Putative 60S ribosomal protein L23a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L23a, putative

Species:

Leishmania mexicana

UniProt:

E9AKT6_LEIMU

TriTrypDb:

LmxM.06.0570 , LmxM.06.0580

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

E9AKT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKT6

PDB structure(s): 6az3_V

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14
GO:0005488	binding	1	14
GO:0019843	rRNA binding	5	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.297
CLV_NRD_NRD_1	26	28	PF00675	0.503
CLV_NRD_NRD_1	36	38	PF00675	0.480
CLV_NRD_NRD_1	41	43	PF00675	0.483
CLV_PCSK_KEX2_1	36	38	PF00082	0.518
CLV_PCSK_PC7_1	32	38	PF00082	0.481
CLV_PCSK_SKI1_1	109	113	PF00082	0.297
CLV_PCSK_SKI1_1	14	18	PF00082	0.559
CLV_PCSK_SKI1_1	20	24	PF00082	0.444
CLV_PCSK_SKI1_1	43	47	PF00082	0.449
CLV_PCSK_SKI1_1	6	10	PF00082	0.653
CLV_PCSK_SKI1_1	74	78	PF00082	0.294
DOC_CYCLIN_yClb1_LxF_4	82	88	PF00134	0.297
DOC_MAPK_gen_1	123	129	PF00069	0.353
DOC_MAPK_gen_1	14	24	PF00069	0.647
DOC_PP4_FxxP_1	35	38	PF00568	0.490
DOC_USP7_MATH_1	47	51	PF00917	0.563
DOC_USP7_UBL2_3	100	104	PF12436	0.297
DOC_USP7_UBL2_3	6	10	PF12436	0.677
DOC_USP7_UBL2_3	74	78	PF12436	0.312
DOC_USP7_UBL2_3	95	99	PF12436	0.297
LIG_14-3-3_CanoR_1	128	136	PF00244	0.402
LIG_14-3-3_CanoR_1	27	31	PF00244	0.606
LIG_14-3-3_CanoR_1	36	42	PF00244	0.390
LIG_14-3-3_CanoR_1	52	56	PF00244	0.458
LIG_14-3-3_CanoR_1	67	76	PF00244	0.225
LIG_14-3-3_CanoR_1	92	102	PF00244	0.333
LIG_Actin_WH2_2	109	125	PF00022	0.297
LIG_FHA_1	17	23	PF00498	0.601
LIG_FHA_1	84	90	PF00498	0.299
LIG_LIR_Apic_2	29	33	PF02991	0.555
LIG_LIR_Apic_2	40	44	PF02991	0.419
LIG_LRP6_Inhibitor_1	61	67	PF00058	0.375
LIG_SH2_CRK	30	34	PF00017	0.483
LIG_SH2_CRK	41	45	PF00017	0.484
LIG_SH2_NCK_1	30	34	PF00017	0.483
LIG_SH2_PTP2	126	129	PF00017	0.393
LIG_SH2_STAT5	126	129	PF00017	0.361
LIG_SH2_STAT5	30	33	PF00017	0.485
MOD_GlcNHglycan	129	132	PF01048	0.420
MOD_GSK3_1	22	29	PF00069	0.600
MOD_GSK3_1	43	50	PF00069	0.501
MOD_N-GLC_1	81	86	PF02516	0.297
MOD_N-GLC_1	93	98	PF02516	0.297
MOD_PKA_2	127	133	PF00069	0.401
MOD_PKA_2	26	32	PF00069	0.580
MOD_PKA_2	51	57	PF00069	0.598
MOD_Plk_1	81	87	PF00069	0.297
MOD_Plk_4	112	118	PF00069	0.312
MOD_Plk_4	83	89	PF00069	0.312
MOD_SUMO_rev_2	13	19	PF00179	0.448
MOD_SUMO_rev_2	50	60	PF00179	0.597
MOD_SUMO_rev_2	91	101	PF00179	0.308
TRG_DiLeu_BaEn_4	80	86	PF01217	0.297
TRG_ENDOCYTIC_2	126	129	PF00928	0.393
TRG_ER_diArg_1	35	37	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4X7	Leptomonas seymouri	94%	100%
A0A0S4J345	Bodo saltans	77%	88%
A0A1D8PPS1	Candida albicans (strain SC5314 / ATCC MYA-2876)	46%	100%
A0A1X0NMB1	Trypanosomatidae	80%	89%
A0A1X0NMD0	Trypanosomatidae	83%	93%
A0A3S5IQT9	Trypanosoma rangeli	79%	99%
A0A3S7WPH7	Leishmania donovani	98%	100%
A4H4M3	Leishmania braziliensis	95%	100%
A4H4M4	Leishmania braziliensis	94%	100%
A4HSU9	Leishmania infantum	98%	100%
C9ZTF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	88%
E9AG68	Leishmania infantum	98%	100%
O22644	Fritillaria agrestis	48%	94%
O74391	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
P04456	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P08792	Cyberlindnera jadinii	44%	100%
P0DJ57	Tetrahymena thermophila (strain SB210)	46%	97%
P41165	Trypanosoma brucei brucei	83%	88%
P48045	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	44%	100%
P48162	Caenorhabditis elegans	50%	99%
P51997	Puccinia graminis	50%	92%
P62750	Homo sapiens	54%	93%
P62751	Mus musculus	54%	93%
P62752	Rattus norvegicus	54%	93%
Q07761	Nicotiana tabacum	49%	94%
Q10330	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
Q20647	Caenorhabditis elegans	47%	99%
Q24JY1	Bos taurus	54%	93%
Q4QJ20	Leishmania major	99%	100%
Q54BQ3	Dictyostelium discoideum	46%	86%
Q8LD46	Arabidopsis thaliana	55%	94%
Q9AT35	Daucus carota	50%	94%
Q9M3C3	Arabidopsis thaliana	49%	94%