Basic immunoglobulin-like variable motif-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKT3_LEIMU

TriTrypDb:

LmxM.06.0540

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.704
CLV_C14_Caspase3-7	43	47	PF00656	0.582
CLV_C14_Caspase3-7	468	472	PF00656	0.619
CLV_C14_Caspase3-7	477	481	PF00656	0.571
CLV_C14_Caspase3-7	577	581	PF00656	0.657
CLV_C14_Caspase3-7	693	697	PF00656	0.638
CLV_NRD_NRD_1	339	341	PF00675	0.522
CLV_NRD_NRD_1	368	370	PF00675	0.614
CLV_NRD_NRD_1	371	373	PF00675	0.653
CLV_NRD_NRD_1	56	58	PF00675	0.631
CLV_NRD_NRD_1	62	64	PF00675	0.661
CLV_PCSK_KEX2_1	368	370	PF00082	0.614
CLV_PCSK_KEX2_1	373	375	PF00082	0.654
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.546
CLV_PCSK_PC7_1	369	375	PF00082	0.516
CLV_PCSK_SKI1_1	138	142	PF00082	0.532
CLV_PCSK_SKI1_1	156	160	PF00082	0.386
CLV_PCSK_SKI1_1	276	280	PF00082	0.469
CLV_PCSK_SKI1_1	63	67	PF00082	0.781
CLV_PCSK_SKI1_1	8	12	PF00082	0.756
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DEG_SPOP_SBC_1	394	398	PF00917	0.575
DEG_SPOP_SBC_1	474	478	PF00917	0.629
DEG_SPOP_SBC_1	608	612	PF00917	0.764
DOC_CKS1_1	582	587	PF01111	0.586
DOC_CYCLIN_yCln2_LP_2	502	508	PF00134	0.736
DOC_MAPK_MEF2A_6	150	159	PF00069	0.379
DOC_PP2B_LxvP_1	159	162	PF13499	0.504
DOC_PP2B_LxvP_1	502	505	PF13499	0.586
DOC_PP4_FxxP_1	214	217	PF00568	0.507
DOC_PP4_FxxP_1	310	313	PF00568	0.535
DOC_PP4_FxxP_1	525	528	PF00568	0.681
DOC_USP7_MATH_1	120	124	PF00917	0.649
DOC_USP7_MATH_1	15	19	PF00917	0.728
DOC_USP7_MATH_1	255	259	PF00917	0.464
DOC_USP7_MATH_1	378	382	PF00917	0.598
DOC_USP7_MATH_1	409	413	PF00917	0.614
DOC_USP7_MATH_1	473	477	PF00917	0.689
DOC_USP7_MATH_1	490	494	PF00917	0.596
DOC_USP7_MATH_1	513	517	PF00917	0.699
DOC_USP7_MATH_1	526	530	PF00917	0.603
DOC_USP7_MATH_1	532	536	PF00917	0.590
DOC_USP7_MATH_1	570	574	PF00917	0.708
DOC_USP7_MATH_1	590	594	PF00917	0.563
DOC_USP7_MATH_1	597	601	PF00917	0.682
DOC_USP7_MATH_1	608	612	PF00917	0.606
DOC_USP7_MATH_1	634	638	PF00917	0.752
DOC_USP7_MATH_1	643	647	PF00917	0.654
DOC_USP7_UBL2_3	373	377	PF12436	0.700
DOC_USP7_UBL2_3	64	68	PF12436	0.635
DOC_WW_Pin1_4	118	123	PF00397	0.679
DOC_WW_Pin1_4	350	355	PF00397	0.526
DOC_WW_Pin1_4	442	447	PF00397	0.589
DOC_WW_Pin1_4	488	493	PF00397	0.724
DOC_WW_Pin1_4	497	502	PF00397	0.663
DOC_WW_Pin1_4	507	512	PF00397	0.615
DOC_WW_Pin1_4	565	570	PF00397	0.699
DOC_WW_Pin1_4	581	586	PF00397	0.618
DOC_WW_Pin1_4	609	614	PF00397	0.716
DOC_WW_Pin1_4	630	635	PF00397	0.715
DOC_WW_Pin1_4	639	644	PF00397	0.722
LIG_14-3-3_CanoR_1	340	349	PF00244	0.485
LIG_14-3-3_CanoR_1	372	380	PF00244	0.552
LIG_14-3-3_CanoR_1	429	435	PF00244	0.640
LIG_14-3-3_CanoR_1	475	482	PF00244	0.691
LIG_14-3-3_CanoR_1	688	693	PF00244	0.730
LIG_BIR_III_4	531	535	PF00653	0.660
LIG_BRCT_BRCA1_1	352	356	PF00533	0.531
LIG_BRCT_BRCA1_1	690	694	PF00533	0.583
LIG_deltaCOP1_diTrp_1	220	226	PF00928	0.525
LIG_FHA_1	110	116	PF00498	0.700
LIG_FHA_1	259	265	PF00498	0.518
LIG_FHA_1	267	273	PF00498	0.428
LIG_FHA_1	306	312	PF00498	0.498
LIG_FHA_1	321	327	PF00498	0.386
LIG_FHA_1	390	396	PF00498	0.606
LIG_FHA_1	438	444	PF00498	0.682
LIG_FHA_1	489	495	PF00498	0.701
LIG_FHA_1	515	521	PF00498	0.683
LIG_FHA_1	593	599	PF00498	0.633
LIG_FHA_2	147	153	PF00498	0.531
LIG_FHA_2	312	318	PF00498	0.430
LIG_FHA_2	41	47	PF00498	0.611
LIG_FHA_2	475	481	PF00498	0.731
LIG_FHA_2	546	552	PF00498	0.619
LIG_FHA_2	582	588	PF00498	0.586
LIG_FHA_2	64	70	PF00498	0.630
LIG_FHA_2	700	706	PF00498	0.598
LIG_LIR_Apic_2	308	313	PF02991	0.529
LIG_LIR_Apic_2	524	528	PF02991	0.680
LIG_LIR_Gen_1	182	191	PF02991	0.535
LIG_LIR_Nem_3	182	187	PF02991	0.523
LIG_LIR_Nem_3	215	221	PF02991	0.501
LIG_LIR_Nem_3	353	359	PF02991	0.510
LIG_LYPXL_SIV_4	434	442	PF13949	0.626
LIG_MLH1_MIPbox_1	352	356	PF16413	0.531
LIG_PALB2_WD40_1	231	239	PF16756	0.448
LIG_PCNA_yPIPBox_3	229	241	PF02747	0.457
LIG_Pex14_1	50	54	PF04695	0.669
LIG_Pex14_2	214	218	PF04695	0.498
LIG_PTAP_UEV_1	121	126	PF05743	0.535
LIG_PTB_Apo_2	182	189	PF02174	0.434
LIG_PTB_Phospho_1	182	188	PF10480	0.434
LIG_REV1ctd_RIR_1	354	361	PF16727	0.511
LIG_SH2_CRK	184	188	PF00017	0.510
LIG_SH2_CRK	294	298	PF00017	0.441
LIG_SH2_GRB2like	265	268	PF00017	0.471
LIG_SH2_NCK_1	435	439	PF00017	0.625
LIG_SH2_NCK_1	671	675	PF00017	0.626
LIG_SH2_SRC	186	189	PF00017	0.453
LIG_SH2_SRC	300	303	PF00017	0.468
LIG_SH2_SRC	671	674	PF00017	0.616
LIG_SH2_STAP1	338	342	PF00017	0.507
LIG_SH2_STAP1	435	439	PF00017	0.672
LIG_SH2_STAT5	186	189	PF00017	0.472
LIG_SH2_STAT5	250	253	PF00017	0.463
LIG_SH3_1	579	585	PF00018	0.587
LIG_SH3_1	602	608	PF00018	0.584
LIG_SH3_3	119	125	PF00018	0.659
LIG_SH3_3	383	389	PF00018	0.557
LIG_SH3_3	411	417	PF00018	0.704
LIG_SH3_3	440	446	PF00018	0.622
LIG_SH3_3	489	495	PF00018	0.722
LIG_SH3_3	498	504	PF00018	0.660
LIG_SH3_3	579	585	PF00018	0.645
LIG_SH3_3	598	604	PF00018	0.651
LIG_SUMO_SIM_anti_2	466	471	PF11976	0.675
LIG_SUMO_SIM_par_1	391	398	PF11976	0.571
LIG_SUMO_SIM_par_1	439	445	PF11976	0.636
LIG_TRAF2_1	204	207	PF00917	0.509
LIG_TRAF2_1	548	551	PF00917	0.655
LIG_TYR_ITIM	298	303	PF00017	0.458
LIG_WRC_WIRS_1	591	596	PF05994	0.632
LIG_WW_2	504	507	PF00397	0.585
MOD_CDC14_SPxK_1	642	645	PF00782	0.703
MOD_CDK_SPK_2	609	614	PF00069	0.719
MOD_CDK_SPxK_1	639	645	PF00069	0.710
MOD_CDK_SPxxK_3	609	616	PF00069	0.723
MOD_CK1_1	118	124	PF00069	0.627
MOD_CK1_1	179	185	PF00069	0.435
MOD_CK1_1	258	264	PF00069	0.528
MOD_CK1_1	4	10	PF00069	0.669
MOD_CK1_1	452	458	PF00069	0.730
MOD_CK1_1	493	499	PF00069	0.598
MOD_CK1_1	537	543	PF00069	0.676
MOD_CK1_1	633	639	PF00069	0.686
MOD_CK1_1	690	696	PF00069	0.715
MOD_CK1_1	698	704	PF00069	0.664
MOD_CK2_1	311	317	PF00069	0.429
MOD_CK2_1	545	551	PF00069	0.623
MOD_CK2_1	581	587	PF00069	0.670
MOD_CK2_1	590	596	PF00069	0.726
MOD_CK2_1	63	69	PF00069	0.635
MOD_GlcNHglycan	117	120	PF01048	0.706
MOD_GlcNHglycan	122	125	PF01048	0.638
MOD_GlcNHglycan	193	196	PF01048	0.511
MOD_GlcNHglycan	257	260	PF01048	0.527
MOD_GlcNHglycan	3	6	PF01048	0.727
MOD_GlcNHglycan	34	37	PF01048	0.665
MOD_GlcNHglycan	435	438	PF01048	0.692
MOD_GlcNHglycan	451	454	PF01048	0.608
MOD_GlcNHglycan	495	498	PF01048	0.667
MOD_GlcNHglycan	517	520	PF01048	0.644
MOD_GlcNHglycan	572	575	PF01048	0.685
MOD_GSK3_1	102	109	PF00069	0.564
MOD_GSK3_1	114	121	PF00069	0.638
MOD_GSK3_1	224	231	PF00069	0.503
MOD_GSK3_1	311	318	PF00069	0.514
MOD_GSK3_1	389	396	PF00069	0.711
MOD_GSK3_1	4	11	PF00069	0.739
MOD_GSK3_1	40	47	PF00069	0.590
MOD_GSK3_1	429	436	PF00069	0.731
MOD_GSK3_1	493	500	PF00069	0.594
MOD_GSK3_1	532	539	PF00069	0.662
MOD_GSK3_1	570	577	PF00069	0.676
MOD_GSK3_1	59	66	PF00069	0.670
MOD_GSK3_1	630	637	PF00069	0.685
MOD_GSK3_1	639	646	PF00069	0.674
MOD_GSK3_1	686	693	PF00069	0.710
MOD_GSK3_1	695	702	PF00069	0.644
MOD_GSK3_1	86	93	PF00069	0.716
MOD_N-GLC_1	1	6	PF02516	0.580
MOD_N-GLC_1	228	233	PF02516	0.462
MOD_N-GLC_1	266	271	PF02516	0.513
MOD_N-GLC_1	696	701	PF02516	0.688
MOD_NEK2_1	1	6	PF00069	0.580
MOD_NEK2_1	165	170	PF00069	0.443
MOD_NEK2_1	191	196	PF00069	0.568
MOD_NEK2_1	9	14	PF00069	0.586
MOD_NEK2_2	320	325	PF00069	0.483
MOD_NEK2_2	574	579	PF00069	0.601
MOD_NEK2_2	597	602	PF00069	0.594
MOD_PIKK_1	17	23	PF00454	0.747
MOD_PIKK_1	340	346	PF00454	0.492
MOD_PIKK_1	409	415	PF00454	0.670
MOD_PIKK_1	44	50	PF00454	0.689
MOD_PIKK_1	615	621	PF00454	0.714
MOD_PIKK_1	634	640	PF00454	0.592
MOD_PIKK_1	77	83	PF00454	0.631
MOD_PKA_1	340	346	PF00069	0.492
MOD_PKA_1	372	378	PF00069	0.641
MOD_PKA_1	63	69	PF00069	0.635
MOD_PKA_2	428	434	PF00069	0.646
MOD_PKA_2	474	480	PF00069	0.685
MOD_PKA_2	687	693	PF00069	0.626
MOD_PKA_2	69	75	PF00069	0.610
MOD_PKB_1	77	85	PF00069	0.662
MOD_Plk_1	228	234	PF00069	0.464
MOD_Plk_1	320	326	PF00069	0.482
MOD_Plk_2-3	418	424	PF00069	0.618
MOD_Plk_4	106	112	PF00069	0.699
MOD_Plk_4	179	185	PF00069	0.435
MOD_Plk_4	186	192	PF00069	0.397
MOD_Plk_4	207	213	PF00069	0.489
MOD_Plk_4	228	234	PF00069	0.464
MOD_Plk_4	320	326	PF00069	0.482
MOD_Plk_4	437	443	PF00069	0.726
MOD_ProDKin_1	118	124	PF00069	0.676
MOD_ProDKin_1	350	356	PF00069	0.520
MOD_ProDKin_1	442	448	PF00069	0.591
MOD_ProDKin_1	488	494	PF00069	0.724
MOD_ProDKin_1	497	503	PF00069	0.665
MOD_ProDKin_1	507	513	PF00069	0.613
MOD_ProDKin_1	565	571	PF00069	0.701
MOD_ProDKin_1	581	587	PF00069	0.619
MOD_ProDKin_1	609	615	PF00069	0.718
MOD_ProDKin_1	630	636	PF00069	0.716
MOD_ProDKin_1	639	645	PF00069	0.721
MOD_SUMO_rev_2	348	354	PF00179	0.502
MOD_SUMO_rev_2	583	591	PF00179	0.589
TRG_DiLeu_BaEn_3	206	212	PF01217	0.489
TRG_DiLeu_BaEn_4	410	416	PF01217	0.615
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.496
TRG_ENDOCYTIC_2	184	187	PF00928	0.532
TRG_ENDOCYTIC_2	188	191	PF00928	0.499
TRG_ENDOCYTIC_2	300	303	PF00928	0.468
TRG_ER_diArg_1	245	248	PF00400	0.479
TRG_ER_diArg_1	371	374	PF00400	0.532
TRG_ER_diArg_1	76	79	PF00400	0.639
TRG_NLS_MonoExtN_4	369	376	PF00514	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPG2	Leishmania donovani	84%	81%
A4H4M0	Leishmania braziliensis	62%	100%
E9AG67	Leishmania infantum	85%	72%
Q4QJ24	Leishmania major	84%	100%