Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKN4_LEIMU

TriTrypDb:

LmxM.06.0060

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AKN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.419
CLV_C14_Caspase3-7	302	306	PF00656	0.553
CLV_NRD_NRD_1	168	170	PF00675	0.511
CLV_NRD_NRD_1	197	199	PF00675	0.499
CLV_NRD_NRD_1	240	242	PF00675	0.727
CLV_NRD_NRD_1	58	60	PF00675	0.550
CLV_NRD_NRD_1	73	75	PF00675	0.618
CLV_NRD_NRD_1	87	89	PF00675	0.497
CLV_PCSK_KEX2_1	168	170	PF00082	0.366
CLV_PCSK_KEX2_1	197	199	PF00082	0.499
CLV_PCSK_KEX2_1	58	60	PF00082	0.590
CLV_PCSK_KEX2_1	87	89	PF00082	0.501
CLV_PCSK_SKI1_1	88	92	PF00082	0.483
CLV_Separin_Metazoa	265	269	PF03568	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.796
DOC_USP7_MATH_1	134	138	PF00917	0.521
DOC_USP7_MATH_1	224	228	PF00917	0.583
DOC_USP7_MATH_1	266	270	PF00917	0.563
DOC_USP7_MATH_1	290	294	PF00917	0.725
DOC_USP7_MATH_1	298	302	PF00917	0.711
DOC_WW_Pin1_4	233	238	PF00397	0.764
DOC_WW_Pin1_4	304	309	PF00397	0.733
LIG_14-3-3_CanoR_1	182	192	PF00244	0.568
LIG_14-3-3_CanoR_1	223	232	PF00244	0.570
LIG_14-3-3_CanoR_1	268	272	PF00244	0.623
LIG_14-3-3_CanoR_1	88	94	PF00244	0.572
LIG_Actin_WH2_2	204	222	PF00022	0.567
LIG_Actin_WH2_2	43	60	PF00022	0.458
LIG_BIR_III_2	305	309	PF00653	0.539
LIG_FHA_1	144	150	PF00498	0.624
LIG_FHA_1	184	190	PF00498	0.426
LIG_FHA_2	123	129	PF00498	0.576
LIG_FHA_2	234	240	PF00498	0.758
LIG_FHA_2	43	49	PF00498	0.567
LIG_FHA_2	90	96	PF00498	0.565
LIG_GBD_Chelix_1	103	111	PF00786	0.341
LIG_MYND_1	251	255	PF01753	0.605
LIG_PCNA_yPIPBox_3	91	104	PF02747	0.566
LIG_SH2_NCK_1	176	180	PF00017	0.530
LIG_SH2_STAP1	119	123	PF00017	0.543
LIG_SH2_STAT5	80	83	PF00017	0.578
LIG_SH3_3	281	287	PF00018	0.777
LIG_SH3_3	305	311	PF00018	0.596
LIG_SH3_3	59	65	PF00018	0.492
LIG_TRAF2_1	206	209	PF00917	0.639
LIG_TRAF2_1	236	239	PF00917	0.675
LIG_WRC_WIRS_1	315	320	PF05994	0.522
MOD_CDK_SPK_2	304	309	PF00069	0.541
MOD_CK1_1	143	149	PF00069	0.661
MOD_CK1_1	183	189	PF00069	0.542
MOD_CK1_1	7	13	PF00069	0.673
MOD_CK1_1	79	85	PF00069	0.553
MOD_CK2_1	122	128	PF00069	0.573
MOD_CK2_1	134	140	PF00069	0.482
MOD_CK2_1	171	177	PF00069	0.628
MOD_CK2_1	203	209	PF00069	0.542
MOD_CK2_1	233	239	PF00069	0.762
MOD_CK2_1	42	48	PF00069	0.382
MOD_Cter_Amidation	72	75	PF01082	0.603
MOD_GlcNHglycan	114	117	PF01048	0.536
MOD_GlcNHglycan	172	176	PF01048	0.552
MOD_GlcNHglycan	226	229	PF01048	0.711
MOD_GlcNHglycan	246	249	PF01048	0.718
MOD_GlcNHglycan	7	10	PF01048	0.675
MOD_GSK3_1	180	187	PF00069	0.520
MOD_GSK3_1	233	240	PF00069	0.698
MOD_GSK3_1	267	274	PF00069	0.527
MOD_GSK3_1	310	317	PF00069	0.574
MOD_NEK2_1	184	189	PF00069	0.516
MOD_NEK2_1	271	276	PF00069	0.720
MOD_NEK2_1	42	47	PF00069	0.591
MOD_NEK2_1	5	10	PF00069	0.643
MOD_PIKK_1	122	128	PF00454	0.545
MOD_PIKK_1	277	283	PF00454	0.604
MOD_PIKK_1	52	58	PF00454	0.367
MOD_PKA_1	74	80	PF00069	0.607
MOD_PKA_1	98	104	PF00069	0.564
MOD_PKA_2	267	273	PF00069	0.529
MOD_Plk_1	171	177	PF00069	0.628
MOD_Plk_4	226	232	PF00069	0.432
MOD_Plk_4	76	82	PF00069	0.618
MOD_ProDKin_1	233	239	PF00069	0.764
MOD_ProDKin_1	304	310	PF00069	0.728
MOD_SUMO_rev_2	137	144	PF00179	0.509
MOD_SUMO_rev_2	55	65	PF00179	0.511
MOD_SUMO_rev_2	94	100	PF00179	0.587
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.469
TRG_ER_diArg_1	167	169	PF00400	0.535
TRG_ER_diArg_1	197	199	PF00400	0.604
TRG_ER_diArg_1	218	221	PF00400	0.582
TRG_ER_diArg_1	57	59	PF00400	0.531
TRG_ER_diArg_1	86	88	PF00400	0.503
TRG_NES_CRM1_1	51	66	PF08389	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D4	Leptomonas seymouri	37%	80%
A0A3S5H5M8	Leishmania donovani	82%	100%
A4H4H4	Leishmania braziliensis	67%	100%
A4HSP9	Leishmania infantum	83%	100%
Q4QJ73	Leishmania major	80%	100%