Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 34

Species:

Leishmania mexicana

UniProt:

E9AKQ2_LEIMU

TriTrypDb:

LmxM.06.0240

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	3
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AKQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.644
CLV_NRD_NRD_1	225	227	PF00675	0.623
CLV_NRD_NRD_1	552	554	PF00675	0.655
CLV_NRD_NRD_1	710	712	PF00675	0.779
CLV_PCSK_KEX2_1	225	227	PF00082	0.623
CLV_PCSK_KEX2_1	4	6	PF00082	0.566
CLV_PCSK_KEX2_1	552	554	PF00082	0.653
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.566
CLV_PCSK_SKI1_1	150	154	PF00082	0.325
CLV_PCSK_SKI1_1	196	200	PF00082	0.719
CLV_PCSK_SKI1_1	558	562	PF00082	0.560
CLV_PCSK_SKI1_1	653	657	PF00082	0.730
DOC_CKS1_1	154	159	PF01111	0.630
DOC_CKS1_1	537	542	PF01111	0.778
DOC_CYCLIN_RxL_1	147	158	PF00134	0.539
DOC_CYCLIN_RxL_1	274	285	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	752	758	PF00134	0.646
DOC_MAPK_gen_1	274	283	PF00069	0.599
DOC_MAPK_gen_1	304	312	PF00069	0.399
DOC_MAPK_MEF2A_6	274	283	PF00069	0.557
DOC_MAPK_MEF2A_6	36	45	PF00069	0.480
DOC_MAPK_MEF2A_6	496	503	PF00069	0.540
DOC_PP1_RVXF_1	148	155	PF00149	0.472
DOC_PP1_RVXF_1	594	600	PF00149	0.585
DOC_PP2B_LxvP_1	466	469	PF13499	0.599
DOC_PP2B_PxIxI_1	592	598	PF00149	0.475
DOC_PP4_FxxP_1	154	157	PF00568	0.522
DOC_PP4_FxxP_1	296	299	PF00568	0.685
DOC_PP4_FxxP_1	404	407	PF00568	0.513
DOC_PP4_FxxP_1	671	674	PF00568	0.727
DOC_USP7_MATH_1	159	163	PF00917	0.546
DOC_USP7_MATH_1	366	370	PF00917	0.628
DOC_USP7_MATH_1	380	384	PF00917	0.502
DOC_USP7_MATH_1	411	415	PF00917	0.473
DOC_USP7_MATH_1	538	542	PF00917	0.650
DOC_USP7_MATH_1	626	630	PF00917	0.778
DOC_USP7_MATH_1	692	696	PF00917	0.726
DOC_USP7_MATH_1	718	722	PF00917	0.727
DOC_USP7_MATH_1	724	728	PF00917	0.692
DOC_USP7_MATH_1	773	777	PF00917	0.666
DOC_USP7_MATH_2	513	519	PF00917	0.706
DOC_WW_Pin1_4	153	158	PF00397	0.502
DOC_WW_Pin1_4	22	27	PF00397	0.430
DOC_WW_Pin1_4	509	514	PF00397	0.686
DOC_WW_Pin1_4	536	541	PF00397	0.765
DOC_WW_Pin1_4	700	705	PF00397	0.715
LIG_14-3-3_CanoR_1	124	130	PF00244	0.438
LIG_14-3-3_CanoR_1	136	141	PF00244	0.529
LIG_14-3-3_CanoR_1	150	155	PF00244	0.485
LIG_14-3-3_CanoR_1	307	311	PF00244	0.558
LIG_14-3-3_CanoR_1	382	392	PF00244	0.725
LIG_14-3-3_CanoR_1	423	432	PF00244	0.459
LIG_14-3-3_CanoR_1	465	469	PF00244	0.582
LIG_14-3-3_CanoR_1	569	579	PF00244	0.549
LIG_14-3-3_CanoR_1	586	590	PF00244	0.534
LIG_14-3-3_CanoR_1	711	716	PF00244	0.486
LIG_APCC_ABBA_1	345	350	PF00400	0.515
LIG_BRCT_BRCA1_1	24	28	PF00533	0.559
LIG_BRCT_BRCA1_1	413	417	PF00533	0.402
LIG_BRCT_BRCA1_1	425	429	PF00533	0.444
LIG_BRCT_BRCA1_1	733	737	PF00533	0.705
LIG_EH_1	664	668	PF12763	0.604
LIG_EVH1_1	536	540	PF00568	0.479
LIG_EVH1_1	671	675	PF00568	0.771
LIG_FHA_1	240	246	PF00498	0.691
LIG_FHA_1	307	313	PF00498	0.507
LIG_FHA_1	425	431	PF00498	0.499
LIG_FHA_1	489	495	PF00498	0.576
LIG_FHA_1	498	504	PF00498	0.476
LIG_FHA_1	509	515	PF00498	0.436
LIG_FHA_1	531	537	PF00498	0.492
LIG_FHA_1	88	94	PF00498	0.498
LIG_FHA_2	242	248	PF00498	0.699
LIG_FHA_2	45	51	PF00498	0.540
LIG_FHA_2	473	479	PF00498	0.607
LIG_FHA_2	56	62	PF00498	0.457
LIG_FHA_2	629	635	PF00498	0.805
LIG_Integrin_RGD_1	741	743	PF01839	0.739
LIG_LIR_Apic_2	128	134	PF02991	0.487
LIG_LIR_Apic_2	153	157	PF02991	0.497
LIG_LIR_Apic_2	402	407	PF02991	0.485
LIG_LIR_Gen_1	102	111	PF02991	0.441
LIG_LIR_Gen_1	143	154	PF02991	0.432
LIG_LIR_Gen_1	160	171	PF02991	0.445
LIG_LIR_Gen_1	343	353	PF02991	0.509
LIG_LIR_Gen_1	357	367	PF02991	0.462
LIG_LIR_Gen_1	414	422	PF02991	0.477
LIG_LIR_Gen_1	426	437	PF02991	0.292
LIG_LIR_Gen_1	451	462	PF02991	0.617
LIG_LIR_Nem_3	102	106	PF02991	0.474
LIG_LIR_Nem_3	143	149	PF02991	0.386
LIG_LIR_Nem_3	160	166	PF02991	0.474
LIG_LIR_Nem_3	25	31	PF02991	0.450
LIG_LIR_Nem_3	343	348	PF02991	0.502
LIG_LIR_Nem_3	357	362	PF02991	0.417
LIG_LIR_Nem_3	402	408	PF02991	0.396
LIG_LIR_Nem_3	414	418	PF02991	0.436
LIG_LIR_Nem_3	426	432	PF02991	0.285
LIG_LIR_Nem_3	44	48	PF02991	0.366
LIG_LIR_Nem_3	451	457	PF02991	0.615
LIG_LIR_Nem_3	559	564	PF02991	0.642
LIG_PAM2_1	662	674	PF00658	0.712
LIG_Pex14_1	212	216	PF04695	0.722
LIG_Pex14_1	401	405	PF04695	0.487
LIG_Pex14_2	24	28	PF04695	0.559
LIG_Pex14_2	599	603	PF04695	0.572
LIG_Pex14_2	667	671	PF04695	0.642
LIG_PROFILIN_1	672	678	PF00235	0.484
LIG_REV1ctd_RIR_1	26	36	PF16727	0.467
LIG_SH2_CRK	146	150	PF00017	0.552
LIG_SH2_CRK	175	179	PF00017	0.635
LIG_SH2_CRK	454	458	PF00017	0.624
LIG_SH2_NCK_1	233	237	PF00017	0.690
LIG_SH2_PTP2	131	134	PF00017	0.533
LIG_SH2_PTP2	405	408	PF00017	0.524
LIG_SH2_SRC	146	149	PF00017	0.540
LIG_SH2_SRC	233	236	PF00017	0.638
LIG_SH2_SRC	405	408	PF00017	0.524
LIG_SH2_STAP1	216	220	PF00017	0.710
LIG_SH2_STAP1	604	608	PF00017	0.556
LIG_SH2_STAT3	267	270	PF00017	0.553
LIG_SH2_STAT3	571	574	PF00017	0.521
LIG_SH2_STAT3	63	66	PF00017	0.569
LIG_SH2_STAT5	103	106	PF00017	0.413
LIG_SH2_STAT5	131	134	PF00017	0.416
LIG_SH2_STAT5	163	166	PF00017	0.515
LIG_SH2_STAT5	267	270	PF00017	0.562
LIG_SH2_STAT5	359	362	PF00017	0.560
LIG_SH2_STAT5	405	408	PF00017	0.442
LIG_SH2_STAT5	454	457	PF00017	0.534
LIG_SH2_STAT5	571	574	PF00017	0.496
LIG_SH2_STAT5	670	673	PF00017	0.710
LIG_SH2_STAT5	680	683	PF00017	0.698
LIG_SH2_STAT5	778	781	PF00017	0.630
LIG_SH2_STAT5	793	796	PF00017	0.667
LIG_SH3_1	542	548	PF00018	0.805
LIG_SH3_1	670	676	PF00018	0.770
LIG_SH3_2	537	542	PF14604	0.743
LIG_SH3_3	163	169	PF00018	0.631
LIG_SH3_3	20	26	PF00018	0.539
LIG_SH3_3	45	51	PF00018	0.582
LIG_SH3_3	473	479	PF00018	0.549
LIG_SH3_3	534	540	PF00018	0.736
LIG_SH3_3	542	548	PF00018	0.763
LIG_SH3_3	669	675	PF00018	0.692
LIG_SUMO_SIM_anti_2	333	343	PF11976	0.674
LIG_SUMO_SIM_anti_2	449	454	PF11976	0.671
LIG_SUMO_SIM_par_1	308	313	PF11976	0.561
LIG_SUMO_SIM_par_1	38	44	PF11976	0.632
LIG_TRAF2_1	475	478	PF00917	0.683
LIG_TRAF2_1	58	61	PF00917	0.507
LIG_TRAF2_1	748	751	PF00917	0.622
LIG_TYR_ITIM	452	457	PF00017	0.614
LIG_WRC_WIRS_1	151	156	PF05994	0.366
LIG_WRC_WIRS_1	42	47	PF05994	0.569
LIG_WRC_WIRS_1	429	434	PF05994	0.434
LIG_WW_1	677	680	PF00397	0.508
MOD_CDK_SPxK_1	536	542	PF00069	0.737
MOD_CK1_1	306	312	PF00069	0.620
MOD_CK1_1	346	352	PF00069	0.431
MOD_CK1_1	383	389	PF00069	0.550
MOD_CK1_1	509	515	PF00069	0.698
MOD_CK1_1	628	634	PF00069	0.763
MOD_CK1_1	643	649	PF00069	0.575
MOD_CK1_1	694	700	PF00069	0.817
MOD_CK1_1	745	751	PF00069	0.676
MOD_CK1_1	776	782	PF00069	0.621
MOD_CK2_1	422	428	PF00069	0.410
MOD_CK2_1	44	50	PF00069	0.535
MOD_CK2_1	472	478	PF00069	0.628
MOD_CK2_1	509	515	PF00069	0.689
MOD_CK2_1	55	61	PF00069	0.449
MOD_CK2_1	745	751	PF00069	0.655
MOD_CK2_1	771	777	PF00069	0.600
MOD_Cter_Amidation	223	226	PF01082	0.712
MOD_GlcNHglycan	199	202	PF01048	0.573
MOD_GlcNHglycan	325	328	PF01048	0.692
MOD_GlcNHglycan	356	359	PF01048	0.635
MOD_GlcNHglycan	368	371	PF01048	0.568
MOD_GlcNHglycan	401	404	PF01048	0.408
MOD_GlcNHglycan	419	422	PF01048	0.445
MOD_GlcNHglycan	518	521	PF01048	0.735
MOD_GlcNHglycan	619	622	PF01048	0.798
MOD_GlcNHglycan	631	634	PF01048	0.747
MOD_GlcNHglycan	694	697	PF01048	0.785
MOD_GlcNHglycan	720	723	PF01048	0.708
MOD_GlcNHglycan	725	729	PF01048	0.708
MOD_GlcNHglycan	773	776	PF01048	0.604
MOD_GSK3_1	132	139	PF00069	0.526
MOD_GSK3_1	153	160	PF00069	0.490
MOD_GSK3_1	237	244	PF00069	0.712
MOD_GSK3_1	354	361	PF00069	0.530
MOD_GSK3_1	380	387	PF00069	0.664
MOD_GSK3_1	407	414	PF00069	0.537
MOD_GSK3_1	424	431	PF00069	0.477
MOD_GSK3_1	432	439	PF00069	0.493
MOD_GSK3_1	464	471	PF00069	0.577
MOD_GSK3_1	505	512	PF00069	0.639
MOD_GSK3_1	552	559	PF00069	0.675
MOD_GSK3_1	580	587	PF00069	0.543
MOD_GSK3_1	613	620	PF00069	0.771
MOD_GSK3_1	625	632	PF00069	0.728
MOD_GSK3_1	639	646	PF00069	0.594
MOD_GSK3_1	691	698	PF00069	0.751
MOD_GSK3_1	699	706	PF00069	0.711
MOD_GSK3_1	776	783	PF00069	0.597
MOD_N-GLC_1	323	328	PF02516	0.649
MOD_NEK2_1	125	130	PF00069	0.393
MOD_NEK2_1	197	202	PF00069	0.745
MOD_NEK2_1	417	422	PF00069	0.432
MOD_NEK2_1	432	437	PF00069	0.460
MOD_NEK2_1	464	469	PF00069	0.582
MOD_NEK2_1	506	511	PF00069	0.618
MOD_NEK2_1	771	776	PF00069	0.551
MOD_NEK2_1	780	785	PF00069	0.546
MOD_NEK2_1	86	91	PF00069	0.406
MOD_NEK2_2	114	119	PF00069	0.427
MOD_NEK2_2	411	416	PF00069	0.462
MOD_PIKK_1	570	576	PF00454	0.594
MOD_PIKK_1	580	586	PF00454	0.623
MOD_PIKK_1	640	646	PF00454	0.683
MOD_PIKK_1	731	737	PF00454	0.786
MOD_PIKK_1	742	748	PF00454	0.730
MOD_PK_1	136	142	PF00069	0.520
MOD_PK_1	556	562	PF00069	0.603
MOD_PK_1	711	717	PF00069	0.485
MOD_PKA_1	552	558	PF00069	0.658
MOD_PKA_1	711	717	PF00069	0.563
MOD_PKA_2	303	309	PF00069	0.650
MOD_PKA_2	383	389	PF00069	0.736
MOD_PKA_2	422	428	PF00069	0.441
MOD_PKA_2	464	470	PF00069	0.587
MOD_PKA_2	552	558	PF00069	0.671
MOD_PKA_2	585	591	PF00069	0.613
MOD_PKB_1	382	390	PF00069	0.645
MOD_Plk_1	584	590	PF00069	0.603
MOD_Plk_1	72	78	PF00069	0.493
MOD_Plk_1	776	782	PF00069	0.555
MOD_Plk_4	159	165	PF00069	0.480
MOD_Plk_4	306	312	PF00069	0.517
MOD_Plk_4	358	364	PF00069	0.571
MOD_Plk_4	432	438	PF00069	0.481
MOD_Plk_4	448	454	PF00069	0.463
MOD_Plk_4	676	682	PF00069	0.715
MOD_ProDKin_1	153	159	PF00069	0.515
MOD_ProDKin_1	22	28	PF00069	0.433
MOD_ProDKin_1	509	515	PF00069	0.689
MOD_ProDKin_1	536	542	PF00069	0.771
MOD_ProDKin_1	700	706	PF00069	0.714
MOD_SUMO_for_1	31	34	PF00179	0.537
TRG_DiLeu_BaEn_2	764	770	PF01217	0.519
TRG_DiLeu_BaEn_4	659	665	PF01217	0.656
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.538
TRG_ENDOCYTIC_2	103	106	PF00928	0.413
TRG_ENDOCYTIC_2	146	149	PF00928	0.549
TRG_ENDOCYTIC_2	163	166	PF00928	0.471
TRG_ENDOCYTIC_2	359	362	PF00928	0.560
TRG_ENDOCYTIC_2	405	408	PF00928	0.425
TRG_ENDOCYTIC_2	454	457	PF00928	0.619
TRG_ER_diArg_1	225	227	PF00400	0.624
TRG_NES_CRM1_1	110	123	PF08389	0.328
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6D8	Leptomonas seymouri	58%	79%
A0A3S5H5N9	Leishmania donovani	86%	95%
A0A422MY92	Trypanosoma rangeli	29%	95%
A4H4J0	Leishmania braziliensis	79%	100%
A4HSR5	Leishmania infantum	86%	95%
C9ZTB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
Q4QJ55	Leishmania major	89%	100%
V5BEV7	Trypanosoma cruzi	28%	95%