD_CK2_1	137	143	PF00069	0.566
MOD_CK2_1	55	61	PF00069	0.610
MOD_CMANNOS	162	165	PF00535	0.506
MOD_GlcNHglycan	12	15	PF01048	0.696
MOD_GlcNHglycan	135	138	PF01048	0.411
MOD_GlcNHglycan	87	90	PF01048	0.746
MOD_GSK3_1	133	140	PF00069	0.545
MOD_GSK3_1	44	51	PF00069	0.690
MOD_NEK2_1	161	166	PF00069	0.530
MOD_NEK2_1	198	203	PF00069	0.654
MOD_NEK2_1	85	90	PF00069	0.586
MOD_NMyristoyl	1	7	PF02799	0.647
MOD_PKA_2	170	176	PF00069	0.609
MOD_Plk_1	149	155	PF00069	0.484
MOD_Plk_1	48	54	PF00069	0.715
MOD_Plk_2-3	114	120	PF00069	0.560
MOD_Plk_4	170	176	PF00069	0.609
MOD_ProDKin_1	17	23	PF00069	0.575
MOD_ProDKin_1	44	50	PF00069	0.697
MOD_ProDKin_1	55	61	PF00069	0.631
MOD_ProDKin_1	71	77	PF00069	0.598
TRG_ENDOCYTIC_2	175	178	PF00928	0.589
TRG_ENDOCYTIC_2	69	72	PF00928	0.565
TRG_ER_diArg_1	79	81	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5D1	Leptomonas seymouri	70%	100%
A0A0S4J9I1	Bodo saltans	46%	100%
A0A1X0NL39	Trypanosomatidae	51%	100%
A0A3R7LT07	Trypanosoma rangeli	53%	100%
A0A3S5H5R9	Leishmania donovani	86%	100%
A4H4N3	Leishmania braziliensis	77%	100%
A4HSV9	Leishmania infantum	86%	100%
C9ZTH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QJ10	Leishmania major	86%	100%