Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKS1_LEIMU

TriTrypDb:

LmxM.06.0420

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.538
CLV_C14_Caspase3-7	490	494	PF00656	0.509
CLV_NRD_NRD_1	369	371	PF00675	0.716
CLV_NRD_NRD_1	413	415	PF00675	0.624
CLV_NRD_NRD_1	423	425	PF00675	0.599
CLV_NRD_NRD_1	497	499	PF00675	0.681
CLV_NRD_NRD_1	502	504	PF00675	0.673
CLV_NRD_NRD_1	511	513	PF00675	0.572
CLV_NRD_NRD_1	535	537	PF00675	0.624
CLV_NRD_NRD_1	58	60	PF00675	0.450
CLV_NRD_NRD_1	81	83	PF00675	0.461
CLV_PCSK_FUR_1	367	371	PF00082	0.653
CLV_PCSK_KEX2_1	222	224	PF00082	0.610
CLV_PCSK_KEX2_1	256	258	PF00082	0.698
CLV_PCSK_KEX2_1	369	371	PF00082	0.716
CLV_PCSK_KEX2_1	413	415	PF00082	0.620
CLV_PCSK_KEX2_1	422	424	PF00082	0.606
CLV_PCSK_KEX2_1	501	503	PF00082	0.712
CLV_PCSK_KEX2_1	511	513	PF00082	0.599
CLV_PCSK_KEX2_1	58	60	PF00082	0.450
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.610
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.692
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.712
CLV_PCSK_PC7_1	419	425	PF00082	0.509
CLV_PCSK_PC7_1	498	504	PF00082	0.704
CLV_PCSK_PC7_1	507	513	PF00082	0.612
CLV_PCSK_SKI1_1	121	125	PF00082	0.490
CLV_PCSK_SKI1_1	143	147	PF00082	0.545
CLV_PCSK_SKI1_1	257	261	PF00082	0.802
DEG_APCC_DBOX_1	256	264	PF00400	0.649
DEG_APCC_DBOX_1	353	361	PF00400	0.505
DOC_CKS1_1	124	129	PF01111	0.439
DOC_MAPK_gen_1	256	263	PF00069	0.674
DOC_MAPK_gen_1	339	348	PF00069	0.680
DOC_PP2B_LxvP_1	261	264	PF13499	0.514
DOC_PP4_FxxP_1	124	127	PF00568	0.426
DOC_USP7_MATH_1	164	168	PF00917	0.643
DOC_USP7_MATH_1	170	174	PF00917	0.620
DOC_USP7_MATH_1	177	181	PF00917	0.572
DOC_USP7_MATH_1	199	203	PF00917	0.771
DOC_USP7_MATH_1	205	209	PF00917	0.643
DOC_USP7_MATH_1	215	219	PF00917	0.608
DOC_USP7_MATH_1	255	259	PF00917	0.743
DOC_USP7_MATH_1	338	342	PF00917	0.639
DOC_USP7_MATH_1	37	41	PF00917	0.618
DOC_USP7_MATH_1	396	400	PF00917	0.625
DOC_USP7_MATH_1	407	411	PF00917	0.614
DOC_USP7_MATH_1	450	454	PF00917	0.612
DOC_USP7_MATH_1	459	463	PF00917	0.571
DOC_USP7_MATH_2	45	51	PF00917	0.566
DOC_WW_Pin1_4	123	128	PF00397	0.520
DOC_WW_Pin1_4	129	134	PF00397	0.512
DOC_WW_Pin1_4	166	171	PF00397	0.474
DOC_WW_Pin1_4	188	193	PF00397	0.619
DOC_WW_Pin1_4	271	276	PF00397	0.675
DOC_WW_Pin1_4	33	38	PF00397	0.580
DOC_WW_Pin1_4	332	337	PF00397	0.683
DOC_WW_Pin1_4	374	379	PF00397	0.584
DOC_WW_Pin1_4	41	46	PF00397	0.599
DOC_WW_Pin1_4	546	551	PF00397	0.584
LIG_14-3-3_CanoR_1	121	127	PF00244	0.398
LIG_14-3-3_CanoR_1	267	275	PF00244	0.630
LIG_14-3-3_CanoR_1	382	390	PF00244	0.648
LIG_14-3-3_CanoR_1	424	430	PF00244	0.576
LIG_14-3-3_CanoR_1	464	472	PF00244	0.514
LIG_14-3-3_CanoR_1	502	506	PF00244	0.674
LIG_14-3-3_CanoR_1	546	550	PF00244	0.628
LIG_APCC_ABBAyCdc20_2	277	283	PF00400	0.664
LIG_Clathr_ClatBox_1	316	320	PF01394	0.491
LIG_deltaCOP1_diTrp_1	89	97	PF00928	0.478
LIG_FHA_1	312	318	PF00498	0.643
LIG_FHA_1	348	354	PF00498	0.570
LIG_FHA_1	549	555	PF00498	0.559
LIG_FHA_1	97	103	PF00498	0.440
LIG_FHA_2	293	299	PF00498	0.726
LIG_FHA_2	488	494	PF00498	0.676
LIG_LIR_Gen_1	483	489	PF02991	0.603
LIG_LIR_Nem_3	160	165	PF02991	0.476
LIG_LIR_Nem_3	483	488	PF02991	0.600
LIG_Pex14_2	120	124	PF04695	0.365
LIG_PTB_Apo_2	481	488	PF02174	0.557
LIG_PTB_Phospho_1	481	487	PF10480	0.556
LIG_SH2_CRK	426	430	PF00017	0.629
LIG_SH2_SRC	447	450	PF00017	0.614
LIG_SH2_STAP1	109	113	PF00017	0.440
LIG_SH2_STAP1	98	102	PF00017	0.389
LIG_SH2_STAT3	98	101	PF00017	0.401
LIG_SH2_STAT5	41	44	PF00017	0.679
LIG_SH2_STAT5	447	450	PF00017	0.614
LIG_SH2_STAT5	485	488	PF00017	0.655
LIG_SH2_STAT5	517	520	PF00017	0.643
LIG_SH2_STAT5	98	101	PF00017	0.401
LIG_SH3_3	276	282	PF00018	0.808
LIG_SH3_3	467	473	PF00018	0.634
LIG_Sin3_3	386	393	PF02671	0.616
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.493
LIG_SUMO_SIM_par_1	314	320	PF11976	0.594
MOD_CDC14_SPxK_1	274	277	PF00782	0.614
MOD_CDK_SPK_2	33	38	PF00069	0.580
MOD_CDK_SPK_2	41	46	PF00069	0.599
MOD_CDK_SPxK_1	166	172	PF00069	0.479
MOD_CDK_SPxK_1	271	277	PF00069	0.609
MOD_CDK_SPxxK_3	332	339	PF00069	0.645
MOD_CK1_1	157	163	PF00069	0.604
MOD_CK1_1	24	30	PF00069	0.637
MOD_CK1_1	271	277	PF00069	0.665
MOD_CK1_1	302	308	PF00069	0.739
MOD_CK1_1	312	318	PF00069	0.565
MOD_CK1_1	347	353	PF00069	0.638
MOD_CK1_1	374	380	PF00069	0.584
MOD_CK1_1	40	46	PF00069	0.627
MOD_CK1_1	400	406	PF00069	0.543
MOD_CK1_1	412	418	PF00069	0.509
MOD_CK1_1	50	56	PF00069	0.643
MOD_CK1_1	545	551	PF00069	0.599
MOD_CK2_1	146	152	PF00069	0.666
MOD_CK2_1	200	206	PF00069	0.655
MOD_CK2_1	41	47	PF00069	0.660
MOD_GlcNHglycan	159	162	PF01048	0.637
MOD_GlcNHglycan	166	169	PF01048	0.559
MOD_GlcNHglycan	172	175	PF01048	0.596
MOD_GlcNHglycan	179	182	PF01048	0.559
MOD_GlcNHglycan	188	191	PF01048	0.572
MOD_GlcNHglycan	202	205	PF01048	0.555
MOD_GlcNHglycan	23	26	PF01048	0.677
MOD_GlcNHglycan	240	243	PF01048	0.750
MOD_GlcNHglycan	246	249	PF01048	0.577
MOD_GlcNHglycan	257	260	PF01048	0.579
MOD_GlcNHglycan	270	273	PF01048	0.615
MOD_GlcNHglycan	311	314	PF01048	0.516
MOD_GlcNHglycan	332	335	PF01048	0.610
MOD_GlcNHglycan	350	353	PF01048	0.567
MOD_GlcNHglycan	379	382	PF01048	0.765
MOD_GlcNHglycan	384	387	PF01048	0.604
MOD_GlcNHglycan	391	394	PF01048	0.541
MOD_GlcNHglycan	398	402	PF01048	0.603
MOD_GlcNHglycan	407	410	PF01048	0.627
MOD_GlcNHglycan	433	436	PF01048	0.725
MOD_GlcNHglycan	465	468	PF01048	0.690
MOD_GlcNHglycan	490	493	PF01048	0.630
MOD_GlcNHglycan	507	510	PF01048	0.573
MOD_GlcNHglycan	52	55	PF01048	0.472
MOD_GSK3_1	129	136	PF00069	0.622
MOD_GSK3_1	166	173	PF00069	0.586
MOD_GSK3_1	175	182	PF00069	0.612
MOD_GSK3_1	184	191	PF00069	0.579
MOD_GSK3_1	211	218	PF00069	0.662
MOD_GSK3_1	288	295	PF00069	0.614
MOD_GSK3_1	33	40	PF00069	0.591
MOD_GSK3_1	338	345	PF00069	0.622
MOD_GSK3_1	348	355	PF00069	0.643
MOD_GSK3_1	396	403	PF00069	0.541
MOD_GSK3_1	405	412	PF00069	0.574
MOD_GSK3_1	41	48	PF00069	0.719
MOD_GSK3_1	425	432	PF00069	0.620
MOD_GSK3_1	433	440	PF00069	0.567
MOD_GSK3_1	459	466	PF00069	0.541
MOD_GSK3_1	501	508	PF00069	0.652
MOD_GSK3_1	511	518	PF00069	0.652
MOD_GSK3_1	541	548	PF00069	0.759
MOD_N-GLC_1	215	220	PF02516	0.611
MOD_N-GLC_1	223	228	PF02516	0.603
MOD_N-GLC_1	437	442	PF02516	0.642
MOD_N-GLC_1	494	499	PF02516	0.645
MOD_NEK2_1	116	121	PF00069	0.481
MOD_NEK2_1	268	273	PF00069	0.711
MOD_NEK2_1	348	353	PF00069	0.633
MOD_NEK2_1	372	377	PF00069	0.540
MOD_NEK2_1	389	394	PF00069	0.630
MOD_NEK2_1	397	402	PF00069	0.529
MOD_NEK2_1	429	434	PF00069	0.639
MOD_NEK2_1	475	480	PF00069	0.651
MOD_NEK2_1	505	510	PF00069	0.665
MOD_PK_1	342	348	PF00069	0.622
MOD_PKA_1	501	507	PF00069	0.709
MOD_PKA_1	511	517	PF00069	0.603
MOD_PKA_2	11	17	PF00069	0.555
MOD_PKA_2	237	243	PF00069	0.586
MOD_PKA_2	266	272	PF00069	0.625
MOD_PKA_2	302	308	PF00069	0.620
MOD_PKA_2	338	344	PF00069	0.598
MOD_PKA_2	37	43	PF00069	0.626
MOD_PKA_2	401	407	PF00069	0.623
MOD_PKA_2	412	418	PF00069	0.564
MOD_PKA_2	45	51	PF00069	0.526
MOD_PKA_2	463	469	PF00069	0.534
MOD_PKA_2	480	486	PF00069	0.551
MOD_PKA_2	501	507	PF00069	0.709
MOD_PKA_2	511	517	PF00069	0.603
MOD_PKA_2	545	551	PF00069	0.629
MOD_Plk_1	116	122	PF00069	0.458
MOD_Plk_1	437	443	PF00069	0.628
MOD_Plk_1	46	52	PF00069	0.627
MOD_Plk_4	292	298	PF00069	0.586
MOD_Plk_4	312	318	PF00069	0.488
MOD_Plk_4	37	43	PF00069	0.580
MOD_ProDKin_1	123	129	PF00069	0.526
MOD_ProDKin_1	166	172	PF00069	0.479
MOD_ProDKin_1	188	194	PF00069	0.622
MOD_ProDKin_1	271	277	PF00069	0.677
MOD_ProDKin_1	33	39	PF00069	0.582
MOD_ProDKin_1	332	338	PF00069	0.674
MOD_ProDKin_1	374	380	PF00069	0.584
MOD_ProDKin_1	41	47	PF00069	0.598
MOD_ProDKin_1	546	552	PF00069	0.581
TRG_ENDOCYTIC_2	426	429	PF00928	0.667
TRG_ENDOCYTIC_2	485	488	PF00928	0.655
TRG_ER_diArg_1	366	369	PF00400	0.680
TRG_ER_diArg_1	422	424	PF00400	0.566
TRG_NLS_MonoCore_2	497	502	PF00514	0.664
TRG_NLS_MonoExtC_3	497	502	PF00514	0.664
TRG_NLS_MonoExtN_4	498	505	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T6	Leptomonas seymouri	36%	100%
A0A3S7WPD6	Leishmania donovani	77%	98%
A4HST4	Leishmania infantum	77%	98%
E9AI22	Leishmania braziliensis	54%	99%
Q4QJ36	Leishmania major	72%	100%