Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-like protein

Species:

Leishmania mexicana

UniProt:

E9AKP6_LEIMU

TriTrypDb:

LmxM.06.0180

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	2
GO:0005875	microtubule associated complex	2	2
GO:0005929	cilium	4	1
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AKP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKP6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	13
GO:0007018	microtubule-based movement	3	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003774	cytoskeletal motor activity	1	13
GO:0003777	microtubule motor activity	2	13
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0005524	ATP binding	5	13
GO:0008017	microtubule binding	5	13
GO:0008092	cytoskeletal protein binding	3	13
GO:0015631	tubulin binding	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003824	catalytic activity	1	3
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.330
CLV_C14_Caspase3-7	340	344	PF00656	0.435
CLV_NRD_NRD_1	191	193	PF00675	0.369
CLV_NRD_NRD_1	197	199	PF00675	0.355
CLV_NRD_NRD_1	200	202	PF00675	0.325
CLV_NRD_NRD_1	213	215	PF00675	0.246
CLV_NRD_NRD_1	506	508	PF00675	0.495
CLV_NRD_NRD_1	514	516	PF00675	0.536
CLV_NRD_NRD_1	568	570	PF00675	0.794
CLV_PCSK_KEX2_1	191	193	PF00082	0.369
CLV_PCSK_KEX2_1	197	199	PF00082	0.355
CLV_PCSK_KEX2_1	514	516	PF00082	0.557
CLV_PCSK_SKI1_1	191	195	PF00082	0.367
CLV_PCSK_SKI1_1	201	205	PF00082	0.349
CLV_PCSK_SKI1_1	367	371	PF00082	0.407
CLV_PCSK_SKI1_1	38	42	PF00082	0.537
CLV_PCSK_SKI1_1	395	399	PF00082	0.336
CLV_PCSK_SKI1_1	496	500	PF00082	0.564
CLV_PCSK_SKI1_1	514	518	PF00082	0.347
CLV_Separin_Metazoa	57	61	PF03568	0.507
DEG_APCC_KENBOX_2	507	511	PF00400	0.420
DEG_Nend_UBRbox_2	1	3	PF02207	0.776
DEG_SPOP_SBC_1	347	351	PF00917	0.282
DEG_SPOP_SBC_1	359	363	PF00917	0.188
DEG_SPOP_SBC_1	614	618	PF00917	0.674
DOC_CYCLIN_RxL_1	392	399	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.330
DOC_MAPK_gen_1	289	298	PF00069	0.394
DOC_MAPK_gen_1	305	314	PF00069	0.242
DOC_MAPK_gen_1	364	373	PF00069	0.369
DOC_MAPK_gen_1	479	489	PF00069	0.488
DOC_MAPK_MEF2A_6	364	373	PF00069	0.364
DOC_MAPK_MEF2A_6	482	489	PF00069	0.557
DOC_PP1_RVXF_1	365	371	PF00149	0.361
DOC_PP2B_LxvP_1	123	126	PF13499	0.330
DOC_PP2B_LxvP_1	517	520	PF13499	0.483
DOC_PP2B_LxvP_1	59	62	PF13499	0.542
DOC_PP4_FxxP_1	546	549	PF00568	0.466
DOC_USP7_MATH_1	110	114	PF00917	0.330
DOC_USP7_MATH_1	233	237	PF00917	0.437
DOC_USP7_MATH_1	243	247	PF00917	0.361
DOC_USP7_MATH_1	273	277	PF00917	0.384
DOC_USP7_MATH_1	335	339	PF00917	0.270
DOC_USP7_MATH_1	359	363	PF00917	0.375
DOC_USP7_MATH_1	412	416	PF00917	0.445
DOC_USP7_MATH_1	421	425	PF00917	0.405
DOC_USP7_MATH_1	432	436	PF00917	0.315
DOC_USP7_MATH_1	582	586	PF00917	0.732
DOC_USP7_MATH_1	590	594	PF00917	0.705
DOC_USP7_MATH_1	643	647	PF00917	0.461
DOC_USP7_MATH_1	7	11	PF00917	0.727
DOC_USP7_MATH_1	83	87	PF00917	0.518
DOC_USP7_UBL2_3	202	206	PF12436	0.222
DOC_WW_Pin1_4	10	15	PF00397	0.790
DOC_WW_Pin1_4	168	173	PF00397	0.417
DOC_WW_Pin1_4	348	353	PF00397	0.406
DOC_WW_Pin1_4	407	412	PF00397	0.320
DOC_WW_Pin1_4	456	461	PF00397	0.304
DOC_WW_Pin1_4	481	486	PF00397	0.490
DOC_WW_Pin1_4	49	54	PF00397	0.535
DOC_WW_Pin1_4	564	569	PF00397	0.628
DOC_WW_Pin1_4	606	611	PF00397	0.686
DOC_WW_Pin1_4	623	628	PF00397	0.800
DOC_WW_Pin1_4	79	84	PF00397	0.620
LIG_14-3-3_CanoR_1	197	203	PF00244	0.440
LIG_14-3-3_CanoR_1	268	278	PF00244	0.382
LIG_14-3-3_CanoR_1	378	384	PF00244	0.389
LIG_14-3-3_CanoR_1	38	46	PF00244	0.588
LIG_14-3-3_CanoR_1	434	438	PF00244	0.348
LIG_14-3-3_CanoR_1	48	53	PF00244	0.560
LIG_14-3-3_CanoR_1	563	568	PF00244	0.782
LIG_14-3-3_CanoR_1	606	610	PF00244	0.696
LIG_14-3-3_CterR_2	658	662	PF00244	0.639
LIG_Actin_WH2_2	182	199	PF00022	0.451
LIG_Actin_WH2_2	366	382	PF00022	0.407
LIG_Actin_WH2_2	499	516	PF00022	0.562
LIG_APCC_ABBA_1	248	253	PF00400	0.283
LIG_APCC_ABBA_1	323	328	PF00400	0.393
LIG_BRCT_BRCA1_1	275	279	PF00533	0.330
LIG_Clathr_ClatBox_1	368	372	PF01394	0.361
LIG_FHA_1	149	155	PF00498	0.318
LIG_FHA_1	171	177	PF00498	0.431
LIG_FHA_1	236	242	PF00498	0.281
LIG_FHA_1	388	394	PF00498	0.342
LIG_FHA_1	437	443	PF00498	0.290
LIG_FHA_1	450	456	PF00498	0.307
LIG_FHA_1	482	488	PF00498	0.472
LIG_FHA_1	600	606	PF00498	0.669
LIG_FHA_1	642	648	PF00498	0.488
LIG_FHA_1	98	104	PF00498	0.345
LIG_FHA_2	112	118	PF00498	0.375
LIG_FHA_2	335	341	PF00498	0.282
LIG_FHA_2	616	622	PF00498	0.733
LIG_Integrin_RGD_1	18	20	PF01839	0.468
LIG_LIR_Gen_1	117	128	PF02991	0.362
LIG_LIR_Gen_1	246	255	PF02991	0.311
LIG_LIR_Gen_1	292	298	PF02991	0.361
LIG_LIR_Nem_3	117	123	PF02991	0.335
LIG_LIR_Nem_3	246	250	PF02991	0.331
LIG_LIR_Nem_3	253	259	PF02991	0.317
LIG_LIR_Nem_3	292	297	PF02991	0.370
LIG_LIR_Nem_3	324	329	PF02991	0.290
LIG_MLH1_MIPbox_1	275	279	PF16413	0.330
LIG_NRBOX	254	260	PF00104	0.361
LIG_NRBOX	437	443	PF00104	0.323
LIG_Pex14_2	323	327	PF04695	0.407
LIG_REV1ctd_RIR_1	324	334	PF16727	0.330
LIG_SH2_CRK	183	187	PF00017	0.330
LIG_SH2_CRK	256	260	PF00017	0.327
LIG_SH2_SRC	251	254	PF00017	0.330
LIG_SH2_STAP1	33	37	PF00017	0.481
LIG_SH2_STAP1	474	478	PF00017	0.302
LIG_SH2_STAT5	108	111	PF00017	0.404
LIG_SH2_STAT5	188	191	PF00017	0.407
LIG_SH3_1	570	576	PF00018	0.455
LIG_SH3_1	581	587	PF00018	0.582
LIG_SH3_2	429	434	PF14604	0.407
LIG_SH3_2	75	80	PF14604	0.605
LIG_SH3_3	426	432	PF00018	0.358
LIG_SH3_3	55	61	PF00018	0.557
LIG_SH3_3	570	576	PF00018	0.594
LIG_SH3_3	581	587	PF00018	0.678
LIG_SH3_3	72	78	PF00018	0.734
LIG_SH3_CIN85_PxpxPR_1	572	577	PF14604	0.456
LIG_SUMO_SIM_anti_2	292	300	PF11976	0.343
LIG_SUMO_SIM_anti_2	644	649	PF11976	0.447
LIG_SUMO_SIM_par_1	292	300	PF11976	0.371
LIG_SUMO_SIM_par_1	402	408	PF11976	0.407
LIG_SUMO_SIM_par_1	643	649	PF11976	0.488
LIG_TRAF2_1	114	117	PF00917	0.410
LIG_TRAF2_1	498	501	PF00917	0.544
LIG_TYR_ITIM	181	186	PF00017	0.330
LIG_TYR_ITIM	31	36	PF00017	0.453
LIG_WW_3	553	557	PF00397	0.523
LIG_WW_3	560	564	PF00397	0.506
MOD_CDK_SPK_2	564	569	PF00069	0.567
MOD_CDK_SPxK_1	564	570	PF00069	0.547
MOD_CK1_1	10	16	PF00069	0.647
MOD_CK1_1	148	154	PF00069	0.323
MOD_CK1_1	227	233	PF00069	0.434
MOD_CK1_1	236	242	PF00069	0.382
MOD_CK1_1	316	322	PF00069	0.313
MOD_CK1_1	384	390	PF00069	0.253
MOD_CK1_1	396	402	PF00069	0.373
MOD_CK1_1	415	421	PF00069	0.193
MOD_CK1_1	436	442	PF00069	0.322
MOD_CK1_1	468	474	PF00069	0.340
MOD_CK1_1	594	600	PF00069	0.636
MOD_CK1_1	609	615	PF00069	0.754
MOD_CK1_1	617	623	PF00069	0.749
MOD_CK1_1	97	103	PF00069	0.392
MOD_CK2_1	111	117	PF00069	0.348
MOD_CK2_1	243	249	PF00069	0.289
MOD_CK2_1	334	340	PF00069	0.282
MOD_CK2_1	613	619	PF00069	0.666
MOD_DYRK1A_RPxSP_1	606	610	PF00069	0.509
MOD_GlcNHglycan	147	150	PF01048	0.325
MOD_GlcNHglycan	154	157	PF01048	0.326
MOD_GlcNHglycan	163	166	PF01048	0.332
MOD_GlcNHglycan	216	219	PF01048	0.322
MOD_GlcNHglycan	226	229	PF01048	0.271
MOD_GlcNHglycan	233	236	PF01048	0.349
MOD_GlcNHglycan	271	274	PF01048	0.340
MOD_GlcNHglycan	337	340	PF01048	0.330
MOD_GlcNHglycan	386	389	PF01048	0.236
MOD_GlcNHglycan	407	410	PF01048	0.409
MOD_GlcNHglycan	423	426	PF01048	0.373
MOD_GlcNHglycan	460	463	PF01048	0.407
MOD_GlcNHglycan	556	559	PF01048	0.724
MOD_GlcNHglycan	593	596	PF01048	0.676
MOD_GlcNHglycan	599	602	PF01048	0.693
MOD_GlcNHglycan	70	73	PF01048	0.709
MOD_GlcNHglycan	9	12	PF01048	0.658
MOD_GSK3_1	148	155	PF00069	0.335
MOD_GSK3_1	166	173	PF00069	0.415
MOD_GSK3_1	227	234	PF00069	0.398
MOD_GSK3_1	235	242	PF00069	0.391
MOD_GSK3_1	269	276	PF00069	0.424
MOD_GSK3_1	389	396	PF00069	0.407
MOD_GSK3_1	407	414	PF00069	0.307
MOD_GSK3_1	432	439	PF00069	0.323
MOD_GSK3_1	44	51	PF00069	0.561
MOD_GSK3_1	590	597	PF00069	0.669
MOD_GSK3_1	605	612	PF00069	0.763
MOD_GSK3_1	613	620	PF00069	0.776
MOD_GSK3_1	623	630	PF00069	0.592
MOD_GSK3_1	79	86	PF00069	0.636
MOD_N-GLC_1	393	398	PF02516	0.307
MOD_NEK2_1	143	148	PF00069	0.361
MOD_NEK2_1	196	201	PF00069	0.427
MOD_NEK2_1	360	365	PF00069	0.461
MOD_NEK2_1	379	384	PF00069	0.280
MOD_NEK2_1	465	470	PF00069	0.348
MOD_NEK2_1	591	596	PF00069	0.576
MOD_NEK2_1	605	610	PF00069	0.709
MOD_NEK2_2	251	256	PF00069	0.407
MOD_NEK2_2	274	279	PF00069	0.384
MOD_PIKK_1	112	118	PF00454	0.358
MOD_PIKK_1	415	421	PF00454	0.204
MOD_PIKK_1	436	442	PF00454	0.300
MOD_PIKK_1	490	496	PF00454	0.525
MOD_PKA_1	197	203	PF00069	0.467
MOD_PKA_1	214	220	PF00069	0.263
MOD_PKA_2	196	202	PF00069	0.410
MOD_PKA_2	207	213	PF00069	0.271
MOD_PKA_2	23	29	PF00069	0.580
MOD_PKA_2	269	275	PF00069	0.327
MOD_PKA_2	306	312	PF00069	0.346
MOD_PKA_2	433	439	PF00069	0.307
MOD_PKA_2	44	50	PF00069	0.658
MOD_PKA_2	562	568	PF00069	0.738
MOD_PKA_2	605	611	PF00069	0.672
MOD_Plk_1	393	399	PF00069	0.307
MOD_Plk_1	465	471	PF00069	0.327
MOD_Plk_4	136	142	PF00069	0.342
MOD_Plk_4	236	242	PF00069	0.365
MOD_Plk_4	243	249	PF00069	0.321
MOD_Plk_4	251	257	PF00069	0.303
MOD_Plk_4	274	280	PF00069	0.361
MOD_Plk_4	393	399	PF00069	0.396
MOD_Plk_4	433	439	PF00069	0.359
MOD_Plk_4	609	615	PF00069	0.655
MOD_Plk_4	643	649	PF00069	0.583
MOD_ProDKin_1	10	16	PF00069	0.790
MOD_ProDKin_1	168	174	PF00069	0.417
MOD_ProDKin_1	348	354	PF00069	0.406
MOD_ProDKin_1	407	413	PF00069	0.320
MOD_ProDKin_1	456	462	PF00069	0.304
MOD_ProDKin_1	481	487	PF00069	0.490
MOD_ProDKin_1	49	55	PF00069	0.530
MOD_ProDKin_1	564	570	PF00069	0.644
MOD_ProDKin_1	606	612	PF00069	0.687
MOD_ProDKin_1	623	629	PF00069	0.801
MOD_ProDKin_1	79	85	PF00069	0.621
TRG_DiLeu_BaEn_1	292	297	PF01217	0.386
TRG_DiLeu_BaEn_3	117	123	PF01217	0.330
TRG_ENDOCYTIC_2	183	186	PF00928	0.330
TRG_ENDOCYTIC_2	256	259	PF00928	0.294
TRG_ENDOCYTIC_2	33	36	PF00928	0.497
TRG_ER_diArg_1	191	193	PF00400	0.349
TRG_ER_diArg_1	196	198	PF00400	0.326
TRG_ER_diArg_1	267	270	PF00400	0.361
TRG_ER_diArg_1	513	515	PF00400	0.545
TRG_NLS_Bipartite_1	191	205	PF00514	0.385
TRG_NLS_MonoExtN_4	198	205	PF00514	0.270
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY56	Leptomonas seymouri	59%	97%
A0A0N1I0Y5	Leptomonas seymouri	27%	100%
A0A0S4IP49	Bodo saltans	28%	82%
A0A0S4JUR0	Bodo saltans	26%	76%
A0A0S4KL43	Bodo saltans	30%	100%
A0A1X0NQ03	Trypanosomatidae	26%	80%
A0A1X0P9E3	Trypanosomatidae	29%	100%
A0A3R7MC35	Trypanosoma rangeli	38%	100%
A0A3R7R330	Trypanosoma rangeli	27%	100%
A0A3S5H5N6	Leishmania donovani	91%	100%
A0A3S5IRH3	Trypanosoma rangeli	25%	100%
A0A422N2N4	Trypanosoma rangeli	24%	77%
A0A422NE49	Trypanosoma rangeli	26%	74%
A0A422NEQ8	Trypanosoma rangeli	25%	88%
A4H4I4	Leishmania braziliensis	77%	99%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HCA1	Leishmania braziliensis	25%	74%
A4HHY2	Leishmania braziliensis	27%	100%
A4HSA6	Leishmania infantum	26%	100%
A4HSQ9	Leishmania infantum	91%	100%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	82%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	74%
E9B004	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	69%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
F4IL57	Arabidopsis thaliana	28%	67%
O14343	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	75%
O35231	Mus musculus	25%	80%
O59751	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	84%
P46864	Arabidopsis thaliana	28%	89%
P46865	Leishmania chagasi	27%	69%
P46870	Chlamydomonas reinhardtii	29%	85%
P53086	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	82%
P97329	Mus musculus	25%	75%
Q0E2L3	Oryza sativa subsp. japonica	25%	68%
Q29RT6	Bos taurus	25%	75%
Q4Q348	Leishmania major	30%	70%
Q4QJ61	Leishmania major	87%	100%
Q6ZMV9	Homo sapiens	26%	81%
Q9LPC6	Arabidopsis thaliana	25%	74%
V5BK25	Trypanosoma cruzi	30%	92%
V5BLH7	Trypanosoma cruzi	26%	77%