DUF89 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative Phosphatase/Protein of unknown function DUF89, putative

Species:

Leishmania mexicana

UniProt:

E9AKU1_LEIMU

TriTrypDb:

LmxM.06.0620

Length:

1010

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKU1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0016829	lyase activity	2	1
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016832	aldehyde-lyase activity	4	1
GO:0097023	fructose 6-phosphate aldolase activity	5	1
GO:0103026	fructose-1-phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	531	535	PF00656	0.588
CLV_C14_Caspase3-7	840	844	PF00656	0.708
CLV_MEL_PAP_1	419	425	PF00089	0.665
CLV_MEL_PAP_1	995	1001	PF00089	0.428
CLV_NRD_NRD_1	200	202	PF00675	0.341
CLV_NRD_NRD_1	272	274	PF00675	0.339
CLV_NRD_NRD_1	34	36	PF00675	0.400
CLV_NRD_NRD_1	356	358	PF00675	0.554
CLV_NRD_NRD_1	39	41	PF00675	0.349
CLV_NRD_NRD_1	421	423	PF00675	0.593
CLV_NRD_NRD_1	539	541	PF00675	0.624
CLV_NRD_NRD_1	66	68	PF00675	0.352
CLV_NRD_NRD_1	894	896	PF00675	0.287
CLV_NRD_NRD_1	919	921	PF00675	0.758
CLV_PCSK_KEX2_1	272	274	PF00082	0.339
CLV_PCSK_KEX2_1	34	36	PF00082	0.400
CLV_PCSK_KEX2_1	349	351	PF00082	0.551
CLV_PCSK_KEX2_1	356	358	PF00082	0.554
CLV_PCSK_KEX2_1	39	41	PF00082	0.349
CLV_PCSK_KEX2_1	421	423	PF00082	0.660
CLV_PCSK_KEX2_1	539	541	PF00082	0.621
CLV_PCSK_KEX2_1	780	782	PF00082	0.371
CLV_PCSK_KEX2_1	894	896	PF00082	0.287
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.548
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.368
CLV_PCSK_PC7_1	35	41	PF00082	0.352
CLV_PCSK_SKI1_1	314	318	PF00082	0.533
CLV_PCSK_SKI1_1	335	339	PF00082	0.501
CLV_PCSK_SKI1_1	343	347	PF00082	0.429
CLV_PCSK_SKI1_1	40	44	PF00082	0.470
CLV_PCSK_SKI1_1	577	581	PF00082	0.303
CLV_PCSK_SKI1_1	617	621	PF00082	0.298
CLV_PCSK_SKI1_1	780	784	PF00082	0.380
CLV_PCSK_SKI1_1	785	789	PF00082	0.358
CLV_PCSK_SKI1_1	801	805	PF00082	0.237
CLV_PCSK_SKI1_1	828	832	PF00082	0.424
CLV_PCSK_SKI1_1	971	975	PF00082	0.366
CLV_Separin_Metazoa	378	382	PF03568	0.518
CLV_Separin_Metazoa	556	560	PF03568	0.584
DEG_APCC_DBOX_1	780	788	PF00400	0.589
DEG_Nend_UBRbox_1	1	4	PF02207	0.673
DOC_CKS1_1	939	944	PF01111	0.739
DOC_CYCLIN_RxL_1	34	46	PF00134	0.297
DOC_CYCLIN_yCln2_LP_2	993	999	PF00134	0.439
DOC_MAPK_gen_1	371	379	PF00069	0.593
DOC_MAPK_gen_1	582	591	PF00069	0.528
DOC_MAPK_gen_1	971	981	PF00069	0.393
DOC_MAPK_gen_1	986	995	PF00069	0.507
DOC_MAPK_MEF2A_6	6	15	PF00069	0.297
DOC_MAPK_RevD_3	524	540	PF00069	0.639
DOC_PP1_RVXF_1	202	208	PF00149	0.339
DOC_PP1_RVXF_1	45	51	PF00149	0.402
DOC_PP2B_LxvP_1	159	162	PF13499	0.576
DOC_PP2B_LxvP_1	434	437	PF13499	0.522
DOC_PP2B_LxvP_1	979	982	PF13499	0.606
DOC_PP2B_LxvP_1	993	996	PF13499	0.465
DOC_PP4_MxPP_1	388	391	PF00568	0.466
DOC_USP7_MATH_1	162	166	PF00917	0.714
DOC_USP7_MATH_1	179	183	PF00917	0.671
DOC_USP7_MATH_1	287	291	PF00917	0.487
DOC_USP7_MATH_1	406	410	PF00917	0.654
DOC_USP7_MATH_1	70	74	PF00917	0.450
DOC_USP7_MATH_1	863	867	PF00917	0.807
DOC_USP7_MATH_1	966	970	PF00917	0.427
DOC_WW_Pin1_4	100	105	PF00397	0.578
DOC_WW_Pin1_4	421	426	PF00397	0.649
DOC_WW_Pin1_4	502	507	PF00397	0.686
DOC_WW_Pin1_4	751	756	PF00397	0.499
DOC_WW_Pin1_4	938	943	PF00397	0.677
DOC_WW_Pin1_4	946	951	PF00397	0.696
LIG_14-3-3_CanoR_1	234	244	PF00244	0.384
LIG_14-3-3_CanoR_1	343	348	PF00244	0.417
LIG_14-3-3_CanoR_1	501	506	PF00244	0.728
LIG_14-3-3_CanoR_1	6	10	PF00244	0.405
LIG_14-3-3_CanoR_1	781	785	PF00244	0.530
LIG_14-3-3_CanoR_1	828	838	PF00244	0.382
LIG_14-3-3_CanoR_1	925	933	PF00244	0.442
LIG_14-3-3_CanoR_1	971	981	PF00244	0.420
LIG_Actin_WH2_1	904	922	PF00022	0.507
LIG_Actin_WH2_2	51	69	PF00022	0.400
LIG_BRCT_BRCA1_1	948	952	PF00533	0.445
LIG_Clathr_ClatBox_1	10	14	PF01394	0.324
LIG_Clathr_ClatBox_1	130	134	PF01394	0.471
LIG_deltaCOP1_diTrp_1	899	907	PF00928	0.487
LIG_EH1_1	274	282	PF00400	0.384
LIG_FHA_1	22	28	PF00498	0.384
LIG_FHA_1	236	242	PF00498	0.385
LIG_FHA_1	480	486	PF00498	0.580
LIG_FHA_1	503	509	PF00498	0.620
LIG_FHA_1	695	701	PF00498	0.531
LIG_FHA_1	830	836	PF00498	0.428
LIG_FHA_1	903	909	PF00498	0.596
LIG_FHA_1	960	966	PF00498	0.477
LIG_FHA_2	16	22	PF00498	0.339
LIG_FHA_2	336	342	PF00498	0.370
LIG_FHA_2	676	682	PF00498	0.429
LIG_FHA_2	752	758	PF00498	0.487
LIG_FHA_2	762	768	PF00498	0.487
LIG_FHA_2	949	955	PF00498	0.587
LIG_IBAR_NPY_1	154	156	PF08397	0.519
LIG_LIR_Apic_2	809	815	PF02991	0.487
LIG_LIR_Gen_1	409	419	PF02991	0.649
LIG_LIR_Gen_1	482	491	PF02991	0.534
LIG_LIR_Gen_1	590	599	PF02991	0.641
LIG_LIR_Gen_1	8	17	PF02991	0.339
LIG_LIR_Gen_1	82	90	PF02991	0.450
LIG_LIR_Gen_1	924	934	PF02991	0.666
LIG_LIR_Gen_1	949	959	PF02991	0.449
LIG_LIR_LC3C_4	8	12	PF02991	0.297
LIG_LIR_LC3C_4	882	886	PF02991	0.412
LIG_LIR_Nem_3	1000	1006	PF02991	0.421
LIG_LIR_Nem_3	14	20	PF02991	0.339
LIG_LIR_Nem_3	153	159	PF02991	0.436
LIG_LIR_Nem_3	255	259	PF02991	0.386
LIG_LIR_Nem_3	341	345	PF02991	0.436
LIG_LIR_Nem_3	409	414	PF02991	0.630
LIG_LIR_Nem_3	448	454	PF02991	0.406
LIG_LIR_Nem_3	482	486	PF02991	0.542
LIG_LIR_Nem_3	571	576	PF02991	0.593
LIG_LIR_Nem_3	590	594	PF02991	0.572
LIG_LIR_Nem_3	608	614	PF02991	0.482
LIG_LIR_Nem_3	8	12	PF02991	0.339
LIG_LIR_Nem_3	816	821	PF02991	0.519
LIG_LIR_Nem_3	82	87	PF02991	0.358
LIG_LIR_Nem_3	890	896	PF02991	0.514
LIG_LIR_Nem_3	924	929	PF02991	0.681
LIG_LIR_Nem_3	949	955	PF02991	0.462
LIG_NRBOX	683	689	PF00104	0.589
LIG_PCNA_PIPBox_1	80	89	PF02747	0.339
LIG_PDZ_Class_2	1005	1010	PF00595	0.383
LIG_Pex14_1	207	211	PF04695	0.328
LIG_Pex14_1	401	405	PF04695	0.402
LIG_PTB_Apo_2	151	158	PF02174	0.571
LIG_PTB_Apo_2	401	408	PF02174	0.550
LIG_PTB_Apo_2	490	497	PF02174	0.624
LIG_PTB_Apo_2	824	831	PF02174	0.539
LIG_PTB_Phospho_1	151	157	PF10480	0.567
LIG_PTB_Phospho_1	401	407	PF10480	0.547
LIG_SH2_CRK	256	260	PF00017	0.384
LIG_SH2_CRK	405	409	PF00017	0.484
LIG_SH2_CRK	411	415	PF00017	0.558
LIG_SH2_CRK	611	615	PF00017	0.589
LIG_SH2_CRK	893	897	PF00017	0.589
LIG_SH2_GRB2like	411	414	PF00017	0.624
LIG_SH2_GRB2like	721	724	PF00017	0.541
LIG_SH2_NCK_1	17	21	PF00017	0.219
LIG_SH2_NCK_1	411	415	PF00017	0.662
LIG_SH2_NCK_1	926	930	PF00017	0.546
LIG_SH2_NCK_1	94	98	PF00017	0.411
LIG_SH2_SRC	405	408	PF00017	0.552
LIG_SH2_SRC	411	414	PF00017	0.631
LIG_SH2_STAP1	157	161	PF00017	0.548
LIG_SH2_STAP1	554	558	PF00017	0.525
LIG_SH2_STAP1	94	98	PF00017	0.411
LIG_SH2_STAT3	211	214	PF00017	0.328
LIG_SH2_STAT3	721	724	PF00017	0.589
LIG_SH2_STAT5	17	20	PF00017	0.219
LIG_SH2_STAT5	256	259	PF00017	0.363
LIG_SH2_STAT5	407	410	PF00017	0.596
LIG_SH2_STAT5	450	453	PF00017	0.384
LIG_SH2_STAT5	683	686	PF00017	0.577
LIG_SH2_STAT5	721	724	PF00017	0.589
LIG_SH2_STAT5	749	752	PF00017	0.515
LIG_SH2_STAT5	86	89	PF00017	0.481
LIG_SH3_3	173	179	PF00018	0.576
LIG_SH3_3	191	197	PF00018	0.539
LIG_SH3_3	259	265	PF00018	0.438
LIG_SH3_3	387	393	PF00018	0.482
LIG_SH3_3	420	426	PF00018	0.556
LIG_SH3_3	506	512	PF00018	0.706
LIG_SH3_3	523	529	PF00018	0.624
LIG_SH3_3	555	561	PF00018	0.671
LIG_SH3_3	75	81	PF00018	0.467
LIG_SH3_3	784	790	PF00018	0.556
LIG_SH3_3	832	838	PF00018	0.632
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.297
LIG_SUMO_SIM_par_1	8	14	PF11976	0.297
LIG_TRAF2_1	338	341	PF00917	0.453
LIG_TRAF2_1	912	915	PF00917	0.722
LIG_TYR_ITIM	891	896	PF00017	0.589
LIG_UBA3_1	588	593	PF00899	0.541
LIG_WW_2	390	393	PF00397	0.518
LIG_WW_3	821	825	PF00397	0.554
MOD_CDK_SPK_2	751	756	PF00069	0.590
MOD_CK1_1	363	369	PF00069	0.518
MOD_CK1_1	628	634	PF00069	0.512
MOD_CK1_1	751	757	PF00069	0.493
MOD_CK1_1	836	842	PF00069	0.696
MOD_CK1_1	969	975	PF00069	0.461
MOD_CK2_1	335	341	PF00069	0.433
MOD_CK2_1	675	681	PF00069	0.421
MOD_CK2_1	924	930	PF00069	0.646
MOD_CMANNOS	618	621	PF00535	0.298
MOD_Cter_Amidation	32	35	PF01082	0.400
MOD_GlcNHglycan	166	169	PF01048	0.456
MOD_GlcNHglycan	365	368	PF01048	0.678
MOD_GlcNHglycan	517	520	PF01048	0.673
MOD_GlcNHglycan	561	564	PF01048	0.689
MOD_GlcNHglycan	735	738	PF01048	0.376
MOD_GlcNHglycan	835	838	PF01048	0.630
MOD_GlcNHglycan	839	842	PF01048	0.709
MOD_GlcNHglycan	850	853	PF01048	0.595
MOD_GlcNHglycan	865	868	PF01048	0.588
MOD_GlcNHglycan	881	884	PF01048	0.242
MOD_GlcNHglycan	926	929	PF01048	0.615
MOD_GlcNHglycan	956	959	PF01048	0.515
MOD_GlcNHglycan	999	1002	PF01048	0.451
MOD_GSK3_1	528	535	PF00069	0.588
MOD_GSK3_1	761	768	PF00069	0.562
MOD_GSK3_1	776	783	PF00069	0.455
MOD_GSK3_1	829	836	PF00069	0.463
MOD_GSK3_1	844	851	PF00069	0.621
MOD_GSK3_1	902	909	PF00069	0.509
MOD_GSK3_1	946	953	PF00069	0.504
MOD_N-GLC_1	363	368	PF02516	0.545
MOD_N-GLC_1	414	419	PF02516	0.694
MOD_N-GLC_1	694	699	PF02516	0.363
MOD_N-GLC_2	225	227	PF02516	0.339
MOD_N-GLC_2	827	829	PF02516	0.306
MOD_NEK2_1	15	20	PF00069	0.338
MOD_NEK2_1	226	231	PF00069	0.371
MOD_NEK2_1	235	240	PF00069	0.378
MOD_NEK2_1	43	48	PF00069	0.341
MOD_NEK2_1	53	58	PF00069	0.377
MOD_NEK2_1	758	763	PF00069	0.589
MOD_NEK2_1	765	770	PF00069	0.589
MOD_NEK2_1	848	853	PF00069	0.744
MOD_NEK2_1	857	862	PF00069	0.715
MOD_NEK2_1	907	912	PF00069	0.473
MOD_NEK2_2	568	573	PF00069	0.599
MOD_NEK2_2	966	971	PF00069	0.387
MOD_PIKK_1	162	168	PF00454	0.574
MOD_PIKK_1	484	490	PF00454	0.627
MOD_PIKK_1	494	500	PF00454	0.607
MOD_PIKK_1	571	577	PF00454	0.536
MOD_PIKK_1	810	816	PF00454	0.522
MOD_PIKK_1	829	835	PF00454	0.376
MOD_PIKK_1	935	941	PF00454	0.647
MOD_PIKK_1	959	965	PF00454	0.468
MOD_PK_1	350	356	PF00069	0.581
MOD_PK_1	528	534	PF00069	0.602
MOD_PKA_1	780	786	PF00069	0.541
MOD_PKA_2	200	206	PF00069	0.388
MOD_PKA_2	380	386	PF00069	0.419
MOD_PKA_2	5	11	PF00069	0.407
MOD_PKA_2	780	786	PF00069	0.631
MOD_PKA_2	924	930	PF00069	0.667
MOD_PKA_2	997	1003	PF00069	0.404
MOD_PKB_1	333	341	PF00069	0.452
MOD_Plk_1	15	21	PF00069	0.324
MOD_Plk_1	363	369	PF00069	0.524
MOD_Plk_1	43	49	PF00069	0.219
MOD_Plk_1	625	631	PF00069	0.508
MOD_Plk_1	758	764	PF00069	0.545
MOD_Plk_1	765	771	PF00069	0.556
MOD_Plk_1	929	935	PF00069	0.651
MOD_Plk_2-3	21	27	PF00069	0.336
MOD_Plk_2-3	72	78	PF00069	0.400
MOD_Plk_2-3	948	954	PF00069	0.573
MOD_Plk_4	15	21	PF00069	0.324
MOD_Plk_4	226	232	PF00069	0.428
MOD_Plk_4	237	243	PF00069	0.332
MOD_Plk_4	327	333	PF00069	0.511
MOD_Plk_4	350	356	PF00069	0.581
MOD_Plk_4	5	11	PF00069	0.392
MOD_Plk_4	53	59	PF00069	0.363
MOD_Plk_4	532	538	PF00069	0.578
MOD_Plk_4	568	574	PF00069	0.694
MOD_Plk_4	625	631	PF00069	0.509
MOD_Plk_4	807	813	PF00069	0.546
MOD_Plk_4	929	935	PF00069	0.645
MOD_ProDKin_1	100	106	PF00069	0.571
MOD_ProDKin_1	421	427	PF00069	0.655
MOD_ProDKin_1	502	508	PF00069	0.685
MOD_ProDKin_1	751	757	PF00069	0.499
MOD_ProDKin_1	938	944	PF00069	0.681
MOD_ProDKin_1	946	952	PF00069	0.677
MOD_SUMO_for_1	912	915	PF00179	0.684
MOD_SUMO_for_1	973	976	PF00179	0.374
MOD_SUMO_rev_2	72	81	PF00179	0.461
TRG_DiLeu_BaEn_4	914	920	PF01217	0.621
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.339
TRG_DiLeu_BaLyEn_6	683	688	PF01217	0.589
TRG_ENDOCYTIC_2	1003	1006	PF00928	0.418
TRG_ENDOCYTIC_2	156	159	PF00928	0.544
TRG_ENDOCYTIC_2	17	20	PF00928	0.219
TRG_ENDOCYTIC_2	256	259	PF00928	0.384
TRG_ENDOCYTIC_2	405	408	PF00928	0.468
TRG_ENDOCYTIC_2	411	414	PF00928	0.548
TRG_ENDOCYTIC_2	452	455	PF00928	0.412
TRG_ENDOCYTIC_2	554	557	PF00928	0.516
TRG_ENDOCYTIC_2	576	579	PF00928	0.339
TRG_ENDOCYTIC_2	611	614	PF00928	0.589
TRG_ENDOCYTIC_2	818	821	PF00928	0.487
TRG_ENDOCYTIC_2	893	896	PF00928	0.589
TRG_ENDOCYTIC_2	926	929	PF00928	0.512
TRG_ER_diArg_1	263	266	PF00400	0.324
TRG_ER_diArg_1	355	357	PF00400	0.489
TRG_ER_diArg_1	373	376	PF00400	0.413
TRG_ER_diArg_1	39	41	PF00400	0.352
TRG_ER_diArg_1	421	423	PF00400	0.593
TRG_ER_diArg_1	538	540	PF00400	0.607
TRG_ER_diArg_1	893	895	PF00400	0.487
TRG_NES_CRM1_1	114	127	PF08389	0.429
TRG_NES_CRM1_1	312	322	PF08389	0.544
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	686	691	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	894	899	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC9	Leptomonas seymouri	67%	100%
A0A0S4J9G5	Bodo saltans	34%	100%
A0A1X0NKN4	Trypanosomatidae	40%	100%
A0A3R7MAF3	Trypanosoma rangeli	39%	100%
A0A3S5H5R3	Leishmania donovani	92%	100%
A4H4M8	Leishmania braziliensis	82%	100%
A4HSV3	Leishmania infantum	92%	100%
C9ZTG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QJ16	Leishmania major	91%	100%
V5BT19	Trypanosoma cruzi	40%	100%