LeishMANIAdb
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Putative ATP-binding cassette protein subfamily G, member 3

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATP-binding cassette protein subfamily G, member 3
Gene product:
ATP-binding cassette protein subfamily G, member 3, putative
Species:
Leishmania mexicana
UniProt:
E9AKN8_LEIMU
TriTrypDb:
LmxM.06.0100
Length:
248

Annotations

LeishMANIAdb annotations

Proteins belonging to the subfamily G of Eukaryotic ABC transporters. Probably functional as dimers, with broad substrate specificity.. Expanded in Kinetoplastids (also in free-living forms)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9AKN8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKN8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0009987 cellular process 1 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 3
GO:0005215 transporter activity 1 3
GO:0005488 binding 1 3
GO:0005524 ATP binding 5 3
GO:0015399 primary active transmembrane transporter activity 4 3
GO:0017076 purine nucleotide binding 4 3
GO:0022804 active transmembrane transporter activity 3 3
GO:0022857 transmembrane transporter activity 2 3
GO:0030554 adenyl nucleotide binding 5 3
GO:0032553 ribonucleotide binding 3 3
GO:0032555 purine ribonucleotide binding 4 3
GO:0032559 adenyl ribonucleotide binding 5 3
GO:0035639 purine ribonucleoside triphosphate binding 4 3
GO:0036094 small molecule binding 2 3
GO:0042626 ATPase-coupled transmembrane transporter activity 2 3
GO:0043167 ion binding 2 3
GO:0043168 anion binding 3 3
GO:0097159 organic cyclic compound binding 2 3
GO:0097367 carbohydrate derivative binding 2 3
GO:0140359 ABC-type transporter activity 3 3
GO:0140657 ATP-dependent activity 1 3
GO:1901265 nucleoside phosphate binding 3 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 95 99 PF00656 0.520
CLV_NRD_NRD_1 244 246 PF00675 0.619
CLV_NRD_NRD_1 74 76 PF00675 0.457
CLV_PCSK_KEX2_1 244 246 PF00082 0.619
CLV_PCSK_KEX2_1 72 74 PF00082 0.481
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.481
CLV_PCSK_SKI1_1 76 80 PF00082 0.513
DEG_Nend_Nbox_1 1 3 PF02207 0.518
DEG_ODPH_VHL_1 166 179 PF01847 0.351
DOC_AGCK_PIF_1 156 161 PF00069 0.356
DOC_CKS1_1 82 87 PF01111 0.735
DOC_MAPK_MEF2A_6 111 120 PF00069 0.695
DOC_PP4_FxxP_1 45 48 PF00568 0.629
DOC_USP7_UBL2_3 72 76 PF12436 0.654
DOC_WW_Pin1_4 112 117 PF00397 0.699
DOC_WW_Pin1_4 166 171 PF00397 0.360
DOC_WW_Pin1_4 49 54 PF00397 0.629
DOC_WW_Pin1_4 81 86 PF00397 0.731
LIG_14-3-3_CanoR_1 186 190 PF00244 0.378
LIG_14-3-3_CanoR_1 193 198 PF00244 0.391
LIG_14-3-3_CanoR_1 205 209 PF00244 0.390
LIG_14-3-3_CanoR_1 83 92 PF00244 0.754
LIG_BRCT_BRCA1_1 41 45 PF00533 0.629
LIG_FHA_1 174 180 PF00498 0.392
LIG_FHA_1 64 70 PF00498 0.629
LIG_FHA_1 7 13 PF00498 0.629
LIG_FHA_1 85 91 PF00498 0.725
LIG_FHA_2 125 131 PF00498 0.678
LIG_FHA_2 50 56 PF00498 0.629
LIG_GBD_Chelix_1 150 158 PF00786 0.270
LIG_GSK3_LRP6_1 171 176 PF00069 0.350
LIG_LIR_Apic_2 42 48 PF02991 0.629
LIG_LIR_Gen_1 14 22 PF02991 0.629
LIG_LIR_Gen_1 160 168 PF02991 0.370
LIG_LIR_Gen_1 38 48 PF02991 0.629
LIG_LIR_Gen_1 54 65 PF02991 0.445
LIG_LIR_Nem_3 14 19 PF02991 0.629
LIG_LIR_Nem_3 160 164 PF02991 0.357
LIG_LIR_Nem_3 38 43 PF02991 0.629
LIG_LIR_Nem_3 54 60 PF02991 0.445
LIG_RPA_C_Fungi 91 103 PF08784 0.651
LIG_SH2_CRK 57 61 PF00017 0.520
LIG_SH2_SRC 215 218 PF00017 0.432
LIG_SH2_STAP1 121 125 PF00017 0.350
LIG_SH2_STAT3 141 144 PF00017 0.520
LIG_SH2_STAT5 108 111 PF00017 0.622
LIG_SH2_STAT5 137 140 PF00017 0.505
LIG_SH2_STAT5 15 18 PF00017 0.328
LIG_SH2_STAT5 215 218 PF00017 0.454
LIG_SH2_STAT5 3 6 PF00017 0.629
LIG_SH2_STAT5 39 42 PF00017 0.520
LIG_SH2_STAT5 51 54 PF00017 0.328
LIG_SH2_STAT5 77 80 PF00017 0.638
LIG_SH3_1 79 85 PF00018 0.662
LIG_SH3_3 165 171 PF00018 0.423
LIG_SH3_3 79 85 PF00018 0.662
LIG_SUMO_SIM_anti_2 17 23 PF11976 0.520
LIG_SUMO_SIM_par_1 127 132 PF11976 0.400
LIG_SUMO_SIM_par_1 173 181 PF11976 0.468
LIG_SUMO_SIM_par_1 57 64 PF11976 0.520
LIG_TYR_ITSM 52 59 PF00017 0.520
LIG_WRC_WIRS_1 158 163 PF05994 0.371
MOD_CK1_1 132 138 PF00069 0.485
MOD_CK1_1 178 184 PF00069 0.417
MOD_CK1_1 196 202 PF00069 0.495
MOD_CK1_1 204 210 PF00069 0.592
MOD_CK1_1 218 224 PF00069 0.477
MOD_CK1_1 64 70 PF00069 0.301
MOD_CK1_1 97 103 PF00069 0.431
MOD_CK2_1 124 130 PF00069 0.590
MOD_CMANNOS 180 183 PF00535 0.457
MOD_GlcNHglycan 180 183 PF01048 0.395
MOD_GlcNHglycan 198 201 PF01048 0.399
MOD_GlcNHglycan 98 102 PF01048 0.586
MOD_GSK3_1 166 173 PF00069 0.420
MOD_GSK3_1 192 199 PF00069 0.491
MOD_GSK3_1 204 211 PF00069 0.472
MOD_GSK3_1 29 36 PF00069 0.520
MOD_GSK3_1 92 99 PF00069 0.656
MOD_NEK2_1 1 6 PF00069 0.548
MOD_NEK2_1 20 25 PF00069 0.465
MOD_NEK2_1 208 213 PF00069 0.491
MOD_NEK2_1 61 66 PF00069 0.520
MOD_NEK2_1 92 97 PF00069 0.671
MOD_NEK2_2 121 126 PF00069 0.354
MOD_NEK2_2 210 215 PF00069 0.362
MOD_PIKK_1 20 26 PF00454 0.520
MOD_PK_1 193 199 PF00069 0.470
MOD_PKA_2 132 138 PF00069 0.537
MOD_PKA_2 185 191 PF00069 0.401
MOD_PKA_2 192 198 PF00069 0.402
MOD_PKA_2 201 207 PF00069 0.483
MOD_PKB_1 94 102 PF00069 0.413
MOD_Plk_1 121 127 PF00069 0.351
MOD_Plk_2-3 11 17 PF00069 0.520
MOD_Plk_4 11 17 PF00069 0.520
MOD_Plk_4 132 138 PF00069 0.485
MOD_Plk_4 175 181 PF00069 0.591
MOD_Plk_4 193 199 PF00069 0.679
MOD_Plk_4 210 216 PF00069 0.529
MOD_ProDKin_1 112 118 PF00069 0.618
MOD_ProDKin_1 166 172 PF00069 0.421
MOD_ProDKin_1 49 55 PF00069 0.520
MOD_ProDKin_1 81 87 PF00069 0.660
TRG_ENDOCYTIC_2 56 59 PF00928 0.520
TRG_NES_CRM1_1 11 24 PF08389 0.520
TRG_NLS_MonoExtC_3 71 76 PF00514 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
Q4QJ69 Leishmania major 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS