FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKQ6_LEIMU

TriTrypDb:

LmxM.06.0280

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0030870	Mre11 complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0140513	nuclear protein-containing complex	2	8
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKQ6

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	8
GO:0000077	DNA damage checkpoint signaling	5	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006302	double-strand break repair	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0007093	mitotic cell cycle checkpoint signaling	4	8
GO:0007095	mitotic G2 DNA damage checkpoint signaling	6	8
GO:0007165	signal transduction	2	8
GO:0007346	regulation of mitotic cell cycle	5	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	8
GO:0010564	regulation of cell cycle process	5	8
GO:0010948	negative regulation of cell cycle process	6	8
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	8
GO:0022402	cell cycle process	2	8
GO:0031570	DNA integrity checkpoint signaling	5	8
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0035556	intracellular signal transduction	3	8
GO:0042770	signal transduction in response to DNA damage	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044773	mitotic DNA damage checkpoint signaling	6	8
GO:0044774	mitotic DNA integrity checkpoint signaling	5	8
GO:0044818	mitotic G2/M transition checkpoint	5	8
GO:0045786	negative regulation of cell cycle	5	8
GO:0045930	negative regulation of mitotic cell cycle	6	8
GO:0046483	heterocycle metabolic process	3	8
GO:0048519	negative regulation of biological process	3	8
GO:0048523	negative regulation of cellular process	4	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0051726	regulation of cell cycle	4	8
GO:0065007	biological regulation	1	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901987	regulation of cell cycle phase transition	6	8
GO:1901988	negative regulation of cell cycle phase transition	7	8
GO:1901990	regulation of mitotic cell cycle phase transition	6	8
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	8
GO:1902749	regulation of cell cycle G2/M phase transition	7	8
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	8
GO:1903047	mitotic cell cycle process	3	8
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0051276	chromosome organization	5	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	610	614	PF00656	0.642
CLV_C14_Caspase3-7	66	70	PF00656	0.419
CLV_NRD_NRD_1	408	410	PF00675	0.459
CLV_NRD_NRD_1	574	576	PF00675	0.645
CLV_NRD_NRD_1	605	607	PF00675	0.662
CLV_NRD_NRD_1	708	710	PF00675	0.579
CLV_NRD_NRD_1	766	768	PF00675	0.616
CLV_NRD_NRD_1	772	774	PF00675	0.599
CLV_NRD_NRD_1	803	805	PF00675	0.553
CLV_PCSK_FUR_1	706	710	PF00082	0.536
CLV_PCSK_KEX2_1	135	137	PF00082	0.702
CLV_PCSK_KEX2_1	408	410	PF00082	0.454
CLV_PCSK_KEX2_1	574	576	PF00082	0.673
CLV_PCSK_KEX2_1	605	607	PF00082	0.648
CLV_PCSK_KEX2_1	708	710	PF00082	0.579
CLV_PCSK_KEX2_1	765	767	PF00082	0.616
CLV_PCSK_KEX2_1	772	774	PF00082	0.596
CLV_PCSK_KEX2_1	803	805	PF00082	0.553
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.702
CLV_PCSK_PC7_1	799	805	PF00082	0.558
CLV_PCSK_SKI1_1	348	352	PF00082	0.488
CLV_PCSK_SKI1_1	409	413	PF00082	0.419
CLV_PCSK_SKI1_1	461	465	PF00082	0.552
CLV_PCSK_SKI1_1	476	480	PF00082	0.340
CLV_PCSK_SKI1_1	620	624	PF00082	0.654
CLV_PCSK_SKI1_1	683	687	PF00082	0.563
CLV_PCSK_SKI1_1	690	694	PF00082	0.529
DEG_APCC_DBOX_1	347	355	PF00400	0.413
DEG_APCC_DBOX_1	460	468	PF00400	0.462
DEG_COP1_1	714	723	PF00400	0.620
DEG_Nend_Nbox_1	1	3	PF02207	0.310
DEG_SCF_FBW7_1	254	261	PF00400	0.631
DEG_SPOP_SBC_1	377	381	PF00917	0.469
DEG_SPOP_SBC_1	455	459	PF00917	0.522
DOC_CKS1_1	314	319	PF01111	0.376
DOC_CYCLIN_RxL_1	405	416	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	649	655	PF00134	0.574
DOC_MAPK_gen_1	21	31	PF00069	0.433
DOC_MAPK_gen_1	282	292	PF00069	0.399
DOC_MAPK_gen_1	473	481	PF00069	0.418
DOC_MAPK_MEF2A_6	145	154	PF00069	0.534
DOC_MAPK_MEF2A_6	326	333	PF00069	0.396
DOC_MAPK_MEF2A_6	39	48	PF00069	0.365
DOC_PP1_RVXF_1	182	188	PF00149	0.331
DOC_PP1_RVXF_1	436	442	PF00149	0.438
DOC_PP2B_LxvP_1	449	452	PF13499	0.485
DOC_PP2B_LxvP_1	521	524	PF13499	0.436
DOC_PP4_FxxP_1	375	378	PF00568	0.478
DOC_PP4_FxxP_1	618	621	PF00568	0.660
DOC_PP4_FxxP_1	661	664	PF00568	0.468
DOC_USP7_MATH_1	334	338	PF00917	0.504
DOC_USP7_MATH_1	342	346	PF00917	0.331
DOC_USP7_MATH_1	358	362	PF00917	0.545
DOC_USP7_MATH_1	386	390	PF00917	0.649
DOC_USP7_MATH_1	394	398	PF00917	0.412
DOC_USP7_MATH_1	455	459	PF00917	0.561
DOC_USP7_MATH_1	466	470	PF00917	0.438
DOC_USP7_MATH_1	548	552	PF00917	0.459
DOC_USP7_MATH_1	637	641	PF00917	0.655
DOC_USP7_MATH_1	836	840	PF00917	0.557
DOC_USP7_UBL2_3	686	690	PF12436	0.553
DOC_WW_Pin1_4	107	112	PF00397	0.461
DOC_WW_Pin1_4	254	259	PF00397	0.624
DOC_WW_Pin1_4	260	265	PF00397	0.632
DOC_WW_Pin1_4	313	318	PF00397	0.364
DOC_WW_Pin1_4	325	330	PF00397	0.387
DOC_WW_Pin1_4	373	378	PF00397	0.658
DOC_WW_Pin1_4	6	11	PF00397	0.437
DOC_WW_Pin1_4	784	789	PF00397	0.593
DOC_WW_Pin1_4	90	95	PF00397	0.738
LIG_14-3-3_CanoR_1	138	148	PF00244	0.651
LIG_14-3-3_CanoR_1	166	170	PF00244	0.410
LIG_14-3-3_CanoR_1	285	291	PF00244	0.386
LIG_14-3-3_CanoR_1	447	452	PF00244	0.553
LIG_14-3-3_CanoR_1	454	464	PF00244	0.353
LIG_14-3-3_CanoR_1	498	504	PF00244	0.421
LIG_14-3-3_CanoR_1	574	582	PF00244	0.584
LIG_14-3-3_CanoR_1	672	679	PF00244	0.472
LIG_Actin_WH2_2	169	186	PF00022	0.419
LIG_APCC_ABBA_1	3	8	PF00400	0.366
LIG_APCC_ABBA_1	478	483	PF00400	0.404
LIG_BIR_III_2	577	581	PF00653	0.645
LIG_BRCT_BRCA1_1	748	752	PF00533	0.557
LIG_BRCT_BRCA1_1	838	842	PF00533	0.559
LIG_Clathr_ClatBox_1	185	189	PF01394	0.393
LIG_Clathr_ClatBox_1	699	703	PF01394	0.614
LIG_deltaCOP1_diTrp_1	613	618	PF00928	0.660
LIG_EVH1_1	521	525	PF00568	0.450
LIG_EVH1_1	655	659	PF00568	0.551
LIG_FHA_1	153	159	PF00498	0.473
LIG_FHA_1	171	177	PF00498	0.513
LIG_FHA_1	221	227	PF00498	0.582
LIG_FHA_1	293	299	PF00498	0.335
LIG_FHA_1	300	306	PF00498	0.330
LIG_FHA_1	41	47	PF00498	0.409
LIG_FHA_1	414	420	PF00498	0.396
LIG_FHA_1	482	488	PF00498	0.550
LIG_FHA_1	643	649	PF00498	0.636
LIG_FHA_1	715	721	PF00498	0.589
LIG_FHA_1	73	79	PF00498	0.423
LIG_FHA_1	818	824	PF00498	0.522
LIG_FHA_2	533	539	PF00498	0.483
LIG_FHA_2	555	561	PF00498	0.596
LIG_FHA_2	785	791	PF00498	0.508
LIG_FHA_2	87	93	PF00498	0.583
LIG_Integrin_RGD_1	595	597	PF01839	0.555
LIG_LIR_Apic_2	157	163	PF02991	0.425
LIG_LIR_Apic_2	337	342	PF02991	0.474
LIG_LIR_Apic_2	373	378	PF02991	0.484
LIG_LIR_Apic_2	617	621	PF02991	0.621
LIG_LIR_Gen_1	167	176	PF02991	0.431
LIG_LIR_Gen_1	416	425	PF02991	0.387
LIG_LIR_Gen_1	535	544	PF02991	0.456
LIG_LIR_Gen_1	613	622	PF02991	0.652
LIG_LIR_Gen_1	749	759	PF02991	0.614
LIG_LIR_Gen_1	839	850	PF02991	0.593
LIG_LIR_Nem_3	167	172	PF02991	0.439
LIG_LIR_Nem_3	344	350	PF02991	0.413
LIG_LIR_Nem_3	410	415	PF02991	0.356
LIG_LIR_Nem_3	416	420	PF02991	0.319
LIG_LIR_Nem_3	505	511	PF02991	0.333
LIG_LIR_Nem_3	535	539	PF02991	0.527
LIG_LIR_Nem_3	613	618	PF02991	0.655
LIG_LIR_Nem_3	749	755	PF02991	0.613
LIG_LIR_Nem_3	839	845	PF02991	0.601
LIG_LIR_Nem_3	9	15	PF02991	0.402
LIG_OCRL_FandH_1	469	481	PF00620	0.417
LIG_Pex14_1	2	6	PF04695	0.312
LIG_Pex14_1	346	350	PF04695	0.425
LIG_REV1ctd_RIR_1	468	477	PF16727	0.430
LIG_SH2_CRK	287	291	PF00017	0.416
LIG_SH2_CRK	508	512	PF00017	0.390
LIG_SH2_CRK	653	657	PF00017	0.609
LIG_SH2_GRB2like	431	434	PF00017	0.248
LIG_SH2_NCK_1	122	126	PF00017	0.554
LIG_SH2_NCK_1	287	291	PF00017	0.410
LIG_SH2_NCK_1	653	657	PF00017	0.609
LIG_SH2_SRC	122	125	PF00017	0.550
LIG_SH2_SRC	339	342	PF00017	0.425
LIG_SH2_SRC	425	428	PF00017	0.324
LIG_SH2_SRC	431	434	PF00017	0.355
LIG_SH2_STAP1	425	429	PF00017	0.366
LIG_SH2_STAT5	339	342	PF00017	0.425
LIG_SH2_STAT5	401	404	PF00017	0.425
LIG_SH2_STAT5	431	434	PF00017	0.406
LIG_SH3_1	326	332	PF00018	0.394
LIG_SH3_1	519	525	PF00018	0.445
LIG_SH3_1	653	659	PF00018	0.611
LIG_SH3_3	326	332	PF00018	0.394
LIG_SH3_3	351	357	PF00018	0.365
LIG_SH3_3	483	489	PF00018	0.481
LIG_SH3_3	519	525	PF00018	0.485
LIG_SH3_3	527	533	PF00018	0.480
LIG_SH3_3	577	583	PF00018	0.604
LIG_SH3_3	653	659	PF00018	0.567
LIG_SH3_3	692	698	PF00018	0.599
LIG_SUMO_SIM_anti_2	645	650	PF11976	0.612
LIG_SUMO_SIM_par_1	63	72	PF11976	0.427
LIG_SUMO_SIM_par_1	697	703	PF11976	0.614
LIG_SUMO_SIM_par_1	808	817	PF11976	0.644
LIG_TRAF2_1	535	538	PF00917	0.489
LIG_TRAF2_1	557	560	PF00917	0.638
LIG_TRAF2_1	561	564	PF00917	0.624
LIG_TRFH_1	653	657	PF08558	0.609
LIG_TYR_ITIM	506	511	PF00017	0.329
LIG_WRC_WIRS_1	467	472	PF05994	0.414
MOD_CDK_SPxxK_3	784	791	PF00069	0.629
MOD_CK1_1	139	145	PF00069	0.628
MOD_CK1_1	222	228	PF00069	0.581
MOD_CK1_1	244	250	PF00069	0.559
MOD_CK1_1	373	379	PF00069	0.623
MOD_CK1_1	413	419	PF00069	0.416
MOD_CK1_1	456	462	PF00069	0.603
MOD_CK1_1	502	508	PF00069	0.417
MOD_CK1_1	632	638	PF00069	0.536
MOD_CK1_1	714	720	PF00069	0.753
MOD_CK2_1	224	230	PF00069	0.616
MOD_CK2_1	532	538	PF00069	0.495
MOD_CK2_1	554	560	PF00069	0.589
MOD_Cter_Amidation	572	575	PF01082	0.681
MOD_GlcNHglycan	138	141	PF01048	0.736
MOD_GlcNHglycan	142	145	PF01048	0.769
MOD_GlcNHglycan	189	193	PF01048	0.348
MOD_GlcNHglycan	226	229	PF01048	0.577
MOD_GlcNHglycan	233	236	PF01048	0.605
MOD_GlcNHglycan	251	254	PF01048	0.552
MOD_GlcNHglycan	258	261	PF01048	0.626
MOD_GlcNHglycan	388	391	PF01048	0.518
MOD_GlcNHglycan	412	415	PF01048	0.420
MOD_GlcNHglycan	449	452	PF01048	0.521
MOD_GlcNHglycan	550	553	PF01048	0.405
MOD_GlcNHglycan	639	642	PF01048	0.600
MOD_GlcNHglycan	748	751	PF01048	0.553
MOD_GlcNHglycan	780	783	PF01048	0.673
MOD_GlcNHglycan	835	839	PF01048	0.586
MOD_GSK3_1	136	143	PF00069	0.683
MOD_GSK3_1	215	222	PF00069	0.502
MOD_GSK3_1	224	231	PF00069	0.582
MOD_GSK3_1	242	249	PF00069	0.478
MOD_GSK3_1	254	261	PF00069	0.713
MOD_GSK3_1	274	281	PF00069	0.350
MOD_GSK3_1	288	295	PF00069	0.327
MOD_GSK3_1	33	40	PF00069	0.376
MOD_GSK3_1	366	373	PF00069	0.614
MOD_GSK3_1	376	383	PF00069	0.668
MOD_GSK3_1	386	393	PF00069	0.496
MOD_GSK3_1	453	460	PF00069	0.528
MOD_GSK3_1	544	551	PF00069	0.520
MOD_GSK3_1	626	633	PF00069	0.669
MOD_GSK3_1	63	70	PF00069	0.404
MOD_GSK3_1	670	677	PF00069	0.581
MOD_GSK3_1	778	785	PF00069	0.527
MOD_GSK3_1	86	93	PF00069	0.757
MOD_LATS_1	134	140	PF00433	0.489
MOD_N-GLC_1	432	437	PF02516	0.252
MOD_N-GLC_1	481	486	PF02516	0.461
MOD_N-GLC_1	637	642	PF02516	0.598
MOD_NEK2_1	188	193	PF00069	0.500
MOD_NEK2_1	246	251	PF00069	0.544
MOD_NEK2_1	292	297	PF00069	0.377
MOD_NEK2_1	42	47	PF00069	0.413
MOD_NEK2_1	432	437	PF00069	0.356
MOD_NEK2_1	453	458	PF00069	0.639
MOD_NEK2_1	48	53	PF00069	0.519
MOD_NEK2_1	598	603	PF00069	0.637
MOD_NEK2_1	67	72	PF00069	0.420
MOD_NEK2_1	711	716	PF00069	0.547
MOD_NEK2_2	466	471	PF00069	0.403
MOD_NEK2_2	514	519	PF00069	0.424
MOD_PIKK_1	220	226	PF00454	0.576
MOD_PIKK_1	228	234	PF00454	0.542
MOD_PIKK_1	246	252	PF00454	0.517
MOD_PIKK_1	563	569	PF00454	0.706
MOD_PKA_1	766	772	PF00069	0.666
MOD_PKA_2	165	171	PF00069	0.460
MOD_PKA_2	453	459	PF00069	0.396
MOD_PKA_2	573	579	PF00069	0.594
MOD_PKA_2	671	677	PF00069	0.498
MOD_PKA_2	766	772	PF00069	0.666
MOD_PKB_1	136	144	PF00069	0.673
MOD_Plk_1	188	194	PF00069	0.378
MOD_Plk_1	195	201	PF00069	0.428
MOD_Plk_1	275	281	PF00069	0.378
MOD_Plk_1	33	39	PF00069	0.377
MOD_Plk_1	366	372	PF00069	0.566
MOD_Plk_1	68	74	PF00069	0.428
MOD_Plk_2-3	195	201	PF00069	0.269
MOD_Plk_2-3	86	92	PF00069	0.583
MOD_Plk_4	288	294	PF00069	0.305
MOD_Plk_4	342	348	PF00069	0.396
MOD_Plk_4	466	472	PF00069	0.411
MOD_Plk_4	711	717	PF00069	0.539
MOD_ProDKin_1	107	113	PF00069	0.447
MOD_ProDKin_1	254	260	PF00069	0.623
MOD_ProDKin_1	313	319	PF00069	0.363
MOD_ProDKin_1	325	331	PF00069	0.390
MOD_ProDKin_1	373	379	PF00069	0.661
MOD_ProDKin_1	6	12	PF00069	0.432
MOD_ProDKin_1	784	790	PF00069	0.593
MOD_ProDKin_1	90	96	PF00069	0.740
MOD_SUMO_rev_2	632	637	PF00179	0.715
TRG_DiLeu_BaEn_1	507	512	PF01217	0.389
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.336
TRG_DiLeu_LyEn_5	483	488	PF01217	0.481
TRG_ENDOCYTIC_2	287	290	PF00928	0.416
TRG_ENDOCYTIC_2	425	428	PF00928	0.329
TRG_ENDOCYTIC_2	508	511	PF00928	0.332
TRG_ENDOCYTIC_2	658	661	PF00928	0.555
TRG_ER_diArg_1	605	608	PF00400	0.653
TRG_ER_diArg_1	706	709	PF00400	0.535
TRG_ER_diArg_1	765	767	PF00400	0.655
TRG_ER_diArg_1	803	805	PF00400	0.594
TRG_NES_CRM1_1	410	421	PF08389	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V8	Leptomonas seymouri	46%	95%
A0A3S5H5P2	Leishmania donovani	88%	100%
A0A422NE28	Trypanosoma rangeli	30%	100%
A4H4J4	Leishmania braziliensis	73%	98%
A4HSR9	Leishmania infantum	88%	100%
Q4QJ51	Leishmania major	88%	100%