Thg1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKS7_LEIMU

TriTrypDb:

LmxM.06.0480

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.668
CLV_NRD_NRD_1	16	18	PF00675	0.424
CLV_NRD_NRD_1	79	81	PF00675	0.372
CLV_NRD_NRD_1	95	97	PF00675	0.398
CLV_PCSK_KEX2_1	115	117	PF00082	0.284
CLV_PCSK_KEX2_1	79	81	PF00082	0.516
CLV_PCSK_KEX2_1	95	97	PF00082	0.402
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.537
CLV_PCSK_SKI1_1	168	172	PF00082	0.450
CLV_PCSK_SKI1_1	17	21	PF00082	0.420
CLV_PCSK_SKI1_1	33	37	PF00082	0.463
CLV_Separin_Metazoa	51	55	PF03568	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.374
DOC_CYCLIN_RxL_1	13	23	PF00134	0.460
DOC_MAPK_gen_1	102	111	PF00069	0.406
DOC_MAPK_gen_1	135	144	PF00069	0.455
DOC_MAPK_gen_1	79	87	PF00069	0.546
DOC_MAPK_gen_1	95	101	PF00069	0.385
DOC_MAPK_HePTP_8	99	111	PF00069	0.486
DOC_MAPK_MEF2A_6	102	111	PF00069	0.420
DOC_MAPK_NFAT4_5	104	112	PF00069	0.410
DOC_SPAK_OSR1_1	139	143	PF12202	0.259
DOC_USP7_MATH_1	170	174	PF00917	0.514
DOC_USP7_MATH_1	270	274	PF00917	0.618
DOC_WW_Pin1_4	278	283	PF00397	0.655
LIG_14-3-3_CanoR_1	139	145	PF00244	0.412
LIG_14-3-3_CanoR_1	175	180	PF00244	0.299
LIG_CtBP_PxDLS_1	49	53	PF00389	0.389
LIG_deltaCOP1_diTrp_1	131	140	PF00928	0.312
LIG_FHA_1	253	259	PF00498	0.529
LIG_FHA_1	92	98	PF00498	0.495
LIG_FHA_2	122	128	PF00498	0.651
LIG_FHA_2	180	186	PF00498	0.379
LIG_FHA_2	203	209	PF00498	0.472
LIG_FHA_2	282	288	PF00498	0.655
LIG_FHA_2	45	51	PF00498	0.411
LIG_IBAR_NPY_1	245	247	PF08397	0.584
LIG_LIR_Gen_1	173	184	PF02991	0.486
LIG_LIR_Gen_1	287	296	PF02991	0.648
LIG_LIR_Nem_3	173	179	PF02991	0.515
LIG_LIR_Nem_3	287	291	PF02991	0.642
LIG_NRBOX	80	86	PF00104	0.257
LIG_PCNA_yPIPBox_3	183	196	PF02747	0.511
LIG_SH2_CRK	176	180	PF00017	0.511
LIG_SH2_CRK	223	227	PF00017	0.562
LIG_SH2_STAP1	146	150	PF00017	0.483
LIG_SH2_STAP1	176	180	PF00017	0.605
LIG_SH2_STAT5	247	250	PF00017	0.543
LIG_SH2_STAT5	9	12	PF00017	0.393
LIG_SH3_3	197	203	PF00018	0.530
LIG_TYR_ITIM	174	179	PF00017	0.295
MOD_CK1_1	273	279	PF00069	0.681
MOD_CK1_1	281	287	PF00069	0.696
MOD_CK2_1	179	185	PF00069	0.379
MOD_CK2_1	202	208	PF00069	0.458
MOD_CK2_1	281	287	PF00069	0.709
MOD_CK2_1	44	50	PF00069	0.444
MOD_GlcNHglycan	191	195	PF01048	0.561
MOD_GlcNHglycan	276	279	PF01048	0.701
MOD_GlcNHglycan	59	62	PF01048	0.579
MOD_GSK3_1	170	177	PF00069	0.549
MOD_GSK3_1	270	277	PF00069	0.675
MOD_NEK2_1	140	145	PF00069	0.409
MOD_NEK2_1	179	184	PF00069	0.553
MOD_NEK2_2	170	175	PF00069	0.347
MOD_PIKK_1	270	276	PF00454	0.655
MOD_PK_1	102	108	PF00069	0.260
MOD_PKA_2	140	146	PF00069	0.408
MOD_PKA_2	174	180	PF00069	0.505
MOD_PKA_2	57	63	PF00069	0.640
MOD_Plk_1	102	108	PF00069	0.517
MOD_Plk_2-3	44	50	PF00069	0.489
MOD_Plk_4	175	181	PF00069	0.456
MOD_Plk_4	202	208	PF00069	0.446
MOD_Plk_4	210	216	PF00069	0.453
MOD_ProDKin_1	278	284	PF00069	0.655
TRG_ENDOCYTIC_2	176	179	PF00928	0.564
TRG_ENDOCYTIC_2	212	215	PF00928	0.517
TRG_ENDOCYTIC_2	223	226	PF00928	0.453
TRG_ENDOCYTIC_2	238	241	PF00928	0.417
TRG_ENDOCYTIC_2	9	12	PF00928	0.398
TRG_ER_diArg_1	134	137	PF00400	0.575
TRG_ER_diArg_1	79	81	PF00400	0.542
TRG_ER_diArg_1	95	97	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD6	Leptomonas seymouri	56%	96%
A0A0S4KF96	Bodo saltans	32%	100%
A0A1X0NKJ3	Trypanosomatidae	44%	100%
A0A3S5H5Q7	Leishmania donovani	91%	97%
A4H4L4	Leishmania braziliensis	80%	100%
A4HSU0	Leishmania infantum	91%	97%
C9ZTF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QJ30	Leishmania major	90%	100%
V5B7V1	Trypanosoma cruzi	49%	100%