Carbonic anhydrase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Carbonic anhydrase

Gene product:

carbonic anhydrase family protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKU0_LEIMU

TriTrypDb:

LmxM.06.0610

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKU0

Function

Biological processes
Term	Name	Level	Count
GO:0009605	response to external stimulus	2	8
GO:0009991	response to extracellular stimulus	3	8
GO:0015976	carbon utilization	5	8
GO:0031667	response to nutrient levels	4	8
GO:0050896	response to stimulus	1	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004089	carbonate dehydratase activity	5	8
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	8
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.354
CLV_NRD_NRD_1	284	286	PF00675	0.426
CLV_NRD_NRD_1	44	46	PF00675	0.467
CLV_PCSK_KEX2_1	196	198	PF00082	0.278
CLV_PCSK_KEX2_1	200	202	PF00082	0.278
CLV_PCSK_KEX2_1	248	250	PF00082	0.324
CLV_PCSK_KEX2_1	284	286	PF00082	0.426
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.278
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.337
CLV_PCSK_SKI1_1	200	204	PF00082	0.356
CLV_PCSK_SKI1_1	277	281	PF00082	0.346
DEG_APCC_DBOX_1	199	207	PF00400	0.384
DEG_APCC_DBOX_1	208	216	PF00400	0.283
DEG_COP1_1	12	21	PF00400	0.576
DEG_MDM2_SWIB_1	78	86	PF02201	0.385
DOC_CYCLIN_RxL_1	274	281	PF00134	0.348
DOC_MAPK_gen_1	99	108	PF00069	0.391
DOC_MAPK_JIP1_4	102	108	PF00069	0.356
DOC_PP2B_LxvP_1	16	19	PF13499	0.614
DOC_USP7_MATH_1	67	71	PF00917	0.442
DOC_WW_Pin1_4	23	28	PF00397	0.601
LIG_14-3-3_CanoR_1	277	283	PF00244	0.343
LIG_14-3-3_CanoR_1	56	62	PF00244	0.485
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BRCT_BRCA1_1	19	23	PF00533	0.588
LIG_FHA_1	13	19	PF00498	0.628
LIG_FHA_1	171	177	PF00498	0.468
LIG_FHA_1	228	234	PF00498	0.335
LIG_FHA_1	24	30	PF00498	0.450
LIG_FHA_1	39	45	PF00498	0.385
LIG_LIR_Gen_1	92	98	PF02991	0.444
LIG_LIR_Nem_3	297	303	PF02991	0.427
LIG_LIR_Nem_3	92	97	PF02991	0.373
LIG_MLH1_MIPbox_1	19	23	PF16413	0.582
LIG_Pex14_2	78	82	PF04695	0.397
LIG_PTB_Apo_2	87	94	PF02174	0.367
LIG_PTB_Phospho_1	87	93	PF10480	0.367
LIG_SH2_STAT5	105	108	PF00017	0.348
LIG_SH2_STAT5	22	25	PF00017	0.731
LIG_SH2_STAT5	93	96	PF00017	0.381
LIG_Sin3_3	145	152	PF02671	0.335
LIG_SUMO_SIM_par_1	14	20	PF11976	0.578
LIG_WW_3	65	69	PF00397	0.442
MOD_CK1_1	2	8	PF00069	0.657
MOD_CK1_1	36	42	PF00069	0.584
MOD_CK2_1	283	289	PF00069	0.432
MOD_GlcNHglycan	163	166	PF01048	0.367
MOD_GlcNHglycan	191	194	PF01048	0.335
MOD_GlcNHglycan	69	72	PF01048	0.436
MOD_GSK3_1	17	24	PF00069	0.566
MOD_GSK3_1	201	208	PF00069	0.306
MOD_GSK3_1	235	242	PF00069	0.168
MOD_GSK3_1	32	39	PF00069	0.577
MOD_N-GLC_1	33	38	PF02516	0.640
MOD_NEK2_1	189	194	PF00069	0.335
MOD_NEK2_1	21	26	PF00069	0.581
MOD_NEK2_1	57	62	PF00069	0.420
MOD_PIKK_1	251	257	PF00454	0.316
MOD_PKA_2	251	257	PF00069	0.335
MOD_PKA_2	283	289	PF00069	0.372
MOD_PKA_2	32	38	PF00069	0.446
MOD_PKA_2	67	73	PF00069	0.434
MOD_Plk_4	17	23	PF00069	0.628
MOD_Plk_4	48	54	PF00069	0.470
MOD_ProDKin_1	23	29	PF00069	0.600
MOD_SUMO_for_1	247	250	PF00179	0.312
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.345
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.399
TRG_ENDOCYTIC_2	105	108	PF00928	0.275
TRG_ENDOCYTIC_2	303	306	PF00928	0.436
TRG_ER_diArg_1	199	201	PF00400	0.361
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX68	Leptomonas seymouri	76%	78%
A0A1X0NKJ0	Trypanosomatidae	59%	84%
A0A3S5H5R2	Leishmania donovani	95%	100%
A4H4M7	Leishmania braziliensis	87%	100%
A4HSV2	Leishmania infantum	95%	100%
O94255	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	93%
P27134	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	29%	100%
P45148	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	38%	100%
P53615	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P61517	Escherichia coli (strain K12)	42%	100%
P61518	Shigella flexneri	42%	100%
Q4QJ17	Leishmania major	94%	100%
Q5AJ71	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	100%
Q5BCC5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	100%
Q9ZN54	Helicobacter pylori (strain J99 / ATCC 700824)	27%	100%