Leucine zipper transcription factor-like protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKQ3_LEIMU

TriTrypDb:

LmxM.06.0250

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AKQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKQ3

Function

Biological processes
Term	Name	Level	Count
GO:0032879	regulation of localization	3	1
GO:0032880	regulation of protein localization	5	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060341	regulation of cellular localization	4	1
GO:0065007	biological regulation	1	1
GO:1903564	regulation of protein localization to cilium	6	1
GO:1903565	negative regulation of protein localization to cilium	6	1
GO:1903828	negative regulation of protein localization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.273
CLV_C14_Caspase3-7	184	188	PF00656	0.496
CLV_NRD_NRD_1	155	157	PF00675	0.342
CLV_NRD_NRD_1	201	203	PF00675	0.535
CLV_PCSK_KEX2_1	155	157	PF00082	0.419
CLV_PCSK_KEX2_1	201	203	PF00082	0.535
CLV_PCSK_KEX2_1	225	227	PF00082	0.530
CLV_PCSK_KEX2_1	30	32	PF00082	0.371
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.530
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.395
CLV_PCSK_SKI1_1	104	108	PF00082	0.519
CLV_PCSK_SKI1_1	121	125	PF00082	0.418
CLV_PCSK_SKI1_1	242	246	PF00082	0.429
CLV_PCSK_SKI1_1	31	35	PF00082	0.465
CLV_PCSK_SKI1_1	86	90	PF00082	0.489
CLV_Separin_Metazoa	198	202	PF03568	0.351
CLV_Separin_Metazoa	83	87	PF03568	0.490
DEG_Nend_UBRbox_2	1	3	PF02207	0.596
DOC_CYCLIN_RxL_1	118	125	PF00134	0.446
DOC_MAPK_gen_1	28	35	PF00069	0.480
DOC_MAPK_gen_1	94	103	PF00069	0.475
DOC_MAPK_MEF2A_6	94	103	PF00069	0.486
DOC_MAPK_NFAT4_5	94	102	PF00069	0.440
LIG_14-3-3_CanoR_1	175	183	PF00244	0.517
LIG_14-3-3_CanoR_1	23	27	PF00244	0.554
LIG_14-3-3_CanoR_1	231	241	PF00244	0.438
LIG_14-3-3_CanoR_1	94	100	PF00244	0.486
LIG_FHA_1	177	183	PF00498	0.496
LIG_FHA_1	40	46	PF00498	0.378
LIG_FHA_1	96	102	PF00498	0.448
LIG_FHA_2	133	139	PF00498	0.497
LIG_FHA_2	49	55	PF00498	0.403
LIG_FHA_2	70	76	PF00498	0.506
LIG_GBD_Chelix_1	55	63	PF00786	0.468
LIG_LIR_Gen_1	165	172	PF02991	0.406
LIG_LIR_Gen_1	235	246	PF02991	0.483
LIG_LIR_Nem_3	165	171	PF02991	0.405
LIG_LIR_Nem_3	235	241	PF02991	0.486
LIG_LIR_Nem_3	263	269	PF02991	0.476
LIG_PCNA_TLS_4	12	19	PF02747	0.400
LIG_Pex14_1	46	50	PF04695	0.555
LIG_REV1ctd_RIR_1	16	24	PF16727	0.491
LIG_SH2_CRK	168	172	PF00017	0.414
LIG_SH2_CRK	238	242	PF00017	0.520
LIG_SH2_NCK_1	50	54	PF00017	0.427
LIG_SH2_SRC	262	265	PF00017	0.449
LIG_SH2_STAP1	168	172	PF00017	0.414
LIG_SH2_STAT5	168	171	PF00017	0.475
LIG_SH2_STAT5	50	53	PF00017	0.411
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.318
LIG_SUMO_SIM_par_1	132	138	PF11976	0.501
LIG_SUMO_SIM_par_1	97	102	PF11976	0.488
LIG_TRAF2_1	135	138	PF00917	0.549
LIG_TYR_ITSM	234	241	PF00017	0.495
MOD_CK1_1	176	182	PF00069	0.500
MOD_CK1_1	22	28	PF00069	0.476
MOD_CK2_1	132	138	PF00069	0.617
MOD_CK2_1	174	180	PF00069	0.559
MOD_CK2_1	48	54	PF00069	0.436
MOD_CK2_1	69	75	PF00069	0.536
MOD_GlcNHglycan	124	127	PF01048	0.530
MOD_GlcNHglycan	137	142	PF01048	0.495
MOD_GlcNHglycan	80	83	PF01048	0.435
MOD_GSK3_1	162	169	PF00069	0.438
MOD_GSK3_1	174	181	PF00069	0.417
MOD_GSK3_1	31	38	PF00069	0.434
MOD_GSK3_1	6	13	PF00069	0.394
MOD_GSK3_1	74	81	PF00069	0.508
MOD_NEK2_1	19	24	PF00069	0.398
MOD_NEK2_1	232	237	PF00069	0.452
MOD_NEK2_1	74	79	PF00069	0.479
MOD_PIKK_1	166	172	PF00454	0.527
MOD_PIKK_1	233	239	PF00454	0.448
MOD_PIKK_1	69	75	PF00454	0.422
MOD_PKA_2	174	180	PF00069	0.514
MOD_PKA_2	19	25	PF00069	0.481
MOD_PKA_2	95	101	PF00069	0.424
MOD_Plk_1	31	37	PF00069	0.483
MOD_Plk_2-3	10	16	PF00069	0.297
MOD_Plk_4	102	108	PF00069	0.480
MOD_Plk_4	178	184	PF00069	0.502
MOD_Plk_4	35	41	PF00069	0.308
MOD_SUMO_for_1	224	227	PF00179	0.537
MOD_SUMO_rev_2	100	106	PF00179	0.472
TRG_ENDOCYTIC_2	168	171	PF00928	0.454
TRG_ENDOCYTIC_2	238	241	PF00928	0.461
TRG_ER_diArg_1	154	156	PF00400	0.353
TRG_ER_diArg_1	200	202	PF00400	0.353
TRG_ER_diArg_1	94	97	PF00400	0.509
TRG_NES_CRM1_1	57	71	PF08389	0.488
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I805	Leptomonas seymouri	77%	100%
A0A1X0NJT8	Trypanosomatidae	40%	82%
A0A3S7WPD4	Leishmania donovani	96%	100%
A0A422MY50	Trypanosoma rangeli	46%	92%
A4H4J1	Leishmania braziliensis	86%	100%
A4HSR6	Leishmania infantum	96%	100%
Q3ZBL4	Bos taurus	25%	93%
Q4QJ54	Leishmania major	95%	100%
Q4R6V9	Macaca fascicularis	25%	93%
Q562C6	Rattus norvegicus	24%	93%
Q5RBR4	Pongo abelii	25%	93%
Q9JHQ5	Mus musculus	25%	93%
Q9NQ48	Homo sapiens	24%	93%
V5BAA5	Trypanosoma cruzi	43%	98%