SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SpoU rRNA Methylase family, putative

Species:

Leishmania mexicana

UniProt:

E9AKS9_LEIMU

TriTrypDb:

LmxM.06.0500

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKS9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043412	macromolecule modification	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016435	rRNA (guanine) methyltransferase activity	6	1
GO:0140102	catalytic activity, acting on a rRNA	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.572
CLV_C14_Caspase3-7	69	73	PF00656	0.573
CLV_NRD_NRD_1	167	169	PF00675	0.678
CLV_NRD_NRD_1	209	211	PF00675	0.491
CLV_NRD_NRD_1	495	497	PF00675	0.641
CLV_PCSK_KEX2_1	209	211	PF00082	0.491
CLV_PCSK_KEX2_1	495	497	PF00082	0.641
CLV_PCSK_SKI1_1	14	18	PF00082	0.647
CLV_PCSK_SKI1_1	181	185	PF00082	0.502
CLV_PCSK_SKI1_1	270	274	PF00082	0.290
CLV_PCSK_SKI1_1	403	407	PF00082	0.295
DEG_APCC_DBOX_1	107	115	PF00400	0.441
DEG_APCC_DBOX_1	198	206	PF00400	0.429
DEG_SPOP_SBC_1	239	243	PF00917	0.607
DEG_SPOP_SBC_1	309	313	PF00917	0.565
DEG_SPOP_SBC_1	329	333	PF00917	0.350
DEG_SPOP_SBC_1	381	385	PF00917	0.379
DEG_SPOP_SBC_1	74	78	PF00917	0.610
DOC_CYCLIN_RxL_1	400	411	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.525
DOC_MAPK_gen_1	209	216	PF00069	0.451
DOC_MAPK_gen_1	499	507	PF00069	0.654
DOC_MAPK_MEF2A_6	188	196	PF00069	0.429
DOC_MAPK_MEF2A_6	501	509	PF00069	0.517
DOC_PP1_SILK_1	266	271	PF00149	0.562
DOC_PP2B_LxvP_1	190	193	PF13499	0.526
DOC_PP2B_LxvP_1	542	545	PF13499	0.474
DOC_USP7_MATH_1	291	295	PF00917	0.501
DOC_USP7_MATH_1	309	313	PF00917	0.461
DOC_USP7_MATH_1	330	334	PF00917	0.498
DOC_USP7_MATH_1	359	363	PF00917	0.515
DOC_USP7_MATH_1	439	443	PF00917	0.559
DOC_USP7_MATH_1	467	471	PF00917	0.692
DOC_USP7_MATH_1	472	476	PF00917	0.736
DOC_USP7_MATH_1	477	481	PF00917	0.669
DOC_USP7_MATH_1	91	95	PF00917	0.577
DOC_USP7_MATH_1	99	103	PF00917	0.705
DOC_WW_Pin1_4	25	30	PF00397	0.599
DOC_WW_Pin1_4	365	370	PF00397	0.595
DOC_WW_Pin1_4	427	432	PF00397	0.532
LIG_14-3-3_CanoR_1	11	17	PF00244	0.567
LIG_14-3-3_CanoR_1	176	183	PF00244	0.511
LIG_14-3-3_CanoR_1	284	293	PF00244	0.516
LIG_14-3-3_CanoR_1	295	301	PF00244	0.425
LIG_14-3-3_CanoR_1	318	324	PF00244	0.566
LIG_14-3-3_CanoR_1	440	444	PF00244	0.708
LIG_14-3-3_CanoR_1	96	102	PF00244	0.608
LIG_Actin_WH2_2	37	54	PF00022	0.541
LIG_Actin_WH2_2	421	439	PF00022	0.562
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BIR_III_2	90	94	PF00653	0.492
LIG_BIR_III_4	72	76	PF00653	0.507
LIG_BRCT_BRCA1_1	296	300	PF00533	0.513
LIG_BRCT_BRCA1_1	312	316	PF00533	0.513
LIG_FHA_1	11	17	PF00498	0.664
LIG_FHA_1	288	294	PF00498	0.490
LIG_FHA_1	296	302	PF00498	0.491
LIG_FHA_1	48	54	PF00498	0.452
LIG_FHA_1	62	68	PF00498	0.671
LIG_FHA_2	239	245	PF00498	0.633
LIG_LIR_Apic_2	396	401	PF02991	0.379
LIG_LIR_Gen_1	175	185	PF02991	0.479
LIG_LIR_Gen_1	384	395	PF02991	0.379
LIG_LIR_Nem_3	175	180	PF02991	0.489
LIG_LIR_Nem_3	271	277	PF02991	0.482
LIG_LIR_Nem_3	384	390	PF02991	0.379
LIG_SH2_CRK	177	181	PF00017	0.528
LIG_SH2_CRK	38	42	PF00017	0.547
LIG_SH2_PTP2	387	390	PF00017	0.379
LIG_SH2_STAP1	38	42	PF00017	0.547
LIG_SH2_STAT3	221	224	PF00017	0.574
LIG_SH2_STAT5	115	118	PF00017	0.469
LIG_SH2_STAT5	177	180	PF00017	0.484
LIG_SH2_STAT5	387	390	PF00017	0.379
LIG_SH3_3	28	34	PF00018	0.540
LIG_SH3_3	520	526	PF00018	0.582
LIG_SH3_3	538	544	PF00018	0.443
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.425
LIG_SUMO_SIM_anti_2	339	347	PF11976	0.585
LIG_SxIP_EBH_1	23	32	PF03271	0.589
LIG_TRAF2_1	120	123	PF00917	0.595
LIG_TRAF2_1	447	450	PF00917	0.691
LIG_WRC_WIRS_1	484	489	PF05994	0.413
LIG_WW_1	35	38	PF00397	0.620
MOD_CDK_SPK_2	427	432	PF00069	0.562
MOD_CDK_SPxxK_3	25	32	PF00069	0.645
MOD_CK1_1	175	181	PF00069	0.585
MOD_CK1_1	294	300	PF00069	0.513
MOD_CK1_1	310	316	PF00069	0.461
MOD_CK1_1	331	337	PF00069	0.577
MOD_CK1_1	368	374	PF00069	0.557
MOD_CK1_1	377	383	PF00069	0.573
MOD_CK1_1	480	486	PF00069	0.710
MOD_CK2_1	117	123	PF00069	0.526
MOD_CK2_1	336	342	PF00069	0.597
MOD_CK2_1	444	450	PF00069	0.755
MOD_GlcNHglycan	22	25	PF01048	0.605
MOD_GlcNHglycan	246	249	PF01048	0.644
MOD_GlcNHglycan	312	315	PF01048	0.351
MOD_GlcNHglycan	325	328	PF01048	0.335
MOD_GlcNHglycan	338	341	PF01048	0.319
MOD_GlcNHglycan	361	364	PF01048	0.329
MOD_GlcNHglycan	372	376	PF01048	0.368
MOD_GlcNHglycan	480	483	PF01048	0.732
MOD_GlcNHglycan	517	520	PF01048	0.471
MOD_GlcNHglycan	77	80	PF01048	0.790
MOD_GSK3_1	145	152	PF00069	0.771
MOD_GSK3_1	240	247	PF00069	0.730
MOD_GSK3_1	287	294	PF00069	0.493
MOD_GSK3_1	329	336	PF00069	0.572
MOD_GSK3_1	343	350	PF00069	0.430
MOD_GSK3_1	377	384	PF00069	0.558
MOD_GSK3_1	43	50	PF00069	0.461
MOD_GSK3_1	473	480	PF00069	0.768
MOD_N-GLC_1	19	24	PF02516	0.559
MOD_N-GLC_1	359	364	PF02516	0.326
MOD_NEK2_1	10	15	PF00069	0.635
MOD_NEK2_1	186	191	PF00069	0.554
MOD_NEK2_1	216	221	PF00069	0.453
MOD_NEK2_1	317	322	PF00069	0.468
MOD_NEK2_1	473	478	PF00069	0.745
MOD_PIKK_1	317	323	PF00454	0.511
MOD_PKA_2	10	16	PF00069	0.561
MOD_PKA_2	175	181	PF00069	0.522
MOD_PKA_2	294	300	PF00069	0.487
MOD_PKA_2	317	323	PF00069	0.577
MOD_PKA_2	439	445	PF00069	0.605
MOD_PKA_2	67	73	PF00069	0.607
MOD_Plk_1	117	123	PF00069	0.600
MOD_Plk_1	216	222	PF00069	0.461
MOD_Plk_1	377	383	PF00069	0.585
MOD_Plk_1	473	479	PF00069	0.772
MOD_Plk_1	503	509	PF00069	0.509
MOD_Plk_4	249	255	PF00069	0.565
MOD_Plk_4	344	350	PF00069	0.519
MOD_Plk_4	43	49	PF00069	0.410
MOD_Plk_4	99	105	PF00069	0.688
MOD_ProDKin_1	25	31	PF00069	0.594
MOD_ProDKin_1	365	371	PF00069	0.595
MOD_ProDKin_1	427	433	PF00069	0.532
TRG_ENDOCYTIC_2	177	180	PF00928	0.412
TRG_ENDOCYTIC_2	38	41	PF00928	0.549
TRG_ENDOCYTIC_2	387	390	PF00928	0.379
TRG_ER_diArg_1	494	496	PF00400	0.603
TRG_NLS_MonoCore_2	167	172	PF00514	0.393
TRG_NLS_MonoExtN_4	165	172	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C1	Leptomonas seymouri	49%	100%
A0A1X0NKH6	Trypanosomatidae	30%	100%
A0A3R7KE58	Trypanosoma rangeli	32%	100%
A0A3S5H5Q8	Leishmania donovani	88%	100%
A4H4L6	Leishmania braziliensis	71%	100%
A4HSU2	Leishmania infantum	88%	100%
C9ZTF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QJ28	Leishmania major	89%	100%
V5BT12	Trypanosoma cruzi	31%	100%