UL124

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UL124

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKP8_LEIMU

TriTrypDb:

LmxM.06.0200

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.647
CLV_NRD_NRD_1	135	137	PF00675	0.726
CLV_NRD_NRD_1	156	158	PF00675	0.689
CLV_NRD_NRD_1	189	191	PF00675	0.595
CLV_NRD_NRD_1	198	200	PF00675	0.504
CLV_NRD_NRD_1	213	215	PF00675	0.627
CLV_NRD_NRD_1	247	249	PF00675	0.615
CLV_NRD_NRD_1	263	265	PF00675	0.668
CLV_NRD_NRD_1	50	52	PF00675	0.741
CLV_NRD_NRD_1	77	79	PF00675	0.764
CLV_PCSK_KEX2_1	135	137	PF00082	0.726
CLV_PCSK_KEX2_1	155	157	PF00082	0.679
CLV_PCSK_KEX2_1	188	190	PF00082	0.613
CLV_PCSK_KEX2_1	198	200	PF00082	0.501
CLV_PCSK_KEX2_1	213	215	PF00082	0.627
CLV_PCSK_KEX2_1	247	249	PF00082	0.615
CLV_PCSK_KEX2_1	263	265	PF00082	0.668
CLV_PCSK_KEX2_1	287	289	PF00082	0.628
CLV_PCSK_KEX2_1	489	491	PF00082	0.485
CLV_PCSK_KEX2_1	50	52	PF00082	0.741
CLV_PCSK_KEX2_1	77	79	PF00082	0.764
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.624
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.485
CLV_PCSK_PC7_1	46	52	PF00082	0.672
CLV_PCSK_PC7_1	485	491	PF00082	0.434
CLV_PCSK_SKI1_1	198	202	PF00082	0.531
CLV_PCSK_SKI1_1	227	231	PF00082	0.733
CLV_PCSK_SKI1_1	485	489	PF00082	0.412
CLV_PCSK_SKI1_1	78	82	PF00082	0.613
DEG_APCC_DBOX_1	77	85	PF00400	0.632
DEG_SCF_FBW7_1	297	303	PF00400	0.517
DEG_SPOP_SBC_1	113	117	PF00917	0.509
DEG_SPOP_SBC_1	306	310	PF00917	0.510
DEG_SPOP_SBC_1	462	466	PF00917	0.406
DOC_CKS1_1	297	302	PF01111	0.514
DOC_MAPK_gen_1	425	435	PF00069	0.467
DOC_MAPK_MEF2A_6	4	11	PF00069	0.611
DOC_MAPK_MEF2A_6	428	435	PF00069	0.453
DOC_PP2B_LxvP_1	250	253	PF13499	0.696
DOC_PP2B_LxvP_1	328	331	PF13499	0.615
DOC_USP7_MATH_1	105	109	PF00917	0.561
DOC_USP7_MATH_1	121	125	PF00917	0.615
DOC_USP7_MATH_1	174	178	PF00917	0.678
DOC_USP7_MATH_1	228	232	PF00917	0.628
DOC_USP7_MATH_1	300	304	PF00917	0.700
DOC_USP7_MATH_1	31	35	PF00917	0.607
DOC_USP7_MATH_1	320	324	PF00917	0.698
DOC_USP7_MATH_1	377	381	PF00917	0.547
DOC_USP7_MATH_1	434	438	PF00917	0.478
DOC_USP7_MATH_1	462	466	PF00917	0.451
DOC_USP7_UBL2_3	428	432	PF12436	0.474
DOC_WW_Pin1_4	10	15	PF00397	0.637
DOC_WW_Pin1_4	296	301	PF00397	0.577
LIG_14-3-3_CanoR_1	135	139	PF00244	0.726
LIG_14-3-3_CanoR_1	23	28	PF00244	0.625
LIG_14-3-3_CanoR_1	263	272	PF00244	0.753
LIG_14-3-3_CanoR_1	288	293	PF00244	0.611
LIG_14-3-3_CanoR_1	327	331	PF00244	0.627
LIG_14-3-3_CanoR_1	391	397	PF00244	0.358
LIG_14-3-3_CanoR_1	418	424	PF00244	0.452
LIG_14-3-3_CanoR_1	456	461	PF00244	0.464
LIG_14-3-3_CanoR_1	463	471	PF00244	0.381
LIG_Actin_WH2_2	403	420	PF00022	0.419
LIG_Actin_WH2_2	471	487	PF00022	0.322
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_Clathr_ClatBox_1	407	411	PF01394	0.337
LIG_FHA_1	16	22	PF00498	0.531
LIG_FHA_1	199	205	PF00498	0.618
LIG_FHA_1	228	234	PF00498	0.677
LIG_FHA_1	235	241	PF00498	0.598
LIG_FHA_1	253	259	PF00498	0.697
LIG_FHA_1	360	366	PF00498	0.656
LIG_FHA_1	39	45	PF00498	0.629
LIG_FHA_1	407	413	PF00498	0.414
LIG_FHA_1	428	434	PF00498	0.514
LIG_FHA_1	441	447	PF00498	0.351
LIG_FHA_2	219	225	PF00498	0.814
LIG_FHA_2	475	481	PF00498	0.404
LIG_FHA_2	86	92	PF00498	0.609
LIG_LIR_Apic_2	291	295	PF02991	0.682
LIG_LIR_Gen_1	455	462	PF02991	0.434
LIG_LIR_Nem_3	267	272	PF02991	0.658
LIG_LIR_Nem_3	455	461	PF02991	0.441
LIG_NRP_CendR_1	489	491	PF00754	0.474
LIG_SH2_CRK	458	462	PF00017	0.375
LIG_SH2_NCK_1	458	462	PF00017	0.433
LIG_SH2_STAP1	458	462	PF00017	0.375
LIG_SH2_STAT3	315	318	PF00017	0.705
LIG_SH2_STAT5	315	318	PF00017	0.597
LIG_SH2_STAT5	388	391	PF00017	0.404
LIG_SH2_STAT5	458	461	PF00017	0.379
LIG_SH3_3	239	245	PF00018	0.616
LIG_SH3_3	292	298	PF00018	0.662
LIG_SH3_3	313	319	PF00018	0.665
LIG_SH3_3	69	75	PF00018	0.577
LIG_SH3_3	8	14	PF00018	0.639
LIG_SUMO_SIM_par_1	16	22	PF11976	0.591
LIG_SUMO_SIM_par_1	405	411	PF11976	0.354
LIG_SUMO_SIM_par_1	437	444	PF11976	0.477
LIG_SxIP_EBH_1	248	262	PF03271	0.496
LIG_WRC_WIRS_1	397	402	PF05994	0.407
LIG_WW_3	74	78	PF00397	0.505
MOD_CK1_1	108	114	PF00069	0.723
MOD_CK1_1	122	128	PF00069	0.565
MOD_CK1_1	13	19	PF00069	0.620
MOD_CK1_1	148	154	PF00069	0.724
MOD_CK1_1	167	173	PF00069	0.689
MOD_CK1_1	236	242	PF00069	0.723
MOD_CK1_1	26	32	PF00069	0.643
MOD_CK1_1	267	273	PF00069	0.790
MOD_CK1_1	278	284	PF00069	0.716
MOD_CK1_1	310	316	PF00069	0.602
MOD_CK1_1	89	95	PF00069	0.590
MOD_CK2_1	148	154	PF00069	0.703
MOD_CK2_1	288	294	PF00069	0.663
MOD_CK2_1	474	480	PF00069	0.406
MOD_CK2_1	85	91	PF00069	0.609
MOD_GlcNHglycan	107	110	PF01048	0.571
MOD_GlcNHglycan	121	124	PF01048	0.577
MOD_GlcNHglycan	150	153	PF01048	0.770
MOD_GlcNHglycan	175	179	PF01048	0.765
MOD_GlcNHglycan	216	219	PF01048	0.641
MOD_GlcNHglycan	230	233	PF01048	0.745
MOD_GlcNHglycan	29	32	PF01048	0.766
MOD_GlcNHglycan	322	325	PF01048	0.581
MOD_GlcNHglycan	33	36	PF01048	0.772
MOD_GlcNHglycan	341	344	PF01048	0.668
MOD_GlcNHglycan	379	382	PF01048	0.601
MOD_GlcNHglycan	404	407	PF01048	0.384
MOD_GlcNHglycan	46	49	PF01048	0.707
MOD_GlcNHglycan	98	101	PF01048	0.689
MOD_GSK3_1	104	111	PF00069	0.599
MOD_GSK3_1	112	119	PF00069	0.603
MOD_GSK3_1	13	20	PF00069	0.605
MOD_GSK3_1	160	167	PF00069	0.669
MOD_GSK3_1	214	221	PF00069	0.593
MOD_GSK3_1	23	30	PF00069	0.673
MOD_GSK3_1	252	259	PF00069	0.721
MOD_GSK3_1	270	277	PF00069	0.767
MOD_GSK3_1	278	285	PF00069	0.579
MOD_GSK3_1	296	303	PF00069	0.570
MOD_GSK3_1	306	313	PF00069	0.608
MOD_GSK3_1	31	38	PF00069	0.566
MOD_GSK3_1	392	399	PF00069	0.388
MOD_GSK3_1	40	47	PF00069	0.721
MOD_GSK3_1	402	409	PF00069	0.392
MOD_GSK3_1	462	469	PF00069	0.416
MOD_GSK3_1	85	92	PF00069	0.665
MOD_N-GLC_1	148	153	PF02516	0.702
MOD_N-GLC_1	219	224	PF02516	0.608
MOD_N-GLC_1	274	279	PF02516	0.727
MOD_N-GLC_1	359	364	PF02516	0.547
MOD_N-GLC_1	86	91	PF02516	0.529
MOD_NEK2_1	104	109	PF00069	0.583
MOD_NEK2_1	160	165	PF00069	0.679
MOD_NEK2_1	19	24	PF00069	0.556
MOD_NEK2_1	233	238	PF00069	0.545
MOD_NEK2_1	279	284	PF00069	0.693
MOD_NEK2_1	396	401	PF00069	0.429
MOD_NEK2_1	417	422	PF00069	0.518
MOD_NEK2_1	44	49	PF00069	0.641
MOD_NEK2_2	427	432	PF00069	0.529
MOD_PIKK_1	300	306	PF00454	0.712
MOD_PIKK_1	35	41	PF00454	0.504
MOD_PIKK_1	417	423	PF00454	0.503
MOD_PIKK_1	466	472	PF00454	0.410
MOD_PK_1	23	29	PF00069	0.625
MOD_PKA_1	198	204	PF00069	0.614
MOD_PKA_2	113	119	PF00069	0.689
MOD_PKA_2	134	140	PF00069	0.727
MOD_PKA_2	198	204	PF00069	0.614
MOD_PKA_2	310	316	PF00069	0.706
MOD_PKA_2	326	332	PF00069	0.468
MOD_PKA_2	417	423	PF00069	0.436
MOD_PKA_2	462	468	PF00069	0.413
MOD_Plk_1	174	180	PF00069	0.685
MOD_Plk_1	274	280	PF00069	0.637
MOD_Plk_4	310	316	PF00069	0.706
MOD_Plk_4	40	46	PF00069	0.677
MOD_Plk_4	434	440	PF00069	0.484
MOD_Plk_4	456	462	PF00069	0.399
MOD_ProDKin_1	10	16	PF00069	0.636
MOD_ProDKin_1	296	302	PF00069	0.582
TRG_ENDOCYTIC_2	458	461	PF00928	0.379
TRG_ER_diArg_1	155	157	PF00400	0.599
TRG_ER_diArg_1	188	190	PF00400	0.607
TRG_ER_diArg_1	197	199	PF00400	0.502
TRG_ER_diArg_1	212	214	PF00400	0.623
TRG_ER_diArg_1	263	266	PF00400	0.668
TRG_ER_diArg_1	49	51	PF00400	0.671
TRG_ER_diArg_1	76	78	PF00400	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H1	Leptomonas seymouri	40%	86%
A0A3S5H5N7	Leishmania donovani	87%	99%
A4H4I6	Leishmania braziliensis	72%	99%
A4HSR1	Leishmania infantum	87%	99%
Q4QJ59	Leishmania major	87%	100%