Pyr_redox_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKS8_LEIMU

TriTrypDb:

LmxM.06.0490

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.582
CLV_C14_Caspase3-7	395	399	PF00656	0.537
CLV_NRD_NRD_1	37	39	PF00675	0.627
CLV_NRD_NRD_1	425	427	PF00675	0.543
CLV_NRD_NRD_1	462	464	PF00675	0.559
CLV_PCSK_KEX2_1	266	268	PF00082	0.568
CLV_PCSK_KEX2_1	37	39	PF00082	0.641
CLV_PCSK_KEX2_1	425	427	PF00082	0.543
CLV_PCSK_KEX2_1	48	50	PF00082	0.628
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.568
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.439
CLV_PCSK_SKI1_1	123	127	PF00082	0.510
CLV_PCSK_SKI1_1	266	270	PF00082	0.582
CLV_PCSK_SKI1_1	28	32	PF00082	0.754
CLV_PCSK_SKI1_1	282	286	PF00082	0.546
CLV_PCSK_SKI1_1	344	348	PF00082	0.617
CLV_PCSK_SKI1_1	378	382	PF00082	0.452
CLV_PCSK_SKI1_1	470	474	PF00082	0.553
DEG_APCC_DBOX_1	362	370	PF00400	0.552
DEG_SCF_FBW7_1	18	24	PF00400	0.731
DEG_SCF_FBW7_1	97	104	PF00400	0.478
DOC_ANK_TNKS_1	56	63	PF00023	0.475
DOC_CKS1_1	18	23	PF01111	0.730
DOC_CKS1_1	278	283	PF01111	0.551
DOC_CKS1_1	362	367	PF01111	0.580
DOC_CKS1_1	98	103	PF01111	0.481
DOC_CYCLIN_RxL_1	120	128	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.502
DOC_MAPK_DCC_7	215	225	PF00069	0.486
DOC_MAPK_gen_1	246	255	PF00069	0.497
DOC_MAPK_MEF2A_6	246	255	PF00069	0.534
DOC_MAPK_MEF2A_6	296	305	PF00069	0.539
DOC_PP1_RVXF_1	121	128	PF00149	0.505
DOC_PP1_RVXF_1	194	200	PF00149	0.415
DOC_PP1_RVXF_1	244	251	PF00149	0.517
DOC_PP1_RVXF_1	318	324	PF00149	0.655
DOC_PP2B_LxvP_1	253	256	PF13499	0.557
DOC_PP2B_LxvP_1	303	306	PF13499	0.701
DOC_PP2B_LxvP_1	65	68	PF13499	0.500
DOC_PP4_FxxP_1	367	370	PF00568	0.542
DOC_USP7_MATH_1	116	120	PF00917	0.505
DOC_USP7_MATH_1	21	25	PF00917	0.775
DOC_USP7_MATH_1	386	390	PF00917	0.614
DOC_USP7_UBL2_3	460	464	PF12436	0.635
DOC_WW_Pin1_4	145	150	PF00397	0.521
DOC_WW_Pin1_4	17	22	PF00397	0.767
DOC_WW_Pin1_4	266	271	PF00397	0.582
DOC_WW_Pin1_4	277	282	PF00397	0.537
DOC_WW_Pin1_4	361	366	PF00397	0.561
DOC_WW_Pin1_4	97	102	PF00397	0.484
LIG_14-3-3_CanoR_1	123	128	PF00244	0.511
LIG_14-3-3_CanoR_1	313	323	PF00244	0.560
LIG_14-3-3_CanoR_1	344	354	PF00244	0.553
LIG_14-3-3_CanoR_1	438	442	PF00244	0.678
LIG_AP2alpha_1	402	406	PF02296	0.509
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BRCT_BRCA1_1	147	151	PF00533	0.501
LIG_FHA_1	300	306	PF00498	0.585
LIG_FHA_1	329	335	PF00498	0.543
LIG_FHA_1	94	100	PF00498	0.496
LIG_FHA_2	224	230	PF00498	0.544
LIG_FHA_2	278	284	PF00498	0.567
LIG_FHA_2	302	308	PF00498	0.584
LIG_Integrin_RGD_1	49	51	PF01839	0.481
LIG_LIR_Apic_2	364	370	PF02991	0.555
LIG_LIR_Gen_1	126	134	PF02991	0.535
LIG_LIR_Gen_1	247	258	PF02991	0.610
LIG_LIR_Gen_1	389	399	PF02991	0.612
LIG_LIR_Nem_3	126	130	PF02991	0.526
LIG_LIR_Nem_3	206	210	PF02991	0.408
LIG_LIR_Nem_3	247	253	PF02991	0.614
LIG_LIR_Nem_3	295	301	PF02991	0.547
LIG_LIR_Nem_3	389	394	PF02991	0.592
LIG_LIR_Nem_3	440	444	PF02991	0.677
LIG_LIR_Nem_3	468	472	PF02991	0.612
LIG_Pex14_2	264	268	PF04695	0.589
LIG_Pex14_2	343	347	PF04695	0.612
LIG_Pex14_2	402	406	PF04695	0.509
LIG_SH2_CRK	362	366	PF00017	0.560
LIG_SH2_PTP2	476	479	PF00017	0.596
LIG_SH2_STAT5	207	210	PF00017	0.395
LIG_SH2_STAT5	337	340	PF00017	0.538
LIG_SH2_STAT5	45	48	PF00017	0.615
LIG_SH2_STAT5	476	479	PF00017	0.596
LIG_SH2_STAT5	58	61	PF00017	0.298
LIG_SH3_3	110	116	PF00018	0.496
LIG_SH3_3	12	18	PF00018	0.730
LIG_SH3_3	174	180	PF00018	0.389
LIG_SH3_3	253	259	PF00018	0.497
LIG_SH3_3	95	101	PF00018	0.484
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.518
LIG_SUMO_SIM_par_1	274	280	PF11976	0.518
LIG_SUMO_SIM_par_1	301	307	PF11976	0.596
LIG_SUMO_SIM_par_1	95	100	PF11976	0.483
LIG_TRAF2_1	226	229	PF00917	0.557
LIG_TYR_ITIM	439	444	PF00017	0.691
LIG_WRC_WIRS_1	124	129	PF05994	0.513
LIG_WW_2	256	259	PF00397	0.494
MOD_CDK_SPK_2	277	282	PF00069	0.537
MOD_CK1_1	114	120	PF00069	0.520
MOD_CK1_1	316	322	PF00069	0.598
MOD_CK1_1	437	443	PF00069	0.674
MOD_CK1_1	468	474	PF00069	0.538
MOD_CK2_1	223	229	PF00069	0.536
MOD_Cter_Amidation	4	7	PF01082	0.749
MOD_GlcNHglycan	116	119	PF01048	0.507
MOD_GlcNHglycan	160	163	PF01048	0.496
MOD_GlcNHglycan	200	203	PF01048	0.480
MOD_GlcNHglycan	23	26	PF01048	0.771
MOD_GlcNHglycan	331	334	PF01048	0.591
MOD_GlcNHglycan	357	360	PF01048	0.590
MOD_GlcNHglycan	8	11	PF01048	0.625
MOD_GSK3_1	158	165	PF00069	0.519
MOD_GSK3_1	17	24	PF00069	0.686
MOD_GSK3_1	240	247	PF00069	0.655
MOD_GSK3_1	284	291	PF00069	0.542
MOD_GSK3_1	394	401	PF00069	0.604
MOD_GSK3_1	404	411	PF00069	0.580
MOD_GSK3_1	93	100	PF00069	0.489
MOD_N-GLC_1	111	116	PF02516	0.505
MOD_N-GLC_1	299	304	PF02516	0.573
MOD_N-GLC_1	352	357	PF02516	0.678
MOD_NEK2_1	111	116	PF00069	0.512
MOD_NEK2_1	244	249	PF00069	0.669
MOD_NEK2_1	292	297	PF00069	0.577
MOD_NEK2_1	314	319	PF00069	0.573
MOD_NEK2_1	328	333	PF00069	0.538
MOD_NEK2_1	354	359	PF00069	0.569
MOD_NEK2_1	408	413	PF00069	0.550
MOD_NEK2_2	284	289	PF00069	0.549
MOD_NEK2_2	386	391	PF00069	0.617
MOD_OFUCOSY	167	174	PF10250	0.446
MOD_PIKK_1	101	107	PF00454	0.360
MOD_PIKK_1	269	275	PF00454	0.560
MOD_PIKK_1	51	57	PF00454	0.558
MOD_PIKK_1	85	91	PF00454	0.592
MOD_PKA_1	6	12	PF00069	0.624
MOD_PKA_2	240	246	PF00069	0.699
MOD_PKA_2	288	294	PF00069	0.550
MOD_PKA_2	437	443	PF00069	0.674
MOD_PKA_2	93	99	PF00069	0.491
MOD_Plk_1	111	117	PF00069	0.517
MOD_Plk_1	221	227	PF00069	0.526
MOD_Plk_1	299	305	PF00069	0.578
MOD_Plk_2-3	398	404	PF00069	0.574
MOD_Plk_4	116	122	PF00069	0.501
MOD_Plk_4	147	153	PF00069	0.493
MOD_Plk_4	288	294	PF00069	0.550
MOD_Plk_4	338	344	PF00069	0.528
MOD_Plk_4	41	47	PF00069	0.558
MOD_Plk_4	437	443	PF00069	0.644
MOD_Plk_4	475	481	PF00069	0.554
MOD_Plk_4	93	99	PF00069	0.491
MOD_ProDKin_1	145	151	PF00069	0.512
MOD_ProDKin_1	17	23	PF00069	0.767
MOD_ProDKin_1	266	272	PF00069	0.580
MOD_ProDKin_1	277	283	PF00069	0.545
MOD_ProDKin_1	361	367	PF00069	0.562
MOD_ProDKin_1	97	103	PF00069	0.480
MOD_SUMO_for_1	157	160	PF00179	0.432
MOD_SUMO_rev_2	277	287	PF00179	0.568
TRG_ENDOCYTIC_2	207	210	PF00928	0.401
TRG_ENDOCYTIC_2	441	444	PF00928	0.696
TRG_ENDOCYTIC_2	476	479	PF00928	0.596
TRG_ENDOCYTIC_2	58	61	PF00928	0.375
TRG_ER_diArg_1	425	427	PF00400	0.543
TRG_NLS_MonoExtC_3	462	467	PF00514	0.631
TRG_NLS_MonoExtN_4	460	467	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I218	Leptomonas seymouri	88%	84%
A0A0S4KH91	Bodo saltans	72%	91%
A0A1X0NLE5	Trypanosomatidae	75%	80%
A0A3S5IR64	Trypanosoma rangeli	80%	83%
A0A3S7WPF9	Leishmania donovani	97%	100%
A4H4L5	Leishmania braziliensis	94%	100%
A4HSU1	Leishmania infantum	97%	100%
C9ZTF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	85%
Q4QJ29	Leishmania major	96%	100%