MRP-L46 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

39S mitochondrial ribosomal protein L46, putative

Species:

Leishmania mexicana

UniProt:

E9AKN2_LEIMU

TriTrypDb:

LmxM.06.0040

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

E9AKN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AKN2

PDB structure(s): 7aih_Ac , 7ane_Ac

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.417
CLV_NRD_NRD_1	162	164	PF00675	0.343
CLV_NRD_NRD_1	187	189	PF00675	0.454
CLV_PCSK_KEX2_1	138	140	PF00082	0.245
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.300
CLV_PCSK_SKI1_1	138	142	PF00082	0.315
CLV_PCSK_SKI1_1	278	282	PF00082	0.449
DOC_CYCLIN_RxL_1	2	16	PF00134	0.541
DOC_CYCLIN_RxL_1	272	284	PF00134	0.453
DOC_MAPK_DCC_7	30	39	PF00069	0.431
DOC_MAPK_gen_1	163	171	PF00069	0.349
DOC_MAPK_HePTP_8	161	173	PF00069	0.328
DOC_MAPK_MEF2A_6	164	173	PF00069	0.318
DOC_MAPK_MEF2A_6	30	39	PF00069	0.407
DOC_USP7_MATH_1	13	17	PF00917	0.623
DOC_USP7_MATH_1	201	205	PF00917	0.475
DOC_WW_Pin1_4	132	137	PF00397	0.296
DOC_WW_Pin1_4	28	33	PF00397	0.392
DOC_WW_Pin1_4	60	65	PF00397	0.269
LIG_14-3-3_CanoR_1	139	148	PF00244	0.336
LIG_14-3-3_CanoR_1	14	19	PF00244	0.624
LIG_14-3-3_CanoR_1	158	162	PF00244	0.409
LIG_14-3-3_CanoR_1	195	202	PF00244	0.451
LIG_14-3-3_CanoR_1	23	33	PF00244	0.406
LIG_APCC_ABBA_1	120	125	PF00400	0.220
LIG_BIR_III_2	153	157	PF00653	0.479
LIG_BRCT_BRCA1_1	267	271	PF00533	0.457
LIG_FHA_1	220	226	PF00498	0.414
LIG_FHA_1	29	35	PF00498	0.452
LIG_FHA_2	139	145	PF00498	0.240
LIG_FHA_2	148	154	PF00498	0.441
LIG_FHA_2	258	264	PF00498	0.330
LIG_IRF3_LxIS_1	277	284	PF10401	0.309
LIG_LIR_Apic_2	178	184	PF02991	0.303
LIG_LIR_Gen_1	166	173	PF02991	0.279
LIG_LIR_Nem_3	166	171	PF02991	0.283
LIG_MAD2	128	136	PF02301	0.220
LIG_NRBOX	276	282	PF00104	0.352
LIG_PCNA_yPIPBox_3	200	214	PF02747	0.306
LIG_PDZ_Class_2	286	291	PF00595	0.414
LIG_REV1ctd_RIR_1	92	102	PF16727	0.386
LIG_RPA_C_Fungi	93	105	PF08784	0.141
LIG_SH2_SRC	123	126	PF00017	0.240
LIG_SH2_SRC	170	173	PF00017	0.299
LIG_SH2_STAP1	235	239	PF00017	0.324
LIG_SH2_STAP1	267	271	PF00017	0.406
LIG_SH2_STAT5	134	137	PF00017	0.282
LIG_SH2_STAT5	170	173	PF00017	0.270
LIG_SH2_STAT5	213	216	PF00017	0.340
LIG_SH2_STAT5	239	242	PF00017	0.315
LIG_SH2_STAT5	53	56	PF00017	0.244
LIG_SH2_STAT5	73	76	PF00017	0.300
LIG_SH3_3	29	35	PF00018	0.394
LIG_SH3_3	3	9	PF00018	0.713
LIG_SUMO_SIM_par_1	279	284	PF11976	0.308
LIG_WRC_WIRS_1	246	251	PF05994	0.380
LIG_WW_3	155	159	PF00397	0.472
MOD_CDK_SPxK_1	132	138	PF00069	0.386
MOD_CDK_SPxxK_3	132	139	PF00069	0.386
MOD_CK1_1	21	27	PF00069	0.481
MOD_CK1_1	4	10	PF00069	0.549
MOD_CK1_1	87	93	PF00069	0.300
MOD_CK2_1	257	263	PF00069	0.356
MOD_CK2_1	80	86	PF00069	0.327
MOD_GlcNHglycan	141	144	PF01048	0.446
MOD_GlcNHglycan	272	275	PF01048	0.356
MOD_GlcNHglycan	282	286	PF01048	0.296
MOD_GlcNHglycan	86	89	PF01048	0.269
MOD_GSK3_1	14	21	PF00069	0.638
MOD_GSK3_1	175	182	PF00069	0.348
MOD_GSK3_1	190	197	PF00069	0.458
MOD_GSK3_1	24	31	PF00069	0.430
MOD_GSK3_1	281	288	PF00069	0.316
MOD_GSK3_1	80	87	PF00069	0.251
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	94	99	PF00069	0.334
MOD_NEK2_2	157	162	PF00069	0.505
MOD_NEK2_2	219	224	PF00069	0.371
MOD_NEK2_2	267	272	PF00069	0.452
MOD_PIKK_1	201	207	PF00454	0.389
MOD_PIKK_1	24	30	PF00454	0.398
MOD_PK_1	14	20	PF00069	0.639
MOD_PKA_1	138	144	PF00069	0.300
MOD_PKA_2	13	19	PF00069	0.655
MOD_PKA_2	138	144	PF00069	0.300
MOD_PKA_2	157	163	PF00069	0.398
MOD_PKA_2	194	200	PF00069	0.375
MOD_PKA_2	4	10	PF00069	0.675
MOD_PKA_2	80	86	PF00069	0.300
MOD_Plk_1	190	196	PF00069	0.476
MOD_Plk_1	227	233	PF00069	0.350
MOD_Plk_4	14	20	PF00069	0.551
MOD_Plk_4	219	225	PF00069	0.355
MOD_Plk_4	235	241	PF00069	0.269
MOD_ProDKin_1	132	138	PF00069	0.296
MOD_ProDKin_1	28	34	PF00069	0.396
MOD_ProDKin_1	60	66	PF00069	0.269
MOD_SUMO_rev_2	248	253	PF00179	0.455
TRG_DiLeu_BaEn_1	70	75	PF01217	0.255
TRG_ENDOCYTIC_2	170	173	PF00928	0.270
TRG_NES_CRM1_1	112	125	PF08389	0.252
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH67	Leptomonas seymouri	74%	100%
A0A0S4J242	Bodo saltans	51%	100%
A0A1X0NJC0	Trypanosomatidae	65%	100%
A0A3S7WPC6	Leishmania donovani	94%	100%
A0A422NCS2	Trypanosoma rangeli	64%	100%
A4H4H2	Leishmania braziliensis	85%	100%
A4HSP7	Leishmania infantum	95%	100%
C9ZT91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	98%
Q3SZ22	Bos taurus	26%	100%
Q4QJ75	Leishmania major	95%	100%
Q5RBU2	Pongo abelii	27%	100%
Q5RK00	Rattus norvegicus	27%	100%
Q9EQI8	Mus musculus	28%	100%
Q9H2W6	Homo sapiens	28%	100%
V5AP90	Trypanosoma cruzi	66%	100%