Putative ribonuclease H1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease H1, putative

Species:

Leishmania mexicana

UniProt:

E9AKQ7_LEIMU

TriTrypDb:

LmxM.06.0290

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043137	DNA replication, removal of RNA primer	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0004521	RNA endonuclease activity	5	11
GO:0004523	RNA-DNA hybrid ribonuclease activity	7	11
GO:0004540	RNA nuclease activity	4	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.688
CLV_PCSK_SKI1_1	140	144	PF00082	0.439
CLV_Separin_Metazoa	203	207	PF03568	0.687
DEG_SPOP_SBC_1	19	23	PF00917	0.725
DOC_ANK_TNKS_1	188	195	PF00023	0.631
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.685
DOC_MAPK_MEF2A_6	120	127	PF00069	0.448
DOC_PP4_FxxP_1	64	67	PF00568	0.285
DOC_USP7_MATH_1	8	12	PF00917	0.667
DOC_WW_Pin1_4	23	28	PF00397	0.700
DOC_WW_Pin1_4	6	11	PF00397	0.652
LIG_14-3-3_CanoR_1	173	178	PF00244	0.700
LIG_14-3-3_CanoR_1	62	67	PF00244	0.351
LIG_14-3-3_CterR_2	246	250	PF00244	0.728
LIG_APCC_ABBA_1	125	130	PF00400	0.308
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BIR_III_4	100	104	PF00653	0.173
LIG_FHA_1	103	109	PF00498	0.450
LIG_FHA_1	117	123	PF00498	0.342
LIG_FHA_2	210	216	PF00498	0.674
LIG_KLC1_Yacidic_2	31	36	PF13176	0.366
LIG_LIR_Gen_1	172	179	PF02991	0.704
LIG_LIR_Nem_3	162	167	PF02991	0.321
LIG_LIR_Nem_3	172	177	PF02991	0.567
LIG_SH2_CRK	174	178	PF00017	0.694
LIG_SH2_NCK_1	174	178	PF00017	0.569
LIG_SH2_SRC	34	37	PF00017	0.308
LIG_SH2_STAP1	141	145	PF00017	0.407
LIG_SH2_STAT3	178	181	PF00017	0.690
LIG_SH2_STAT3	207	210	PF00017	0.671
LIG_SH2_STAT5	128	131	PF00017	0.332
LIG_SH2_STAT5	133	136	PF00017	0.283
LIG_SH2_STAT5	207	210	PF00017	0.671
LIG_SH2_STAT5	34	37	PF00017	0.308
LIG_SUMO_SIM_anti_2	215	224	PF11976	0.515
LIG_SUMO_SIM_anti_2	238	245	PF11976	0.616
LIG_TRAF2_2	157	162	PF00917	0.448
MOD_CDK_SPK_2	23	28	PF00069	0.463
MOD_CK1_1	6	12	PF00069	0.662
MOD_CK2_1	150	156	PF00069	0.405
MOD_GlcNHglycan	109	113	PF01048	0.461
MOD_GlcNHglycan	5	8	PF01048	0.687
MOD_GSK3_1	17	24	PF00069	0.713
MOD_GSK3_1	205	212	PF00069	0.701
MOD_GSK3_1	37	44	PF00069	0.382
MOD_GSK3_1	6	13	PF00069	0.711
MOD_GSK3_1	68	75	PF00069	0.411
MOD_LATS_1	224	230	PF00433	0.616
MOD_N-GLC_1	41	46	PF02516	0.405
MOD_N-GLC_1	62	67	PF02516	0.379
MOD_NEK2_1	1	6	PF00069	0.683
MOD_NEK2_1	102	107	PF00069	0.420
MOD_NEK2_1	12	17	PF00069	0.620
MOD_NEK2_1	150	155	PF00069	0.336
MOD_NEK2_1	18	23	PF00069	0.692
MOD_NEK2_1	236	241	PF00069	0.678
MOD_NEK2_1	70	75	PF00069	0.448
MOD_PIKK_1	70	76	PF00454	0.448
MOD_PKA_2	205	211	PF00069	0.745
MOD_PKB_1	171	179	PF00069	0.703
MOD_Plk_4	173	179	PF00069	0.728
MOD_ProDKin_1	23	29	PF00069	0.699
MOD_ProDKin_1	6	12	PF00069	0.652
TRG_DiLeu_BaEn_1	218	223	PF01217	0.742
TRG_ENDOCYTIC_2	174	177	PF00928	0.649
TRG_ENDOCYTIC_2	55	58	PF00928	0.429
TRG_ER_diArg_1	168	171	PF00400	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC83	Leptomonas seymouri	61%	72%
A0A0S4IX23	Bodo saltans	35%	82%
A0A1X0NJL6	Trypanosomatidae	31%	69%
A0A3R7MD61	Trypanosoma rangeli	37%	68%
A0A3S7WPF2	Leishmania donovani	92%	100%
A4H4J5	Leishmania braziliensis	80%	100%
A4HSS0	Leishmania infantum	93%	100%
C9ZTC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	83%
O60930	Homo sapiens	27%	87%
O70338	Mus musculus	26%	88%
Q4QJ50	Leishmania major	92%	100%
Q5BK46	Rattus norvegicus	27%	88%
Q9UST8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	95%
V5BEV1	Trypanosoma cruzi	35%	77%