Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKN5_LEIMU

TriTrypDb:

LmxM.06.0070

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	306	308	PF00675	0.437
CLV_NRD_NRD_1	366	368	PF00675	0.599
CLV_NRD_NRD_1	416	418	PF00675	0.521
CLV_NRD_NRD_1	427	429	PF00675	0.424
CLV_NRD_NRD_1	50	52	PF00675	0.524
CLV_PCSK_KEX2_1	306	308	PF00082	0.437
CLV_PCSK_KEX2_1	416	418	PF00082	0.484
CLV_PCSK_KEX2_1	50	52	PF00082	0.524
CLV_PCSK_PC7_1	46	52	PF00082	0.455
CLV_PCSK_SKI1_1	316	320	PF00082	0.384
CLV_PCSK_SKI1_1	336	340	PF00082	0.383
CLV_PCSK_SKI1_1	368	372	PF00082	0.372
CLV_PCSK_SKI1_1	416	420	PF00082	0.479
DEG_APCC_DBOX_1	308	316	PF00400	0.418
DEG_APCC_DBOX_1	445	453	PF00400	0.350
DOC_CDC14_PxL_1	278	286	PF14671	0.436
DOC_CDC14_PxL_1	294	302	PF14671	0.393
DOC_MAPK_gen_1	306	314	PF00069	0.369
DOC_MAPK_gen_1	377	387	PF00069	0.328
DOC_MAPK_MEF2A_6	132	140	PF00069	0.420
DOC_PP1_RVXF_1	414	421	PF00149	0.455
DOC_PP2B_LxvP_1	161	164	PF13499	0.530
DOC_PP4_FxxP_1	176	179	PF00568	0.508
DOC_PP4_FxxP_1	325	328	PF00568	0.329
DOC_USP7_MATH_1	12	16	PF00917	0.550
DOC_USP7_MATH_1	73	77	PF00917	0.556
DOC_USP7_MATH_1	94	98	PF00917	0.530
DOC_WW_Pin1_4	132	137	PF00397	0.431
DOC_WW_Pin1_4	324	329	PF00397	0.463
DOC_WW_Pin1_4	343	348	PF00397	0.768
DOC_WW_Pin1_4	351	356	PF00397	0.588
LIG_14-3-3_CanoR_1	233	237	PF00244	0.442
LIG_14-3-3_CanoR_1	283	287	PF00244	0.496
LIG_14-3-3_CanoR_1	367	373	PF00244	0.393
LIG_14-3-3_CanoR_1	40	47	PF00244	0.499
LIG_14-3-3_CanoR_1	422	428	PF00244	0.399
LIG_14-3-3_CanoR_1	441	445	PF00244	0.399
LIG_Actin_WH2_2	230	248	PF00022	0.284
LIG_Actin_WH2_2	301	318	PF00022	0.346
LIG_FHA_1	175	181	PF00498	0.348
LIG_FHA_1	229	235	PF00498	0.477
LIG_FHA_1	24	30	PF00498	0.408
LIG_FHA_1	337	343	PF00498	0.626
LIG_FHA_1	369	375	PF00498	0.441
LIG_FHA_1	382	388	PF00498	0.343
LIG_FHA_2	213	219	PF00498	0.514
LIG_FHA_2	57	63	PF00498	0.738
LIG_LIR_Apic_2	175	179	PF02991	0.523
LIG_LIR_Apic_2	324	328	PF02991	0.343
LIG_LIR_Apic_2	352	356	PF02991	0.493
LIG_LIR_Gen_1	139	149	PF02991	0.451
LIG_LIR_Gen_1	187	198	PF02991	0.338
LIG_LIR_Gen_1	369	378	PF02991	0.400
LIG_LIR_Gen_1	431	442	PF02991	0.450
LIG_LIR_Gen_1	86	94	PF02991	0.423
LIG_LIR_LC3C_4	6	11	PF02991	0.578
LIG_LIR_Nem_3	139	145	PF02991	0.340
LIG_LIR_Nem_3	187	193	PF02991	0.295
LIG_LIR_Nem_3	20	24	PF02991	0.475
LIG_LIR_Nem_3	303	308	PF02991	0.358
LIG_LIR_Nem_3	369	375	PF02991	0.385
LIG_LIR_Nem_3	393	398	PF02991	0.346
LIG_LIR_Nem_3	431	437	PF02991	0.466
LIG_LIR_Nem_3	67	71	PF02991	0.504
LIG_LIR_Nem_3	86	90	PF02991	0.416
LIG_PCNA_yPIPBox_3	150	162	PF02747	0.336
LIG_Pex14_1	208	212	PF04695	0.416
LIG_SH2_CRK	142	146	PF00017	0.473
LIG_SH2_CRK	200	204	PF00017	0.279
LIG_SH2_CRK	305	309	PF00017	0.387
LIG_SH2_CRK	87	91	PF00017	0.478
LIG_SH2_SRC	405	408	PF00017	0.525
LIG_SH2_STAP1	123	127	PF00017	0.585
LIG_SH2_STAP1	142	146	PF00017	0.288
LIG_SH2_STAP1	71	75	PF00017	0.421
LIG_SH2_STAT5	200	203	PF00017	0.380
LIG_SH2_STAT5	405	408	PF00017	0.556
LIG_SH2_STAT5	87	90	PF00017	0.501
LIG_SH3_3	344	350	PF00018	0.625
LIG_SH3_3	352	358	PF00018	0.570
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.577
LIG_SUMO_SIM_par_1	177	183	PF11976	0.334
LIG_SUMO_SIM_par_1	327	332	PF11976	0.445
LIG_TYR_ITIM	198	203	PF00017	0.299
LIG_TYR_ITIM	85	90	PF00017	0.513
LIG_TYR_ITSM	301	308	PF00017	0.331
LIG_WRC_WIRS_1	173	178	PF05994	0.407
LIG_WW_1	359	362	PF00397	0.458
MOD_CK1_1	20	26	PF00069	0.332
MOD_CK1_1	397	403	PF00069	0.480
MOD_CK1_1	423	429	PF00069	0.488
MOD_CK1_1	76	82	PF00069	0.575
MOD_CK2_1	212	218	PF00069	0.381
MOD_CK2_1	388	394	PF00069	0.556
MOD_CK2_1	39	45	PF00069	0.429
MOD_DYRK1A_RPxSP_1	132	136	PF00069	0.430
MOD_GlcNHglycan	132	135	PF01048	0.560
MOD_GlcNHglycan	150	153	PF01048	0.373
MOD_GlcNHglycan	168	171	PF01048	0.441
MOD_GlcNHglycan	32	35	PF01048	0.557
MOD_GlcNHglycan	330	334	PF01048	0.494
MOD_GlcNHglycan	343	346	PF01048	0.541
MOD_GlcNHglycan	390	393	PF01048	0.473
MOD_GlcNHglycan	422	425	PF01048	0.538
MOD_GlcNHglycan	452	455	PF01048	0.431
MOD_GlcNHglycan	75	78	PF01048	0.636
MOD_GlcNHglycan	80	84	PF01048	0.606
MOD_GSK3_1	132	139	PF00069	0.413
MOD_GSK3_1	162	169	PF00069	0.474
MOD_GSK3_1	208	215	PF00069	0.425
MOD_GSK3_1	220	227	PF00069	0.347
MOD_GSK3_1	228	235	PF00069	0.289
MOD_GSK3_1	257	264	PF00069	0.553
MOD_GSK3_1	394	401	PF00069	0.377
MOD_GSK3_1	418	425	PF00069	0.523
MOD_LATS_1	222	228	PF00433	0.370
MOD_N-GLC_1	17	22	PF02516	0.390
MOD_NEK2_1	166	171	PF00069	0.547
MOD_NEK2_1	180	185	PF00069	0.435
MOD_NEK2_1	271	276	PF00069	0.356
MOD_NEK2_1	30	35	PF00069	0.549
MOD_NEK2_1	300	305	PF00069	0.367
MOD_NEK2_1	366	371	PF00069	0.544
MOD_NEK2_1	381	386	PF00069	0.424
MOD_NEK2_1	420	425	PF00069	0.403
MOD_NEK2_1	440	445	PF00069	0.493
MOD_NEK2_1	452	457	PF00069	0.456
MOD_NEK2_2	154	159	PF00069	0.413
MOD_PIKK_1	39	45	PF00454	0.497
MOD_PKA_2	208	214	PF00069	0.560
MOD_PKA_2	232	238	PF00069	0.448
MOD_PKA_2	282	288	PF00069	0.418
MOD_PKA_2	366	372	PF00069	0.561
MOD_PKA_2	376	382	PF00069	0.376
MOD_PKA_2	39	45	PF00069	0.497
MOD_PKA_2	440	446	PF00069	0.419
MOD_Plk_1	17	23	PF00069	0.392
MOD_Plk_1	300	306	PF00069	0.330
MOD_Plk_1	79	85	PF00069	0.509
MOD_Plk_2-3	394	400	PF00069	0.411
MOD_Plk_2-3	56	62	PF00069	0.539
MOD_Plk_4	141	147	PF00069	0.372
MOD_Plk_4	17	23	PF00069	0.475
MOD_Plk_4	237	243	PF00069	0.418
MOD_Plk_4	25	31	PF00069	0.393
MOD_Plk_4	264	270	PF00069	0.492
MOD_Plk_4	300	306	PF00069	0.473
MOD_Plk_4	440	446	PF00069	0.377
MOD_Plk_4	85	91	PF00069	0.423
MOD_ProDKin_1	132	138	PF00069	0.423
MOD_ProDKin_1	324	330	PF00069	0.468
MOD_ProDKin_1	343	349	PF00069	0.771
MOD_ProDKin_1	351	357	PF00069	0.587
TRG_DiLeu_BaEn_2	309	315	PF01217	0.305
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.306
TRG_ENDOCYTIC_2	142	145	PF00928	0.467
TRG_ENDOCYTIC_2	200	203	PF00928	0.317
TRG_ENDOCYTIC_2	305	308	PF00928	0.474
TRG_ENDOCYTIC_2	87	90	PF00928	0.407
TRG_ER_diArg_1	243	246	PF00400	0.403
TRG_ER_diArg_1	305	307	PF00400	0.469
TRG_ER_diArg_1	416	418	PF00400	0.515
TRG_ER_diArg_1	50	52	PF00400	0.474
TRG_NES_CRM1_1	310	324	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NL12	Trypanosomatidae	30%	100%
A4H4H5	Leishmania braziliensis	74%	97%
C9ZT97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4QJ72	Leishmania major	89%	100%
V5B4P7	Trypanosoma cruzi	30%	100%