Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKR4_LEIMU

TriTrypDb:

LmxM.06.0360

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.669
CLV_C14_Caspase3-7	431	435	PF00656	0.653
CLV_NRD_NRD_1	103	105	PF00675	0.603
CLV_NRD_NRD_1	259	261	PF00675	0.555
CLV_NRD_NRD_1	339	341	PF00675	0.618
CLV_NRD_NRD_1	396	398	PF00675	0.606
CLV_NRD_NRD_1	402	404	PF00675	0.589
CLV_PCSK_KEX2_1	103	105	PF00082	0.584
CLV_PCSK_KEX2_1	333	335	PF00082	0.562
CLV_PCSK_KEX2_1	339	341	PF00082	0.607
CLV_PCSK_KEX2_1	395	397	PF00082	0.617
CLV_PCSK_KEX2_1	404	406	PF00082	0.575
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.487
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.617
CLV_PCSK_SKI1_1	104	108	PF00082	0.654
CLV_PCSK_SKI1_1	154	158	PF00082	0.592
CLV_PCSK_SKI1_1	217	221	PF00082	0.553
CLV_PCSK_SKI1_1	299	303	PF00082	0.558
CLV_PCSK_SKI1_1	327	331	PF00082	0.718
CLV_PCSK_SKI1_1	334	338	PF00082	0.639
CLV_PCSK_SKI1_1	397	401	PF00082	0.591
DEG_APCC_DBOX_1	216	224	PF00400	0.494
DEG_APCC_DBOX_1	298	306	PF00400	0.391
DEG_SPOP_SBC_1	408	412	PF00917	0.624
DOC_CYCLIN_yClb5_NLxxxL_5	239	245	PF00134	0.560
DOC_MAPK_gen_1	196	204	PF00069	0.641
DOC_MAPK_gen_1	395	401	PF00069	0.730
DOC_PP2B_LxvP_1	233	236	PF13499	0.585
DOC_PP2B_LxvP_1	379	382	PF13499	0.696
DOC_PP4_FxxP_1	107	110	PF00568	0.670
DOC_USP7_MATH_1	169	173	PF00917	0.488
DOC_USP7_MATH_1	18	22	PF00917	0.364
DOC_USP7_MATH_1	286	290	PF00917	0.611
DOC_USP7_MATH_1	408	412	PF00917	0.652
DOC_USP7_MATH_1	419	423	PF00917	0.579
DOC_USP7_MATH_1	50	54	PF00917	0.628
DOC_USP7_MATH_1	60	64	PF00917	0.558
DOC_WW_Pin1_4	205	210	PF00397	0.600
DOC_WW_Pin1_4	266	271	PF00397	0.554
LIG_14-3-3_CanoR_1	154	159	PF00244	0.560
LIG_14-3-3_CanoR_1	184	188	PF00244	0.548
LIG_14-3-3_CanoR_1	239	244	PF00244	0.467
LIG_14-3-3_CanoR_1	249	257	PF00244	0.422
LIG_14-3-3_CanoR_1	260	265	PF00244	0.491
LIG_14-3-3_CanoR_1	284	289	PF00244	0.698
LIG_14-3-3_CanoR_1	327	336	PF00244	0.528
LIG_14-3-3_CanoR_1	33	39	PF00244	0.626
LIG_14-3-3_CanoR_1	405	415	PF00244	0.732
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_Clathr_ClatBox_1	254	258	PF01394	0.592
LIG_Clathr_ClatBox_1	436	440	PF01394	0.718
LIG_deltaCOP1_diTrp_1	212	219	PF00928	0.604
LIG_DLG_GKlike_1	260	267	PF00625	0.502
LIG_FHA_1	250	256	PF00498	0.491
LIG_FHA_1	290	296	PF00498	0.656
LIG_FHA_1	347	353	PF00498	0.489
LIG_FHA_1	423	429	PF00498	0.643
LIG_FHA_1	431	437	PF00498	0.713
LIG_FHA_2	196	202	PF00498	0.628
LIG_FHA_2	429	435	PF00498	0.690
LIG_FHA_2	8	14	PF00498	0.622
LIG_GBD_Chelix_1	88	96	PF00786	0.700
LIG_LIR_Gen_1	222	232	PF02991	0.495
LIG_LIR_Gen_1	263	272	PF02991	0.431
LIG_LIR_Gen_1	35	45	PF02991	0.596
LIG_LIR_Gen_1	367	374	PF02991	0.645
LIG_LIR_Nem_3	222	227	PF02991	0.467
LIG_LIR_Nem_3	231	235	PF02991	0.519
LIG_LIR_Nem_3	263	267	PF02991	0.406
LIG_LIR_Nem_3	35	41	PF02991	0.504
LIG_LIR_Nem_3	367	371	PF02991	0.652
LIG_NRBOX	222	228	PF00104	0.516
LIG_PDZ_Class_3	446	451	PF00595	0.692
LIG_SH2_NCK_1	145	149	PF00017	0.306
LIG_SH2_STAP1	145	149	PF00017	0.306
LIG_SH2_STAP1	264	268	PF00017	0.417
LIG_SH2_STAT5	161	164	PF00017	0.559
LIG_SH2_STAT5	232	235	PF00017	0.451
LIG_SH2_STAT5	373	376	PF00017	0.635
LIG_SH2_STAT5	74	77	PF00017	0.396
LIG_Sin3_1	223	233	PF02671	0.479
LIG_SUMO_SIM_par_1	251	258	PF11976	0.572
LIG_SUMO_SIM_par_1	269	276	PF11976	0.299
LIG_SUMO_SIM_par_1	431	440	PF11976	0.720
LIG_TYR_ITIM	262	267	PF00017	0.419
LIG_UBA3_1	92	101	PF00899	0.584
LIG_WRC_WIRS_1	174	179	PF05994	0.522
MOD_CK1_1	21	27	PF00069	0.623
MOD_CK1_1	248	254	PF00069	0.468
MOD_CK1_1	289	295	PF00069	0.597
MOD_CK1_1	307	313	PF00069	0.680
MOD_CK1_1	389	395	PF00069	0.669
MOD_CK1_1	422	428	PF00069	0.587
MOD_CK2_1	134	140	PF00069	0.698
MOD_CK2_1	195	201	PF00069	0.639
MOD_CK2_1	23	29	PF00069	0.622
MOD_CK2_1	231	237	PF00069	0.500
MOD_CK2_1	260	266	PF00069	0.572
MOD_Cter_Amidation	258	261	PF01082	0.560
MOD_Cter_Amidation	331	334	PF01082	0.753
MOD_GlcNHglycan	166	169	PF01048	0.524
MOD_GlcNHglycan	171	174	PF01048	0.478
MOD_GlcNHglycan	214	217	PF01048	0.554
MOD_GlcNHglycan	284	287	PF01048	0.669
MOD_GlcNHglycan	306	309	PF01048	0.508
MOD_GlcNHglycan	323	327	PF01048	0.446
MOD_GlcNHglycan	34	37	PF01048	0.620
MOD_GlcNHglycan	388	391	PF01048	0.660
MOD_GlcNHglycan	52	55	PF01048	0.500
MOD_GlcNHglycan	56	59	PF01048	0.605
MOD_GlcNHglycan	75	78	PF01048	0.399
MOD_GlcNHglycan	80	83	PF01048	0.635
MOD_GSK3_1	108	115	PF00069	0.741
MOD_GSK3_1	169	176	PF00069	0.497
MOD_GSK3_1	19	26	PF00069	0.586
MOD_GSK3_1	207	214	PF00069	0.571
MOD_GSK3_1	244	251	PF00069	0.434
MOD_GSK3_1	262	269	PF00069	0.314
MOD_GSK3_1	273	280	PF00069	0.462
MOD_GSK3_1	282	289	PF00069	0.349
MOD_GSK3_1	403	410	PF00069	0.721
MOD_GSK3_1	50	57	PF00069	0.647
MOD_N-GLC_1	134	139	PF02516	0.588
MOD_N-GLC_1	159	164	PF02516	0.652
MOD_N-GLC_1	239	244	PF02516	0.545
MOD_NEK2_1	134	139	PF00069	0.532
MOD_NEK2_1	19	24	PF00069	0.562
MOD_NEK2_1	219	224	PF00069	0.446
MOD_NEK2_1	244	249	PF00069	0.454
MOD_NEK2_1	277	282	PF00069	0.553
MOD_NEK2_1	304	309	PF00069	0.664
MOD_NEK2_1	34	39	PF00069	0.612
MOD_NEK2_1	358	363	PF00069	0.595
MOD_NEK2_1	92	97	PF00069	0.575
MOD_OFUCOSY	105	112	PF10250	0.737
MOD_PIKK_1	114	120	PF00454	0.741
MOD_PK_1	284	290	PF00069	0.622
MOD_PKA_1	260	266	PF00069	0.504
MOD_PKA_1	403	409	PF00069	0.684
MOD_PKA_2	183	189	PF00069	0.487
MOD_PKA_2	248	254	PF00069	0.449
MOD_PKA_2	32	38	PF00069	0.645
MOD_PKA_2	406	412	PF00069	0.459
MOD_PKB_1	405	413	PF00069	0.669
MOD_Plk_1	239	245	PF00069	0.495
MOD_Plk_2-3	231	237	PF00069	0.500
MOD_Plk_4	183	189	PF00069	0.517
MOD_Plk_4	219	225	PF00069	0.459
MOD_Plk_4	239	245	PF00069	0.230
MOD_Plk_4	419	425	PF00069	0.534
MOD_Plk_4	92	98	PF00069	0.595
MOD_ProDKin_1	205	211	PF00069	0.605
MOD_ProDKin_1	266	272	PF00069	0.553
MOD_SUMO_rev_2	325	335	PF00179	0.722
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.581
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.605
TRG_ENDOCYTIC_2	161	164	PF00928	0.497
TRG_ENDOCYTIC_2	232	235	PF00928	0.481
TRG_ENDOCYTIC_2	264	267	PF00928	0.407
TRG_ENDOCYTIC_2	38	41	PF00928	0.474
TRG_ER_diArg_1	338	340	PF00400	0.643
TRG_ER_diArg_1	395	397	PF00400	0.674
TRG_NLS_MonoExtC_3	402	407	PF00514	0.663
TRG_NLS_MonoExtN_4	403	408	PF00514	0.729

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ7	Leptomonas seymouri	46%	100%
A0A1X0NL47	Trypanosomatidae	32%	98%
A0A3S5H5P7	Leishmania donovani	92%	100%
A0A3S5IR10	Trypanosoma rangeli	30%	97%
A4H4K1	Leishmania braziliensis	78%	100%
A4HSS7	Leishmania infantum	92%	100%
C9ZTC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	98%
Q4QJ43	Leishmania major	92%	100%
V5BA95	Trypanosoma cruzi	31%	98%