Kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKS2_LEIMU

TriTrypDb:

LmxM.06.0430

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKS2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003774	cytoskeletal motor activity	1	2
GO:0003777	microtubule motor activity	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140657	ATP-dependent activity	1	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.751
CLV_NRD_NRD_1	281	283	PF00675	0.596
CLV_NRD_NRD_1	304	306	PF00675	0.426
CLV_NRD_NRD_1	424	426	PF00675	0.567
CLV_NRD_NRD_1	469	471	PF00675	0.567
CLV_NRD_NRD_1	517	519	PF00675	0.559
CLV_NRD_NRD_1	607	609	PF00675	0.519
CLV_NRD_NRD_1	637	639	PF00675	0.622
CLV_PCSK_FUR_1	422	426	PF00082	0.571
CLV_PCSK_FUR_1	635	639	PF00082	0.579
CLV_PCSK_KEX2_1	304	306	PF00082	0.426
CLV_PCSK_KEX2_1	424	426	PF00082	0.567
CLV_PCSK_KEX2_1	517	519	PF00082	0.445
CLV_PCSK_KEX2_1	609	611	PF00082	0.553
CLV_PCSK_KEX2_1	637	639	PF00082	0.622
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.570
CLV_PCSK_SKI1_1	275	279	PF00082	0.529
CLV_PCSK_SKI1_1	409	413	PF00082	0.459
CLV_PCSK_SKI1_1	42	46	PF00082	0.551
CLV_PCSK_SKI1_1	567	571	PF00082	0.305
CLV_PCSK_SKI1_1	60	64	PF00082	0.447
DEG_APCC_KENBOX_2	196	200	PF00400	0.768
DEG_Nend_UBRbox_2	1	3	PF02207	0.601
DEG_SPOP_SBC_1	13	17	PF00917	0.815
DEG_SPOP_SBC_1	62	66	PF00917	0.661
DEG_SPOP_SBC_1	86	90	PF00917	0.604
DOC_CYCLIN_yCln2_LP_2	356	362	PF00134	0.411
DOC_MAPK_DCC_7	352	362	PF00069	0.481
DOC_MAPK_gen_1	304	312	PF00069	0.388
DOC_MAPK_gen_1	608	619	PF00069	0.565
DOC_MAPK_MEF2A_6	540	548	PF00069	0.456
DOC_PP4_FxxP_1	255	258	PF00568	0.489
DOC_USP7_MATH_1	127	131	PF00917	0.416
DOC_USP7_MATH_1	158	162	PF00917	0.594
DOC_USP7_MATH_1	21	25	PF00917	0.766
DOC_USP7_MATH_1	273	277	PF00917	0.525
DOC_USP7_MATH_1	337	341	PF00917	0.572
DOC_USP7_MATH_1	450	454	PF00917	0.643
DOC_USP7_MATH_1	593	597	PF00917	0.442
DOC_USP7_MATH_1	62	66	PF00917	0.659
DOC_USP7_MATH_1	80	84	PF00917	0.756
DOC_USP7_MATH_1	86	90	PF00917	0.757
DOC_USP7_UBL2_3	42	46	PF12436	0.578
DOC_WW_Pin1_4	15	20	PF00397	0.732
DOC_WW_Pin1_4	154	159	PF00397	0.476
LIG_14-3-3_CanoR_1	113	121	PF00244	0.526
LIG_14-3-3_CanoR_1	150	155	PF00244	0.435
LIG_14-3-3_CanoR_1	304	308	PF00244	0.414
LIG_14-3-3_CanoR_1	388	396	PF00244	0.423
LIG_14-3-3_CanoR_1	540	548	PF00244	0.574
LIG_14-3-3_CanoR_1	6	11	PF00244	0.702
LIG_14-3-3_CanoR_1	60	70	PF00244	0.533
LIG_14-3-3_CanoR_1	626	633	PF00244	0.621
LIG_14-3-3_CanoR_1	643	651	PF00244	0.512
LIG_14-3-3_CterR_2	686	691	PF00244	0.674
LIG_Actin_WH2_2	562	577	PF00022	0.558
LIG_BIR_III_4	193	197	PF00653	0.752
LIG_BRCT_BRCA1_1	102	106	PF00533	0.476
LIG_BRCT_BRCA1_1	136	140	PF00533	0.395
LIG_BRCT_BRCA1_1	509	513	PF00533	0.566
LIG_DLG_GKlike_1	6	14	PF00625	0.554
LIG_EH1_1	396	404	PF00400	0.427
LIG_FHA_1	203	209	PF00498	0.791
LIG_FHA_1	222	228	PF00498	0.612
LIG_FHA_1	285	291	PF00498	0.377
LIG_FHA_1	352	358	PF00498	0.356
LIG_FHA_1	464	470	PF00498	0.460
LIG_FHA_1	507	513	PF00498	0.540
LIG_FHA_1	628	634	PF00498	0.656
LIG_FHA_2	193	199	PF00498	0.781
LIG_FHA_2	309	315	PF00498	0.355
LIG_FHA_2	353	359	PF00498	0.383
LIG_FHA_2	502	508	PF00498	0.595
LIG_LIR_Apic_2	153	158	PF02991	0.444
LIG_LIR_Apic_2	254	258	PF02991	0.491
LIG_LIR_Gen_1	137	146	PF02991	0.441
LIG_LIR_Gen_1	309	318	PF02991	0.358
LIG_LIR_Gen_1	510	519	PF02991	0.559
LIG_LIR_Gen_1	64	75	PF02991	0.500
LIG_LIR_Nem_3	137	141	PF02991	0.477
LIG_LIR_Nem_3	228	234	PF02991	0.502
LIG_LIR_Nem_3	309	315	PF02991	0.360
LIG_LIR_Nem_3	510	516	PF02991	0.560
LIG_LIR_Nem_3	64	70	PF02991	0.508
LIG_NRBOX	352	358	PF00104	0.356
LIG_Pex14_1	102	106	PF04695	0.475
LIG_SH2_CRK	155	159	PF00017	0.469
LIG_SH2_CRK	67	71	PF00017	0.487
LIG_SH2_NCK_1	296	300	PF00017	0.464
LIG_SH2_PTP2	138	141	PF00017	0.508
LIG_SH2_PTP2	364	367	PF00017	0.382
LIG_SH2_SRC	121	124	PF00017	0.476
LIG_SH2_SRC	296	299	PF00017	0.457
LIG_SH2_STAP1	10	14	PF00017	0.682
LIG_SH2_STAP1	121	125	PF00017	0.539
LIG_SH2_STAT5	138	141	PF00017	0.390
LIG_SH2_STAT5	364	367	PF00017	0.386
LIG_SH2_STAT5	572	575	PF00017	0.521
LIG_SH2_STAT5	67	70	PF00017	0.528
LIG_SH3_3	121	127	PF00018	0.419
LIG_SH3_3	139	145	PF00018	0.305
LIG_SH3_3	250	256	PF00018	0.469
LIG_SH3_3	259	265	PF00018	0.433
LIG_SH3_3	274	280	PF00018	0.333
LIG_SH3_3	292	298	PF00018	0.377
LIG_SH3_3	670	676	PF00018	0.734
LIG_SH3_3	69	75	PF00018	0.615
LIG_SUMO_SIM_par_1	366	372	PF11976	0.466
LIG_TYR_ITIM	362	367	PF00017	0.406
LIG_UBA3_1	173	182	PF00899	0.572
LIG_UBA3_1	603	611	PF00899	0.589
MOD_CK1_1	130	136	PF00069	0.476
MOD_CK1_1	148	154	PF00069	0.311
MOD_CK1_1	15	21	PF00069	0.739
MOD_CK1_1	207	213	PF00069	0.739
MOD_CK1_1	306	312	PF00069	0.387
MOD_CK1_1	369	375	PF00069	0.360
MOD_CK1_1	382	388	PF00069	0.389
MOD_CK1_1	391	397	PF00069	0.528
MOD_CK1_1	47	53	PF00069	0.557
MOD_CK1_1	639	645	PF00069	0.521
MOD_CK1_1	65	71	PF00069	0.375
MOD_CK1_1	663	669	PF00069	0.678
MOD_CK1_1	677	683	PF00069	0.696
MOD_CK1_1	87	93	PF00069	0.801
MOD_CK2_1	192	198	PF00069	0.796
MOD_CK2_1	210	216	PF00069	0.482
MOD_CK2_1	352	358	PF00069	0.371
MOD_CK2_1	501	507	PF00069	0.563
MOD_CK2_1	53	59	PF00069	0.496
MOD_CK2_1	546	552	PF00069	0.456
MOD_Cter_Amidation	302	305	PF01082	0.469
MOD_Cter_Amidation	606	609	PF01082	0.577
MOD_GlcNHglycan	133	136	PF01048	0.442
MOD_GlcNHglycan	147	150	PF01048	0.382
MOD_GlcNHglycan	202	205	PF01048	0.675
MOD_GlcNHglycan	212	215	PF01048	0.780
MOD_GlcNHglycan	23	26	PF01048	0.801
MOD_GlcNHglycan	341	344	PF01048	0.601
MOD_GlcNHglycan	373	376	PF01048	0.404
MOD_GlcNHglycan	547	551	PF01048	0.542
MOD_GlcNHglycan	55	58	PF01048	0.573
MOD_GlcNHglycan	575	578	PF01048	0.578
MOD_GlcNHglycan	644	647	PF01048	0.642
MOD_GlcNHglycan	681	684	PF01048	0.704
MOD_GlcNHglycan	686	689	PF01048	0.644
MOD_GlcNHglycan	82	85	PF01048	0.783
MOD_GSK3_1	127	134	PF00069	0.460
MOD_GSK3_1	15	22	PF00069	0.664
MOD_GSK3_1	150	157	PF00069	0.450
MOD_GSK3_1	2	9	PF00069	0.624
MOD_GSK3_1	200	207	PF00069	0.731
MOD_GSK3_1	216	223	PF00069	0.535
MOD_GSK3_1	299	306	PF00069	0.511
MOD_GSK3_1	348	355	PF00069	0.428
MOD_GSK3_1	530	537	PF00069	0.548
MOD_GSK3_1	58	65	PF00069	0.505
MOD_GSK3_1	593	600	PF00069	0.605
MOD_GSK3_1	650	657	PF00069	0.580
MOD_GSK3_1	659	666	PF00069	0.602
MOD_GSK3_1	80	87	PF00069	0.660
MOD_LATS_1	51	57	PF00433	0.489
MOD_N-GLC_1	106	111	PF02516	0.445
MOD_N-GLC_1	130	135	PF02516	0.527
MOD_N-GLC_1	450	455	PF02516	0.589
MOD_NEK2_1	106	111	PF00069	0.461
MOD_NEK2_1	285	290	PF00069	0.297
MOD_NEK2_1	348	353	PF00069	0.513
MOD_NEK2_1	379	384	PF00069	0.434
MOD_NEK2_1	4	9	PF00069	0.661
MOD_NEK2_1	463	468	PF00069	0.558
MOD_NEK2_1	535	540	PF00069	0.592
MOD_NEK2_1	546	551	PF00069	0.522
MOD_NEK2_1	654	659	PF00069	0.650
MOD_PIKK_1	100	106	PF00454	0.657
MOD_PIKK_1	148	154	PF00454	0.449
MOD_PIKK_1	202	208	PF00454	0.748
MOD_PIKK_1	507	513	PF00454	0.504
MOD_PIKK_1	522	528	PF00454	0.451
MOD_PIKK_1	535	541	PF00454	0.508
MOD_PIKK_1	587	593	PF00454	0.601
MOD_PIKK_1	667	673	PF00454	0.714
MOD_PIKK_1	674	680	PF00454	0.666
MOD_PIKK_1	8	14	PF00454	0.750
MOD_PIKK_1	87	93	PF00454	0.760
MOD_PKA_2	303	309	PF00069	0.412
MOD_PKA_2	442	448	PF00069	0.538
MOD_PKA_2	539	545	PF00069	0.573
MOD_PKA_2	625	631	PF00069	0.605
MOD_PKA_2	636	642	PF00069	0.444
MOD_PKA_2	654	660	PF00069	0.656
MOD_Plk_1	106	112	PF00069	0.442
MOD_Plk_1	285	291	PF00069	0.377
MOD_Plk_1	324	330	PF00069	0.486
MOD_Plk_1	546	552	PF00069	0.456
MOD_Plk_1	587	593	PF00069	0.621
MOD_Plk_4	134	140	PF00069	0.449
MOD_Plk_4	150	156	PF00069	0.391
MOD_Plk_4	273	279	PF00069	0.498
MOD_Plk_4	308	314	PF00069	0.405
MOD_Plk_4	352	358	PF00069	0.359
MOD_ProDKin_1	15	21	PF00069	0.732
MOD_ProDKin_1	154	160	PF00069	0.479
MOD_SUMO_rev_2	276	285	PF00179	0.545
MOD_SUMO_rev_2	345	354	PF00179	0.473
MOD_SUMO_rev_2	547	555	PF00179	0.497
MOD_SUMO_rev_2	566	571	PF00179	0.271
MOD_SUMO_rev_2	670	676	PF00179	0.497
TRG_DiLeu_BaEn_1	325	330	PF01217	0.365
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.462
TRG_ENDOCYTIC_2	121	124	PF00928	0.432
TRG_ENDOCYTIC_2	138	141	PF00928	0.390
TRG_ENDOCYTIC_2	231	234	PF00928	0.493
TRG_ENDOCYTIC_2	296	299	PF00928	0.413
TRG_ENDOCYTIC_2	364	367	PF00928	0.382
TRG_ENDOCYTIC_2	67	70	PF00928	0.471
TRG_ER_diArg_1	265	268	PF00400	0.536
TRG_ER_diArg_1	421	424	PF00400	0.577
TRG_ER_diArg_1	516	518	PF00400	0.561
TRG_ER_diArg_1	610	613	PF00400	0.563
TRG_ER_diArg_1	637	640	PF00400	0.639
TRG_ER_diArg_1	70	73	PF00400	0.577
TRG_NLS_MonoCore_2	607	612	PF00514	0.600
TRG_NLS_MonoExtC_3	607	612	PF00514	0.557
TRG_NLS_MonoExtN_4	608	613	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC06	Leptomonas seymouri	71%	99%
A0A0S4KIG4	Bodo saltans	29%	94%
A0A1X0NKL3	Trypanosomatidae	54%	100%
A0A3R7LWH4	Trypanosoma rangeli	52%	100%
A0A3S5H5Q4	Leishmania donovani	96%	100%
A4H4K9	Leishmania braziliensis	88%	99%
A4HST5	Leishmania infantum	97%	100%
C9ZTE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QJ35	Leishmania major	95%	100%
V5DPG4	Trypanosoma cruzi	52%	100%