U-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U-box domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKT0_LEIMU

TriTrypDb:

LmxM.06.0510

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AKT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKT0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.768
CLV_C14_Caspase3-7	164	168	PF00656	0.645
CLV_NRD_NRD_1	236	238	PF00675	0.611
CLV_NRD_NRD_1	493	495	PF00675	0.450
CLV_NRD_NRD_1	66	68	PF00675	0.500
CLV_PCSK_FUR_1	64	68	PF00082	0.610
CLV_PCSK_KEX2_1	236	238	PF00082	0.611
CLV_PCSK_KEX2_1	493	495	PF00082	0.428
CLV_PCSK_KEX2_1	596	598	PF00082	0.346
CLV_PCSK_KEX2_1	64	66	PF00082	0.498
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.346
CLV_PCSK_PC7_1	232	238	PF00082	0.410
CLV_PCSK_SKI1_1	188	192	PF00082	0.485
CLV_PCSK_SKI1_1	242	246	PF00082	0.510
CLV_PCSK_SKI1_1	282	286	PF00082	0.484
CLV_PCSK_SKI1_1	306	310	PF00082	0.519
CLV_PCSK_SKI1_1	314	318	PF00082	0.491
CLV_PCSK_SKI1_1	486	490	PF00082	0.458
CLV_PCSK_SKI1_1	499	503	PF00082	0.319
CLV_PCSK_SKI1_1	561	565	PF00082	0.435
CLV_PCSK_SKI1_1	59	63	PF00082	0.599
DEG_APCC_DBOX_1	498	506	PF00400	0.570
DEG_Nend_UBRbox_3	1	3	PF02207	0.576
DEG_ODPH_VHL_1	39	51	PF01847	0.638
DEG_SCF_FBW7_1	98	105	PF00400	0.733
DEG_SPOP_SBC_1	103	107	PF00917	0.816
DEG_SPOP_SBC_1	284	288	PF00917	0.583
DEG_SPOP_SBC_1	445	449	PF00917	0.542
DEG_SPOP_SBC_1	562	566	PF00917	0.739
DOC_CKS1_1	569	574	PF01111	0.715
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.774
DOC_CYCLIN_yCln2_LP_2	504	510	PF00134	0.764
DOC_MAPK_MEF2A_6	38	47	PF00069	0.411
DOC_MAPK_MEF2A_6	499	506	PF00069	0.706
DOC_MAPK_NFAT4_5	499	507	PF00069	0.556
DOC_MAPK_RevD_3	49	65	PF00069	0.789
DOC_PP1_RVXF_1	501	507	PF00149	0.711
DOC_PP1_RVXF_1	57	64	PF00149	0.797
DOC_PP1_RVXF_1	638	644	PF00149	0.530
DOC_PP2B_LxvP_1	47	50	PF13499	0.584
DOC_PP2B_LxvP_1	508	511	PF13499	0.674
DOC_PP2B_LxvP_1	513	516	PF13499	0.644
DOC_PP4_FxxP_1	506	509	PF00568	0.768
DOC_USP7_MATH_1	103	107	PF00917	0.747
DOC_USP7_MATH_1	200	204	PF00917	0.698
DOC_USP7_MATH_1	265	269	PF00917	0.681
DOC_USP7_MATH_1	284	288	PF00917	0.703
DOC_USP7_MATH_1	335	339	PF00917	0.747
DOC_USP7_MATH_1	352	356	PF00917	0.716
DOC_USP7_MATH_1	444	448	PF00917	0.562
DOC_USP7_MATH_1	459	463	PF00917	0.363
DOC_USP7_MATH_1	74	78	PF00917	0.792
DOC_WW_Pin1_4	323	328	PF00397	0.813
DOC_WW_Pin1_4	333	338	PF00397	0.737
DOC_WW_Pin1_4	357	362	PF00397	0.770
DOC_WW_Pin1_4	455	460	PF00397	0.399
DOC_WW_Pin1_4	520	525	PF00397	0.707
DOC_WW_Pin1_4	568	573	PF00397	0.793
DOC_WW_Pin1_4	574	579	PF00397	0.722
DOC_WW_Pin1_4	98	103	PF00397	0.730
LIG_14-3-3_CanoR_1	127	131	PF00244	0.726
LIG_14-3-3_CanoR_1	150	155	PF00244	0.739
LIG_14-3-3_CanoR_1	162	166	PF00244	0.682
LIG_14-3-3_CanoR_1	188	194	PF00244	0.672
LIG_14-3-3_CanoR_1	311	321	PF00244	0.601
LIG_14-3-3_CanoR_1	367	372	PF00244	0.749
LIG_14-3-3_CanoR_1	430	436	PF00244	0.511
LIG_14-3-3_CanoR_1	46	50	PF00244	0.776
LIG_14-3-3_CanoR_1	561	569	PF00244	0.632
LIG_APCC_ABBA_1	529	534	PF00400	0.708
LIG_BIR_III_2	575	579	PF00653	0.771
LIG_BRCT_BRCA1_1	202	206	PF00533	0.636
LIG_BRCT_BRCA1_1	285	289	PF00533	0.787
LIG_EVH1_1	506	510	PF00568	0.691
LIG_FHA_1	151	157	PF00498	0.685
LIG_FHA_1	341	347	PF00498	0.785
LIG_FHA_1	408	414	PF00498	0.483
LIG_FHA_1	430	436	PF00498	0.531
LIG_FHA_1	581	587	PF00498	0.654
LIG_FHA_1	624	630	PF00498	0.523
LIG_FHA_2	565	571	PF00498	0.755
LIG_Integrin_isoDGR_2	428	430	PF01839	0.717
LIG_LIR_Apic_2	331	337	PF02991	0.794
LIG_LIR_Gen_1	129	138	PF02991	0.760
LIG_LIR_Gen_1	149	157	PF02991	0.683
LIG_LIR_LC3C_4	42	45	PF02991	0.222
LIG_LIR_Nem_3	129	133	PF02991	0.762
LIG_LIR_Nem_3	149	155	PF02991	0.697
LIG_LIR_Nem_3	22	28	PF02991	0.326
LIG_LIR_Nem_3	590	595	PF02991	0.549
LIG_PDZ_Class_1	660	665	PF00595	0.701
LIG_Pex14_1	130	134	PF04695	0.766
LIG_Pex14_1	30	34	PF04695	0.411
LIG_Pex14_2	193	197	PF04695	0.674
LIG_SH2_CRK	334	338	PF00017	0.840
LIG_SH2_NCK_1	334	338	PF00017	0.757
LIG_SH2_NCK_1	656	660	PF00017	0.633
LIG_SH2_STAP1	122	126	PF00017	0.772
LIG_SH2_STAP1	451	455	PF00017	0.462
LIG_SH2_STAP1	656	660	PF00017	0.688
LIG_SH2_STAT5	154	157	PF00017	0.681
LIG_SH2_STAT5	212	215	PF00017	0.694
LIG_SH2_STAT5	376	379	PF00017	0.492
LIG_SH2_STAT5	656	659	PF00017	0.613
LIG_SH2_STAT5	78	81	PF00017	0.755
LIG_SH3_1	334	340	PF00018	0.837
LIG_SH3_2	509	514	PF14604	0.663
LIG_SH3_3	142	148	PF00018	0.702
LIG_SH3_3	334	340	PF00018	0.827
LIG_SH3_3	437	443	PF00018	0.517
LIG_SH3_3	504	510	PF00018	0.700
LIG_SH3_3	566	572	PF00018	0.741
LIG_SUMO_SIM_anti_2	410	417	PF11976	0.542
LIG_SUMO_SIM_par_1	139	146	PF11976	0.759
LIG_TRAF2_1	518	521	PF00917	0.640
LIG_TRAF2_1	616	619	PF00917	0.563
LIG_TRAF2_2	603	608	PF00917	0.546
LIG_TRFH_1	506	510	PF08558	0.758
LIG_UBA3_1	591	596	PF00899	0.546
LIG_WRC_WIRS_1	190	195	PF05994	0.667
MOD_CDK_SPK_2	576	581	PF00069	0.753
MOD_CDK_SPxxK_3	574	581	PF00069	0.760
MOD_CK1_1	107	113	PF00069	0.741
MOD_CK1_1	116	122	PF00069	0.767
MOD_CK1_1	143	149	PF00069	0.685
MOD_CK1_1	192	198	PF00069	0.677
MOD_CK1_1	219	225	PF00069	0.725
MOD_CK1_1	248	254	PF00069	0.724
MOD_CK1_1	287	293	PF00069	0.709
MOD_CK1_1	298	304	PF00069	0.697
MOD_CK1_1	336	342	PF00069	0.784
MOD_CK1_1	360	366	PF00069	0.797
MOD_CK1_1	447	453	PF00069	0.593
MOD_CK1_1	77	83	PF00069	0.717
MOD_CK2_1	265	271	PF00069	0.716
MOD_CK2_1	285	291	PF00069	0.603
MOD_CK2_1	323	329	PF00069	0.854
MOD_CK2_1	613	619	PF00069	0.602
MOD_Cter_Amidation	234	237	PF01082	0.615
MOD_GlcNHglycan	10	13	PF01048	0.565
MOD_GlcNHglycan	118	121	PF01048	0.591
MOD_GlcNHglycan	200	203	PF01048	0.549
MOD_GlcNHglycan	221	224	PF01048	0.527
MOD_GlcNHglycan	233	236	PF01048	0.546
MOD_GlcNHglycan	297	300	PF01048	0.571
MOD_GlcNHglycan	362	365	PF01048	0.561
MOD_GlcNHglycan	387	390	PF01048	0.411
MOD_GlcNHglycan	538	542	PF01048	0.482
MOD_GlcNHglycan	572	575	PF01048	0.607
MOD_GlcNHglycan	649	652	PF01048	0.453
MOD_GlcNHglycan	83	86	PF01048	0.555
MOD_GSK3_1	146	153	PF00069	0.703
MOD_GSK3_1	157	164	PF00069	0.595
MOD_GSK3_1	188	195	PF00069	0.670
MOD_GSK3_1	208	215	PF00069	0.526
MOD_GSK3_1	227	234	PF00069	0.751
MOD_GSK3_1	245	252	PF00069	0.743
MOD_GSK3_1	283	290	PF00069	0.791
MOD_GSK3_1	336	343	PF00069	0.772
MOD_GSK3_1	352	359	PF00069	0.628
MOD_GSK3_1	363	370	PF00069	0.797
MOD_GSK3_1	399	406	PF00069	0.546
MOD_GSK3_1	4	11	PF00069	0.514
MOD_GSK3_1	445	452	PF00069	0.578
MOD_GSK3_1	455	462	PF00069	0.399
MOD_GSK3_1	564	571	PF00069	0.737
MOD_GSK3_1	576	583	PF00069	0.673
MOD_GSK3_1	623	630	PF00069	0.483
MOD_GSK3_1	73	80	PF00069	0.760
MOD_GSK3_1	98	105	PF00069	0.733
MOD_N-GLC_1	74	79	PF02516	0.524
MOD_NEK2_1	1	6	PF00069	0.522
MOD_NEK2_1	126	131	PF00069	0.738
MOD_NEK2_1	140	145	PF00069	0.574
MOD_NEK2_1	157	162	PF00069	0.655
MOD_NEK2_1	189	194	PF00069	0.672
MOD_NEK2_1	205	210	PF00069	0.688
MOD_NEK2_1	245	250	PF00069	0.766
MOD_NEK2_1	277	282	PF00069	0.815
MOD_NEK2_1	285	290	PF00069	0.690
MOD_NEK2_1	295	300	PF00069	0.560
MOD_NEK2_1	312	317	PF00069	0.600
MOD_NEK2_1	34	39	PF00069	0.400
MOD_NEK2_1	356	361	PF00069	0.619
MOD_NEK2_1	385	390	PF00069	0.372
MOD_NEK2_1	634	639	PF00069	0.530
MOD_NEK2_1	654	659	PF00069	0.692
MOD_NEK2_1	79	84	PF00069	0.796
MOD_NEK2_1	8	13	PF00069	0.483
MOD_NEK2_2	227	232	PF00069	0.616
MOD_PIKK_1	157	163	PF00454	0.678
MOD_PIKK_1	367	373	PF00454	0.816
MOD_PKA_2	126	132	PF00069	0.717
MOD_PKA_2	161	167	PF00069	0.702
MOD_PKA_2	231	237	PF00069	0.763
MOD_PKA_2	429	435	PF00069	0.502
MOD_PKA_2	45	51	PF00069	0.659
MOD_PKA_2	580	586	PF00069	0.671
MOD_PKA_2	613	619	PF00069	0.537
MOD_Plk_1	206	212	PF00069	0.552
MOD_Plk_1	634	640	PF00069	0.530
MOD_Plk_1	74	80	PF00069	0.747
MOD_Plk_2-3	608	614	PF00069	0.546
MOD_Plk_4	107	113	PF00069	0.623
MOD_Plk_4	140	146	PF00069	0.720
MOD_Plk_4	193	199	PF00069	0.683
MOD_Plk_4	200	206	PF00069	0.688
MOD_Plk_4	208	214	PF00069	0.700
MOD_Plk_4	29	35	PF00069	0.389
MOD_Plk_4	352	358	PF00069	0.764
MOD_Plk_4	39	45	PF00069	0.389
MOD_Plk_4	4	10	PF00069	0.452
MOD_Plk_4	74	80	PF00069	0.800
MOD_ProDKin_1	323	329	PF00069	0.814
MOD_ProDKin_1	333	339	PF00069	0.737
MOD_ProDKin_1	357	363	PF00069	0.771
MOD_ProDKin_1	455	461	PF00069	0.394
MOD_ProDKin_1	520	526	PF00069	0.706
MOD_ProDKin_1	568	574	PF00069	0.792
MOD_ProDKin_1	576	582	PF00069	0.673
MOD_ProDKin_1	98	104	PF00069	0.733
TRG_DiLeu_BaEn_1	291	296	PF01217	0.566
TRG_DiLeu_BaEn_1	500	505	PF01217	0.553
TRG_DiLeu_BaEn_1	525	530	PF01217	0.625
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.760
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.793
TRG_ENDOCYTIC_2	154	157	PF00928	0.681
TRG_ER_diArg_1	483	486	PF00400	0.716
TRG_ER_diArg_1	493	495	PF00400	0.587
TRG_ER_diArg_1	63	66	PF00400	0.698
TRG_ER_diArg_1	643	646	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	597	602	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIV8	Leptomonas seymouri	50%	100%
A0A3S5H5Q9	Leishmania donovani	90%	100%
A4H4L7	Leishmania braziliensis	77%	100%
A4HSU3	Leishmania infantum	91%	100%
Q4QJ27	Leishmania major	88%	99%