Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AKS4_LEIMU

TriTrypDb:

LmxM.06.0450

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.650
CLV_C14_Caspase3-7	277	281	PF00656	0.651
CLV_C14_Caspase3-7	28	32	PF00656	0.749
CLV_C14_Caspase3-7	68	72	PF00656	0.636
CLV_NRD_NRD_1	212	214	PF00675	0.625
CLV_NRD_NRD_1	247	249	PF00675	0.614
CLV_NRD_NRD_1	301	303	PF00675	0.660
CLV_NRD_NRD_1	443	445	PF00675	0.471
CLV_NRD_NRD_1	5	7	PF00675	0.600
CLV_PCSK_KEX2_1	246	248	PF00082	0.609
CLV_PCSK_KEX2_1	387	389	PF00082	0.495
CLV_PCSK_KEX2_1	4	6	PF00082	0.602
CLV_PCSK_KEX2_1	443	445	PF00082	0.471
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.495
CLV_PCSK_SKI1_1	258	262	PF00082	0.547
CLV_PCSK_SKI1_1	424	428	PF00082	0.565
CLV_Separin_Metazoa	195	199	PF03568	0.560
DEG_SPOP_SBC_1	10	14	PF00917	0.644
DEG_SPOP_SBC_1	264	268	PF00917	0.611
DEG_SPOP_SBC_1	48	52	PF00917	0.609
DEG_SPOP_SBC_1	64	68	PF00917	0.679
DEG_SPOP_SBC_1	70	74	PF00917	0.603
DEG_SPOP_SBC_1	81	85	PF00917	0.499
DOC_ANK_TNKS_1	352	359	PF00023	0.494
DOC_CYCLIN_yClb1_LxF_4	256	261	PF00134	0.541
DOC_MAPK_DCC_7	337	346	PF00069	0.613
DOC_MAPK_DCC_7	444	454	PF00069	0.528
DOC_MAPK_gen_1	113	123	PF00069	0.618
DOC_MAPK_gen_1	396	405	PF00069	0.589
DOC_MAPK_gen_1	443	449	PF00069	0.476
DOC_MAPK_MEF2A_6	219	226	PF00069	0.675
DOC_MAPK_MEF2A_6	337	346	PF00069	0.613
DOC_MAPK_NFAT4_5	219	227	PF00069	0.674
DOC_MAPK_RevD_3	200	214	PF00069	0.503
DOC_MAPK_RevD_3	233	248	PF00069	0.481
DOC_PP1_RVXF_1	256	262	PF00149	0.544
DOC_PP4_FxxP_1	18	21	PF00568	0.656
DOC_USP7_MATH_1	102	106	PF00917	0.620
DOC_USP7_MATH_1	335	339	PF00917	0.726
DOC_USP7_MATH_1	422	426	PF00917	0.682
DOC_USP7_MATH_1	69	73	PF00917	0.587
DOC_USP7_UBL2_3	387	391	PF12436	0.679
DOC_WW_Pin1_4	163	168	PF00397	0.706
DOC_WW_Pin1_4	265	270	PF00397	0.607
LIG_14-3-3_CanoR_1	138	144	PF00244	0.702
LIG_14-3-3_CanoR_1	300	306	PF00244	0.589
LIG_14-3-3_CanoR_1	43	49	PF00244	0.679
LIG_14-3-3_CanoR_1	5	11	PF00244	0.605
LIG_BRCT_BRCA1_1	14	18	PF00533	0.651
LIG_CSL_BTD_1	200	203	PF09270	0.542
LIG_FHA_1	155	161	PF00498	0.617
LIG_FHA_1	178	184	PF00498	0.636
LIG_FHA_1	230	236	PF00498	0.569
LIG_FHA_1	380	386	PF00498	0.555
LIG_FHA_1	65	71	PF00498	0.633
LIG_FHA_2	15	21	PF00498	0.521
LIG_FHA_2	151	157	PF00498	0.545
LIG_FHA_2	206	212	PF00498	0.627
LIG_FHA_2	346	352	PF00498	0.616
LIG_FHA_2	378	384	PF00498	0.565
LIG_LIR_Apic_2	15	21	PF02991	0.654
LIG_LIR_Gen_1	406	415	PF02991	0.480
LIG_LIR_Gen_1	75	82	PF02991	0.648
LIG_LIR_Nem_3	39	45	PF02991	0.623
LIG_LIR_Nem_3	406	412	PF02991	0.479
LIG_LIR_Nem_3	75	81	PF02991	0.648
LIG_SH2_CRK	409	413	PF00017	0.475
LIG_SH2_CRK	42	46	PF00017	0.628
LIG_SH2_CRK	7	11	PF00017	0.645
LIG_SH2_GRB2like	126	129	PF00017	0.509
LIG_SH2_NCK_1	409	413	PF00017	0.475
LIG_SH2_NCK_1	7	11	PF00017	0.645
LIG_SH2_SRC	310	313	PF00017	0.448
LIG_SH2_STAT5	310	313	PF00017	0.474
LIG_SH2_STAT5	325	328	PF00017	0.685
LIG_SH3_1	329	335	PF00018	0.572
LIG_SH3_2	332	337	PF14604	0.572
LIG_SH3_3	158	164	PF00018	0.628
LIG_SH3_3	194	200	PF00018	0.619
LIG_SH3_3	234	240	PF00018	0.599
LIG_SH3_3	329	335	PF00018	0.577
LIG_SH3_3	96	102	PF00018	0.699
LIG_SUMO_SIM_par_1	450	455	PF11976	0.487
LIG_TRAF2_1	192	195	PF00917	0.564
LIG_TRAF2_1	240	243	PF00917	0.599
LIG_TRAF2_1	365	368	PF00917	0.611
MOD_CDC14_SPxK_1	268	271	PF00782	0.667
MOD_CDK_SPxK_1	265	271	PF00069	0.665
MOD_CK1_1	141	147	PF00069	0.642
MOD_CK1_1	150	156	PF00069	0.705
MOD_CK1_1	177	183	PF00069	0.612
MOD_CK1_1	19	25	PF00069	0.646
MOD_CK1_1	41	47	PF00069	0.726
MOD_CK1_1	51	57	PF00069	0.624
MOD_CK1_1	65	71	PF00069	0.678
MOD_CK1_1	72	78	PF00069	0.620
MOD_CK1_1	8	14	PF00069	0.671
MOD_CK2_1	14	20	PF00069	0.546
MOD_CK2_1	189	195	PF00069	0.594
MOD_CK2_1	345	351	PF00069	0.762
MOD_CK2_1	362	368	PF00069	0.571
MOD_CK2_1	377	383	PF00069	0.615
MOD_GlcNHglycan	118	121	PF01048	0.703
MOD_GlcNHglycan	14	17	PF01048	0.594
MOD_GlcNHglycan	150	153	PF01048	0.660
MOD_GlcNHglycan	27	30	PF01048	0.618
MOD_GlcNHglycan	272	275	PF01048	0.643
MOD_GlcNHglycan	38	41	PF01048	0.589
MOD_GlcNHglycan	400	403	PF01048	0.532
MOD_GlcNHglycan	424	427	PF01048	0.608
MOD_GlcNHglycan	53	56	PF01048	0.759
MOD_GlcNHglycan	67	70	PF01048	0.609
MOD_GlcNHglycan	85	88	PF01048	0.518
MOD_GSK3_1	112	119	PF00069	0.712
MOD_GSK3_1	139	146	PF00069	0.664
MOD_GSK3_1	150	157	PF00069	0.753
MOD_GSK3_1	222	229	PF00069	0.709
MOD_GSK3_1	25	32	PF00069	0.643
MOD_GSK3_1	321	328	PF00069	0.594
MOD_GSK3_1	43	50	PF00069	0.683
MOD_GSK3_1	5	12	PF00069	0.664
MOD_GSK3_1	51	58	PF00069	0.675
MOD_GSK3_1	59	66	PF00069	0.597
MOD_GSK3_1	72	79	PF00069	0.612
MOD_N-GLC_1	177	182	PF02516	0.639
MOD_N-GLC_1	25	30	PF02516	0.630
MOD_NEK2_1	143	148	PF00069	0.622
MOD_NEK2_1	222	227	PF00069	0.613
MOD_NEK2_1	405	410	PF00069	0.664
MOD_NEK2_1	49	54	PF00069	0.585
MOD_NEK2_1	82	87	PF00069	0.641
MOD_PK_1	443	449	PF00069	0.548
MOD_PK_1	6	12	PF00069	0.645
MOD_PKA_1	443	449	PF00069	0.476
MOD_PKA_1	5	11	PF00069	0.645
MOD_PKA_2	270	276	PF00069	0.647
MOD_PKA_2	301	307	PF00069	0.643
MOD_PKA_2	443	449	PF00069	0.524
MOD_PKA_2	5	11	PF00069	0.645
MOD_PKB_1	396	404	PF00069	0.528
MOD_PKB_1	4	12	PF00069	0.560
MOD_Plk_1	206	212	PF00069	0.642
MOD_Plk_1	405	411	PF00069	0.614
MOD_Plk_4	222	228	PF00069	0.614
MOD_Plk_4	301	307	PF00069	0.580
MOD_Plk_4	31	37	PF00069	0.612
MOD_Plk_4	44	50	PF00069	0.681
MOD_ProDKin_1	163	169	PF00069	0.702
MOD_ProDKin_1	265	271	PF00069	0.612
TRG_ENDOCYTIC_2	409	412	PF00928	0.475
TRG_ENDOCYTIC_2	42	45	PF00928	0.629
TRG_ENDOCYTIC_2	7	10	PF00928	0.642
TRG_ER_diArg_1	246	248	PF00400	0.606
TRG_ER_diArg_1	329	332	PF00400	0.767
TRG_ER_diArg_1	4	6	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T5	Leptomonas seymouri	37%	92%
A0A3S5H5Q5	Leishmania donovani	81%	100%
A4H4L1	Leishmania braziliensis	54%	100%
A4HST7	Leishmania infantum	81%	100%
Q4QJ33	Leishmania major	79%	100%