LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AKS3_LEIMU
TriTrypDb:
LmxM.06.0440
Length:
993

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

E9AKS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKS3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 18 22 PF00656 0.714
CLV_C14_Caspase3-7 484 488 PF00656 0.664
CLV_C14_Caspase3-7 918 922 PF00656 0.731
CLV_C14_Caspase3-7 940 944 PF00656 0.775
CLV_NRD_NRD_1 294 296 PF00675 0.633
CLV_NRD_NRD_1 297 299 PF00675 0.607
CLV_NRD_NRD_1 414 416 PF00675 0.637
CLV_NRD_NRD_1 660 662 PF00675 0.802
CLV_PCSK_FUR_1 295 299 PF00082 0.645
CLV_PCSK_FUR_1 653 657 PF00082 0.560
CLV_PCSK_KEX2_1 293 295 PF00082 0.618
CLV_PCSK_KEX2_1 297 299 PF00082 0.591
CLV_PCSK_KEX2_1 414 416 PF00082 0.637
CLV_PCSK_KEX2_1 655 657 PF00082 0.848
CLV_PCSK_KEX2_1 660 662 PF00082 0.772
CLV_PCSK_KEX2_1 770 772 PF00082 0.677
CLV_PCSK_PC1ET2_1 655 657 PF00082 0.770
CLV_PCSK_PC1ET2_1 770 772 PF00082 0.677
CLV_PCSK_PC7_1 293 299 PF00082 0.644
CLV_PCSK_PC7_1 656 662 PF00082 0.745
CLV_PCSK_SKI1_1 235 239 PF00082 0.527
CLV_PCSK_SKI1_1 25 29 PF00082 0.702
CLV_PCSK_SKI1_1 414 418 PF00082 0.602
CLV_PCSK_SKI1_1 427 431 PF00082 0.730
CLV_PCSK_SKI1_1 755 759 PF00082 0.549
CLV_PCSK_SKI1_1 803 807 PF00082 0.708
CLV_PCSK_SKI1_1 925 929 PF00082 0.759
CLV_PCSK_SKI1_1 981 985 PF00082 0.556
CLV_Separin_Metazoa 188 192 PF03568 0.629
DEG_APCC_DBOX_1 24 32 PF00400 0.744
DEG_APCC_DBOX_1 430 438 PF00400 0.768
DEG_APCC_DBOX_1 924 932 PF00400 0.761
DEG_Nend_Nbox_1 1 3 PF02207 0.828
DEG_SCF_FBW7_1 178 183 PF00400 0.479
DEG_SCF_FBW7_2 134 141 PF00400 0.559
DEG_SCF_FBW7_2 180 187 PF00400 0.447
DEG_SPOP_SBC_1 547 551 PF00917 0.723
DOC_CKS1_1 135 140 PF01111 0.584
DOC_CKS1_1 976 981 PF01111 0.536
DOC_CYCLIN_RxL_1 800 811 PF00134 0.669
DOC_CYCLIN_yCln2_LP_2 430 436 PF00134 0.767
DOC_MAPK_MEF2A_6 465 472 PF00069 0.563
DOC_MAPK_MEF2A_6 703 710 PF00069 0.835
DOC_PP2B_LxvP_1 430 433 PF13499 0.650
DOC_PP2B_LxvP_1 75 78 PF13499 0.794
DOC_PP2B_LxvP_1 807 810 PF13499 0.629
DOC_PP2B_LxvP_1 823 826 PF13499 0.797
DOC_PP2B_LxvP_1 87 90 PF13499 0.626
DOC_PP4_FxxP_1 208 211 PF00568 0.534
DOC_PP4_FxxP_1 883 886 PF00568 0.677
DOC_USP7_MATH_1 254 258 PF00917 0.457
DOC_USP7_MATH_1 369 373 PF00917 0.580
DOC_USP7_MATH_1 535 539 PF00917 0.597
DOC_USP7_MATH_1 547 551 PF00917 0.708
DOC_USP7_MATH_1 671 675 PF00917 0.802
DOC_USP7_MATH_1 776 780 PF00917 0.783
DOC_USP7_MATH_1 78 82 PF00917 0.735
DOC_USP7_MATH_1 808 812 PF00917 0.685
DOC_USP7_MATH_1 913 917 PF00917 0.733
DOC_USP7_MATH_1 966 970 PF00917 0.722
DOC_USP7_MATH_1 985 989 PF00917 0.618
DOC_USP7_MATH_2 822 828 PF00917 0.777
DOC_USP7_UBL2_3 530 534 PF12436 0.774
DOC_USP7_UBL2_3 651 655 PF12436 0.659
DOC_WW_Pin1_4 134 139 PF00397 0.607
DOC_WW_Pin1_4 176 181 PF00397 0.703
DOC_WW_Pin1_4 252 257 PF00397 0.506
DOC_WW_Pin1_4 486 491 PF00397 0.650
DOC_WW_Pin1_4 565 570 PF00397 0.775
DOC_WW_Pin1_4 597 602 PF00397 0.611
DOC_WW_Pin1_4 631 636 PF00397 0.660
DOC_WW_Pin1_4 769 774 PF00397 0.708
DOC_WW_Pin1_4 780 785 PF00397 0.761
DOC_WW_Pin1_4 837 842 PF00397 0.795
DOC_WW_Pin1_4 85 90 PF00397 0.830
DOC_WW_Pin1_4 91 96 PF00397 0.716
DOC_WW_Pin1_4 972 977 PF00397 0.709
LIG_14-3-3_CanoR_1 191 200 PF00244 0.541
LIG_14-3-3_CanoR_1 298 307 PF00244 0.653
LIG_14-3-3_CanoR_1 390 398 PF00244 0.531
LIG_14-3-3_CanoR_1 588 594 PF00244 0.665
LIG_14-3-3_CanoR_1 603 612 PF00244 0.564
LIG_14-3-3_CanoR_1 70 76 PF00244 0.626
LIG_14-3-3_CanoR_1 755 765 PF00244 0.545
LIG_14-3-3_CterR_2 989 993 PF00244 0.804
LIG_BIR_III_4 943 947 PF00653 0.773
LIG_CtBP_PxDLS_1 707 711 PF00389 0.758
LIG_deltaCOP1_diTrp_1 351 358 PF00928 0.579
LIG_EVH1_2 95 99 PF00568 0.512
LIG_FHA_1 177 183 PF00498 0.694
LIG_FHA_1 216 222 PF00498 0.578
LIG_FHA_1 302 308 PF00498 0.666
LIG_FHA_1 330 336 PF00498 0.601
LIG_FHA_1 377 383 PF00498 0.578
LIG_FHA_1 390 396 PF00498 0.430
LIG_FHA_1 70 76 PF00498 0.718
LIG_FHA_1 794 800 PF00498 0.804
LIG_FHA_1 858 864 PF00498 0.661
LIG_FHA_1 892 898 PF00498 0.735
LIG_FHA_1 92 98 PF00498 0.519
LIG_FHA_2 137 143 PF00498 0.378
LIG_FHA_2 742 748 PF00498 0.639
LIG_FHA_2 847 853 PF00498 0.621
LIG_FHA_2 916 922 PF00498 0.830
LIG_HCF-1_HBM_1 949 952 PF13415 0.515
LIG_LIR_Apic_2 205 211 PF02991 0.552
LIG_LIR_Apic_2 556 562 PF02991 0.743
LIG_LIR_Gen_1 156 164 PF02991 0.518
LIG_LIR_Gen_1 194 202 PF02991 0.524
LIG_LIR_Nem_3 156 162 PF02991 0.605
LIG_LIR_Nem_3 194 200 PF02991 0.516
LIG_LIR_Nem_3 408 413 PF02991 0.527
LIG_LIR_Nem_3 495 499 PF02991 0.480
LIG_LIR_Nem_3 591 597 PF02991 0.528
LIG_LIR_Nem_3 818 823 PF02991 0.794
LIG_MYND_1 134 138 PF01753 0.630
LIG_PCNA_yPIPBox_3 530 543 PF02747 0.765
LIG_Pex14_2 864 868 PF04695 0.628
LIG_PTAP_UEV_1 772 777 PF05743 0.742
LIG_SH2_CRK 159 163 PF00017 0.616
LIG_SH2_CRK 266 270 PF00017 0.477
LIG_SH2_CRK 559 563 PF00017 0.667
LIG_SH2_CRK 567 571 PF00017 0.733
LIG_SH2_GRB2like 378 381 PF00017 0.631
LIG_SH2_GRB2like 9 12 PF00017 0.542
LIG_SH2_NCK_1 159 163 PF00017 0.519
LIG_SH2_NCK_1 567 571 PF00017 0.730
LIG_SH2_NCK_1 889 893 PF00017 0.672
LIG_SH2_SRC 575 578 PF00017 0.754
LIG_SH2_SRC 9 12 PF00017 0.542
LIG_SH2_STAP1 159 163 PF00017 0.519
LIG_SH2_STAP1 378 382 PF00017 0.626
LIG_SH2_STAP1 575 579 PF00017 0.840
LIG_SH2_STAT3 499 502 PF00017 0.806
LIG_SH2_STAT3 798 801 PF00017 0.506
LIG_SH2_STAT5 378 381 PF00017 0.560
LIG_SH2_STAT5 798 801 PF00017 0.551
LIG_SH2_STAT5 875 878 PF00017 0.754
LIG_SH2_STAT5 889 892 PF00017 0.479
LIG_SH3_1 128 134 PF00018 0.515
LIG_SH3_1 770 776 PF00018 0.653
LIG_SH3_2 976 981 PF14604 0.536
LIG_SH3_3 10 16 PF00018 0.531
LIG_SH3_3 128 134 PF00018 0.766
LIG_SH3_3 430 436 PF00018 0.665
LIG_SH3_3 688 694 PF00018 0.732
LIG_SH3_3 701 707 PF00018 0.742
LIG_SH3_3 770 776 PF00018 0.665
LIG_SH3_3 83 89 PF00018 0.737
LIG_SH3_3 92 98 PF00018 0.709
LIG_SH3_3 923 929 PF00018 0.816
LIG_SH3_3 970 976 PF00018 0.532
LIG_SUMO_SIM_par_1 821 827 PF11976 0.780
LIG_TRAF2_1 185 188 PF00917 0.693
LIG_TRAF2_1 391 394 PF00917 0.516
LIG_UBA3_1 212 217 PF00899 0.611
LIG_WRC_WIRS_1 407 412 PF05994 0.629
LIG_WW_2 95 98 PF00397 0.505
MOD_CDK_SPxK_1 597 603 PF00069 0.642
MOD_CDK_SPxK_1 975 981 PF00069 0.750
MOD_CK1_1 372 378 PF00069 0.577
MOD_CK1_1 40 46 PF00069 0.787
MOD_CK1_1 621 627 PF00069 0.845
MOD_CK1_1 628 634 PF00069 0.831
MOD_CK1_1 659 665 PF00069 0.715
MOD_CK1_1 675 681 PF00069 0.611
MOD_CK1_1 750 756 PF00069 0.793
MOD_CK1_1 769 775 PF00069 0.587
MOD_CK1_1 81 87 PF00069 0.845
MOD_CK1_1 812 818 PF00069 0.511
MOD_CK1_1 857 863 PF00069 0.773
MOD_CK1_1 935 941 PF00069 0.832
MOD_CK1_1 967 973 PF00069 0.811
MOD_CK1_1 975 981 PF00069 0.684
MOD_CK2_1 236 242 PF00069 0.518
MOD_CK2_1 345 351 PF00069 0.558
MOD_CK2_1 933 939 PF00069 0.831
MOD_Cter_Amidation 653 656 PF01082 0.777
MOD_GlcNHglycan 301 304 PF01048 0.522
MOD_GlcNHglycan 309 312 PF01048 0.617
MOD_GlcNHglycan 509 512 PF01048 0.831
MOD_GlcNHglycan 526 529 PF01048 0.772
MOD_GlcNHglycan 555 558 PF01048 0.556
MOD_GlcNHglycan 571 574 PF01048 0.788
MOD_GlcNHglycan 577 580 PF01048 0.722
MOD_GlcNHglycan 583 586 PF01048 0.626
MOD_GlcNHglycan 59 62 PF01048 0.821
MOD_GlcNHglycan 605 608 PF01048 0.711
MOD_GlcNHglycan 627 630 PF01048 0.777
MOD_GlcNHglycan 712 715 PF01048 0.594
MOD_GlcNHglycan 773 776 PF01048 0.810
MOD_GlcNHglycan 784 787 PF01048 0.648
MOD_GlcNHglycan 811 814 PF01048 0.719
MOD_GlcNHglycan 826 829 PF01048 0.732
MOD_GlcNHglycan 832 835 PF01048 0.807
MOD_GlcNHglycan 855 859 PF01048 0.759
MOD_GlcNHglycan 921 924 PF01048 0.753
MOD_GlcNHglycan 935 938 PF01048 0.721
MOD_GSK3_1 176 183 PF00069 0.681
MOD_GSK3_1 252 259 PF00069 0.311
MOD_GSK3_1 27 34 PF00069 0.612
MOD_GSK3_1 365 372 PF00069 0.470
MOD_GSK3_1 37 44 PF00069 0.786
MOD_GSK3_1 376 383 PF00069 0.472
MOD_GSK3_1 453 460 PF00069 0.618
MOD_GSK3_1 512 519 PF00069 0.760
MOD_GSK3_1 542 549 PF00069 0.701
MOD_GSK3_1 55 62 PF00069 0.620
MOD_GSK3_1 565 572 PF00069 0.819
MOD_GSK3_1 575 582 PF00069 0.662
MOD_GSK3_1 583 590 PF00069 0.682
MOD_GSK3_1 621 628 PF00069 0.613
MOD_GSK3_1 642 649 PF00069 0.650
MOD_GSK3_1 671 678 PF00069 0.737
MOD_GSK3_1 746 753 PF00069 0.754
MOD_GSK3_1 756 763 PF00069 0.695
MOD_GSK3_1 776 783 PF00069 0.710
MOD_GSK3_1 808 815 PF00069 0.791
MOD_GSK3_1 81 88 PF00069 0.845
MOD_GSK3_1 842 849 PF00069 0.572
MOD_GSK3_1 887 894 PF00069 0.672
MOD_GSK3_1 904 911 PF00069 0.557
MOD_GSK3_1 913 920 PF00069 0.678
MOD_GSK3_1 927 934 PF00069 0.601
MOD_GSK3_1 935 942 PF00069 0.739
MOD_GSK3_1 967 974 PF00069 0.757
MOD_GSK3_1 984 991 PF00069 0.607
MOD_LATS_1 455 461 PF00433 0.594
MOD_N-GLC_1 180 185 PF02516 0.638
MOD_N-GLC_1 299 304 PF02516 0.671
MOD_N-GLC_1 314 319 PF02516 0.550
MOD_N-GLC_1 513 518 PF02516 0.712
MOD_N-GLC_1 522 527 PF02516 0.706
MOD_N-GLC_2 261 263 PF02516 0.448
MOD_NEK2_1 216 221 PF00069 0.477
MOD_NEK2_1 285 290 PF00069 0.475
MOD_NEK2_1 299 304 PF00069 0.540
MOD_NEK2_1 307 312 PF00069 0.553
MOD_NEK2_1 468 473 PF00069 0.468
MOD_NEK2_1 505 510 PF00069 0.818
MOD_NEK2_1 542 547 PF00069 0.654
MOD_NEK2_1 548 553 PF00069 0.557
MOD_NEK2_1 55 60 PF00069 0.817
MOD_NEK2_1 581 586 PF00069 0.805
MOD_NEK2_1 69 74 PF00069 0.575
MOD_NEK2_1 710 715 PF00069 0.595
MOD_NEK2_1 756 761 PF00069 0.678
MOD_NEK2_1 931 936 PF00069 0.765
MOD_NEK2_1 984 989 PF00069 0.823
MOD_PIKK_1 115 121 PF00454 0.549
MOD_PIKK_1 202 208 PF00454 0.417
MOD_PIKK_1 345 351 PF00454 0.607
MOD_PIKK_1 389 395 PF00454 0.515
MOD_PIKK_1 537 543 PF00454 0.829
MOD_PIKK_1 664 670 PF00454 0.643
MOD_PIKK_1 756 762 PF00454 0.799
MOD_PIKK_1 915 921 PF00454 0.775
MOD_PKA_2 369 375 PF00069 0.575
MOD_PKA_2 389 395 PF00069 0.287
MOD_PKA_2 587 593 PF00069 0.701
MOD_PKA_2 659 665 PF00069 0.798
MOD_PKA_2 69 75 PF00069 0.644
MOD_PKA_2 747 753 PF00069 0.642
MOD_PKA_2 766 772 PF00069 0.609
MOD_PKB_1 522 530 PF00069 0.776
MOD_Plk_1 31 37 PF00069 0.709
MOD_Plk_1 985 991 PF00069 0.815
MOD_Plk_2-3 939 945 PF00069 0.562
MOD_Plk_4 380 386 PF00069 0.611
MOD_Plk_4 816 822 PF00069 0.753
MOD_ProDKin_1 134 140 PF00069 0.594
MOD_ProDKin_1 176 182 PF00069 0.699
MOD_ProDKin_1 252 258 PF00069 0.500
MOD_ProDKin_1 486 492 PF00069 0.654
MOD_ProDKin_1 565 571 PF00069 0.778
MOD_ProDKin_1 597 603 PF00069 0.613
MOD_ProDKin_1 631 637 PF00069 0.654
MOD_ProDKin_1 769 775 PF00069 0.707
MOD_ProDKin_1 780 786 PF00069 0.761
MOD_ProDKin_1 837 843 PF00069 0.789
MOD_ProDKin_1 85 91 PF00069 0.830
MOD_ProDKin_1 972 978 PF00069 0.711
MOD_SUMO_rev_2 214 219 PF00179 0.599
MOD_SUMO_rev_2 441 449 PF00179 0.487
TRG_DiLeu_BaEn_3 187 193 PF01217 0.528
TRG_DiLeu_BaLyEn_6 208 213 PF01217 0.642
TRG_DiLeu_BaLyEn_6 561 566 PF01217 0.649
TRG_ENDOCYTIC_2 159 162 PF00928 0.608
TRG_ENDOCYTIC_2 197 200 PF00928 0.515
TRG_ENDOCYTIC_2 266 269 PF00928 0.468
TRG_ENDOCYTIC_2 594 597 PF00928 0.639
TRG_ENDOCYTIC_2 820 823 PF00928 0.805
TRG_ENDOCYTIC_2 888 891 PF00928 0.637
TRG_ER_diArg_1 293 295 PF00400 0.632
TRG_ER_diArg_1 297 299 PF00400 0.591
TRG_ER_diArg_1 413 415 PF00400 0.629
TRG_NES_CRM1_1 146 156 PF08389 0.592
TRG_NES_CRM1_1 281 292 PF08389 0.498
TRG_NLS_MonoExtN_4 653 659 PF00514 0.561
TRG_Pf-PMV_PEXEL_1 191 195 PF00026 0.627
TRG_Pf-PMV_PEXEL_1 245 249 PF00026 0.527

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3R7KMM4 Trypanosoma rangeli 36% 100%
A0A3S7WPE9 Leishmania donovani 85% 100%
A4H4L0 Leishmania braziliensis 67% 95%
A4HST6 Leishmania infantum 84% 100%
Q4QJ34 Leishmania major 84% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS