PUM-HD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AKN3_LEIMU

TriTrypDb:

LmxM.06.0050

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AKN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKN3

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0003723	RNA binding	4	16
GO:0005488	binding	1	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.539
CLV_NRD_NRD_1	258	260	PF00675	0.381
CLV_PCSK_KEX2_1	258	260	PF00082	0.381
CLV_PCSK_KEX2_1	309	311	PF00082	0.365
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.427
CLV_PCSK_SKI1_1	184	188	PF00082	0.377
CLV_PCSK_SKI1_1	258	262	PF00082	0.399
DEG_APCC_DBOX_1	183	191	PF00400	0.363
DEG_APCC_DBOX_1	257	265	PF00400	0.392
DEG_MDM2_SWIB_1	353	360	PF02201	0.322
DEG_SCF_FBW7_1	130	137	PF00400	0.616
DEG_SCF_FBW7_2	230	236	PF00400	0.381
DOC_CKS1_1	230	235	PF01111	0.381
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.683
DOC_MAPK_gen_1	182	190	PF00069	0.459
DOC_MAPK_gen_1	382	391	PF00069	0.427
DOC_MAPK_MEF2A_6	182	190	PF00069	0.434
DOC_MAPK_MEF2A_6	67	74	PF00069	0.633
DOC_PP4_FxxP_1	49	52	PF00568	0.692
DOC_PP4_MxPP_1	132	135	PF00568	0.584
DOC_USP7_MATH_1	106	110	PF00917	0.581
DOC_USP7_MATH_1	135	139	PF00917	0.692
DOC_USP7_MATH_1	178	182	PF00917	0.434
DOC_USP7_MATH_1	63	67	PF00917	0.646
DOC_USP7_MATH_1	94	98	PF00917	0.493
DOC_USP7_UBL2_3	305	309	PF12436	0.381
DOC_USP7_UBL2_3	84	88	PF12436	0.738
DOC_WW_Pin1_4	130	135	PF00397	0.609
DOC_WW_Pin1_4	229	234	PF00397	0.396
DOC_WW_Pin1_4	26	31	PF00397	0.739
DOC_WW_Pin1_4	427	432	PF00397	0.410
DOC_WW_Pin1_4	433	438	PF00397	0.326
DOC_WW_Pin1_4	460	465	PF00397	0.647
DOC_WW_Pin1_4	54	59	PF00397	0.698
DOC_WW_Pin1_4	98	103	PF00397	0.625
LIG_14-3-3_CanoR_1	286	295	PF00244	0.324
LIG_14-3-3_CanoR_1	310	320	PF00244	0.367
LIG_APCC_ABBA_1	238	243	PF00400	0.445
LIG_BIR_III_2	9	13	PF00653	0.669
LIG_BRCT_BRCA1_1	113	117	PF00533	0.728
LIG_EH1_1	330	338	PF00400	0.322
LIG_FHA_1	140	146	PF00498	0.651
LIG_FHA_1	255	261	PF00498	0.394
LIG_FHA_1	428	434	PF00498	0.509
LIG_FHA_1	67	73	PF00498	0.783
LIG_FHA_2	108	114	PF00498	0.732
LIG_FHA_2	223	229	PF00498	0.361
LIG_FHA_2	461	467	PF00498	0.627
LIG_GBD_Chelix_1	332	340	PF00786	0.318
LIG_GBD_Chelix_1	373	381	PF00786	0.381
LIG_IBAR_NPY_1	93	95	PF08397	0.482
LIG_LIR_Apic_2	302	306	PF02991	0.427
LIG_LIR_Apic_2	451	457	PF02991	0.349
LIG_LIR_Apic_2	46	52	PF02991	0.664
LIG_LIR_Gen_1	164	175	PF02991	0.479
LIG_LIR_Gen_1	341	350	PF02991	0.500
LIG_LIR_Nem_3	141	146	PF02991	0.687
LIG_LIR_Nem_3	164	170	PF02991	0.409
LIG_LIR_Nem_3	341	346	PF02991	0.506
LIG_LIR_Nem_3	403	407	PF02991	0.319
LIG_LIR_Nem_3	421	425	PF02991	0.251
LIG_PCNA_yPIPBox_3	382	390	PF02747	0.437
LIG_Pex14_2	353	357	PF04695	0.388
LIG_SH2_CRK	27	31	PF00017	0.713
LIG_SH2_CRK	303	307	PF00017	0.427
LIG_SH2_CRK	422	426	PF00017	0.474
LIG_SH2_CRK	454	458	PF00017	0.551
LIG_SH2_NCK_1	303	307	PF00017	0.427
LIG_SH2_NCK_1	32	36	PF00017	0.672
LIG_SH2_NCK_1	426	430	PF00017	0.435
LIG_SH2_NCK_1	454	458	PF00017	0.406
LIG_SH2_PTP2	241	244	PF00017	0.459
LIG_SH2_PTP2	343	346	PF00017	0.488
LIG_SH2_SRC	241	244	PF00017	0.413
LIG_SH2_SRC	420	423	PF00017	0.427
LIG_SH2_STAP1	203	207	PF00017	0.436
LIG_SH2_STAP1	365	369	PF00017	0.427
LIG_SH2_STAT3	331	334	PF00017	0.304
LIG_SH2_STAT3	407	410	PF00017	0.391
LIG_SH2_STAT5	229	232	PF00017	0.374
LIG_SH2_STAT5	241	244	PF00017	0.463
LIG_SH2_STAT5	331	334	PF00017	0.282
LIG_SH2_STAT5	343	346	PF00017	0.349
LIG_SH2_STAT5	407	410	PF00017	0.391
LIG_SH2_STAT5	90	93	PF00017	0.528
LIG_SH3_3	33	39	PF00018	0.522
LIG_SH3_3	62	68	PF00018	0.745
LIG_SH3_4	305	312	PF00018	0.381
LIG_SUMO_SIM_par_1	275	283	PF11976	0.432
LIG_TYR_ITIM	424	429	PF00017	0.429
LIG_UBA3_1	226	234	PF00899	0.153
LIG_UBA3_1	297	305	PF00899	0.381
LIG_UBA3_1	319	325	PF00899	0.381
LIG_WRC_WIRS_1	350	355	PF05994	0.496
MOD_CDK_SPK_2	229	234	PF00069	0.153
MOD_CK1_1	107	113	PF00069	0.591
MOD_CK1_1	115	121	PF00069	0.520
MOD_CK1_1	138	144	PF00069	0.672
MOD_CK1_1	149	155	PF00069	0.595
MOD_CK1_1	43	49	PF00069	0.647
MOD_CK1_1	54	60	PF00069	0.561
MOD_CK1_1	66	72	PF00069	0.548
MOD_CK1_1	80	86	PF00069	0.644
MOD_CK1_1	97	103	PF00069	0.528
MOD_CK2_1	107	113	PF00069	0.748
MOD_CK2_1	149	155	PF00069	0.533
MOD_CK2_1	222	228	PF00069	0.358
MOD_GlcNHglycan	313	316	PF01048	0.427
MOD_GlcNHglycan	33	36	PF01048	0.613
MOD_GlcNHglycan	414	417	PF01048	0.410
MOD_GlcNHglycan	85	88	PF01048	0.724
MOD_GSK3_1	104	111	PF00069	0.615
MOD_GSK3_1	112	119	PF00069	0.538
MOD_GSK3_1	130	137	PF00069	0.507
MOD_GSK3_1	173	180	PF00069	0.463
MOD_GSK3_1	250	257	PF00069	0.419
MOD_GSK3_1	26	33	PF00069	0.602
MOD_GSK3_1	37	44	PF00069	0.614
MOD_GSK3_1	47	54	PF00069	0.583
MOD_GSK3_1	76	83	PF00069	0.717
MOD_GSK3_1	94	101	PF00069	0.545
MOD_NEK2_1	112	117	PF00069	0.599
MOD_NEK2_1	250	255	PF00069	0.475
MOD_NEK2_1	287	292	PF00069	0.329
MOD_NEK2_1	319	324	PF00069	0.444
MOD_NEK2_1	349	354	PF00069	0.445
MOD_NEK2_1	377	382	PF00069	0.417
MOD_NEK2_1	400	405	PF00069	0.359
MOD_NEK2_1	432	437	PF00069	0.407
MOD_OFUCOSY	99	105	PF10250	0.448
MOD_PIKK_1	104	110	PF00454	0.717
MOD_PIKK_1	251	257	PF00454	0.403
MOD_PIKK_1	287	293	PF00454	0.323
MOD_PIKK_1	43	49	PF00454	0.711
MOD_PKA_2	285	291	PF00069	0.229
MOD_PKA_2	66	72	PF00069	0.752
MOD_Plk_1	112	118	PF00069	0.687
MOD_Plk_4	117	123	PF00069	0.726
MOD_Plk_4	166	172	PF00069	0.487
MOD_Plk_4	66	72	PF00069	0.693
MOD_ProDKin_1	130	136	PF00069	0.610
MOD_ProDKin_1	229	235	PF00069	0.396
MOD_ProDKin_1	26	32	PF00069	0.741
MOD_ProDKin_1	427	433	PF00069	0.407
MOD_ProDKin_1	460	466	PF00069	0.680
MOD_ProDKin_1	54	60	PF00069	0.698
MOD_ProDKin_1	98	104	PF00069	0.628
MOD_SUMO_for_1	233	236	PF00179	0.202
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.481
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.386
TRG_ENDOCYTIC_2	203	206	PF00928	0.437
TRG_ENDOCYTIC_2	343	346	PF00928	0.486
TRG_ENDOCYTIC_2	422	425	PF00928	0.465
TRG_ENDOCYTIC_2	426	429	PF00928	0.471
TRG_ER_diArg_1	258	260	PF00400	0.378
TRG_ER_diArg_1	381	384	PF00400	0.403
TRG_NES_CRM1_1	204	216	PF08389	0.318
TRG_NES_CRM1_1	334	348	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P473	Leptomonas seymouri	28%	84%
A0A0N1HSE0	Leptomonas seymouri	63%	98%
A0A0N1ILR0	Leptomonas seymouri	34%	71%
A0A0S4J2F9	Bodo saltans	48%	100%
A0A1X0NJM4	Trypanosomatidae	48%	100%
A0A3S5IQY1	Trypanosoma rangeli	47%	100%
A0A3S7WPA1	Leishmania donovani	94%	100%
A4H4H3	Leishmania braziliensis	87%	100%
A4HSP8	Leishmania infantum	94%	98%
C9ZT94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QCQ8	Leishmania major	33%	100%
Q4QJ74	Leishmania major	93%	100%
Q9LVC3	Arabidopsis thaliana	24%	79%
V5B968	Trypanosoma cruzi	46%	100%