Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKN9_LEIMU

TriTrypDb:

LmxM.06.0110

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005635	nuclear envelope	4	1
GO:0005794	Golgi apparatus	5	1
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AKN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.546
CLV_NRD_NRD_1	214	216	PF00675	0.497
CLV_NRD_NRD_1	319	321	PF00675	0.343
CLV_NRD_NRD_1	591	593	PF00675	0.491
CLV_PCSK_KEX2_1	154	156	PF00082	0.545
CLV_PCSK_KEX2_1	214	216	PF00082	0.477
CLV_PCSK_KEX2_1	319	321	PF00082	0.419
CLV_PCSK_KEX2_1	591	593	PF00082	0.491
CLV_PCSK_SKI1_1	497	501	PF00082	0.371
CLV_PCSK_SKI1_1	585	589	PF00082	0.466
CLV_PCSK_SKI1_1	7	11	PF00082	0.447
CLV_PCSK_SKI1_1	91	95	PF00082	0.417
DEG_APCC_DBOX_1	90	98	PF00400	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.604
DEG_SPOP_SBC_1	281	285	PF00917	0.723
DEG_SPOP_SBC_1	286	290	PF00917	0.679
DEG_SPOP_SBC_1	594	598	PF00917	0.565
DOC_CYCLIN_RxL_1	2	13	PF00134	0.657
DOC_MAPK_gen_1	214	221	PF00069	0.541
DOC_MAPK_gen_1	497	505	PF00069	0.542
DOC_PP1_RVXF_1	196	203	PF00149	0.681
DOC_PP2B_LxvP_1	291	294	PF13499	0.591
DOC_PP2B_LxvP_1	350	353	PF13499	0.545
DOC_USP7_MATH_1	100	104	PF00917	0.742
DOC_USP7_MATH_1	125	129	PF00917	0.719
DOC_USP7_MATH_1	178	182	PF00917	0.610
DOC_USP7_MATH_1	205	209	PF00917	0.630
DOC_USP7_MATH_1	286	290	PF00917	0.724
DOC_USP7_MATH_1	361	365	PF00917	0.666
DOC_USP7_MATH_1	375	379	PF00917	0.743
DOC_USP7_MATH_1	594	598	PF00917	0.669
DOC_WW_Pin1_4	282	287	PF00397	0.759
DOC_WW_Pin1_4	353	358	PF00397	0.665
DOC_WW_Pin1_4	432	437	PF00397	0.615
LIG_14-3-3_CanoR_1	154	162	PF00244	0.742
LIG_14-3-3_CanoR_1	183	189	PF00244	0.720
LIG_14-3-3_CanoR_1	192	202	PF00244	0.688
LIG_14-3-3_CanoR_1	2	10	PF00244	0.587
LIG_14-3-3_CanoR_1	214	221	PF00244	0.679
LIG_14-3-3_CanoR_1	400	406	PF00244	0.623
LIG_14-3-3_CanoR_1	418	422	PF00244	0.550
LIG_14-3-3_CanoR_1	454	459	PF00244	0.499
LIG_14-3-3_CanoR_1	462	468	PF00244	0.558
LIG_14-3-3_CanoR_1	493	497	PF00244	0.586
LIG_14-3-3_CanoR_1	573	577	PF00244	0.600
LIG_Actin_WH2_2	569	587	PF00022	0.604
LIG_BIR_III_2	167	171	PF00653	0.592
LIG_Clathr_ClatBox_1	9	13	PF01394	0.595
LIG_deltaCOP1_diTrp_1	69	79	PF00928	0.417
LIG_EVH1_1	350	354	PF00568	0.557
LIG_FHA_1	144	150	PF00498	0.732
LIG_FHA_1	32	38	PF00498	0.317
LIG_FHA_1	385	391	PF00498	0.559
LIG_FHA_1	43	49	PF00498	0.336
LIG_FHA_1	511	517	PF00498	0.587
LIG_FHA_1	573	579	PF00498	0.541
LIG_FHA_2	113	119	PF00498	0.712
LIG_FHA_2	194	200	PF00498	0.693
LIG_FHA_2	438	444	PF00498	0.545
LIG_FHA_2	596	602	PF00498	0.733
LIG_FHA_2	6	12	PF00498	0.651
LIG_Integrin_RGD_1	17	19	PF01839	0.358
LIG_LIR_Apic_2	367	373	PF02991	0.740
LIG_LIR_Gen_1	292	303	PF02991	0.622
LIG_LIR_Gen_1	31	40	PF02991	0.394
LIG_LIR_Gen_1	501	507	PF02991	0.608
LIG_LIR_Nem_3	278	282	PF02991	0.706
LIG_LIR_Nem_3	292	298	PF02991	0.545
LIG_LIR_Nem_3	31	35	PF02991	0.394
LIG_LIR_Nem_3	501	505	PF02991	0.522
LIG_LIR_Nem_3	525	530	PF02991	0.517
LIG_LIR_Nem_3	567	572	PF02991	0.617
LIG_NRBOX	388	394	PF00104	0.551
LIG_NRBOX	89	95	PF00104	0.360
LIG_Pex14_1	477	481	PF04695	0.581
LIG_Pex14_2	528	532	PF04695	0.566
LIG_SH2_CRK	569	573	PF00017	0.628
LIG_SH2_GRB2like	260	263	PF00017	0.646
LIG_SH2_SRC	463	466	PF00017	0.606
LIG_SH2_STAP1	415	419	PF00017	0.576
LIG_SH2_STAT3	398	401	PF00017	0.574
LIG_SH2_STAT5	282	285	PF00017	0.578
LIG_SH2_STAT5	398	401	PF00017	0.604
LIG_SH2_STAT5	41	44	PF00017	0.300
LIG_SH2_STAT5	450	453	PF00017	0.504
LIG_SH2_STAT5	463	466	PF00017	0.568
LIG_SH2_STAT5	502	505	PF00017	0.521
LIG_SH2_STAT5	519	522	PF00017	0.525
LIG_SH2_STAT5	527	530	PF00017	0.482
LIG_SH3_2	190	195	PF14604	0.719
LIG_SH3_3	187	193	PF00018	0.722
LIG_SH3_3	348	354	PF00018	0.634
LIG_SH3_3	433	439	PF00018	0.573
LIG_SH3_4	263	270	PF00018	0.702
LIG_SUMO_SIM_anti_2	254	261	PF11976	0.696
LIG_SUMO_SIM_anti_2	34	39	PF11976	0.320
LIG_SUMO_SIM_par_1	574	580	PF11976	0.601
LIG_SUMO_SIM_par_1	61	71	PF11976	0.373
LIG_SUMO_SIM_par_1	8	13	PF11976	0.624
LIG_TRAF2_1	345	348	PF00917	0.570
LIG_TYR_ITIM	563	568	PF00017	0.589
LIG_UBA3_1	488	497	PF00899	0.572
LIG_WRC_WIRS_1	455	460	PF05994	0.482
LIG_WRC_WIRS_1	82	87	PF05994	0.407
MOD_CDC14_SPxK_1	435	438	PF00782	0.533
MOD_CDK_SPxK_1	432	438	PF00069	0.539
MOD_CK1_1	128	134	PF00069	0.795
MOD_CK1_1	136	142	PF00069	0.757
MOD_CK1_1	284	290	PF00069	0.753
MOD_CK1_1	364	370	PF00069	0.784
MOD_CK1_1	434	440	PF00069	0.627
MOD_CK1_1	466	472	PF00069	0.583
MOD_CK1_1	536	542	PF00069	0.640
MOD_CK2_1	112	118	PF00069	0.713
MOD_CK2_1	342	348	PF00069	0.572
MOD_CK2_1	437	443	PF00069	0.587
MOD_CK2_1	546	552	PF00069	0.505
MOD_CK2_1	595	601	PF00069	0.729
MOD_Cter_Amidation	589	592	PF01082	0.465
MOD_GlcNHglycan	102	105	PF01048	0.469
MOD_GlcNHglycan	207	210	PF01048	0.488
MOD_GlcNHglycan	215	218	PF01048	0.475
MOD_GlcNHglycan	221	224	PF01048	0.420
MOD_GlcNHglycan	244	247	PF01048	0.538
MOD_GlcNHglycan	270	273	PF01048	0.522
MOD_GlcNHglycan	363	366	PF01048	0.512
MOD_GlcNHglycan	469	472	PF01048	0.421
MOD_GlcNHglycan	478	481	PF01048	0.468
MOD_GSK3_1	1	8	PF00069	0.666
MOD_GSK3_1	184	191	PF00069	0.702
MOD_GSK3_1	280	287	PF00069	0.755
MOD_GSK3_1	360	367	PF00069	0.725
MOD_GSK3_1	427	434	PF00069	0.644
MOD_GSK3_1	463	470	PF00069	0.573
MOD_GSK3_1	506	513	PF00069	0.621
MOD_GSK3_1	536	543	PF00069	0.632
MOD_GSK3_1	595	602	PF00069	0.800
MOD_LATS_1	266	272	PF00433	0.701
MOD_N-GLC_1	133	138	PF02516	0.540
MOD_N-GLC_1	467	472	PF02516	0.414
MOD_N-GLC_1	536	541	PF02516	0.384
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	492	497	PF00069	0.593
MOD_NEK2_1	540	545	PF00069	0.636
MOD_NEK2_1	81	86	PF00069	0.334
MOD_NEK2_2	178	183	PF00069	0.580
MOD_PIKK_1	133	139	PF00454	0.699
MOD_PIKK_1	399	405	PF00454	0.614
MOD_PIKK_1	510	516	PF00454	0.606
MOD_PKA_1	154	160	PF00069	0.742
MOD_PKA_2	1	7	PF00069	0.595
MOD_PKA_2	125	131	PF00069	0.805
MOD_PKA_2	154	160	PF00069	0.742
MOD_PKA_2	162	168	PF00069	0.675
MOD_PKA_2	213	219	PF00069	0.701
MOD_PKA_2	399	405	PF00069	0.601
MOD_PKA_2	417	423	PF00069	0.557
MOD_PKA_2	437	443	PF00069	0.645
MOD_PKA_2	492	498	PF00069	0.584
MOD_PKA_2	572	578	PF00069	0.613
MOD_PKB_1	124	132	PF00069	0.754
MOD_PKB_1	230	238	PF00069	0.588
MOD_PKB_1	268	276	PF00069	0.700
MOD_PKB_1	531	539	PF00069	0.627
MOD_Plk_1	142	148	PF00069	0.731
MOD_Plk_1	536	542	PF00069	0.558
MOD_Plk_4	136	142	PF00069	0.750
MOD_Plk_4	28	34	PF00069	0.513
MOD_Plk_4	536	542	PF00069	0.590
MOD_Plk_4	546	552	PF00069	0.480
MOD_Plk_4	59	65	PF00069	0.413
MOD_ProDKin_1	282	288	PF00069	0.756
MOD_ProDKin_1	353	359	PF00069	0.668
MOD_ProDKin_1	432	438	PF00069	0.611
MOD_SUMO_rev_2	257	265	PF00179	0.698
TRG_ENDOCYTIC_2	502	505	PF00928	0.503
TRG_ENDOCYTIC_2	527	530	PF00928	0.506
TRG_ENDOCYTIC_2	565	568	PF00928	0.529
TRG_ENDOCYTIC_2	569	572	PF00928	0.537
TRG_ENDOCYTIC_2	82	85	PF00928	0.414
TRG_ER_diArg_1	154	156	PF00400	0.745
TRG_ER_diArg_1	319	321	PF00400	0.618
TRG_ER_diArg_1	75	78	PF00400	0.364
TRG_NES_CRM1_1	552	567	PF08389	0.560
TRG_NES_CRM1_1	577	589	PF08389	0.598
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR5	Leptomonas seymouri	58%	99%
A0A1X0NL56	Trypanosomatidae	36%	100%
A0A3R7NA89	Trypanosoma rangeli	36%	100%
A0A3S5H5N1	Leishmania donovani	91%	100%
A4H4H7	Leishmania braziliensis	83%	100%
A4HSQ2	Leishmania infantum	91%	100%
Q4QJ68	Leishmania major	90%	100%
V5AP94	Trypanosoma cruzi	34%	100%