Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKT2_LEIMU

TriTrypDb:

LmxM.06.0530

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.580
CLV_PCSK_KEX2_1	209	211	PF00082	0.563
CLV_PCSK_KEX2_1	96	98	PF00082	0.469
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.469
CLV_PCSK_SKI1_1	167	171	PF00082	0.650
CLV_PCSK_SKI1_1	93	97	PF00082	0.536
DOC_CKS1_1	235	240	PF01111	0.405
DOC_CYCLIN_RxL_1	241	250	PF00134	0.582
DOC_PP2B_LxvP_1	35	38	PF13499	0.504
DOC_USP7_MATH_1	12	16	PF00917	0.652
DOC_USP7_MATH_1	132	136	PF00917	0.751
DOC_USP7_MATH_1	192	196	PF00917	0.694
DOC_USP7_MATH_1	57	61	PF00917	0.553
DOC_USP7_MATH_1	76	80	PF00917	0.445
DOC_WW_Pin1_4	140	145	PF00397	0.701
DOC_WW_Pin1_4	234	239	PF00397	0.406
DOC_WW_Pin1_4	267	272	PF00397	0.423
DOC_WW_Pin1_4	40	45	PF00397	0.649
LIG_14-3-3_CanoR_1	160	169	PF00244	0.635
LIG_14-3-3_CanoR_1	173	179	PF00244	0.438
LIG_14-3-3_CanoR_1	290	295	PF00244	0.628
LIG_14-3-3_CanoR_1	83	91	PF00244	0.588
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BRCT_BRCA1_1	165	169	PF00533	0.411
LIG_BRCT_BRCA1_1	2	6	PF00533	0.571
LIG_BRCT_BRCA1_1	292	296	PF00533	0.633
LIG_CSL_BTD_1	222	225	PF09270	0.391
LIG_CSL_BTD_1	235	238	PF09270	0.410
LIG_FHA_1	17	23	PF00498	0.696
LIG_FHA_1	172	178	PF00498	0.563
LIG_FHA_1	235	241	PF00498	0.405
LIG_FHA_1	243	249	PF00498	0.386
LIG_FHA_1	28	34	PF00498	0.532
LIG_FHA_2	268	274	PF00498	0.262
LIG_HCF-1_HBM_1	250	253	PF13415	0.450
LIG_LIR_Gen_1	250	260	PF02991	0.367
LIG_LIR_Nem_3	214	218	PF02991	0.609
LIG_LIR_Nem_3	250	256	PF02991	0.389
LIG_REV1ctd_RIR_1	88	97	PF16727	0.492
LIG_SH2_CRK	253	257	PF00017	0.424
LIG_SH2_NCK_1	69	73	PF00017	0.450
LIG_SH2_SRC	69	72	PF00017	0.512
LIG_SH2_STAP1	274	278	PF00017	0.387
LIG_SH2_STAP1	80	84	PF00017	0.416
LIG_SH2_STAT5	157	160	PF00017	0.639
LIG_SH2_STAT5	247	250	PF00017	0.456
LIG_SH3_3	195	201	PF00018	0.665
LIG_SH3_3	41	47	PF00018	0.643
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.523
LIG_TRAF2_1	143	146	PF00917	0.636
LIG_UBA3_1	33	39	PF00899	0.538
MOD_CAAXbox	294	297	PF01239	0.652
MOD_CK1_1	15	21	PF00069	0.643
MOD_CK1_1	183	189	PF00069	0.567
MOD_CK1_1	190	196	PF00069	0.684
MOD_CK1_1	2	8	PF00069	0.585
MOD_CK1_1	43	49	PF00069	0.529
MOD_CK2_1	130	136	PF00069	0.710
MOD_CK2_1	140	146	PF00069	0.649
MOD_CMANNOS	223	226	PF00535	0.499
MOD_GlcNHglycan	15	18	PF01048	0.623
MOD_GlcNHglycan	174	177	PF01048	0.533
MOD_GlcNHglycan	189	192	PF01048	0.554
MOD_GlcNHglycan	7	10	PF01048	0.673
MOD_GlcNHglycan	85	88	PF01048	0.602
MOD_GSK3_1	111	118	PF00069	0.622
MOD_GSK3_1	12	19	PF00069	0.680
MOD_GSK3_1	159	166	PF00069	0.570
MOD_GSK3_1	183	190	PF00069	0.520
MOD_N-GLC_1	12	17	PF02516	0.747
MOD_N-GLC_1	130	135	PF02516	0.586
MOD_NEK2_1	256	261	PF00069	0.429
MOD_PIKK_1	160	166	PF00454	0.617
MOD_PIKK_1	180	186	PF00454	0.401
MOD_PKA_2	159	165	PF00069	0.559
MOD_PKA_2	172	178	PF00069	0.443
MOD_PKA_2	256	262	PF00069	0.392
MOD_PKA_2	284	290	PF00069	0.542
MOD_PKB_1	288	296	PF00069	0.680
MOD_Plk_4	202	208	PF00069	0.520
MOD_Plk_4	211	217	PF00069	0.495
MOD_ProDKin_1	140	146	PF00069	0.696
MOD_ProDKin_1	234	240	PF00069	0.405
MOD_ProDKin_1	267	273	PF00069	0.423
MOD_ProDKin_1	40	46	PF00069	0.642
MOD_SUMO_for_1	169	172	PF00179	0.652
TRG_ENDOCYTIC_2	253	256	PF00928	0.367
TRG_ER_diArg_1	208	210	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B6	Leptomonas seymouri	69%	98%
A0A1X0NKM4	Trypanosomatidae	42%	98%
A0A3S7WPG5	Leishmania donovani	92%	100%
A0A422NGX7	Trypanosoma rangeli	41%	100%
A4H4L9	Leishmania braziliensis	80%	100%
A4HSU5	Leishmania infantum	92%	100%
C9ZTF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QJ25	Leishmania major	89%	100%
V5B7V6	Trypanosoma cruzi	43%	100%