Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome beta 6 subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AKP2_LEIMU

TriTrypDb:

LmxM.06.0140

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0005839	proteasome core complex	3	11
GO:0016020	membrane	2	1
GO:0019774	proteasome core complex, beta-subunit complex	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11

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Expansion

Sequence features

E9AKP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKP2

PDB structure(s): 6qm7_a , 6qm7_M , 6qm8_a , 6qm8_M , 6tcz_m , 6td5_m

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0010498	proteasomal protein catabolic process	5	11
GO:0019538	protein metabolic process	3	11
GO:0030163	protein catabolic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.310
CLV_NRD_NRD_1	244	246	PF00675	0.477
CLV_PCSK_KEX2_1	133	135	PF00082	0.310
CLV_PCSK_SKI1_1	133	137	PF00082	0.310
CLV_PCSK_SKI1_1	210	214	PF00082	0.310
DEG_APCC_DBOX_1	93	101	PF00400	0.523
DEG_Nend_Nbox_1	1	3	PF02207	0.627
DOC_AGCK_PIF_1	136	141	PF00069	0.510
DOC_CKS1_1	78	83	PF01111	0.589
DOC_PP1_RVXF_1	102	108	PF00149	0.502

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILF0	Leptomonas seymouri	86%	100%
A0A0N1PB37	Leptomonas seymouri	27%	88%
A0A0N1PCD1	Leptomonas seymouri	25%	100%
A0A0S4IV44	Bodo saltans	25%	100%
A0A0S4J7A1	Bodo saltans	67%	100%
A0A0S4KNR5	Bodo saltans	27%	80%
A0A1X0NK57	Trypanosomatidae	74%	100%
A0A1X0NVR6	Trypanosomatidae	26%	100%
A0A3R7KX47	Trypanosoma rangeli	74%	100%
A0A3S5H6K1	Leishmania donovani	27%	87%

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