FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AKP9_LEIMU

TriTrypDb:

LmxM.06.0210

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKP9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.362
CLV_C14_Caspase3-7	358	362	PF00656	0.611
CLV_C14_Caspase3-7	531	535	PF00656	0.417
CLV_C14_Caspase3-7	78	82	PF00656	0.208
CLV_NRD_NRD_1	331	333	PF00675	0.682
CLV_NRD_NRD_1	430	432	PF00675	0.802
CLV_NRD_NRD_1	588	590	PF00675	0.599
CLV_NRD_NRD_1	593	595	PF00675	0.608
CLV_PCSK_FUR_1	428	432	PF00082	0.533
CLV_PCSK_KEX2_1	331	333	PF00082	0.686
CLV_PCSK_KEX2_1	427	429	PF00082	0.715
CLV_PCSK_KEX2_1	430	432	PF00082	0.728
CLV_PCSK_KEX2_1	443	445	PF00082	0.560
CLV_PCSK_KEX2_1	593	595	PF00082	0.637
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.628
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.595
CLV_PCSK_PC7_1	589	595	PF00082	0.651
CLV_PCSK_SKI1_1	222	226	PF00082	0.468
CLV_PCSK_SKI1_1	230	234	PF00082	0.452
CLV_PCSK_SKI1_1	309	313	PF00082	0.671
CLV_PCSK_SKI1_1	582	586	PF00082	0.499
DEG_SPOP_SBC_1	70	74	PF00917	0.362
DOC_CKS1_1	115	120	PF01111	0.362
DOC_CKS1_1	248	253	PF01111	0.649
DOC_CKS1_1	618	623	PF01111	0.448
DOC_CYCLIN_RxL_1	265	276	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	660	666	PF00134	0.522
DOC_MAPK_DCC_7	364	373	PF00069	0.500
DOC_MAPK_gen_1	502	511	PF00069	0.520
DOC_MAPK_MEF2A_6	505	513	PF00069	0.481
DOC_MAPK_MEF2A_6	525	532	PF00069	0.251
DOC_PP1_RVXF_1	551	558	PF00149	0.399
DOC_PP2B_LxvP_1	217	220	PF13499	0.450
DOC_PP4_FxxP_1	301	304	PF00568	0.601
DOC_USP7_MATH_1	236	240	PF00917	0.484
DOC_USP7_MATH_1	266	270	PF00917	0.652
DOC_USP7_MATH_1	326	330	PF00917	0.718
DOC_USP7_MATH_1	422	426	PF00917	0.730
DOC_USP7_MATH_1	494	498	PF00917	0.708
DOC_USP7_MATH_1	512	516	PF00917	0.260
DOC_USP7_MATH_1	573	577	PF00917	0.617
DOC_USP7_MATH_1	646	650	PF00917	0.405
DOC_USP7_MATH_1	71	75	PF00917	0.359
DOC_USP7_MATH_1	86	90	PF00917	0.222
DOC_USP7_MATH_2	472	478	PF00917	0.522
DOC_WW_Pin1_4	104	109	PF00397	0.299
DOC_WW_Pin1_4	114	119	PF00397	0.252
DOC_WW_Pin1_4	130	135	PF00397	0.358
DOC_WW_Pin1_4	212	217	PF00397	0.428
DOC_WW_Pin1_4	247	252	PF00397	0.629
DOC_WW_Pin1_4	28	33	PF00397	0.448
DOC_WW_Pin1_4	289	294	PF00397	0.576
DOC_WW_Pin1_4	300	305	PF00397	0.593
DOC_WW_Pin1_4	362	367	PF00397	0.693
DOC_WW_Pin1_4	420	425	PF00397	0.668
DOC_WW_Pin1_4	430	435	PF00397	0.573
DOC_WW_Pin1_4	479	484	PF00397	0.633
DOC_WW_Pin1_4	614	619	PF00397	0.550
DOC_WW_Pin1_4	654	659	PF00397	0.465
DOC_WW_Pin1_4	88	93	PF00397	0.364
LIG_14-3-3_CanoR_1	13	19	PF00244	0.390
LIG_14-3-3_CanoR_1	200	207	PF00244	0.552
LIG_14-3-3_CanoR_1	21	27	PF00244	0.406
LIG_14-3-3_CanoR_1	331	337	PF00244	0.755
LIG_14-3-3_CanoR_1	466	470	PF00244	0.438
LIG_Actin_WH2_2	52	67	PF00022	0.208
LIG_BIR_II_1	1	5	PF00653	0.417
LIG_BIR_III_4	396	400	PF00653	0.537
LIG_BRCT_BRCA1_1	47	51	PF00533	0.362
LIG_BRCT_BRCA1_1	648	652	PF00533	0.313
LIG_deltaCOP1_diTrp_1	551	557	PF00928	0.394
LIG_deltaCOP1_diTrp_1	626	632	PF00928	0.380
LIG_DLG_GKlike_1	332	340	PF00625	0.660
LIG_eIF4E_1	187	193	PF01652	0.419
LIG_eIF4E_1	212	218	PF01652	0.486
LIG_FHA_1	131	137	PF00498	0.369
LIG_FHA_1	213	219	PF00498	0.437
LIG_FHA_1	258	264	PF00498	0.601
LIG_FHA_1	300	306	PF00498	0.658
LIG_FHA_1	351	357	PF00498	0.778
LIG_FHA_1	363	369	PF00498	0.659
LIG_FHA_1	457	463	PF00498	0.406
LIG_FHA_1	516	522	PF00498	0.378
LIG_FHA_1	596	602	PF00498	0.686
LIG_FHA_1	606	612	PF00498	0.655
LIG_FHA_2	105	111	PF00498	0.362
LIG_FHA_2	121	127	PF00498	0.216
LIG_FHA_2	281	287	PF00498	0.625
LIG_FHA_2	314	320	PF00498	0.592
LIG_FHA_2	343	349	PF00498	0.681
LIG_FHA_2	76	82	PF00498	0.333
LIG_LIR_Apic_2	185	190	PF02991	0.436
LIG_LIR_Gen_1	459	465	PF02991	0.366
LIG_LIR_Gen_1	474	483	PF02991	0.543
LIG_LIR_Gen_1	6	16	PF02991	0.360
LIG_LIR_Gen_1	649	660	PF02991	0.344
LIG_LIR_Nem_3	474	479	PF02991	0.544
LIG_LIR_Nem_3	6	12	PF02991	0.347
LIG_LIR_Nem_3	649	655	PF02991	0.318
LIG_Pex14_1	628	632	PF04695	0.365
LIG_Pex14_2	281	285	PF04695	0.486
LIG_PTB_Apo_2	389	396	PF02174	0.452
LIG_PTB_Phospho_1	389	395	PF10480	0.504
LIG_SH2_CRK	385	389	PF00017	0.445
LIG_SH2_PTP2	508	511	PF00017	0.401
LIG_SH2_STAT3	636	639	PF00017	0.404
LIG_SH2_STAT5	103	106	PF00017	0.208
LIG_SH2_STAT5	137	140	PF00017	0.299
LIG_SH2_STAT5	212	215	PF00017	0.469
LIG_SH2_STAT5	508	511	PF00017	0.401
LIG_SH3_3	21	27	PF00018	0.459
LIG_SH3_3	240	246	PF00018	0.508
LIG_SH3_3	373	379	PF00018	0.523
LIG_SH3_3	449	455	PF00018	0.538
LIG_SH3_3	506	512	PF00018	0.476
LIG_SH3_3	517	523	PF00018	0.326
LIG_SH3_3	615	621	PF00018	0.524
LIG_SH3_3	638	644	PF00018	0.400
LIG_SH3_3	9	15	PF00018	0.344
LIG_SUMO_SIM_anti_2	260	265	PF11976	0.483
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.658
LIG_SUMO_SIM_par_1	14	19	PF11976	0.287
LIG_SUMO_SIM_par_1	223	229	PF11976	0.526
LIG_SUMO_SIM_par_1	3	8	PF11976	0.267
LIG_SUMO_SIM_par_1	643	649	PF11976	0.458
LIG_TRAF2_1	316	319	PF00917	0.661
LIG_TRAF2_1	349	352	PF00917	0.689
LIG_TRAF2_1	401	404	PF00917	0.662
LIG_TYR_ITIM	383	388	PF00017	0.465
LIG_UBA3_1	59	65	PF00899	0.299
LIG_WRC_WIRS_1	207	212	PF05994	0.343
MOD_CDK_SPK_2	130	135	PF00069	0.216
MOD_CDK_SPK_2	289	294	PF00069	0.570
MOD_CDK_SPxK_1	435	441	PF00069	0.619
MOD_CDK_SPxxK_3	420	427	PF00069	0.670
MOD_CDK_SPxxK_3	479	486	PF00069	0.677
MOD_CDK_SPxxK_3	617	624	PF00069	0.455
MOD_CK1_1	144	150	PF00069	0.333
MOD_CK1_1	247	253	PF00069	0.680
MOD_CK1_1	28	34	PF00069	0.529
MOD_CK1_1	303	309	PF00069	0.684
MOD_CK1_1	433	439	PF00069	0.680
MOD_CK1_1	497	503	PF00069	0.744
MOD_CK1_1	515	521	PF00069	0.257
MOD_CK1_1	617	623	PF00069	0.522
MOD_CK1_1	66	72	PF00069	0.332
MOD_CK1_1	665	671	PF00069	0.542
MOD_CK1_1	74	80	PF00069	0.318
MOD_CK2_1	313	319	PF00069	0.594
MOD_CK2_1	342	348	PF00069	0.677
MOD_CMANNOS	554	557	PF00535	0.369
MOD_Cter_Amidation	329	332	PF01082	0.669
MOD_GlcNHglycan	201	204	PF01048	0.584
MOD_GlcNHglycan	252	255	PF01048	0.699
MOD_GlcNHglycan	275	279	PF01048	0.738
MOD_GlcNHglycan	328	331	PF01048	0.721
MOD_GlcNHglycan	420	423	PF01048	0.763
MOD_GlcNHglycan	424	427	PF01048	0.695
MOD_GlcNHglycan	435	438	PF01048	0.554
MOD_GlcNHglycan	496	499	PF01048	0.684
MOD_GlcNHglycan	546	549	PF01048	0.504
MOD_GlcNHglycan	575	578	PF01048	0.721
MOD_GlcNHglycan	648	651	PF01048	0.355
MOD_GlcNHglycan	667	670	PF01048	0.588
MOD_GSK3_1	136	143	PF00069	0.339
MOD_GSK3_1	206	213	PF00069	0.604
MOD_GSK3_1	232	239	PF00069	0.457
MOD_GSK3_1	299	306	PF00069	0.789
MOD_GSK3_1	309	316	PF00069	0.647
MOD_GSK3_1	326	333	PF00069	0.637
MOD_GSK3_1	418	425	PF00069	0.689
MOD_GSK3_1	45	52	PF00069	0.445
MOD_GSK3_1	497	504	PF00069	0.664
MOD_GSK3_1	511	518	PF00069	0.306
MOD_GSK3_1	66	73	PF00069	0.356
MOD_GSK3_1	667	674	PF00069	0.539
MOD_GSK3_1	82	89	PF00069	0.221
MOD_LATS_1	307	313	PF00433	0.670
MOD_N-GLC_1	144	149	PF02516	0.299
MOD_N-GLC_1	28	33	PF02516	0.408
MOD_N-GLC_1	391	396	PF02516	0.491
MOD_NEK2_1	141	146	PF00069	0.308
MOD_NEK2_1	210	215	PF00069	0.441
MOD_NEK2_1	22	27	PF00069	0.468
MOD_NEK2_1	232	237	PF00069	0.450
MOD_NEK2_1	458	463	PF00069	0.441
MOD_NEK2_1	49	54	PF00069	0.299
MOD_NEK2_1	595	600	PF00069	0.623
MOD_PIKK_1	336	342	PF00454	0.658
MOD_PIKK_1	453	459	PF00454	0.512
MOD_PIKK_1	50	56	PF00454	0.299
MOD_PIKK_1	557	563	PF00454	0.514
MOD_PK_1	597	603	PF00069	0.653
MOD_PKA_2	199	205	PF00069	0.537
MOD_PKA_2	22	28	PF00069	0.466
MOD_PKA_2	244	250	PF00069	0.495
MOD_PKA_2	330	336	PF00069	0.635
MOD_PKA_2	465	471	PF00069	0.316
MOD_PKA_2	501	507	PF00069	0.579
MOD_Plk_1	313	319	PF00069	0.654
MOD_Plk_1	391	397	PF00069	0.469
MOD_Plk_4	144	150	PF00069	0.333
MOD_Plk_4	244	250	PF00069	0.488
MOD_Plk_4	332	338	PF00069	0.662
MOD_Plk_4	45	51	PF00069	0.329
MOD_Plk_4	515	521	PF00069	0.373
MOD_Plk_4	55	61	PF00069	0.377
MOD_Plk_4	662	668	PF00069	0.465
MOD_ProDKin_1	104	110	PF00069	0.299
MOD_ProDKin_1	114	120	PF00069	0.252
MOD_ProDKin_1	130	136	PF00069	0.358
MOD_ProDKin_1	212	218	PF00069	0.430
MOD_ProDKin_1	247	253	PF00069	0.629
MOD_ProDKin_1	28	34	PF00069	0.444
MOD_ProDKin_1	289	295	PF00069	0.577
MOD_ProDKin_1	300	306	PF00069	0.592
MOD_ProDKin_1	362	368	PF00069	0.690
MOD_ProDKin_1	420	426	PF00069	0.668
MOD_ProDKin_1	430	436	PF00069	0.574
MOD_ProDKin_1	479	485	PF00069	0.639
MOD_ProDKin_1	614	620	PF00069	0.536
MOD_ProDKin_1	654	660	PF00069	0.477
MOD_ProDKin_1	88	94	PF00069	0.364
TRG_DiLeu_BaEn_1	228	233	PF01217	0.458
TRG_DiLeu_BaEn_4	228	234	PF01217	0.519
TRG_ENDOCYTIC_2	385	388	PF00928	0.450
TRG_ENDOCYTIC_2	508	511	PF00928	0.374
TRG_ER_diArg_1	21	24	PF00400	0.402
TRG_ER_diArg_1	428	431	PF00400	0.714
TRG_ER_diArg_1	593	595	PF00400	0.497
TRG_NLS_MonoCore_2	426	431	PF00514	0.532
TRG_NLS_MonoExtC_3	426	431	PF00514	0.607
TRG_NLS_MonoExtN_4	424	431	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z7	Leptomonas seymouri	43%	100%
A0A3S7WPD3	Leishmania donovani	88%	100%
A4HSR2	Leishmania infantum	88%	100%
Q4QJ58	Leishmania major	87%	100%