Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKQ5_LEIMU

TriTrypDb:

LmxM.06.0270

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AKQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.619
CLV_C14_Caspase3-7	56	60	PF00656	0.544
CLV_C14_Caspase3-7	62	66	PF00656	0.463
CLV_NRD_NRD_1	129	131	PF00675	0.608
CLV_NRD_NRD_1	280	282	PF00675	0.665
CLV_NRD_NRD_1	283	285	PF00675	0.662
CLV_NRD_NRD_1	29	31	PF00675	0.507
CLV_PCSK_KEX2_1	129	131	PF00082	0.633
CLV_PCSK_KEX2_1	280	282	PF00082	0.643
CLV_PCSK_KEX2_1	29	31	PF00082	0.609
CLV_PCSK_SKI1_1	259	263	PF00082	0.663
DEG_Nend_UBRbox_2	1	3	PF02207	0.716
DOC_MAPK_MEF2A_6	76	85	PF00069	0.567
DOC_PP1_RVXF_1	82	88	PF00149	0.426
DOC_PP2B_LxvP_1	20	23	PF13499	0.418
DOC_PP4_FxxP_1	55	58	PF00568	0.558
DOC_USP7_MATH_1	273	277	PF00917	0.675
DOC_WW_Pin1_4	110	115	PF00397	0.570
DOC_WW_Pin1_4	176	181	PF00397	0.575
DOC_WW_Pin1_4	263	268	PF00397	0.648
LIG_14-3-3_CanoR_1	129	137	PF00244	0.550
LIG_14-3-3_CanoR_1	212	217	PF00244	0.624
LIG_14-3-3_CanoR_1	84	92	PF00244	0.439
LIG_FHA_1	120	126	PF00498	0.616
LIG_FHA_1	183	189	PF00498	0.674
LIG_FHA_1	44	50	PF00498	0.491
LIG_FHA_1	52	58	PF00498	0.435
LIG_FHA_2	2	8	PF00498	0.653
LIG_FHA_2	60	66	PF00498	0.495
LIG_LIR_Apic_2	2	8	PF02991	0.653
LIG_LIR_Apic_2	215	219	PF02991	0.718
LIG_LIR_Apic_2	54	58	PF02991	0.560
LIG_LIR_Gen_1	15	23	PF02991	0.425
LIG_LIR_Gen_1	182	190	PF02991	0.731
LIG_LIR_Gen_1	89	100	PF02991	0.485
LIG_LIR_Nem_3	15	20	PF02991	0.428
LIG_LIR_Nem_3	177	181	PF02991	0.608
LIG_LIR_Nem_3	182	186	PF02991	0.615
LIG_LIR_Nem_3	264	268	PF02991	0.709
LIG_LIR_Nem_3	51	55	PF02991	0.569
LIG_LIR_Nem_3	89	95	PF02991	0.489
LIG_MYND_1	135	139	PF01753	0.605
LIG_PDZ_Class_3	307	312	PF00595	0.789
LIG_SH2_CRK	17	21	PF00017	0.440
LIG_SH2_CRK	265	269	PF00017	0.725
LIG_SH2_NCK_1	265	269	PF00017	0.729
LIG_SH2_STAT5	216	219	PF00017	0.598
LIG_SH3_2	77	82	PF14604	0.584
LIG_SH3_3	187	193	PF00018	0.701
LIG_SH3_3	74	80	PF00018	0.593
LIG_SUMO_SIM_par_1	121	127	PF11976	0.633
LIG_SUMO_SIM_par_1	18	24	PF11976	0.476
LIG_TRAF2_1	158	161	PF00917	0.673
LIG_TRAF2_1	307	310	PF00917	0.749
LIG_TRFH_1	186	190	PF08558	0.648
LIG_WRC_WIRS_1	183	188	PF05994	0.733
MOD_CK1_1	105	111	PF00069	0.578
MOD_CK1_1	124	130	PF00069	0.556
MOD_CK1_1	182	188	PF00069	0.638
MOD_CK1_1	21	27	PF00069	0.564
MOD_CK1_1	226	232	PF00069	0.635
MOD_CK2_1	1	7	PF00069	0.697
MOD_Cter_Amidation	278	281	PF01082	0.640
MOD_GlcNHglycan	67	70	PF01048	0.481
MOD_GlcNHglycan	9	12	PF01048	0.650
MOD_GSK3_1	106	113	PF00069	0.505
MOD_GSK3_1	119	126	PF00069	0.468
MOD_GSK3_1	222	229	PF00069	0.716
MOD_GSK3_1	263	270	PF00069	0.587
MOD_GSK3_1	98	105	PF00069	0.549
MOD_N-GLC_1	273	278	PF02516	0.642
MOD_N-GLC_1	85	90	PF02516	0.497
MOD_NEK2_1	1	6	PF00069	0.648
MOD_NEK2_1	106	111	PF00069	0.541
MOD_NEK2_1	123	128	PF00069	0.455
MOD_NEK2_1	204	209	PF00069	0.701
MOD_NEK2_1	288	293	PF00069	0.720
MOD_PIKK_1	128	134	PF00454	0.599
MOD_PIKK_1	293	299	PF00454	0.558
MOD_PKA_2	128	134	PF00069	0.544
MOD_Plk_1	1	7	PF00069	0.697
MOD_Plk_1	241	247	PF00069	0.626
MOD_Plk_1	273	279	PF00069	0.626
MOD_Plk_2-3	59	65	PF00069	0.600
MOD_Plk_4	182	188	PF00069	0.702
MOD_Plk_4	273	279	PF00069	0.637
MOD_Plk_4	98	104	PF00069	0.612
MOD_ProDKin_1	110	116	PF00069	0.576
MOD_ProDKin_1	176	182	PF00069	0.572
MOD_ProDKin_1	263	269	PF00069	0.644
MOD_SUMO_for_1	118	121	PF00179	0.617
TRG_ENDOCYTIC_2	17	20	PF00928	0.412
TRG_ENDOCYTIC_2	183	186	PF00928	0.733
TRG_ENDOCYTIC_2	265	268	PF00928	0.731
TRG_ENDOCYTIC_2	92	95	PF00928	0.474
TRG_ER_diArg_1	128	130	PF00400	0.553
TRG_ER_diArg_1	135	138	PF00400	0.585
TRG_ER_diArg_1	211	214	PF00400	0.588
TRG_ER_diArg_1	257	260	PF00400	0.690
TRG_ER_diArg_1	28	30	PF00400	0.581
TRG_NLS_MonoCore_2	283	288	PF00514	0.559
TRG_NLS_MonoExtN_4	281	288	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE7	Leptomonas seymouri	70%	98%
A0A0S4J5W3	Bodo saltans	33%	100%
A0A1X0NK79	Trypanosomatidae	45%	81%
A0A3R7NJS2	Trypanosoma rangeli	53%	89%
A0A3S5H5P1	Leishmania donovani	95%	100%
A4H4J3	Leishmania braziliensis	88%	100%
A4HSR8	Leishmania infantum	95%	100%
C9ZTC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	85%
Q4QJ52	Leishmania major	95%	100%
V5AQD0	Trypanosoma cruzi	52%	90%