Oligopeptidase B-like protein (Serine peptidase, clan sc, family s9a-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, clan SC, family S9A-like protein

Species:

Leishmania mexicana

UniProt:

E9AKR2_LEIMU

TriTrypDb:

LmxM.06.0340

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKR2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.261
CLV_NRD_NRD_1	19	21	PF00675	0.547
CLV_NRD_NRD_1	274	276	PF00675	0.292
CLV_NRD_NRD_1	523	525	PF00675	0.446
CLV_NRD_NRD_1	571	573	PF00675	0.314
CLV_NRD_NRD_1	737	739	PF00675	0.301
CLV_NRD_NRD_1	840	842	PF00675	0.546
CLV_PCSK_KEX2_1	147	149	PF00082	0.275
CLV_PCSK_KEX2_1	19	21	PF00082	0.529
CLV_PCSK_KEX2_1	523	525	PF00082	0.446
CLV_PCSK_KEX2_1	570	572	PF00082	0.315
CLV_PCSK_KEX2_1	685	687	PF00082	0.435
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.275
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.435
CLV_PCSK_SKI1_1	281	285	PF00082	0.341
CLV_PCSK_SKI1_1	310	314	PF00082	0.289
CLV_PCSK_SKI1_1	388	392	PF00082	0.281
CLV_PCSK_SKI1_1	405	409	PF00082	0.204
CLV_PCSK_SKI1_1	524	528	PF00082	0.493
CLV_PCSK_SKI1_1	812	816	PF00082	0.528
CLV_PCSK_SKI1_1	841	845	PF00082	0.560
DEG_SCF_FBW7_1	304	311	PF00400	0.541
DOC_AGCK_PIF_2	492	497	PF00069	0.491
DOC_CDC14_PxL_1	651	659	PF14671	0.168
DOC_CKS1_1	305	310	PF01111	0.535
DOC_CKS1_1	538	543	PF01111	0.457
DOC_CYCLIN_yClb5_NLxxxL_5	8	17	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.475
DOC_MAPK_gen_1	146	154	PF00069	0.461
DOC_MAPK_gen_1	275	285	PF00069	0.469
DOC_MAPK_gen_1	441	450	PF00069	0.509
DOC_MAPK_gen_1	570	577	PF00069	0.315
DOC_MAPK_gen_1	822	831	PF00069	0.543
DOC_MAPK_JIP1_4	46	52	PF00069	0.619
DOC_MAPK_JIP1_4	746	752	PF00069	0.423
DOC_MAPK_MEF2A_6	217	226	PF00069	0.461
DOC_MAPK_MEF2A_6	421	429	PF00069	0.461
DOC_PP2B_LxvP_1	256	259	PF13499	0.475
DOC_PP2B_LxvP_1	296	299	PF13499	0.475
DOC_PP4_FxxP_1	851	854	PF00568	0.538
DOC_USP7_MATH_1	308	312	PF00917	0.533
DOC_USP7_MATH_1	322	326	PF00917	0.538
DOC_USP7_MATH_1	626	630	PF00917	0.300
DOC_USP7_MATH_1	854	858	PF00917	0.584
DOC_USP7_MATH_1	875	879	PF00917	0.652
DOC_USP7_UBL2_3	310	314	PF12436	0.535
DOC_USP7_UBL2_3	594	598	PF12436	0.357
DOC_USP7_UBL2_3	727	731	PF12436	0.315
DOC_USP7_UBL2_3	812	816	PF12436	0.548
DOC_WW_Pin1_4	304	309	PF00397	0.539
DOC_WW_Pin1_4	416	421	PF00397	0.523
DOC_WW_Pin1_4	433	438	PF00397	0.368
DOC_WW_Pin1_4	490	495	PF00397	0.514
DOC_WW_Pin1_4	537	542	PF00397	0.469
LIG_14-3-3_CanoR_1	180	188	PF00244	0.461
LIG_14-3-3_CanoR_1	30	34	PF00244	0.589
LIG_14-3-3_CanoR_1	476	484	PF00244	0.564
LIG_14-3-3_CanoR_1	487	495	PF00244	0.462
LIG_14-3-3_CanoR_1	570	576	PF00244	0.315
LIG_14-3-3_CanoR_1	703	707	PF00244	0.326
LIG_Actin_WH2_2	14	32	PF00022	0.557
LIG_AP2alpha_2	60	62	PF02296	0.461
LIG_APCC_ABBA_1	260	265	PF00400	0.461
LIG_APCC_ABBA_1	370	375	PF00400	0.459
LIG_APCC_ABBA_1	50	55	PF00400	0.387
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	222	226	PF00533	0.475
LIG_BRCT_BRCA1_1	488	492	PF00533	0.542
LIG_BRCT_BRCA1_1	556	560	PF00533	0.375
LIG_BRCT_BRCA1_1	87	91	PF00533	0.565
LIG_CSL_BTD_1	6	9	PF09270	0.543
LIG_CSL_BTD_1	851	854	PF09270	0.538
LIG_CtBP_PxDLS_1	669	673	PF00389	0.284
LIG_eIF4E_1	617	623	PF01652	0.334
LIG_FHA_1	129	135	PF00498	0.453
LIG_FHA_1	189	195	PF00498	0.472
LIG_FHA_1	217	223	PF00498	0.565
LIG_FHA_1	434	440	PF00498	0.447
LIG_FHA_1	762	768	PF00498	0.395
LIG_FHA_1	8	14	PF00498	0.628
LIG_FHA_2	491	497	PF00498	0.478
LIG_FHA_2	530	536	PF00498	0.553
LIG_FHA_2	616	622	PF00498	0.332
LIG_FHA_2	660	666	PF00498	0.315
LIG_FHA_2	735	741	PF00498	0.459
LIG_FHA_2	75	81	PF00498	0.511
LIG_FHA_2	784	790	PF00498	0.589
LIG_FHA_2	853	859	PF00498	0.519
LIG_LIR_Apic_2	31	36	PF02991	0.639
LIG_LIR_Apic_2	496	500	PF02991	0.437
LIG_LIR_Apic_2	614	620	PF02991	0.413
LIG_LIR_Apic_2	676	681	PF02991	0.315
LIG_LIR_Apic_2	848	854	PF02991	0.611
LIG_LIR_Gen_1	126	135	PF02991	0.461
LIG_LIR_Gen_1	211	221	PF02991	0.450
LIG_LIR_Gen_1	279	288	PF02991	0.459
LIG_LIR_Gen_1	325	333	PF02991	0.462
LIG_LIR_Gen_1	449	459	PF02991	0.475
LIG_LIR_Gen_1	493	503	PF02991	0.436
LIG_LIR_Nem_3	126	130	PF02991	0.461
LIG_LIR_Nem_3	184	190	PF02991	0.461
LIG_LIR_Nem_3	211	216	PF02991	0.450
LIG_LIR_Nem_3	268	274	PF02991	0.460
LIG_LIR_Nem_3	279	285	PF02991	0.459
LIG_LIR_Nem_3	301	305	PF02991	0.461
LIG_LIR_Nem_3	325	330	PF02991	0.462
LIG_LIR_Nem_3	364	370	PF02991	0.476
LIG_LIR_Nem_3	449	455	PF02991	0.461
LIG_LIR_Nem_3	502	507	PF02991	0.376
LIG_LIR_Nem_3	551	555	PF02991	0.370
LIG_LIR_Nem_3	574	580	PF02991	0.315
LIG_LIR_Nem_3	695	700	PF02991	0.313
LIG_LIR_Nem_3	837	843	PF02991	0.566
LIG_LIR_Nem_3	848	853	PF02991	0.527
LIG_LYPXL_yS_3	706	709	PF13949	0.315
LIG_PCNA_PIPBox_1	861	870	PF02747	0.385
LIG_PCNA_yPIPBox_3	205	216	PF02747	0.461
LIG_PCNA_yPIPBox_3	861	873	PF02747	0.486
LIG_Pex14_1	329	333	PF04695	0.461
LIG_Pex14_1	573	577	PF04695	0.315
LIG_Pex14_1	836	840	PF04695	0.569
LIG_Rb_LxCxE_1	601	621	PF01857	0.322
LIG_Rb_pABgroove_1	63	71	PF01858	0.461
LIG_REV1ctd_RIR_1	310	317	PF16727	0.492
LIG_SH2_CRK	348	352	PF00017	0.541
LIG_SH2_CRK	452	456	PF00017	0.461
LIG_SH2_GRB2like	697	700	PF00017	0.315
LIG_SH2_NCK_1	617	621	PF00017	0.315
LIG_SH2_PTP2	282	285	PF00017	0.476
LIG_SH2_SRC	547	550	PF00017	0.345
LIG_SH2_STAP1	190	194	PF00017	0.461
LIG_SH2_STAP1	452	456	PF00017	0.541
LIG_SH2_STAT5	127	130	PF00017	0.464
LIG_SH2_STAT5	187	190	PF00017	0.461
LIG_SH2_STAT5	200	203	PF00017	0.492
LIG_SH2_STAT5	234	237	PF00017	0.477
LIG_SH2_STAT5	282	285	PF00017	0.445
LIG_SH2_STAT5	352	355	PF00017	0.513
LIG_SH2_STAT5	547	550	PF00017	0.345
LIG_SH2_STAT5	617	620	PF00017	0.315
LIG_SH2_STAT5	728	731	PF00017	0.315
LIG_SH2_STAT5	759	762	PF00017	0.448
LIG_SH2_STAT5	76	79	PF00017	0.445
LIG_SH3_3	3	9	PF00018	0.558
LIG_SH3_3	300	306	PF00018	0.461
LIG_SH3_3	535	541	PF00018	0.533
LIG_SH3_3	663	669	PF00018	0.273
LIG_SH3_3	701	707	PF00018	0.315
LIG_SH3_3	741	747	PF00018	0.465
LIG_SUMO_SIM_anti_2	151	158	PF11976	0.475
LIG_SUMO_SIM_anti_2	687	692	PF11976	0.426
LIG_SUMO_SIM_par_1	190	195	PF11976	0.475
LIG_SUMO_SIM_par_1	219	225	PF11976	0.477
LIG_SUMO_SIM_par_1	667	674	PF11976	0.313
LIG_TRFH_1	302	306	PF08558	0.356
LIG_TRFH_1	560	564	PF08558	0.379
LIG_WRC_WIRS_1	309	314	PF05994	0.541
LIG_WRC_WIRS_1	831	836	PF05994	0.684
LIG_WW_3	457	461	PF00397	0.541
MOD_CDK_SPK_2	416	421	PF00069	0.541
MOD_CDK_SPK_2	537	542	PF00069	0.486
MOD_CDK_SPxK_1	304	310	PF00069	0.541
MOD_CK1_1	433	439	PF00069	0.500
MOD_CK1_1	468	474	PF00069	0.472
MOD_CK1_1	85	91	PF00069	0.565
MOD_CK1_1	878	884	PF00069	0.679
MOD_CK2_1	108	114	PF00069	0.461
MOD_CK2_1	529	535	PF00069	0.554
MOD_CK2_1	548	554	PF00069	0.341
MOD_CK2_1	615	621	PF00069	0.325
MOD_CK2_1	668	674	PF00069	0.315
MOD_CK2_1	74	80	PF00069	0.532
MOD_CK2_1	852	858	PF00069	0.503
MOD_CMANNOS	817	820	PF00535	0.509
MOD_GlcNHglycan	227	230	PF01048	0.313
MOD_GlcNHglycan	324	327	PF01048	0.343
MOD_GlcNHglycan	628	631	PF01048	0.309
MOD_GlcNHglycan	754	757	PF01048	0.445
MOD_GlcNHglycan	880	883	PF01048	0.674
MOD_GSK3_1	216	223	PF00069	0.562
MOD_GSK3_1	304	311	PF00069	0.521
MOD_GSK3_1	412	419	PF00069	0.432
MOD_GSK3_1	446	453	PF00069	0.461
MOD_GSK3_1	465	472	PF00069	0.466
MOD_GSK3_1	482	489	PF00069	0.569
MOD_GSK3_1	507	514	PF00069	0.408
MOD_GSK3_1	70	77	PF00069	0.471
MOD_GSK3_1	82	89	PF00069	0.448
MOD_LATS_1	828	834	PF00433	0.650
MOD_N-GLC_1	136	141	PF02516	0.292
MOD_N-GLC_1	208	213	PF02516	0.261
MOD_N-GLC_1	797	802	PF02516	0.543
MOD_N-GLC_2	766	768	PF02516	0.399
MOD_NEK2_1	13	18	PF00069	0.635
MOD_NEK2_1	188	193	PF00069	0.475
MOD_NEK2_1	29	34	PF00069	0.514
MOD_NEK2_1	391	396	PF00069	0.492
MOD_NEK2_1	450	455	PF00069	0.461
MOD_NEK2_1	615	620	PF00069	0.357
MOD_NEK2_1	709	714	PF00069	0.298
MOD_NEK2_1	752	757	PF00069	0.372
MOD_NEK2_1	773	778	PF00069	0.406
MOD_NEK2_1	799	804	PF00069	0.534
MOD_NEK2_1	86	91	PF00069	0.466
MOD_NEK2_1	93	98	PF00069	0.456
MOD_NEK2_2	308	313	PF00069	0.541
MOD_NEK2_2	875	880	PF00069	0.632
MOD_PIKK_1	470	476	PF00454	0.522
MOD_PIKK_1	482	488	PF00454	0.422
MOD_PIKK_1	53	59	PF00454	0.531
MOD_PIKK_1	70	76	PF00454	0.461
MOD_PIKK_1	773	779	PF00454	0.412
MOD_PK_1	172	178	PF00069	0.541
MOD_PK_1	598	604	PF00069	0.413
MOD_PKA_1	571	577	PF00069	0.315
MOD_PKA_2	179	185	PF00069	0.461
MOD_PKA_2	216	222	PF00069	0.558
MOD_PKA_2	274	280	PF00069	0.492
MOD_PKA_2	29	35	PF00069	0.587
MOD_PKA_2	486	492	PF00069	0.547
MOD_PKA_2	571	577	PF00069	0.315
MOD_PKA_2	70	76	PF00069	0.475
MOD_PKA_2	702	708	PF00069	0.326
MOD_PKA_2	752	758	PF00069	0.407
MOD_PKA_2	875	881	PF00069	0.645
MOD_PKA_2	93	99	PF00069	0.565
MOD_Plk_1	172	178	PF00069	0.541
MOD_Plk_1	208	214	PF00069	0.461
MOD_Plk_4	208	214	PF00069	0.461
MOD_Plk_4	308	314	PF00069	0.541
MOD_Plk_4	446	452	PF00069	0.492
MOD_Plk_4	499	505	PF00069	0.434
MOD_Plk_4	659	665	PF00069	0.315
MOD_ProDKin_1	304	310	PF00069	0.539
MOD_ProDKin_1	416	422	PF00069	0.523
MOD_ProDKin_1	433	439	PF00069	0.368
MOD_ProDKin_1	490	496	PF00069	0.505
MOD_ProDKin_1	537	543	PF00069	0.454
MOD_SUMO_rev_2	103	109	PF00179	0.490
MOD_SUMO_rev_2	273	283	PF00179	0.525
MOD_SUMO_rev_2	287	291	PF00179	0.398
MOD_SUMO_rev_2	311	319	PF00179	0.522
MOD_SUMO_rev_2	364	370	PF00179	0.513
MOD_SUMO_rev_2	856	864	PF00179	0.589
TRG_DiLeu_BaEn_1	366	371	PF01217	0.461
TRG_DiLeu_BaEn_2	768	774	PF01217	0.380
TRG_DiLeu_BaEn_4	769	775	PF01217	0.384
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.356
TRG_ENDOCYTIC_2	127	130	PF00928	0.475
TRG_ENDOCYTIC_2	282	285	PF00928	0.445
TRG_ENDOCYTIC_2	348	351	PF00928	0.541
TRG_ENDOCYTIC_2	452	455	PF00928	0.461
TRG_ENDOCYTIC_2	504	507	PF00928	0.385
TRG_ENDOCYTIC_2	552	555	PF00928	0.379
TRG_ENDOCYTIC_2	565	568	PF00928	0.353
TRG_ENDOCYTIC_2	697	700	PF00928	0.313
TRG_ENDOCYTIC_2	706	709	PF00928	0.326
TRG_ER_diArg_1	145	148	PF00400	0.475
TRG_ER_diArg_1	19	21	PF00400	0.492
TRG_ER_diArg_1	569	572	PF00400	0.315
TRG_ER_diArg_1	750	753	PF00400	0.380
TRG_NES_CRM1_1	769	781	PF08389	0.391
TRG_NLS_MonoExtC_3	145	151	PF00514	0.475
TRG_NLS_MonoExtN_4	838	845	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	894	898	PF00026	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	24%	100%
A0A0N0P803	Leptomonas seymouri	24%	100%
A0A0N1PDP3	Leptomonas seymouri	87%	100%
A0A0S4J065	Bodo saltans	65%	97%
A0A0S4JND1	Bodo saltans	25%	100%
A0A1X0NKN5	Trypanosomatidae	76%	99%
A0A1X0NMH6	Trypanosomatidae	25%	100%
A0A3Q8IGZ3	Leishmania donovani	24%	100%
A0A3Q8IJI4	Leishmania donovani	22%	100%
A0A3S5H5P5	Leishmania donovani	96%	100%
A0A422N761	Trypanosoma rangeli	26%	100%
A4H4J9	Leishmania braziliensis	93%	100%
A4H5Q8	Leishmania braziliensis	24%	95%
A4HQJ7	Leishmania braziliensis	22%	100%
A4HSS5	Leishmania infantum	97%	100%
A4HTZ8	Leishmania infantum	24%	100%
A4ICB5	Leishmania infantum	22%	100%
A5LFV8	Macaca fascicularis	26%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A3P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AMS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	94%
E9AUB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	91%
O07834	Pseudoxanthomonas mexicana	27%	100%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	24%	100%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	26%	100%
Q06903	Aeromonas hydrophila	23%	100%
Q32N48	Xenopus laevis	26%	100%
Q4J6C6	Homo sapiens	25%	100%
Q4Q080	Leishmania major	22%	100%
Q4QHU7	Leishmania major	24%	95%
Q4QJ45	Leishmania major	96%	100%
Q59536	Moraxella lacunata	25%	100%
Q5HZA6	Rattus norvegicus	25%	100%
Q5RAK4	Pongo abelii	25%	100%
Q5ZKL5	Gallus gallus	26%	100%
Q8C167	Mus musculus	24%	100%
Q9XTA2	Bos taurus	21%	100%
V5B5S3	Trypanosoma cruzi	76%	100%
V5B860	Trypanosoma cruzi	25%	100%