LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
Present in the outer mitochondrial membrane proteome 35
Species:
Leishmania mexicana
UniProt:
E9AKR6_LEIMU
TriTrypDb:
LmxM.06.0380
Length:
374

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 12
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005929 cilium 4 14
GO:0042995 cell projection 2 14
GO:0043226 organelle 2 14
GO:0043227 membrane-bounded organelle 3 14
GO:0110165 cellular anatomical entity 1 14
GO:0120025 plasma membrane bounded cell projection 3 14
GO:0005737 cytoplasm 2 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 6
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

E9AKR6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKR6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0003729 mRNA binding 5 10
GO:0005488 binding 1 14
GO:0043167 ion binding 2 14
GO:0043169 cation binding 3 14
GO:0046872 metal ion binding 4 14
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 29 33 PF00656 0.561
CLV_C14_Caspase3-7 75 79 PF00656 0.444
CLV_NRD_NRD_1 200 202 PF00675 0.641
CLV_PCSK_KEX2_1 13 15 PF00082 0.692
CLV_PCSK_KEX2_1 200 202 PF00082 0.750
CLV_PCSK_KEX2_1 230 232 PF00082 0.751
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.673
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.733
CLV_PCSK_SKI1_1 230 234 PF00082 0.705
DEG_SPOP_SBC_1 299 303 PF00917 0.489
DOC_CYCLIN_yCln2_LP_2 314 320 PF00134 0.484
DOC_PP2B_LxvP_1 314 317 PF13499 0.484
DOC_USP7_MATH_1 259 263 PF00917 0.349
DOC_USP7_MATH_1 287 291 PF00917 0.556
DOC_USP7_MATH_1 352 356 PF00917 0.511
DOC_USP7_UBL2_3 230 234 PF12436 0.494
DOC_USP7_UBL2_3 7 11 PF12436 0.389
DOC_WW_Pin1_4 337 342 PF00397 0.566
LIG_14-3-3_CanoR_1 180 185 PF00244 0.503
LIG_14-3-3_CanoR_1 231 237 PF00244 0.490
LIG_APCC_ABBA_1 80 85 PF00400 0.421
LIG_APCC_ABBAyCdc20_2 19 25 PF00400 0.449
LIG_BRCT_BRCA1_1 296 300 PF00533 0.594
LIG_EH_1 191 195 PF12763 0.390
LIG_FHA_1 270 276 PF00498 0.395
LIG_FHA_2 34 40 PF00498 0.471
LIG_LIR_Gen_1 179 189 PF02991 0.382
LIG_LIR_Gen_1 78 88 PF02991 0.376
LIG_LIR_Nem_3 21 26 PF02991 0.470
LIG_LIR_Nem_3 78 83 PF02991 0.407
LIG_SH2_NCK_1 284 288 PF00017 0.424
LIG_SH2_PTP2 266 269 PF00017 0.268
LIG_SH2_SRC 108 111 PF00017 0.319
LIG_SH2_SRC 266 269 PF00017 0.269
LIG_SH2_STAP1 23 27 PF00017 0.438
LIG_SH2_STAT5 108 111 PF00017 0.319
LIG_SH2_STAT5 26 29 PF00017 0.447
LIG_SH2_STAT5 266 269 PF00017 0.255
LIG_SH2_STAT5 51 54 PF00017 0.516
LIG_SH3_3 163 169 PF00018 0.256
LIG_SH3_4 7 14 PF00018 0.397
LIG_SUMO_SIM_anti_2 112 118 PF11976 0.350
LIG_SUMO_SIM_anti_2 360 365 PF11976 0.387
LIG_TRAF2_1 122 125 PF00917 0.228
LIG_TRAF2_1 38 41 PF00917 0.490
LIG_TYR_ITIM 106 111 PF00017 0.376
LIG_UBA3_1 116 121 PF00899 0.350
MOD_CK1_1 100 106 PF00069 0.356
MOD_CK1_1 112 118 PF00069 0.326
MOD_CK1_1 30 36 PF00069 0.618
MOD_CK1_1 301 307 PF00069 0.629
MOD_CK1_1 337 343 PF00069 0.671
MOD_CK2_1 170 176 PF00069 0.401
MOD_GlcNHglycan 133 137 PF01048 0.383
MOD_GlcNHglycan 202 205 PF01048 0.656
MOD_GlcNHglycan 288 292 PF01048 0.650
MOD_GlcNHglycan 29 32 PF01048 0.599
MOD_GlcNHglycan 303 306 PF01048 0.472
MOD_GSK3_1 176 183 PF00069 0.584
MOD_GSK3_1 232 239 PF00069 0.715
MOD_GSK3_1 294 301 PF00069 0.601
MOD_GSK3_1 96 103 PF00069 0.408
MOD_N-GLC_1 97 102 PF02516 0.423
MOD_NEK2_1 132 137 PF00069 0.417
MOD_NEK2_1 150 155 PF00069 0.383
MOD_NEK2_1 162 167 PF00069 0.417
MOD_NEK2_1 232 237 PF00069 0.728
MOD_NEK2_1 300 305 PF00069 0.572
MOD_NEK2_1 359 364 PF00069 0.303
MOD_PIKK_1 346 352 PF00454 0.554
MOD_PK_1 170 176 PF00069 0.401
MOD_PKA_1 18 24 PF00069 0.624
MOD_PKA_1 200 206 PF00069 0.648
MOD_PKA_2 200 206 PF00069 0.533
MOD_PKB_1 307 315 PF00069 0.650
MOD_Plk_1 112 118 PF00069 0.365
MOD_Plk_1 162 168 PF00069 0.445
MOD_Plk_1 170 176 PF00069 0.453
MOD_Plk_1 269 275 PF00069 0.632
MOD_Plk_1 334 340 PF00069 0.761
MOD_Plk_1 42 48 PF00069 0.683
MOD_Plk_1 97 103 PF00069 0.420
MOD_Plk_4 112 118 PF00069 0.347
MOD_Plk_4 162 168 PF00069 0.457
MOD_Plk_4 170 176 PF00069 0.467
MOD_Plk_4 18 24 PF00069 0.725
MOD_Plk_4 232 238 PF00069 0.619
MOD_Plk_4 279 285 PF00069 0.548
MOD_Plk_4 352 358 PF00069 0.571
MOD_Plk_4 359 365 PF00069 0.283
MOD_Plk_4 97 103 PF00069 0.371
MOD_ProDKin_1 337 343 PF00069 0.728
MOD_SUMO_rev_2 203 211 PF00179 0.561
TRG_ENDOCYTIC_2 108 111 PF00928 0.382
TRG_ENDOCYTIC_2 181 184 PF00928 0.465
TRG_ER_diArg_1 199 201 PF00400 0.690
TRG_ER_diArg_1 307 310 PF00400 0.604
TRG_ER_diArg_1 313 316 PF00400 0.564
TRG_NLS_MonoExtC_3 229 234 PF00514 0.647
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.262

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4T9 Leptomonas seymouri 22% 100%
A0A1X0NM91 Trypanosomatidae 53% 90%
A0A3R7KZS1 Trypanosoma rangeli 53% 92%
A0A3S5H5P9 Leishmania donovani 95% 93%
A0A3S7X0C2 Leishmania donovani 21% 100%
A4H4K3 Leishmania braziliensis 85% 100%
A4HFD8 Leishmania braziliensis 22% 100%
A4HSS9 Leishmania infantum 95% 93%
A4I356 Leishmania infantum 21% 100%
C9ZTD5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 95%
Q4QJ41 Leishmania major 94% 100%
V5BXP3 Trypanosoma cruzi 57% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS