Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKU5_LEIMU

TriTrypDb:

LmxM.06.0660

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.778
CLV_C14_Caspase3-7	233	237	PF00656	0.554
CLV_NRD_NRD_1	12	14	PF00675	0.697
CLV_NRD_NRD_1	255	257	PF00675	0.715
CLV_NRD_NRD_1	258	260	PF00675	0.670
CLV_NRD_NRD_1	275	277	PF00675	0.515
CLV_NRD_NRD_1	403	405	PF00675	0.766
CLV_NRD_NRD_1	413	415	PF00675	0.689
CLV_NRD_NRD_1	99	101	PF00675	0.573
CLV_PCSK_KEX2_1	11	13	PF00082	0.847
CLV_PCSK_KEX2_1	255	257	PF00082	0.715
CLV_PCSK_KEX2_1	275	277	PF00082	0.515
CLV_PCSK_KEX2_1	403	405	PF00082	0.766
CLV_PCSK_KEX2_1	413	415	PF00082	0.689
CLV_PCSK_SKI1_1	100	104	PF00082	0.567
CLV_PCSK_SKI1_1	4	8	PF00082	0.545
CLV_PCSK_SKI1_1	404	408	PF00082	0.708
CLV_PCSK_SKI1_1	452	456	PF00082	0.696
DEG_APCC_DBOX_1	403	411	PF00400	0.628
DEG_SPOP_SBC_1	264	268	PF00917	0.665
DEG_SPOP_SBC_1	325	329	PF00917	0.549
DOC_CKS1_1	212	217	PF01111	0.556
DOC_CKS1_1	386	391	PF01111	0.725
DOC_CKS1_1	612	617	PF01111	0.516
DOC_CYCLIN_RxL_1	449	459	PF00134	0.693
DOC_CYCLIN_yClb1_LxF_4	450	455	PF00134	0.674
DOC_MAPK_gen_1	100	108	PF00069	0.567
DOC_MAPK_MEF2A_6	556	565	PF00069	0.755
DOC_PP1_RVXF_1	450	456	PF00149	0.675
DOC_PP2B_LxvP_1	311	314	PF13499	0.651
DOC_PP2B_LxvP_1	506	509	PF13499	0.515
DOC_PP2B_LxvP_1	563	566	PF13499	0.755
DOC_PP4_FxxP_1	406	409	PF00568	0.804
DOC_PP4_MxPP_1	435	438	PF00568	0.791
DOC_USP7_MATH_1	130	134	PF00917	0.708
DOC_USP7_MATH_1	217	221	PF00917	0.776
DOC_USP7_MATH_1	245	249	PF00917	0.847
DOC_USP7_MATH_1	264	268	PF00917	0.827
DOC_USP7_MATH_1	33	37	PF00917	0.668
DOC_USP7_MATH_1	336	340	PF00917	0.717
DOC_USP7_MATH_1	358	362	PF00917	0.575
DOC_USP7_MATH_1	507	511	PF00917	0.770
DOC_USP7_MATH_1	514	518	PF00917	0.671
DOC_USP7_MATH_1	520	524	PF00917	0.587
DOC_USP7_MATH_1	53	57	PF00917	0.711
DOC_USP7_MATH_1	536	540	PF00917	0.628
DOC_USP7_MATH_1	550	554	PF00917	0.631
DOC_USP7_MATH_1	600	604	PF00917	0.561
DOC_USP7_MATH_1	90	94	PF00917	0.796
DOC_WW_Pin1_4	131	136	PF00397	0.717
DOC_WW_Pin1_4	137	142	PF00397	0.774
DOC_WW_Pin1_4	211	216	PF00397	0.811
DOC_WW_Pin1_4	227	232	PF00397	0.586
DOC_WW_Pin1_4	298	303	PF00397	0.729
DOC_WW_Pin1_4	326	331	PF00397	0.813
DOC_WW_Pin1_4	385	390	PF00397	0.748
DOC_WW_Pin1_4	405	410	PF00397	0.581
DOC_WW_Pin1_4	575	580	PF00397	0.613
DOC_WW_Pin1_4	611	616	PF00397	0.513
LIG_14-3-3_CanoR_1	100	108	PF00244	0.562
LIG_14-3-3_CanoR_1	387	397	PF00244	0.603
LIG_14-3-3_CanoR_1	413	419	PF00244	0.688
LIG_14-3-3_CanoR_1	429	435	PF00244	0.707
LIG_14-3-3_CanoR_1	518	528	PF00244	0.611
LIG_14-3-3_CanoR_1	599	608	PF00244	0.539
LIG_BIR_III_2	209	213	PF00653	0.561
LIG_CSL_BTD_1	138	141	PF09270	0.783
LIG_FHA_1	20	26	PF00498	0.642
LIG_FHA_1	202	208	PF00498	0.727
LIG_FHA_1	211	217	PF00498	0.652
LIG_FHA_1	336	342	PF00498	0.582
LIG_FHA_1	437	443	PF00498	0.796
LIG_FHA_1	465	471	PF00498	0.773
LIG_FHA_1	473	479	PF00498	0.667
LIG_FHA_1	519	525	PF00498	0.580
LIG_FHA_2	138	144	PF00498	0.781
LIG_FHA_2	204	210	PF00498	0.778
LIG_FHA_2	362	368	PF00498	0.785
LIG_FHA_2	488	494	PF00498	0.534
LIG_HCF-1_HBM_1	526	529	PF13415	0.512
LIG_LIR_Apic_2	431	437	PF02991	0.793
LIG_LIR_Gen_1	388	398	PF02991	0.620
LIG_LIR_Nem_3	388	393	PF02991	0.625
LIG_LIR_Nem_3	618	624	PF02991	0.636
LIG_Pex14_1	402	406	PF04695	0.649
LIG_SH2_CRK	390	394	PF00017	0.622
LIG_SH2_CRK	434	438	PF00017	0.678
LIG_SH2_CRK	621	625	PF00017	0.724
LIG_SH2_NCK_1	416	420	PF00017	0.827
LIG_SH2_NCK_1	529	533	PF00017	0.570
LIG_SH2_SRC	608	611	PF00017	0.532
LIG_SH2_STAP1	529	533	PF00017	0.512
LIG_SH2_STAT5	298	301	PF00017	0.724
LIG_SH2_STAT5	416	419	PF00017	0.828
LIG_SH2_STAT5	441	444	PF00017	0.675
LIG_SH3_3	15	21	PF00018	0.582
LIG_SH3_3	181	187	PF00018	0.657
LIG_SH3_3	194	200	PF00018	0.776
LIG_SH3_3	209	215	PF00018	0.603
LIG_SH3_3	271	277	PF00018	0.551
LIG_SH3_3	296	302	PF00018	0.757
LIG_SH3_3	345	351	PF00018	0.754
LIG_SH3_3	391	397	PF00018	0.667
LIG_SH3_3	573	579	PF00018	0.547
LIG_SH3_3	609	615	PF00018	0.603
LIG_SH3_3	621	627	PF00018	0.646
LIG_SH3_3	72	78	PF00018	0.695
LIG_SH3_3	84	90	PF00018	0.837
LIG_SxIP_EBH_1	403	416	PF03271	0.810
LIG_TRAF2_1	147	150	PF00917	0.555
LIG_TRAF2_1	623	626	PF00917	0.716
LIG_TYR_ITIM	619	624	PF00017	0.731
LIG_WW_3	306	310	PF00397	0.543
LIG_WW_3	312	316	PF00397	0.522
LIG_WW_3	449	453	PF00397	0.770
MOD_CDC14_SPxK_1	134	137	PF00782	0.568
MOD_CDK_SPK_2	227	232	PF00069	0.831
MOD_CDK_SPxK_1	131	137	PF00069	0.571
MOD_CK1_1	107	113	PF00069	0.630
MOD_CK1_1	133	139	PF00069	0.851
MOD_CK1_1	230	236	PF00069	0.769
MOD_CK1_1	262	268	PF00069	0.586
MOD_CK1_1	328	334	PF00069	0.798
MOD_CK1_1	361	367	PF00069	0.572
MOD_CK1_1	522	528	PF00069	0.717
MOD_CK1_1	552	558	PF00069	0.724
MOD_CK1_1	93	99	PF00069	0.825
MOD_CK2_1	137	143	PF00069	0.785
MOD_CK2_1	153	159	PF00069	0.827
MOD_CK2_1	361	367	PF00069	0.786
MOD_GlcNHglycan	219	222	PF01048	0.559
MOD_GlcNHglycan	243	246	PF01048	0.801
MOD_GlcNHglycan	331	334	PF01048	0.588
MOD_GlcNHglycan	360	363	PF01048	0.601
MOD_GlcNHglycan	381	385	PF01048	0.615
MOD_GlcNHglycan	398	401	PF01048	0.693
MOD_GlcNHglycan	49	52	PF01048	0.694
MOD_GlcNHglycan	533	536	PF01048	0.717
MOD_GlcNHglycan	538	541	PF01048	0.669
MOD_GlcNHglycan	542	545	PF01048	0.589
MOD_GlcNHglycan	615	618	PF01048	0.734
MOD_GSK3_1	131	138	PF00069	0.831
MOD_GSK3_1	230	237	PF00069	0.713
MOD_GSK3_1	241	248	PF00069	0.773
MOD_GSK3_1	255	262	PF00069	0.576
MOD_GSK3_1	263	270	PF00069	0.664
MOD_GSK3_1	324	331	PF00069	0.843
MOD_GSK3_1	332	339	PF00069	0.705
MOD_GSK3_1	349	356	PF00069	0.612
MOD_GSK3_1	361	368	PF00069	0.762
MOD_GSK3_1	43	50	PF00069	0.796
MOD_GSK3_1	455	462	PF00069	0.615
MOD_GSK3_1	496	503	PF00069	0.604
MOD_GSK3_1	514	521	PF00069	0.710
MOD_GSK3_1	527	534	PF00069	0.702
MOD_GSK3_1	536	543	PF00069	0.632
MOD_GSK3_1	546	553	PF00069	0.629
MOD_GSK3_1	96	103	PF00069	0.677
MOD_LATS_1	98	104	PF00433	0.567
MOD_N-GLC_1	241	246	PF02516	0.608
MOD_NEK2_1	379	384	PF00069	0.593
MOD_NEK2_1	455	460	PF00069	0.670
MOD_NEK2_1	500	505	PF00069	0.560
MOD_NEK2_1	531	536	PF00069	0.719
MOD_NMyristoyl	1	7	PF02799	0.827
MOD_PIKK_1	177	183	PF00454	0.755
MOD_PIKK_1	186	192	PF00454	0.651
MOD_PIKK_1	388	394	PF00454	0.784
MOD_PIKK_1	555	561	PF00454	0.776
MOD_PIKK_1	600	606	PF00454	0.537
MOD_PK_1	259	265	PF00069	0.678
MOD_PKA_1	100	106	PF00069	0.567
MOD_PKA_1	255	261	PF00069	0.844
MOD_PKA_2	255	261	PF00069	0.844
MOD_PKA_2	365	371	PF00069	0.781
MOD_PKA_2	428	434	PF00069	0.828
MOD_PKA_2	43	49	PF00069	0.730
MOD_PKA_2	555	561	PF00069	0.756
MOD_PKA_2	96	102	PF00069	0.573
MOD_Plk_1	104	110	PF00069	0.822
MOD_Plk_1	455	461	PF00069	0.542
MOD_Plk_1	582	588	PF00069	0.559
MOD_Plk_4	336	342	PF00069	0.586
MOD_Plk_4	430	436	PF00069	0.777
MOD_ProDKin_1	131	137	PF00069	0.720
MOD_ProDKin_1	211	217	PF00069	0.811
MOD_ProDKin_1	227	233	PF00069	0.588
MOD_ProDKin_1	298	304	PF00069	0.730
MOD_ProDKin_1	326	332	PF00069	0.813
MOD_ProDKin_1	385	391	PF00069	0.744
MOD_ProDKin_1	405	411	PF00069	0.646
MOD_ProDKin_1	575	581	PF00069	0.613
MOD_ProDKin_1	611	617	PF00069	0.515
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.695
TRG_ENDOCYTIC_2	390	393	PF00928	0.624
TRG_ENDOCYTIC_2	621	624	PF00928	0.726
TRG_ER_diArg_1	11	13	PF00400	0.617
TRG_ER_diArg_1	254	256	PF00400	0.711
TRG_ER_diArg_1	274	276	PF00400	0.515
TRG_ER_diArg_1	402	404	PF00400	0.776
TRG_ER_diArg_1	412	414	PF00400	0.699
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.770
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5R7	Leishmania donovani	78%	93%
A4H4N1	Leishmania braziliensis	42%	97%
A4HSV7	Leishmania infantum	78%	93%
Q4QJ12	Leishmania major	73%	100%